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    AQP11 aquaporin 11 [ Homo sapiens (human) ]

    Gene ID: 282679, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Protective roles of peroxiporins AQP0 and AQP11 in human astrocyte and neuronal cell lines in response to oxidative and inflammatory stressors.

    Protective roles of peroxiporins AQP0 and AQP11 in human astrocyte and neuronal cell lines in response to oxidative and inflammatory stressors.
    Amro Z, Collins-Praino LE, Yool AJ., Free PMC Article

    03/27/2024
    Aquaporin 11 alleviates retinal Muller intracellular edema through water efflux in diabetic retinopathy.

    Aquaporin 11 alleviates retinal Müller intracellular edema through water efflux in diabetic retinopathy.
    Zhang C, Luo D, Xie H, Yang Q, Liu D, Tang L, Zhang J, Li W, Tian H, Lu L, Sun X, Xu GT, Zhang J.

    03/7/2023
    Variants in AQP11 may result in autosomal recessive bilateral cystic renal dysgenesis.

    Variants in AQP11 may result in autosomal recessive bilateral cystic renal dysgenesis.
    Price ME, Fishler KP, Muff-Luett M, Mauch TJ, Brunelli L, Euteneuer JC.

    01/21/2023
    Aquaporin-11 Contributes to TGF-beta1-Induced Endoplasmic Reticulum Stress in Human Visceral Adipocytes: Role in Obesity-Associated Inflammation.

    Aquaporin-11 Contributes to TGF-β1-Induced Endoplasmic Reticulum Stress in Human Visceral Adipocytes: Role in Obesity-Associated Inflammation.
    Frühbeck G, Balaguer I, Méndez-Giménez L, Valentí V, Becerril S, Catalán V, Gómez-Ambrosi J, Silva C, Salvador J, Calamita G, Malagón MM, Rodríguez A., Free PMC Article

    03/6/2021
    Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane.

    Human aquaporin-11 guarantees efficient transport of H(2)O(2) across the endoplasmic reticulum membrane.
    Bestetti S, Galli M, Sorrentino I, Pinton P, Rimessi A, Sitia R, Medraño-Fernandez I., Free PMC Article

    10/24/2020
    Hydrogen peroxide in the ER: A tale of triage.

    Hydrogen peroxide in the ER: A tale of triage.
    Rashdan NA, Pattillo CB., Free PMC Article

    10/3/2020
    The AQP11 rs2276415 variant may have a role in chronic kidney disease progression in the Chinese population, independent of traditional risk factors

    Aquaporin 11 rs2276415 variant and progression of chronic kidney disease.
    Han B, Wu X, Huang PP, Zhu FX, Liu S.

    04/18/2020
    These results indicated that hepatitis C virus (HCV) infection induced a miR-27b-mediated reduction in AQP11 expression, leading to a modest reduction in HCV genome levels in the cells.

    miR-27b-mediated suppression of aquaporin-11 expression in hepatocytes reduces HCV genomic RNA levels but not viral titers.
    Sakurai F, Hashimoto R, Inoue C, Wakabayashi K, Tsukamoto T, Imaizumi T, Andres TGM, Sakai E, Itsuki K, Sakamoto N, Wakita T, Mizuguchi H., Free PMC Article

    06/15/2019
    Aquaporins AQP3, -7, -8, and -11 proteins were found in sperm cells and localized in the head (AQP7), in the middle piece (AQP8) and in the tail (AQP3 and -11) in both the plasma membrane and in intracellular structures.

    Aquaporin-Mediated Water and Hydrogen Peroxide Transport Is Involved in Normal Human Spermatozoa Functioning.
    Laforenza U, Pellavio G, Marchetti AL, Omes C, Todaro F, Gastaldi G., Free PMC Article

    04/22/2017
    Identify rs2276415 as a candidate genetic factor predisposing patients with type 2 diabetes to chronic kidney disease.

    Aquaporin 11 variant associates with kidney disease in type 2 diabetic patients.
    Choma DP, Vanacore R, Naylor H, Zimmerman IA, Pavlichenko A, Pavlichenko A, Foye L, Carbone DP, Harris RC, Dikov MM, Tchekneva EE., Free PMC Article

    07/30/2016
    hAQP11 permeates both water and glycerol, localizing in the vicinity of lipid droplets in human adipocytes.

    Human aquaporin-11 is a water and glycerol channel and localizes in the vicinity of lipid droplets in human adipocytes.
    Madeira A, Fernández-Veledo S, Camps M, Zorzano A, Moura TF, Ceperuelo-Mallafré V, Vendrell J, Soveral G.

    08/29/2015
    Built accurate 3D-models for AQP11 and AQP12 and comprehensively compared their sequence and structure to other known aquaporins.

    In silico study of human aquaporin AQP11 and AQP12 channels.
    Calvanese L, Pellegrini-Calace M, Oliva R., Free PMC Article

    08/31/2013
    the corresponding NPC motif of AQP11 is essential for full expression of molecular function.

    The NPC motif of aquaporin-11, unlike the NPA motif of known aquaporins, is essential for full expression of molecular function.
    Ikeda M, Andoo A, Shimono M, Takamatsu N, Taki A, Muta K, Matsushita W, Uechi T, Matsuzaki T, Kenmochi N, Takata K, Sasaki S, Ito K, Ishibashi K., Free PMC Article

    03/26/2011
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