| Genomic alterations and abnormal expression of APE2 in multiple cancers. | Genomic alterations and abnormal expression of APE2 in multiple cancers.
Jensen KA, Shi X, Yan S., Free PMC Article | 11/21/2020 |
| Authors now show by immunoelectron microscopy that VAPB also localizes to the inner nuclear membrane (INM). Using a modified enhanced ascorbate peroxidase 2 (APEX2) approach with rapamycin-dependent targeting of the peroxidase to a protein of interest, we searched for proteins that are in close proximity to VAPB, particularly at the INM. | Proteomic mapping by rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane.
James C, Müller M, Goldberg MW, Lenz C, Urlaub H, Kehlenbach RH., Free PMC Article | 07/25/2020 |
| we propose a two-step APE1/APE2-mediated mechanism for DNA single-strand breaks (SSBs) end resection that couples DNA damage response with SSB repair in a eukaryotic system. | APE1 senses DNA single-strand breaks for repair and signaling.
Lin Y, Raj J, Li J, Ha A, Hossain MA, Richardson C, Mukherjee P, Yan S., Free PMC Article | 03/21/2020 |
| we describe the use of Clustered Regularly Interspaced Short Palindromic Repeats and an engineered ascorbate peroxidase 2 (APEX2) system to investigate local chromatin interactions (CAPLOCUS). We showed that with specific small-guide RNA targets, CAPLOCUS could efficiently identify both repetitive genomic regions and single-copy genomic locus with high resolution. | Determination of local chromatin interactions using a combined CRISPR and peroxidase APEX2 system.
Qiu W, Xu Z, Zhang M, Zhang D, Fan H, Li T, Wang Q, Liu P, Zhu Z, Du D, Tan M, Wen B, Liu Y., Free PMC Article | 11/23/2019 |
| Identified APEX2 and FEN1 as synthetic lethal genes with both BRCA1 and BRCA2 loss of function in tumor cell lines. | Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.
Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJ., Free PMC Article | 06/29/2019 |
| Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2. | Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2.
Hossain MA, Lin Y, Yan S., Free PMC Article | 11/17/2018 |
| Observational study of gene-disease association. (HuGE Navigator) | Variation within DNA repair pathway genes and risk of multiple sclerosis.
Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF, International Multiple Sclerosis Genetics Consortium., Free PMC Article | 06/30/2010 |
| Ape2 may be involved in repair of oxidative DNA damage and PCNA-dependent repair synthesis. | Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage.
Burkovics P, Hajdú I, Szukacsov V, Unk I, Haracska L., Free PMC Article | 01/21/2010 |
| Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. | Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW. | 01/28/2009 |
| Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III | Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III.
Hadi MZ, Ginalski K, Nguyen LH, Wilson DM 3rd. | 01/21/2010 |
| Ape2 exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity. | Human Ape2 protein has a 3'-5' exonuclease activity that acts preferentially on mismatched base pairs.
Burkovics P, Szukacsov V, Unk I, Haracska L., Free PMC Article | 01/21/2010 |