| A novel variant in GAS2 is associated with autosomal dominant nonsyndromic hearing impairment in a Chinese family. | A novel variant in GAS2 is associated with autosomal dominant nonsyndromic hearing impairment in a Chinese family.
Zhang L, Zheng D, Xu L, Wang H, Zhang S, Shi J, Jin N., Free PMC Article | 09/25/2024 |
| Growth arrest-specific protein 2 (GAS2) interacts with CXCR4 to promote T-cell leukemogenesis partially via c-MYC. | Growth arrest-specific protein 2 (GAS2) interacts with CXCR4 to promote T-cell leukemogenesis partially via c-MYC.
Ma W, Wan Y, Zhang J, Yao J, Wang Y, Lu J, Liu H, Huang X, Zhang X, Zhou H, He Y, Wu D, Wang J, Zhao Y., Free PMC Article | 10/29/2022 |
| Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing. | Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing.
Chen T, Rohacek AM, Caporizzo M, Nankali A, Smits JJ, Oostrik J, Lanting CP, Kücük E, Gilissen C, van de Kamp JM, Pennings RJE, Rakowiecki SM, Kaestner KH, Ohlemiller KK, Oghalai JS, Kremer H, Prosser BL, Epstein DJ., Free PMC Article | 10/2/2021 |
| UCHL1 enhances the malignant development of glioma via targeting GAS2. | UCHL1 enhances the malignant development of glioma via targeting GAS2.
Sui R, Piao HZ. | 04/24/2021 |
| Growth arrest-specific 2 protein family: Structure and function. | Growth arrest-specific 2 protein family: Structure and function.
Zhang N, Zhao C, Zhang X, Cui X, Zhao Y, Yang J, Gao X., Free PMC Article | 01/23/2021 |
| GAS2 protein expression was lower in hepatocellular carcinoma (HCC) than in normal tissues. Overexpression of GAS2 inhibited the proliferation of HCC cells with wide type p53, while knockdown of GAS2 promoted the proliferation of hepatocytes. Results suggest that GAS2 plays a vital role in HCC cell proliferation and apoptosis, possibly by regulating the cell cycle and p53-dependent apoptosis pathway. | Growth arrest-specific gene 2 suppresses hepatocarcinogenesis by intervention of cell cycle and p53-dependent apoptosis.
Zhu RX, Cheng ASL, Chan HLY, Yang DY, Seto WK., Free PMC Article | 02/15/2020 |
| This study found a highly significant correlation between colorectal cancers relapse and growth arrest-specific 2 (GAS2) gene expression. Based on cell models, the overexpressed GAS2 was associated with cellular growth rate, cell cycle regulation, and with chemotherapeutic sensitivity. | Upregulation of the growth arrest-specific-2 in recurrent colorectal cancers, and its susceptibility to chemotherapy in a model cell system.
Huang CJ, Lee CL, Yang SH, Chien CC, Huang CC, Yang RN, Chang CC. | 01/26/2019 |
| Taken together, our results demonstrated the deregulation of GAS2 in both AML and ALL and the requirement of GAS2-Calpain2 axis for the growth of leukemic cells. | GAS2-Calpain2 axis contributes to the growth of leukemic cells.
Sun L, Zhou H, Liu H, Ge Y, Zhang X, Ma W, Wu D, Zhao Y. | 07/2/2016 |
| Truncated HBx deregulates cell growth via direct silencing of GAS2 and thereby provides a survival advantage for pre-neoplastic hepatocytes to facilitate cancer development via TP53 signaling. | Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis.
Zhu R, Mok MT, Kang W, Lau SS, Yip WK, Chen Y, Lai PB, Wong VW, To KF, Sung JJ, Cheng AS, Chan HL. | 11/7/2015 |
| GAS2 is up-regulated in chronic myeloid leukemia cells. | Growth arrest specific 2 is up-regulated in chronic myeloid leukemia cells and required for their growth.
Zhou H, Ge Y, Sun L, Ma W, Wu J, Zhang X, Hu X, Eaves CJ, Wu D, Zhao Y., Free PMC Article | 11/8/2014 |
| Studies have identified a Gas2/calpain-dependent mechanism by which ICSBP influences beta-catenin activity in myeloid leukemia. | Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription.
Huang W, Zhou W, Saberwal G, Konieczna I, Horvath E, Katsoulidis E, Platanias LC, Eklund EA., Free PMC Article | 11/27/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K. | 09/15/2010 |
| Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin | The calpain system is involved in the constitutive regulation of beta-catenin signaling functions.
Benetti R, Copetti T, Dell'Orso S, Melloni E, Brancolini C, Monte M, Schneider C. | 01/21/2010 |