Gpx4 Regulates Invariant NKT Cell Homeostasis and Function by Preventing Lipid Peroxidation and Ferroptosis.
Sok SPM, Pipkin K, Popescu NI, Reidy M, Li B, Van Remmen H, Kinter M, Sun XH, Fan Z, Zhao M.,

KLF14 directly downregulates the expression of GPX4 to exert antitumor effects by promoting ferroptosis in cervical cancer.
Ye H, Ding X, Lv X, Du Y, Guo R, Qiu J, Li R, Cao L., Free PMC Article

GSTO2 ameliorates human neuroblastoma cell apoptosis, inflammation, ferroptosis, and oxidative stress by upregulating GPX4 expression in intracerebral hemorrhage.
Liu C, Tian W, Lei D.

GPX4 restricts ferroptosis of NKp46(+)ILC3s to control intestinal inflammation.
Li X, He J, Gao X, Zheng G, Chen C, Chen Y, Xing Z, Wang T, Tang J, Guo Y, He Y., Free PMC Article

Knockdown of lncRNA NEAT1 suppresses streptococcus pneumoniae-induced ferroptosis in alveolar epithelial cells by regulating the Nrf2-GPX4 pathway.
Xu L, Zhang L, Xiang Y, Zhang X.

Silencing CK19 regulates ferroptosis by affecting the expression of GPX4 and ACSL4 in oral squamous cell carcinoma in vivo and in vitro.
Rao Y, Li J, Shi L, Chen X, Hu Y, Mao Y, Zhang X, Liu X., Free PMC Article

Emerging role of glutathione peroxidase 4 in myeloid cell lineage development and acute myeloid leukemia.
Auberger P, Favreau C, Savy C, Jacquel A, Robert G., Free PMC Article

PLAG1 interacts with GPX4 to conquer vulnerability to sorafenib induced ferroptosis through a PVT1/miR-195-5p axis-dependent manner in hepatocellular carcinoma.
Li J, Li Y, Wang D, Liao R, Wu Z., Free PMC Article

Dipeptidase 1 promotes ferroptosis in renal tubular epithelial cells in diabetic nephropathy via inhibition of the GSH/GPX4 axis.
Li Y, Wang X, Zhang Q, Tian D, Bai Y, Feng Y, Liu W, Diao Z.

PITX2 functions as a transcription factor for GPX4 and protects pancreatic cancer cells from ferroptosis.
Wang Z, Wu D, Zhang Y, Chen W, Yang Y, Yang Y, Zu G, An Y, Yu X, Qin Y, Xu X, Chen X.

GPX4 inhibits apoptosis of thyroid cancer cells through regulating the FKBP8/Bcl-2 axis.
Dang T, Yu J, Yu Y, Jiang J, Shi Y, Yu S, Peng C, Min X, Xiong Y, Long P, Zhou W, Dai D., Free PMC Article

GPX4, ferroptosis, and diseases.
Zhang W, Liu Y, Liao Y, Zhu C, Zou Z.

Targeting BMAL1 reverses drug resistance of acute myeloid leukemia cells and promotes ferroptosis through HMGB1-GPX4 signaling pathway.
Zheng H, Wu T, Lin Z, Wang D, Zhang J, Zeng T, Liu L, Shen J, Zhao M, Li JD, Yang M., Free PMC Article

Orexin-A mediates glioblastoma proliferation inhibition by increasing ferroptosis triggered by unstable iron pools and GPX4 depletion.
Huan R, Zhang J, Yue J, Yang S, Han G, Cheng Y, Tan Y., Free PMC Article

Glutathione peroxidase 4 restrains temporomandibular joint osteoarthritis progression by inhibiting ferroptosis.
Pang C, Zhang H, Liu Y, Tang N, Tian K, Mu Y, Li X, Xiao L., Free PMC Article

CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4.
Chen S, Fan J, Xie P, Ahn J, Fernandez M, Billingham LK, Miska J, Wu JD, Wainwright DA, Fang D, Sosman JA, Wan Y, Zhang Y, Chandel NS, Zhang B., Free PMC Article

Targeting GPX4-mediated Ferroptosis Alleviates Liver Steatosis in a Rat Model of Total Parenteral Nutrition.
Cheng S, Wang Y, Zhao Y, Wang N, Yan J, Jiang L, Cai W.

Overexpression of TNFSF11 reduces GPX4 levels and increases sensitivity to ferroptosis inducers in lung adenocarcinoma.
Li Z, Lu W, Yin F, Zeng P, Li H, Huang A., Free PMC Article

Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis.
Zhou XN, Zhang Q, Peng H, Qin YJ, Liu YH, Wang L, Cheng ML, Luo XH, Li H., Free PMC Article

Selenium binding protein 1 protects renal tubular epithelial cells from ferroptosis by upregulating glutathione peroxidase 4.
Zhao W, Nikolic-Paterson DJ, Li K, Li Y, Wang Y, Chen X, Duan Z, Zhang Y, Liu P, Lu S, Fu R, Tian L.

Hypermethylation of the glutathione peroxidase 4 gene promoter is associated with the occurrence of immune tolerance phase in chronic hepatitis B.
Su X, Wang Z, Li J, Gao S, Fan Y, Wang K., Free PMC Article

Depletion of the N(6)-Methyladenosine (m6A) reader protein IGF2BP3 induces ferroptosis in glioma by modulating the expression of GPX4.
Deng L, Di Y, Chen C, Xia J, Lei B, Li N, Zhang Q., Free PMC Article

Ferroptosis-related gene glutathione peroxidase 4 promotes reprogramming of glucose metabolism via Akt-mTOR axis in intrahepatic cholangiocarcinoma.
Hori Y, Yoh T, Nishino H, Okura K, Kurimoto M, Takamatsu Y, Satoh M, Nishio T, Koyama Y, Ishii T, Iwaisako K, Seo S, Hatano E.

GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.
Chen Y, Feng Y, Lin Y, Zhou X, Wang L, Zhou Y, Lin K, Cai L., Free PMC Article

Circular RNA 0016142 Knockdown Induces Ferroptosis in Hepatocellular Carcinoma Cells via Modulation of the MicroRNA-188-3p/Glutathione Peroxidase 4 Axis.
Liu Y, Li J.