| Dimerization of Human Drebrin-like Protein Governs Its Biological Activity. | Dimerization of Human Drebrin-like Protein Governs Its Biological Activity.
Ghosh A, Enderlein J, Butkevich E. | 01/2/2021 |
| findings show that mAbp1 and FHL2 are novel binding partners that differentially regulate Rho GTPase signaling and MTLn3 breast cancer cell invasion | Mammalian Actin-binding Protein-1/Hip-55 Interacts with FHL2 and Negatively Regulates Cell Invasion.
Boateng LR, Bennin D, De Oliveira S, Huttenlocher A., Free PMC Article | 12/24/2016 |
| Data suggest that by binding to both clathrin and F-actin, mammalian actin-binding protein 1 (mAbp1; HIP-55 or SH3P7) is specifically recruited at a late stage of clathrin-coated pits (CCPs) formation, which subsequently recruits dynamin to CCPs. | Mammalian actin-binding protein 1/HIP-55 is essential for the scission of clathrin-coated pits by regulating dynamin-actin interaction.
He K, Xing R, Yan X, Tian A, Zhang M, Yuan J, Lv Z, Fang X, Li Z, Zhang Y. | 08/29/2015 |
| The results presented here indicate that targeting IL-1alpha with subcutaneous MABp1 adminisration has a strong potential therapeutic value in treating psoriasis and may provide a novel future treatment of this often devastating disease. | Open-Label Trial of MABp1, a True Human Monoclonal Antibody Targeting Interleukin 1α, for the Treatment of Psoriasis.
Coleman KM, Gudjonsson JE, Stecher M. | 08/8/2015 |
| Data indicate that fourteen phosphorylation sites along the primary structure of hematopoietic progenitor kinase 1 (HPK1)-interacting protein of 55 kDa (HIP-55) rotein were identified. | Phosphosite mapping of HIP-55 protein in mammalian cells.
Liu N, Sun N, Gao X, Li Z., Free PMC Article | 02/14/2015 |
| HIP-55 expression promoted proliferation, colony formation, migration, and invasion of lung cancer cells and was upregulated in lung cancer cell lines and tumor tissues of lung cancer patients | Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs.
Li Z, Park HR, Shi Z, Li Z, Pham CD, Du Y, Khuri FR, Zhang Y, Han Q, Fu H., Free PMC Article | 01/24/2015 |
| Data suggest that HIP-55 could play an important role in the growth and cellular proliferation and HIP-55 dysfunction could be involved in tumorigenesis. | Regulation of cell survival by the HIP-55 signaling network.
Yang C, Li Z, Shi Z, He K, Tian A, Wu J, Zhang Y, Li Z. | 01/17/2015 |
| mAbp1 is of fundamental importance for spreading and migration under shear stress conditions, which are critical prerequisites for efficient PMN extravasation during inflammation. | The mammalian actin-binding protein 1 is critical for spreading and intraluminal crawling of neutrophils under flow conditions.
Hepper I, Schymeinsky J, Weckbach LT, Jakob SM, Frommhold D, Sixt M, Laschinger M, Sperandio M, Walzog B. | 06/16/2012 |
| Filamentous actin (F-actin)-binding protein 1 (Abp1/SH3P7/HIP-55) has a profound impact on synaptic organization by making a required functional connection between postsynaptic density components and postsynaptic actin dynamics. | The actin-binding protein Abp1 controls dendritic spine morphology and is important for spine head and synapse formation.
Haeckel A, Ahuja R, Gundelfinger ED, Qualmann B, Kessels MM., Free PMC Article | 01/21/2010 |
| HIP-55 has roles in T-cell proliferation, cytokine production, and immune responses | HIP-55 is important for T-cell proliferation, cytokine production, and immune responses.
Han J, Shui JW, Zhang X, Zheng B, Han S, Tan TH., Free PMC Article | 01/21/2010 |
| HIP-55 is a key novel component of the immunological synapse that modulates T cell activation by connecting actin cytoskeleton and TCRs to gene activation and endocytic processes | Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis.
Le Bras S, Foucault I, Foussat A, Brignone C, Acuto O, Deckert M. | 01/21/2010 |
| unexpected role of 3BP2 in endocytic and cytoskeletal regulation through its interaction with CIN85 and HIP-55 | Abl-SH3 binding protein 2, 3BP2, interacts with CIN85 and HIP-55.
Le Bras S, Moon C, Foucault I, Breittmayer JP, Deckert M. | 01/21/2010 |
| substrate for caspase cleavage during apoptosis | Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis.
Chen YR, Kori R, John B, Tan TH. | 01/21/2010 |
| SH3P7 is essential for endocytosis but not lamellipodia formation. | Mammalian actin binding protein 1 is essential for endocytosis but not lamellipodia formation: functional analysis by RNA interference.
Mise-Omata S, Montagne B, Deckert M, Wienands J, Acuto O. | 01/21/2010 |
| HIP-55 plays a functional role in TCR signaling | The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling.
Han J, Kori R, Shui JW, Chen YR, Yao Z, Tan TH. | 01/21/2010 |