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    ANKK1 ankyrin repeat and kinase domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 255239, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    ANKK1 Is a Wnt/PCP Scaffold Protein for Neural F-ACTIN Assembly.

    ANKK1 Is a Wnt/PCP Scaffold Protein for Neural F-ACTIN Assembly.
    Domínguez-Berzosa L, Cantarero L, Rodríguez-Sanz M, Tort G, Garrido E, Troya-Balseca J, Sáez M, Castro-Martínez XH, Fernandez-Lizarbe S, Urquizu E, Calvo E, López JA, Palomo T, Palau F, Hoenicka J., Free PMC Article

    10/23/2024
    The Addiction-Susceptibility TaqIA/Ankk1 Controls Reward and Metabolism Through D2 Receptor-Expressing Neurons.

    The Addiction-Susceptibility TaqIA/Ankk1 Controls Reward and Metabolism Through D(2) Receptor-Expressing Neurons.
    Montalban E, Walle R, Castel J, Ansoult A, Hassouna R, Foppen E, Fang X, Hutelin Z, Mickus S, Perszyk E, Petitbon A, Berthelet J, Rodrigues-Lima F, Cebrian-Serrano A, Gangarossa G, Martin C, Trifilieff P, Bosch-Bouju C, Small DM, Luquet S.

    08/11/2023
    The ANKK1/DRD2 gene TaqIA polymorphism (rs1800497) is associated with the severity of extrapyramidal side effects of haloperidol treatment in CYP2D6 extensive metabolizers with schizophrenia spectrum disorders.

    The ANKK1/DRD2 gene TaqIA polymorphism (rs1800497) is associated with the severity of extrapyramidal side effects of haloperidol treatment in CYP2D6 extensive metabolizers with schizophrenia spectrum disorders.
    Kibitov AA, Kiryanova EM, Salnikova LI, Bure IV, Shmukler AB, Kibitov AO.

    06/16/2023
    Temporomandibular disorder in construction workers associated with ANKK1 and DRD2 genes.

    Temporomandibular disorder in construction workers associated with ANKK1 and DRD2 genes.
    Baratto SSP, Meger MN, Camargo V, Nolasco GMC, Mattos NHR, Roskamp L, Stechman-Neto J, Madalena IR, Küchler EC, Baratto-Filho F., Free PMC Article

    09/3/2022
    Investigating the association between common DRD2/ANKK1 genetic polymorphisms and schizophrenia: a meta-analysis.

    Investigating the association between common DRD2/ANKK1 genetic polymorphisms and schizophrenia: a meta-analysis.
    Habibzadeh P, Nemati A, Dastsooz H, Taghipour-Sheshdeh A, Mariam Paul P, Sahraian A, Ali Faghihi M.

    02/12/2022
    Analysis of Selected Variants of DRD2 and ANKK1 Genes in Combat Athletes.

    Analysis of Selected Variants of DRD2 and ANKK1 Genes in Combat Athletes.
    Michałowska-Sawczyn M, Chmielowiec K, Chmielowiec J, Trybek G, Masiak J, Niewczas M, Cieszczyk P, Bajorek W, Król P, Grzywacz A., Free PMC Article

    02/12/2022
    Regulatory rare variants of the dopaminergic gene ANKK1 as potential risk factors for Parkinson's disease.

    Regulatory rare variants of the dopaminergic gene ANKK1 as potential risk factors for Parkinson's disease.
    Pérez-Santamarina E, García-Ruiz P, Martínez-Rubio D, Ezquerra M, Pla-Navarro I, Puente J, Martí MJ, Palau F, Hoenicka J., Free PMC Article

    10/30/2021
    Genotypes of ANKK1 and DRD2 genes and risk of metabolic syndrome and its components: A cross-sectional study on Iranian women.

    Genotypes of ANKK1 and DRD2 genes and risk of metabolic syndrome and its components: A cross-sectional study on Iranian women.
    Aliasghari F, Mahdavi R, Barati M, Nazm SA, Yasari S, Bonyadi M, Jabbari M.

    10/30/2021
    Associations of the ANKK1 and DRD2 gene polymorphisms with overweight, obesity and hedonic hunger among women from the Northwest of Iran.

    Associations of the ANKK1 and DRD2 gene polymorphisms with overweight, obesity and hedonic hunger among women from the Northwest of Iran.
    Aliasghari F, Nazm SA, Yasari S, Mahdavi R, Bonyadi M.

    07/17/2021
    Association of ANKK1 polymorphism with antipsychotic-induced hyperprolactinemia.

    Association of ANKK1 polymorphism with antipsychotic-induced hyperprolactinemia.
    Fedorenko OY, Paderina DZ, Loonen AJM, Pozhidaev IV, Boiko AS, Kornetova EG, Bokhan NA, Wilffert B, Ivanova SA., Free PMC Article

    06/12/2021
    Genetic diversity of the North African population revealed by the typing of SNPs in the DRD2/ANKK1 genomic region.

    Genetic diversity of the North African population revealed by the typing of SNPs in the DRD2/ANKK1 genomic region.
    Mestiri S, Boussetta S, Pakstis AJ, Elkamel S, Elgaaied ABA, Kidd KK, Cherni L.

    03/28/2021
    Ankyrin Repeat and Kinase Domain Containing 1 Gene, and Addiction Vulnerability.

    Ankyrin Repeat and Kinase Domain Containing 1 Gene, and Addiction Vulnerability.
    Koeneke A, Ponce G, Troya-Balseca J, Palomo T, Hoenicka J., Free PMC Article

    01/16/2021
    Genetic and Epigenetic Analysis Revealing Variants in the NCAM1-TTC12-ANKK1-DRD2 Cluster Associated Significantly With Nicotine Dependence in Chinese Han Smokers.

    Genetic and Epigenetic Analysis Revealing Variants in the NCAM1-TTC12-ANKK1-DRD2 Cluster Associated Significantly With Nicotine Dependence in Chinese Han Smokers.
    Liu Q, Xu Y, Mao Y, Ma Y, Wang M, Han H, Cui W, Yuan W, Payne TJ, Xu Y, Li MD, Yang Z.

    12/19/2020
    Epistatic effect of Ankyrin repeat and kinase domain containing 1 - Dopamine receptor D2 and catechol-o-methyltransferase single nucleotide polymorphisms on the risk for hazardous use of alcohol in Lithuanian population.

    Epistatic effect of Ankyrin repeat and kinase domain containing 1 - Dopamine receptor D2 and catechol-o-methyltransferase single nucleotide polymorphisms on the risk for hazardous use of alcohol in Lithuanian population.
    Kaminskaite M, Jokubka R, Janaviciute J, Lelyte I, Sinkariova L, Pranckeviciene A, Borutaite V, Bunevicius A.

    12/19/2020
    Significant association of <i>DRD2</i> and <i>ANKK1</i> genes with rural heroin dependence and relapse in men.

    Significant association of DRD2 and ANKK1 genes with rural heroin dependence and relapse in men.
    Lachowicz M, Chmielowiec J, Chmielowiec K, Suchanecka A, Masiak J, Michałowska-Sawczyn M, Mroczek B, Mierzecki A, Ciechanowicz I, Grzywacz A.

    09/19/2020
    DRD2 and ANKK1 genes associate with late-onset heroin dependence in men.

    DRD2 and ANKK1 genes associate with late-onset heroin dependence in men.
    Tsou CC, Chou HW, Ho PS, Kuo SC, Chen CY, Huang CC, Liang CS, Lu RB, Huang SY.

    09/5/2020
    Relationship between ANKK1 rs1800497 polymorphism, overweight and executive dysfunction in early psychosis.

    Relationship between ANKK1 rs1800497 polymorphism, overweight and executive dysfunction in early psychosis.
    Sanchez-Gistau V, Mariné R, Martorell L, Cabezas A, Algora MJ, Sole M, Labad J, Vilella E.

    08/29/2020
    interactions between DRD2/ANKK1 TaqIA polymorphism and dietary factors (sugar and fats) influence triglyceride levels in diabetic patients

    Interactions between DRD2/ANKK1 TaqIA Polymorphism and Dietary Factors Influence Plasma Triglyceride Concentrations in Diabetic Patients from Western Mexico: A Cross-sectional Study.
    Ramos-Lopez O, Mejia-Godoy R, Frías-Delgadillo KJ, Torres-Valadez R, Flores-García A, Sánchez-Enríquez S, Aguiar-García P, Martínez-López E, Zepeda-Carrillo EA., Free PMC Article

    06/27/2020
    The results demonstrated a regional specificity with which the functional polymorphism rs686 of the D1 dopamine receptor (DRD1) gene and Taq1A of the ANKK1 gene influenced medial and lateral orbital frontal cortex activation during reward anticipation, respectively.

    Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence.
    Baker TE, Castellanos-Ryan N, Schumann G, Cattrell A, Flor H, Nees F, Banaschewski T, Bokde A, Whelan R, Buechel C, Bromberg U, Papadopoulos Orfanos D, Gallinat J, Garavan H, Heinz A, Walter H, Brühl R, Gowland P, Paus T, Poustka L, Martinot JL, Lemaitre H, Artiges E, Paillère Martinot ML, Smolka MN, Conrod P, IMAGEN consortium.

    05/16/2020
    The presence of the TaqI A1 allele in Mexicans is a genetic risk factor for detrimental dietary quality that may predispose to metabolic disturbances.

    DRD2/ANKK1 TaqI A1 polymorphism associates with overconsumption of unhealthy foods and biochemical abnormalities in a Mexican population.
    Rivera-Iñiguez I, Panduro A, Ramos-Lopez O, Villaseñor-Bayardo SJ, Roman S.

    02/15/2020
    results confirm a significant role of Taq1A polymorphism in Cannabis Use vulnerability.

    Genetic and Environmental Risk Factors for Cannabis Use: Preliminary Results for the Role of Parental Care Perception.
    Gerra MC, Manfredini M, Cortese E, Antonioni MC, Leonardi C, Magnelli F, Somaini L, Jayanthi S, Cadet JL, Donnini C., Free PMC Article

    01/25/2020
    This study shows not only differences in personality traits between addicted and non-addicted subjects, but also the possible impact of ANKK1 on given traits and on addiction itself.

    The Ankyrin Repeat and Kinase Domain Containing 1 Gene Polymorphism (ANKK1Taq1A) and Personality Traits in Addicted Subjects.
    Grzywacz A, Chmielowiec J, Chmielowiec K, Mroczek B, Masiak J, Suchanecka A, Sipak-Szmigiel O, Szumilas K, Trybek G., Free PMC Article

    01/11/2020
    results suggest a gene-environment interaction involving the ANKK1 gene as a predictor of executive function in a pediatric injury population

    The Moderating Effect of the Ankyrin Repeat and Kinase Domain Containing One Gene on the Association of Family Environment with Longitudinal Executive Function following Traumatic Brain Injury in Early Childhood: A Preliminary Study.
    Smith-Paine J, Wade SL, Treble-Barna A, Zhang N, Zang H, Martin LJ, Yeates KO, Taylor HG, Kurowski BG., Free PMC Article

    11/16/2019
    Having two copies of Taq1a polymorphism (rs1800497) in exon 8 of ANKK1 (previously mapped to DRD2) shown to correlate with an increase in reported calorie and sugar consumption and as a potential risk factor for early development of excess adiposity in study of multi-ethnic children.

    Taq1a polymorphism (rs1800497) is associated with obesity-related outcomes and dietary intake in a multi-ethnic sample of children.
    Cardel MI, Lemas DJ, Lee AM, Miller DR, Huo T, Klimentidis YC, Fernandez JR., Free PMC Article

    08/3/2019
    Meta-analysis found that the minor G-allele of rs2236709, mapping TTC12, was associated with self-reported smoking and higher plasma cotinine levels. This risk allele was linked to an increased ventral-striatal blood-oxygen level-dependent response during reward anticipation and with higher DRD2 gene expression in the striatum, but not with TTC12 or ANKK gene expression.

    A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response.
    Macare C, Ducci F, Zhang Y, Ruggeri B, Jia T, Kaakinen M, Kalsi G, Charoen P, Casoni F, Peters J, Bromberg U, Hill M, Buxton J, Blakemore A, Veijola J, Büchel C, Banaschewski T, Bokde ALW, Conrod P, Flor H, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Martinot JL, Paus T, Desrivières S, Munafò M, Järvelin MR, Schumann G, IMAGEN Consortium., Free PMC Article

    06/8/2019
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