| AMCase expression was significantly higher in helminths-infected patients than the noninfected, or protozoa infected. | Acidic mammalian chitinase tuning after enteric helminths eradication in inflammatory respiratory disease patients.
Hasby Saad MA, Watany M, Tomoum M, El-Mehy D, Elsheikh M, Sharshar R. | 08/17/2019 |
| rs10494132 polymorphism of CHIA might be a risk factor for asthma. | Association between risk of asthma and gene polymorphisms in CHI3L1 and CHIA: a systematic meta-analysis.
Zhu Y, Yan X, Zhai C, Yang L, Li M., Free PMC Article | 08/4/2018 |
| we showed that M at the position 61 is highly conserved in the many mammals other than orangutan and humans. In addition, introduction of M61R and M61I to WT mouse AMCase lead to a significant reduction of its chitinolytic activity. Taken together, our present and previous data by Seibold et al. (2009) indicate that G339T (R61M) in humans is associated with asthma protection in the fashion of gain of function | Loss and Gain of Human Acidic Mammalian Chitinase Activity by Nonsynonymous SNPs.
Okawa K, Ohno M, Kashimura A, Kimura M, Kobayashi Y, Sakaguchi M, Sugahara Y, Kamaya M, Kino Y, Bauer PO, Oyama F., Free PMC Article | 07/1/2017 |
| This is the first report on the association between low-frequency and common variants in the chitinases-related genes CHIA and CHI3L1 with the intensity of specific IgE to ABA-1 in a population naturally exposed to Ascaris and with Bet v 1 in a Swedish population. | Genetic Variants in CHIA and CHI3L1 Are Associated with the IgE Response to the Ascaris Resistance Marker ABA-1 and the Birch Pollen Allergen Bet v 1.
Acevedo N, Bornacelly A, Mercado D, Unneberg P, Mittermann I, Valenta R, Kennedy M, Scheynius A, Caraballo L., Free PMC Article | 07/1/2017 |
| These data provide the experimental evidence that telomere shortening and related inflammatory proteins are associated with human IgAN, and it could be a new direction for the disease progression study. | Proteins induced by telomere dysfunction are associated with human IgA nephropathy.
Lu YY, Yang X, Chen WQ, Ju ZY, Shou ZF, Jin J, Zhang XH, Chen JH, Jiang H., Free PMC Article | 01/17/2015 |
| loss of acidic chitinase expression is a promising marker for corpus atrophy | Transcriptome signatures in Helicobacter pylori-infected mucosa identifies acidic mammalian chitinase loss as a corpus atrophy marker.
Nookaew I, Thorell K, Worah K, Wang S, Hibberd ML, Sjövall H, Pettersson S, Nielsen J, Lundin SB., Free PMC Article | 06/28/2014 |
| results showed that the expression of AMCase and CHIT-1 were differently modulated in monocyte macrophages at different stage of maturation. The behavior of these two active chitinase suggests that in the immune response their role is complementary. | Evaluation of AMCase and CHIT-1 expression in monocyte macrophages lineage.
Di Rosa M, De Gregorio C, Malaguarnera G, Tuttobene M, Biazzo F, Malaguarnera L. | 06/29/2013 |
| study demonstrated genetic associations between chitinase gene variants and lung function level and rate of decline in chronic obstructive pulmonary disease patients from the Lung Health Study; also functional effect of the rs3818822 polymorphism on AMCase levels and activity was demonstrated | Genetic association between human chitinases and lung function in COPD.
Aminuddin F, Akhabir L, Stefanowicz D, Paré PD, Connett JE, Anthonisen NR, Fahy JV, Seibold MA, Burchard EG, Eng C, Gulsvik A, Bakke P, Cho MH, Litonjua A, Lomas DA, Anderson WH, Beaty TH, Crapo JD, Silverman EK, Sandford AJ., Free PMC Article | 11/24/2012 |
| increased chitinolytic activity in nasal polyps | Chitinolytic activity in nasal polyps.
Park SK, Heo KW, Hur DY, Yang YI. | 12/3/2011 |
| Report increased CSF chitinase levels in patients with neuromyelitis optica and relapsing remitting multiple sclerosis. | Chitinase effects on immune cell response in neuromyelitis optica and multiple sclerosis.
Correale J, Fiol M. | 10/8/2011 |
| A ten base pair insertion in the second exon in the 5'UTR region of the AMCase gene may modify the gene expression and thus may affect the severity of asthma. | The effects of an insertion in the 5'UTR of the AMCase on gene expression and pulmonary functions.
Birben E, Sackesen C, Kazani S, Tincer G, Karaaslan C, Durgunsu B, Gürsel I, Wechsler ME, Israel E, Kalayci O. | 09/10/2011 |
| AMCase and eotaxin-3 may be important mediators in the pathogenesis of nasal polyps. The increased AMCase and eotaxin-3 might lead to nasal polyp formation and growth. | Expression and role of acidic mammalian chitinase and eotaxin-3 in chronic rhinosinusitis with nasal polyps.
Gu Z, Cao Z, Jin M. | 06/18/2011 |
| Results showed the presence of CHIT1 and AMCase mRNA in gastric mucosa and the correlation with the presence of H. pylori was significant only for CHIT1 but not for AMCase expression. | CHIT1 and AMCase expression in human gastric mucosa: correlation with inflammation and Helicobacter pylori infection.
Cozzarini E, Bellin M, Norberto L, Polese L, Musumeci S, Lanfranchi G, Paoletti MG. | 11/6/2010 |
| Environmental exposure to fungi does not modify the effect of CHIA SNPs on severe asthma exacerbations | Fungal exposure modulates the effect of polymorphisms of chitinases on emergency department visits and hospitalizations.
Wu AC, Lasky-Su J, Rogers CA, Klanderman BJ, Litonjua AA., Free PMC Article | 10/23/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Joint influences of Acidic-Mammalian-Chitinase with Interleukin-4 and Toll-like receptor-10 with Interleukin-13 in the genetics of asthma.
Heinzmann A, Brugger M, Bierbaum S, Mailaparambil B, Kopp MV, Strauch K. | 06/30/2010 |
| The levels of expression of AMCase and chitotriosidase mRNAs and proteins were increased in allergic turbinate mucosa compared with normal turbinate mucosa. | Increased expression of acidic mammalian chitinase and chitotriosidase in the nasal mucosa of patients with allergic rhinitis.
Cho WS, Kim TH, Lee HM, Lee SH, Lee SH, Yoo JH, Kim YS, Lee SH. | 05/31/2010 |
| Our study found no associations between single nucleotide polymorphisms in the genes CHIT1, CHIA, and CHI3L1 and asthma, changes in lung physiology, or allergy-related phenotypes in subjects with mild-to-moderate asthma | Polymorphisms of chitinases are not associated with asthma.
Wu AC, Lasky-Su J, Rogers CA, Klanderman BJ, Litonjua A., Free PMC Article | 04/12/2010 |
| novel asthma susceptibility genes; review of genetic and fuctional studies | The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases.
Ober C, Chupp GL., Free PMC Article | 01/21/2010 |
| Genetic association analyses of AMCase haplotypes for asthma revealed significant protective associations between the variant haplotype in several asthma cohorts. | Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.
Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley RM, Burchard EG., Free PMC Article | 01/21/2010 |
| The three-dimensional (3D) model of the human acidic mammalian chitinase (hAMCase) was constructed based on the crystal structure of the human chitotriosidase (EC 3.2.1.44, PDB code 1HKK) by using InsightII/Homology module. | Analysis of a three-dimensional structure of human acidic mammalian chitinase obtained by homology modeling and ligand binding studies.
Zhao YS, Zheng QC, Zhang HX, Chu HY, Sun CC. | 01/21/2010 |
| The abundant biopolymer chitin appears to be recognized by a yet uncharacterized receptor on sinonasal epithelial cells. Chitin stimulates production of AMCase and eotaxin-3, two pro-Th2 effector proteins. | Chitin stimulates expression of acidic mammalian chitinase and eotaxin-3 by human sinonasal epithelial cells in vitro.
Lalaker A, Nkrumah L, Lee WK, Ramanathan M, Lane AP., Free PMC Article | 01/21/2010 |
| secreted AMCase feeds back in an autocrine and/or paracrine manner to protect pulmonary epithelial cells from growth factor withdrawal- and Fas ligand-induced apoptosis | Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism.
Hartl D, He CH, Koller B, Da Silva CA, Kobayashi Y, Lee CG, Flavell RA, Elias JA., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R. | 03/25/2009 |
| lung epithelial cells secrete AMCase via an EGFR-dependent pathway that is activated by ADAM17 and mediates its effects via Ras. | Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells.
Hartl D, He CH, Koller B, Da Silva CA, Homer R, Lee CG, Elias JA., Free PMC Article | 01/21/2010 |
| results establish a significant association of CHIA with atopic asthma and serum total IgE levels in the Indian population | Genetic association of acidic mammalian chitinase with atopic asthma and serum total IgE levels.
Chatterjee R, Batra J, Das S, Sharma SK, Ghosh B. | 01/21/2010 |