| Role of Glutamine Synthetase on Vascular Permeability in Gliomas. | Role of Glutamine Synthetase on Vascular Permeability in Gliomas.
Wang D, Song T, Hu Z, Wang H, Qian J. | 11/5/2024 |
| Clustered de novo start-loss variants in GLUL result in a developmental and epileptic encephalopathy via stabilization of glutamine synthetase. | Clustered de novo start-loss variants in GLUL result in a developmental and epileptic encephalopathy via stabilization of glutamine synthetase.
Jones AG, Aquilino M, Tinker RJ, Duncan L, Jenkins Z, Carvill GL, DeWard SJ, Grange DK, Hajianpour MJ, Halliday BJ, Holder-Espinasse M, Horvath J, Maitz S, Nigro V, Morleo M, Paul V, Spencer C, Esterhuizen AI, Polster T, Spano A, Gómez-Lozano I, Kumar A, Poke G, Phillips JA 3rd, Underhill HR, Gimenez G, Namba T, Robertson SP., Free PMC Article | 04/17/2024 |
| Leat-associated seizures the possible role of EAAT2, pyruvate carboxylase and glutamine synthetase. | Leat-associated seizures the possible role of EAAT2, pyruvate carboxylase and glutamine synthetase.
Buccoliero AM, Caporalini C, Moscardi S, Cetica V, Mei D, Conti V, Nozzoli F, Bonaudo C, Battista F, Giordano F, Mura R, Spacca B, Mussa F, D'Onofrio V, Guerrini R, Genitori L, Scagnet M. | 01/17/2024 |
| Glutamine synthetase and hepatocellular carcinoma. | Glutamine synthetase and hepatocellular carcinoma.
Jiang J, Hu Y, Fang D, Luo J. | 12/20/2023 |
| PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma. | PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma.
Peng S, Wang Z, Tang P, Wang S, Huang Y, Xie Q, Wang Y, Tan X, Tang T, Yan X, Xu J, Lan W, Wang L, Zhang D, Wang B, Pan T, Qin J, Jiang J, Liu Q., Free PMC Article | 08/4/2023 |
| Single-cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE+CTSZ+TAM in cancers. | Single-cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE+CTSZ+TAM in cancers.
Wei J, Yu W, Chen J, Huang G, Zhang L, Chen Z, Hu M, Gong X, Du H., Free PMC Article | 04/14/2023 |
| Multiple oxidative post-translational modifications of human glutamine synthetase mediate peroxynitrite-dependent enzyme inactivation and aggregation. | Multiple oxidative post-translational modifications of human glutamine synthetase mediate peroxynitrite-dependent enzyme inactivation and aggregation.
Campolo N, Mastrogiovanni M, Mariotti M, Issoglio FM, Estrin D, Hägglund P, Grune T, Davies MJ, Bartesaghi S, Radi R., Free PMC Article | 04/4/2023 |
| Glutamine synthetase limits beta-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1. | Glutamine synthetase limits β-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1.
Dai W, Shen J, Yan J, Bott AJ, Maimouni S, Daguplo HQ, Wang Y, Khayati K, Guo JY, Zhang L, Wang Y, Valvezan A, Ding WX, Chen X, Su X, Gao S, Zong WX., Free PMC Article | 01/14/2023 |
| Glutamine synthetase regulates the immune microenvironment and cancer development through the inflammatory pathway. | Glutamine synthetase regulates the immune microenvironment and cancer development through the inflammatory pathway.
Xuan DTM, Wu CC, Wang WJ, Hsu HP, Ta HDK, Anuraga G, Chiao CC, Wang CY., Free PMC Article | 01/14/2023 |
| Crystal structure of N-terminal degron-truncated human glutamine synthetase. | Crystal structure of N-terminal degron-truncated human glutamine synthetase.
Chek MF, Kim SY, Mori T, Kojima H, Hakoshima T., Free PMC Article | 04/9/2022 |
| Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia. | Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia.
Nguyen TL, Nokin MJ, Terés S, Tomé M, Bodineau C, Galmar O, Pasquet JM, Rousseau B, van Liempd S, Falcon-Perez JM, Richard E, Muzotte E, Rezvani HR, Priault M, Bouchecareilh M, Redonnet-Vernhet I, Calvo J, Uzan B, Pflumio F, Fuentes P, Toribio ML, Khatib AM, Soubeyran P, Murdoch PDS, Durán RV., Free PMC Article | 04/2/2022 |
| Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival. | Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival.
Schmidt A, Armento A, Bussolati O, Chiu M, Ellerkamp V, Scharpf MO, Sander P, Schmid E, Warmann SW, Fuchs J., Free PMC Article | 10/23/2021 |
| Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis. | Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis.
Dong Z, Lei X, Kujawa SA, Bolu N, Zhao H, Wang C., Free PMC Article | 10/16/2021 |
| Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1. | Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1.
Tsai PY, Lee MS, Jadhav U, Naqvi I, Madha S, Adler A, Mistry M, Naumenko S, Lewis CA, Hitchcock DS, Roberts FR, DelNero P, Hank T, Honselmann KC, Morales Oyarvide V, Mino-Kenudson M, Clish CB, Shivdasani RA, Kalaany NY., Free PMC Article | 08/21/2021 |
| Homozygous GLUL deletion is embryonically viable and leads to glutamine synthetase deficiency. | Homozygous GLUL deletion is embryonically viable and leads to glutamine synthetase deficiency.
Roifman M, Niles KM, MacNeil L, Blaser S, Noor A, Godoy R, van Mieghem T, Ryan G, Seaward G, Sondheimer N, Mercimek-Andrews S, Schulze A, Hewson S, Ovadia A, Chitayat D, Morgen EK, Hojilla C, Kolomietz E, Watkins N, Häberle J, Shannon P. | 08/21/2021 |
| Nodular Regenerative Hyperplasia: Expression Pattern of Glutamine Synthetase and a Potential Role for Hepatic Progenitor Cells. | Nodular Regenerative Hyperplasia: Expression Pattern of Glutamine Synthetase and a Potential Role for Hepatic Progenitor Cells.
Guilbert MC, Therrien A, Soucy G, Trudel D, Nguyen BN. | 06/5/2021 |
| Predictive Patterns of Glutamine Synthetase Immunohistochemical Staining in CTNNB1-mutated Hepatocellular Adenomas. | Predictive Patterns of Glutamine Synthetase Immunohistochemical Staining in CTNNB1-mutated Hepatocellular Adenomas.
Sempoux C, Gouw ASH, Dunet V, Paradis V, Balabaud C, Bioulac-Sage P. | 05/15/2021 |
| Utility of glutamine synthetase immunohistochemistry in identifying features of regressed cirrhosis. | Utility of glutamine synthetase immunohistochemistry in identifying features of regressed cirrhosis.
Hadi R, Shin K, Reder N, Alpert L, Koch L, Choi WT, Swanson PE, Hart J, Westerhoff M. | 02/2/2021 |
| MicroRNA-140-5p suppresses invasion and proliferation of glioma cells by targeting glutamate-ammonia ligase (GLUL). | MicroRNA-140-5p suppresses invasion and proliferation of glioma cells by targeting glutamate-ammonia ligase (GLUL).
Zhang R, Zhu JC, Hu H, Lin QY, Shao W, Ji TH. | 08/22/2020 |
| Glutamine Synthetase Promotes Radiation Resistance via Facilitating Nucleotide Metabolism and Subsequent DNA Damage Repair. | Glutamine Synthetase Promotes Radiation Resistance via Facilitating Nucleotide Metabolism and Subsequent DNA Damage Repair.
Fu S, Li Z, Xiao L, Hu W, Zhang L, Xie B, Zhou Q, He J, Qiu Y, Wen M, Peng Y, Gao J, Tan R, Deng Y, Weng L, Sun LQ. | 08/22/2020 |
| Our data reveal time-resolved changes in the regulation of metabolic proteins under oxygen-deprived conditions and elucidate GLUL as a strong responder to HIFs and the hypoxic environment. | Functional Proteomics of Breast Cancer Metabolism Identifies GLUL as Responder during Hypoxic Adaptation.
Bernhardt S, Tönsing C, Mitra D, Erdem N, Müller-Decker K, Korf U, Kreutz C, Timmer J, Wiemann S. | 05/16/2020 |
| High expression of glutamate-ammonia ligase is associated with ovarian cancer. | High expression of glutamate-ammonia ligase is associated with unfavorable prognosis in patients with ovarian cancer.
Fan S, Wang Y, Zhang Z, Lu J, Wu Z, Shan Q, Sun C, Wu D, Li M, Sheng N, Xie Y, Zheng Y. | 05/4/2019 |
| findings reveal that, in addition to the known formation of glutamine, the enzyme glutamine synthetase shows unknown activity in endothelial cell migration during pathological angiogenesis through RHOJ palmitoylation | Role of glutamine synthetase in angiogenesis beyond glutamine synthesis.
Eelen G, Dubois C, Cantelmo AR, Goveia J, Brüning U, DeRan M, Jarugumilli G, van Rijssel J, Saladino G, Comitani F, Zecchin A, Rocha S, Chen R, Huang H, Vandekeere S, Kalucka J, Lange C, Morales-Rodriguez F, Cruys B, Treps L, Ramer L, Vinckier S, Brepoels K, Wyns S, Souffreau J, Schoonjans L, Lamers WH, Wu Y, Haustraete J, Hofkens J, Liekens S, Cubbon R, Ghesquière B, Dewerchin M, Gervasio FL, Li X, van Buul JD, Wu X, Carmeliet P. | 12/22/2018 |
| In silico analysis potentially links GLUL SNPs with major depression disorder. | In Silico Preliminary Association of Ammonia Metabolism Genes GLS, CPS1, and GLUL with Risk of Alzheimer's Disease, Major Depressive Disorder, and Type 2 Diabetes.
Griffin JWD, Liu Y, Bradshaw PC, Wang K. | 09/8/2018 |
| The SNP rs10911021 near glutamate-ammonia ligase is associated with oxidative stress in coronary heart disease patients from Pakistan. | The SNP rs10911021 is associated with oxidative stress in coronary heart disease patients from Pakistan.
Shahid SU, Shabana, Humphries S., Free PMC Article | 08/11/2018 |