| [Tumor-associated fibroblasts promotes proliferation and migration of prostate cancer cells by suppressing FBXL3 via upregulating hsa-miR-18b-5p]. | [Tumor-associated fibroblasts promotes proliferation and migration of prostate cancer cells by suppressing FBXL3 via upregulating hsa-miR-18b-5p].
Luo J, Tao H, Wen Z, Chen L, Hu H, Guan H., Free PMC Article | 08/30/2024 |
| we conclude that homozygous FBXL3 LoF variants likely cause autosomal recessive ID, short stature, developmental delay and facial dysmorphism in humans, and that the Cys358Arg FBXL3 variant likely adds the circadian phenotype because of abnormal interaction with CRY1 and CRY2 | Biallelic variants in FBXL3 cause intellectual disability, delayed motor development and short stature.
Ansar M, Paracha SA, Serretti A, Sarwar MT, Khan J, Ranza E, Falconnet E, Iwaszkiewicz J, Shah SF, Qaisar AA, Santoni FA, Zoete V, Megarbane A, Ahmed J, Colombo R, Makrythanasis P, Antonarakis SE., Free PMC Article | 03/14/2020 |
| FBXL3 was regulated by miR-4735-3p and suppressed cell proliferation and invasion in non-small cell lung cancer. | FBXL3 is regulated by miRNA-4735-3p and suppresses cell proliferation and migration in non-small cell lung cancer.
Wang D, Han X, Li C, Bai W. | 03/23/2019 |
| data indicate an oncogenic role of miR-181d in CRC by promoting glycolysis, and miR-181d/CRY2/FBXL3/c-myc feedback loop might be a therapeutic target for patients with CRC. | miR-181d and c-myc-mediated inhibition of CRY2 and FBXL3 reprograms metabolism in colorectal cancer.
Guo X, Zhu Y, Hong X, Zhang M, Qiu X, Wang Z, Qi Z, Hong X., Free PMC Article | 05/12/2018 |
| These results demonstrate that CRY2 stability controlled by FBXL3 plays a key role in the regulation of human sleep wake behavior. | A Cryptochrome 2 mutation yields advanced sleep phase in humans.
Hirano A, Shi G, Jones CR, Lipzen A, Pennacchio LA, Xu Y, Hallows WC, McMahon T, Yamazaki M, Ptáček LJ, Fu YH., Free PMC Article | 11/4/2017 |
| CRY2 and FBXL3 cooperatively degrade c-MYC preventing the development of cancer. | CRY2 and FBXL3 Cooperatively Degrade c-MYC.
Huber AL, Papp SJ, Chan AB, Henriksson E, Jordan SD, Kriebs A, Nguyen M, Wallace M, Li Z, Metallo CM, Lamia KA., Free PMC Article | 09/2/2017 |
| Data show that CRISPR/Cas9 genome editing generated F-box and leucine-rich repeat protein 3 (Fbxl3) knockout in circadian clock model U2OS cells. | Highly Efficient Genome Editing via CRISPR/Cas9 to Create Clock Gene Knockout Cells.
Korge S, Grudziecki A, Kramer A. | 06/28/2016 |
| Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. | Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
Yumimoto K, Muneoka T, Tsuboi T, Nakayama KI., Free PMC Article | 01/25/2014 |
| Mutation in the Fbxl3 protein reveals distinct roles for CRY1 and CRY2 in the circadian molecular clockwork. | Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation.
Anand SN, Maywood ES, Chesham JE, Joynson G, Banks GT, Hastings MH, Nolan PM., Free PMC Article | 06/29/2013 |
| crystal structures of mammalian CRY2 in its apo, FAD-bound and FBXL3-SKP1-complexed forms | SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket.
Xing W, Busino L, Hinds TR, Marionni ST, Saifee NH, Bush MF, Pagano M, Zheng N., Free PMC Article | 05/4/2013 |
| study demonstrates that the SCF(Fbxl3)ubiquitin ligase controls the oscillations of the circadian clock by mediating the degradation of Cry1 and Cry2 proteins | SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.
Busino L, Bassermann F, Maiolica A, Lee C, Nolan PM, Godinho SI, Draetta GF, Pagano M. | 01/21/2010 |