| Identification of myoferlin as a mitochondria-associated membranes component required for calcium signaling in PDAC cell lines. | Identification of myoferlin as a mitochondria-associated membranes component required for calcium signaling in PDAC cell lines.
Anania S, Farnir M, Peiffer R, Boumahd Y, Thiry M, Agirman F, Maloujahmoum N, Bellahcène A, Peulen O., Free PMC Article | 02/21/2024 |
| A missense variant in MYOF is associated with ARVC and sudden cardiac death. | A missense variant in MYOF is associated with ARVC and sudden cardiac death.
Xiao J, Dong Y, Jin J, Yuan Z, Wang C, Xiang R, Guo Y. | 02/14/2024 |
| Tetraspanin CD82 Associates with Trafficking Vesicle in Muscle Cells and Binds to Dysferlin and Myoferlin. | Tetraspanin CD82 Associates with Trafficking Vesicle in Muscle Cells and Binds to Dysferlin and Myoferlin.
Fontelonga T, Hall AJ, Brown JL, Jung YL, Alexander MS, Dominov JA, Mouly V, Vieira N, Zatz M, Vainzof M, Gussoni E., Free PMC Article | 12/22/2023 |
| HBZ upregulates myoferlin expression to facilitate HTLV-1 infection. | HBZ upregulates myoferlin expression to facilitate HTLV-1 infection.
Polakowski N, Sarker MAK, Hoang K, Boateng G, Rushing AW, Kendle W, Pique C, Green PL, Panfil AR, Lemasson I., Free PMC Article | 03/14/2023 |
| Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis. | Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis.
Zhang Y, Liu W, Yuan W, Cai Z, Ye G, Zheng G, Xu C, Wang X, Zeng C, Mi R, Feng P, Chen F, Wu Y, Shen H, Wang P., Free PMC Article | 09/3/2022 |
| Comprehensive Analysis of Myoferlin in Human Pancreatic Cancer via Bioinformatics. | Comprehensive Analysis of Myoferlin in Human Pancreatic Cancer via Bioinformatics.
Pi R, Chen Y, Du Y, Dong S., Free PMC Article | 01/22/2022 |
| Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth. | Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth.
Gupta S, Yano J, Mercier V, Htwe HH, Shin HR, Rademaker G, Cakir Z, Ituarte T, Wen KW, Kim GE, Zoncu R, Roux A, Dawson DW, Perera RM., Free PMC Article | 05/1/2021 |
| PINCH-1 interacts with myoferlin to promote breast cancer progression and metastasis. | PINCH-1 interacts with myoferlin to promote breast cancer progression and metastasis.
Qian T, Liu C, Ding Y, Guo C, Cai R, Wang X, Wang R, Zhang K, Zhou L, Deng Y, Wu C, Sun Y. | 11/28/2020 |
| Myoferlin silencing inhibits VEGFR2-mediated proliferation of metastatic clear cell renal cell carcinoma. | Myoferlin silencing inhibits VEGFR2-mediated proliferation of metastatic clear cell renal cell carcinoma.
An HJ, Song DH, Koh HM, Kim YM, Ko GH, Lee JH, Lee JS, Yang JW, Kim MH, Seo DH, Jang SM, Kim DC., Free PMC Article | 10/24/2020 |
| Prognostic significance of immunohistochemical staining for myoferlin in clear cell renal cell carcinoma and its association with epidermal growth factor receptor expression. | Prognostic significance of immunohistochemical staining for myoferlin in clear cell renal cell carcinoma and its association with epidermal growth factor receptor expression.
Jung M, Lee C, Park JH, Moon KC. | 08/22/2020 |
| The otoferlin enhances cancer cell proliferation, migration and metabolism by affecting various aspects of membrane biology. | Ferlin Overview: From Membrane to Cancer Biology.
Peulen O, Rademaker G, Anania S, Turtoi A, Bellahcène A, Castronovo V., Free PMC Article | 05/23/2020 |
| This article reviews the physiological function of myoferlin (MYOF) as well as its role in cancer. | Myoferlin, a Membrane Protein with Emerging Oncogenic Roles.
Dong Y, Kang H, Liu H, Wang J, Guo Q, Song C, Sun Y, Zhang Y, Zhang H, Zhang Z, Guan H, Fang Z, Li F., Free PMC Article | 05/2/2020 |
| The initial C2 domains of dysferlin and myoferlin are 57% similar (42% identical). Unlike dysferlin C2A, myoferlin binds two Ca2+ with equivalent affinity. Unlike dysferlin C2A, the membrane binding loop 1 of myoferlin C2A is relatively rigid. | Structural Basis for the Distinct Membrane Binding Activity of the Homologous C2A Domains of Myoferlin and Dysferlin.
Harsini FM, Bui AA, Rice AM, Chebrolu S, Fuson KL, Turtoi A, Bradberry M, Chapman ER, Sutton RB., Free PMC Article | 04/4/2020 |
| Myoferlin hyperexpression can be a useful marker for predicting the development of subsequent primary malignancies in patients with ccRCC. | Identification of Myoferlin Expression for Prediction of Subsequent Primary Malignancy in Patients With Clear Cell Renal Cell Carcinoma.
Koh HM, An HJ, Ko GH, Lee JH, Lee JS, Kim DC, Seo DH, Song DH., Free PMC Article | 12/21/2019 |
| Data show that myoferlin (MYOF) plays an important role in VM and knockdown of MYOF suppresses vasculogenic mimicry (VM) formation via decreasing matrix metallopeptidase 2 (MMP-2) and inducing mesenchymal-to-epithelial transition (MET) in A375 melanoma cells. | Down-regulating Myoferlin inhibits the vasculogenic mimicry of melanoma via decreasing MMP-2 and inducing mesenchymal-to-epithelial transition.
Zhang W, Zhou P, Meng A, Zhang R, Zhou Y., Free PMC Article | 10/26/2019 |
| Results show that the FerA domain is a novel four-helix bundle fold with its own Ca(2+)-dependent phospholipid-binding activity which interaction with the membrane is enhanced by the presence of Ca(2+). | FerA is a Membrane-Associating Four-Helix Bundle Domain in the Ferlin Family of Membrane-Fusion Proteins.
Harsini FM, Chebrolu S, Fuson KL, White MA, Rice AM, Sutton RB., Free PMC Article | 10/19/2019 |
| The observed mitochondrial fission induced by myoferlin depletion led to a decrease of cell proliferation. | Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness.
Rademaker G, Hennequière V, Brohée L, Nokin MJ, Lovinfosse P, Durieux F, Gofflot S, Bellier J, Costanza B, Herfs M, Peiffer R, Bettendorff L, Deroanne C, Thiry M, Delvenne P, Hustinx R, Bellahcène A, Castronovo V, Peulen O., Free PMC Article | 02/23/2019 |
| Myoferlin is a general component of cancer cell derived exosomes from different breast and pancreatic cancer cell lines. | Myoferlin is a novel exosomal protein and functional regulator of cancer-derived exosomes.
Blomme A, Fahmy K, Peulen O, Costanza B, Fontaine M, Struman I, Baiwir D, de Pauw E, Thiry M, Bellahcène A, Castronovo V, Turtoi A., Free PMC Article | 02/10/2018 |
| the cleavage of myoferlin, yielding a membrane-associated dual C2 domain 'mini-myoferlin', is reported. | Enzymatic cleavage of myoferlin releases a dual C2-domain module linked to ERK signalling.
Piper AK, Ross SE, Redpath GM, Lemckert FA, Woolger N, Bournazos A, Greer PA, Sutton RB, Cooper ST., Free PMC Article | 12/2/2017 |
| A novel regulator, myoferlin, of ADAM12 is discovered in HeLa cells and this protein increases ADAM12 expression level, stability, and its enzymatic activity, leading to the reduction of its substrate, E-cadherin, which plays important roles in the regulation of cell adhesion and tumor metastasis. | Quantitative proteomics identifies myoferlin as a novel regulator of A Disintegrin and Metalloproteinase 12 in HeLa cells.
Zhou Y, Xiong L, Zhang Y, Yu R, Jiang X, Xu G. | 12/2/2017 |
| Data show myoferlin depletion did not affect STAT3 transcription factor (STAT3) phosphorylation, but completely blocked STAT3 translocation to nucleus. | A muscle-specific protein 'myoferlin' modulates IL-6/STAT3 signaling by chaperoning activated STAT3 to nucleus.
Yadav A, Kumar B, Lang JC, Teknos TN, Kumar P., Free PMC Article | 12/2/2017 |
| This study is the first to report robust age associations for DNA methylation in MYOF and DDO, both of which have plausible functional roles in aging | Methylome-wide association study of whole blood DNA in the Norfolk Island isolate identifies robust loci associated with age.
Benton MC, Sutherland HG, Macartney-Coxson D, Haupt LM, Lea RA, Griffiths LR., Free PMC Article | 11/18/2017 |
| Results demonstrate for the first time that nuclear myoferlin expression independently predicts poor clinical outcome in OPSCC patients. | High expression of myoferlin is associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with HPV-status.
Kumar B, Brown NV, Swanson BJ, Schmitt AC, Old M, Ozer E, Agrawal A, Schuller DE, Teknos TN, Kumar P., Free PMC Article | 03/4/2017 |
| Myoferlin plays a key role in VEGFA secretion and impacts tumor-associated angiogenesis in human pancreas cancer. | Myoferlin plays a key role in VEGFA secretion and impacts tumor-associated angiogenesis in human pancreas cancer.
Fahmy K, Gonzalez A, Arafa M, Peixoto P, Bellahcène A, Turtoi A, Delvenne P, Thiry M, Castronovo V, Peulen O. | 06/4/2016 |
| MYOF regulates cell adhesions and cell-substrate adhesion strength and may account for the high degree of motility in invasive breast cancer cells. | Myoferlin depletion elevates focal adhesion kinase and paxillin phosphorylation and enhances cell-matrix adhesion in breast cancer cells.
Blackstone BN, Li R, Ackerman WE 4th, Ghadiali SN, Powell HM, Kniss DA. | 07/25/2015 |