| Identification of ASF1A and HJURP by global H3-H4 histone chaperone analysis as a prognostic two-gene model in hepatocellular carcinoma. | Identification of ASF1A and HJURP by global H3-H4 histone chaperone analysis as a prognostic two-gene model in hepatocellular carcinoma.
Liu Y, Liu S, Jing R, Li C, Guo Y, Cai Z, Xi P, Dai P, Jia L, Zhu H, Zhang X., Free PMC Article | 04/4/2024 |
| Histone chaperone ASF1A accelerates chronic myeloid leukemia blast crisis by activating Notch signaling. | Histone chaperone ASF1A accelerates chronic myeloid leukemia blast crisis by activating Notch signaling.
Yin X, Zhou M, Zhang L, Fu Y, Xu M, Wang X, Cui Z, Gao Z, Li M, Dong Y, Feng H, Ma S, Chen C., Free PMC Article | 10/8/2022 |
| Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells. | Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells.
Tang M, Chen Z, Wang C, Feng X, Lee N, Huang M, Zhang H, Li S, Xiong Y, Chen J., Free PMC Article | 07/2/2022 |
| RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity. | RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity.
Feng S, Ma S, Li K, Gao S, Ning S, Shang J, Guo R, Chen Y, Blumenfeld B, Simon I, Li Q, Guo R, Xu D., Free PMC Article | 03/5/2022 |
| Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry. | Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
Simon B, Lou HJ, Huet-Calderwood C, Shi G, Boggon TJ, Turk BE, Calderwood DA., Free PMC Article | 03/5/2022 |
| Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A. | Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A.
Lee KY, Dutta A., Free PMC Article | 01/29/2022 |
| Elevated expression of ASF1B correlates with poor prognosis in human lung adenocarcinoma. | Elevated expression of ASF1B correlates with poor prognosis in human lung adenocarcinoma.
Feng Z, Zhang J, Zheng Y, Wang Q, Min X, Tian T. | 12/18/2021 |
| In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma. | In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma.
Li F, Huang Q, Luster TA, Hu H, Zhang H, Ng WL, Khodadadi-Jamayran A, Wang W, Chen T, Deng J, Ranieri M, Fang Z, Pyon V, Dowling CM, Bagdatlioglu E, Almonte C, Labbe K, Silver H, Rabin AR, Jani K, Tsirigos A, Papagiannakopoulos T, Hammerman PS, Velcheti V, Freeman GJ, Qi J, Miller G, Wong KK., Free PMC Article | 02/2/2021 |
| We demonstrate that the CIA-targeting complex promotes the ability of FBXL5 to degrade iron regulatory proteins. In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation | An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.
Mayank AK, Pandey V, Vashisht AA, Barshop WD, Rayatpisheh S, Sharma T, Haque T, Powers DN, Wohlschlegel JA., Free PMC Article | 01/25/2020 |
| ASF1A regulated H4(Y72ph) and promotes autophagy in colon cancer cells via a kinase activity through regulation of ATG | ASF1A regulates H4(Y72) phosphorylation and promotes autophagy in colon cancer cells via a kinase activity.
Qiu F, Wang Y, Chu X, Wang J. | 12/14/2019 |
| ASF1A depletion leads to increased recruitment of DNA-PKcs to DSBs. | The histone chaperone ASF1 regulates the activation of ATM and DNA-PKcs in response to DNA double-strand breaks.
Huang TH, Shen ZJ, Sleckman BP, Tyler JK., Free PMC Article | 11/16/2019 |
| faithful transmission of histone variants involves ASF1 and can be impacted by replication stress, with ensuing consequences for cell fate and tumorigenesis | High-resolution visualization of H3 variants during replication reveals their controlled recycling.
Clément C, Orsi GA, Gatto A, Boyarchuk E, Forest A, Hajj B, Miné-Hattab J, Garnier M, Gurard-Levin ZA, Quivy JP, Almouzni G., Free PMC Article | 01/12/2019 |
| uncovered DNA-PKcs-dependent DNA damage-induced ASF1A phosphorylation, which enhances chromatin assembly, promoting MMS22L-TONSL recruitment and, hence, Rad51 loading. | The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells.
Huang TH, Fowler F, Chen CC, Shen ZJ, Sleckman B, Tyler JK., Free PMC Article | 01/5/2019 |
| ASF1A is aberrantly over-expressed in GIC tumors and plays key roles in GIC development and progression by stimulating the transcription of beta-catenin target genes. | Histone Chaperone ASF1A Predicts Poor Outcomes for Patients With Gastrointestinal Cancer and Drives Cancer Progression by Stimulating Transcription of β-Catenin Target Genes.
Liang X, Yuan X, Yu J, Wu Y, Li K, Sun C, Li S, Shen L, Kong F, Jia J, Björkholm M, Xu D., Free PMC Article | 04/14/2018 |
| ASF1a promotes non-homologous end joining repair by facilitating phosphorylation of MDC1 by ATM at double-strand breaks. | ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks.
Lee KY, Im JS, Shibata E, Dutta A., Free PMC Article | 10/21/2017 |
| These data suggest that CAF-1- and ASF1A-H3-H4-dependent deposition of the histone (H3-H4)2 tetramers is compatible with MMR and protects the discontinuous daughter strand from unnecessary degradation by MMR machinery. | DNA Mismatch Repair Interacts with CAF-1- and ASF1A-H3-H4-dependent Histone (H3-H4)2 Tetramer Deposition.
Rodriges Blanko E, Kadyrova LY, Kadyrov FA., Free PMC Article | 11/5/2016 |
| Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation. | A conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesis.
Wang C, Chang JF, Yan H, Wang DL, Liu Y, Jing Y, Zhang M, Men YL, Lu D, Yang XM, Chen S, Sun FL., Free PMC Article | 08/6/2016 |
| quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2 | Structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2.
Wang H, Wang M, Yang N, Xu RM., Free PMC Article | 05/28/2016 |
| Thermodynamic analysis of the quaternary complex together with structural modeling support that ASF1 and MCM2 could form a chaperoning module for histones H3 and H4 protecting them from promiscuous interactions. | Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork.
Richet N, Liu D, Legrand P, Velours C, Corpet A, Gaubert A, Bakail M, Moal-Raisin G, Guerois R, Compper C, Besle A, Guichard B, Almouzni G, Ochsenbein F., Free PMC Article | 06/20/2015 |
| Data indicate Tousled-like kinases (TLK1) phosphorylation has an impact on cell cycle proteins Asf1a and Asf1b function. | Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication.
Klimovskaia IM, Young C, Strømme CB, Menard P, Jasencakova Z, Mejlvang J, Ask K, Ploug M, Nielsen ML, Jensen ON, Groth A., Free PMC Article | 12/6/2014 |
| findings show that ASF1A, a histone-remodeling chaperone specifically enriched in the metaphase II oocyte, is necessary for reprogramming of adult dermal fibroblasts into undifferentiated induced pluripotent stem cell | Cell reprogramming. Histone chaperone ASF1A is required for maintenance of pluripotency and cellular reprogramming.
Gonzalez-Muñoz E, Arboleda-Estudillo Y, Otu HH, Cibelli JB. | 09/27/2014 |
| The ATR checkpoint pathway causes a histone chaperone normally associated with the replication fork, ASF1a, to degrade through a CRL1(betaTRCP)-dependent ubiquitination/proteasome pathway, leading to the localized dechromatinization and gene repression. | ATR checkpoint kinase and CRL1βTRCP collaborate to degrade ASF1a and thus repress genes overlapping with clusters of stalled replication forks.
Im JS, Keaton M, Lee KY, Kumar P, Park J, Dutta A., Free PMC Article | 05/31/2014 |
| Co-depletion of the histone chaperones ASF1a and ASF1b in human cells induces all hallmarks of alternative lengthening of telomeres in both primary and cancer cells. | Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1.
O'Sullivan RJ, Arnoult N, Lackner DH, Oganesian L, Haggblom C, Corpet A, Almouzni G, Karlseder J., Free PMC Article | 04/19/2014 |
| Asf1a plays a role in regulating IE genes by assembling chromatin onto histone-free viral DNA by 3 h postinfection with herpes simplex virus 1 | Chromatin assembly on herpes simplex virus 1 DNA early during a lytic infection is Asf1a dependent.
Oh J, Ruskoski N, Fraser NW., Free PMC Article | 01/12/2013 |
| The authors propose that Codanin-1 acts as a negative regulator of Asf1 function in chromatin assembly. | Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply.
Ask K, Jasencakova Z, Menard P, Feng Y, Almouzni G, Groth A., Free PMC Article | 06/16/2012 |