| Hydroperoxidation of Docosahexaenoic Acid by Human ALOX12 and pigALOX15-mini-LOX. | Hydroperoxidation of Docosahexaenoic Acid by Human ALOX12 and pigALOX15-mini-LOX.
Canyelles-Niño M, González-Lafont À, Lluch JM., Free PMC Article | 04/15/2023 |
| Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder. | Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder.
Tran M, Signorelli RL, Yamaguchi A, Chen E, Holinstat M, Iavarone AT, Offenbacher AR, Holman T., Free PMC Article | 01/14/2023 |
| ALOX12: A Novel Insight in Bevacizumab Response, Immunotherapy Effect, and Prognosis of Colorectal Cancer. | ALOX12: A Novel Insight in Bevacizumab Response, Immunotherapy Effect, and Prognosis of Colorectal Cancer.
Weng S, Liu Z, Xu H, Ge X, Ren Y, Dang Q, Liu L, Zhang J, Luo P, Ren J, Han X., Free PMC Article | 07/23/2022 |
| Key Role of 12-Lipoxygenase and Its Metabolite 12-Hydroxyeicosatetraenoic Acid (12-HETE) in Diabetic Retinopathy. | Key Role of 12-Lipoxygenase and Its Metabolite 12-Hydroxyeicosatetraenoic Acid (12-HETE) in Diabetic Retinopathy.
Chen S, Zou H. | 04/23/2022 |
| Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase. | Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase.
Contursi A, Schiavone S, Dovizio M, Hinz C, Fullone R, Tacconelli S, Tyrrell VJ, Grande R, Lanuti P, Marchisio M, Zucchelli M, Ballerini P, Lanas A, O'Donnell VB, Patrignani P., Free PMC Article | 03/26/2022 |
| ALOX12 mutation in a family with dominantly inherited bleeding diathesis. | ALOX12 mutation in a family with dominantly inherited bleeding diathesis.
Mitsui T, Makino S, Tamiya G, Sato H, Kawakami Y, Takahashi Y, Meguro T, Izumino H, Sudo Y, Norota I, Ishii K, Hayasaka K. | 12/11/2021 |
| Antisense overlapping long non-coding RNA regulates coding arachidonate 12-lipoxygenase gene by translational interference. | Antisense overlapping long non-coding RNA regulates coding arachidonate 12-lipoxygenase gene by translational interference.
Sabbir MG, Taylor CG, Zahradka P. | 11/27/2021 |
| Regulation of Tissue Inflammation by 12-Lipoxygenases. | Regulation of Tissue Inflammation by 12-Lipoxygenases.
Kulkarni A, Nadler JL, Mirmira RG, Casimiro I., Free PMC Article | 10/9/2021 |
| Promoter methylation changes in ALOX12 and AIRE1: novel epigenetic markers for atherosclerosis. | Promoter methylation changes in ALOX12 and AIRE1: novel epigenetic markers for atherosclerosis.
Kim JY, Choi BG, Jelinek J, Kim DH, Lee SH, Cho K, Rha SH, Lee YH, Jin HS, Choi DK, Kim GE, Kwon SU, Hwang J, Cha JK, Lee S, Issa JJ, Kim J., Free PMC Article | 08/21/2021 |
| The SP1-12LOX axis promotes chemoresistance and metastasis of ovarian cancer. | The SP1-12LOX axis promotes chemoresistance and metastasis of ovarian cancer.
Zhang Q, Yan G, Lei J, Chen Y, Wang T, Gong J, Zhou Y, Zhao H, Chen H, Zhou Y, Wu L, Zhang J, Zhang X, Wang J, Li Y., Free PMC Article | 08/14/2021 |
| The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma. | The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma.
Oguh-Olayinka L, Agarwal V, Ranatunge D, Campbell A, Laufer S, Cawkwell L, Lind MJ., Free PMC Article | 04/3/2021 |
| Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators. | Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators.
Freedman C, Tran A, Tourdot BE, Kalyanaraman C, Perry S, Holinstat M, Jacobson MP, Holman TR., Free PMC Article | 01/23/2021 |
| Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer. | Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer.
Sarsour EH, Son JM, Kalen AL, Xiao W, Du J, Alexander MS, O'Leary BR, Cullen JJ, Goswami PC., Free PMC Article | 12/26/2020 |
| 12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA2gamma knockout. | 12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA(2)γ knockout.
Liu X, Sims HF, Jenkins CM, Guan S, Dilthey BG, Gross RW., Free PMC Article | 12/19/2020 |
| Inhibition of arachidonate lipoxygenase12 targets lung cancer through inhibiting EMT and suppressing RhoA and NF-kappaB activity. | Inhibition of arachidonate lipoxygenase12 targets lung cancer through inhibiting EMT and suppressing RhoA and NF-κB activity.
Chen J, Tong W, Liao M, Chen D. | 10/24/2020 |
| 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat. | 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.
Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Blüher M, Cypess AM, Kiebish MA, Spite M, Tseng YH., Free PMC Article | 09/5/2020 |
| Alox12 overexpression was sufficient to stimulate growth in normal breast cells but not breast cancer cells. Alox12 depletion inhibited breast cancer growth and survival, and significantly enhanced the chemotherapeutic agents' efficacy. | ALOX12 inhibition sensitizes breast cancer to chemotherapy via AMPK activation and inhibition of lipid synthesis.
Huang Z, Xia L, Zhou X, Wei C, Mo Q. | 06/27/2020 |
| His596 is involved in anchoring the carboxy terminal of arachidonic acid during catalysis, while Leu407 is involved in positioning the substrate correctly. | Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase.
Aleem AM, Tsai WC, Tena J, Alvarez G, Deschamps J, Kalyanaraman C, Jacobson MP, Holman T., Free PMC Article | 10/5/2019 |
| 5-LOX does not react with 5,15-diHpETE, although it can produce lipoxin A4 when 15-HpETE is the substrate. In contrast, both 12-LOX and 15-LOX-1 react with 5,15-diHpETE, forming specifically lipoxin B4. | 5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1.
Green AR, Freedman C, Tena J, Tourdot BE, Liu B, Holinstat M, Holman TR., Free PMC Article | 08/3/2019 |
| The results suggested that genetic variation in ALOX12 might influence BMD variations in our recruited participants. As for the patients with lower serum Se levels, it was observed that serum Se deficiency was accompanied by some ALOX12 variation, contributing to the development of osteoporosis. | ALOX12 gene polymorphisms and serum selenium status in elderly osteoporotic patients.
Al-E-Ahmad A, Parsian H, Fathi M, Faghihzadeh S, Hosseini SR, Nooreddini HG, Mosapour A. | 07/20/2019 |
| ALOX12 missense mutations from human cancers abrogate its ability to oxygenate polyunsaturated fatty acids and to induce p53-mediated ferroptosis. Notably, ALOX12 is dispensable for ferroptosis induced by erastin or GPX4 inhibitors; conversely, ACSL4 is required for ferroptosis upon GPX4 inhibition but dispensable for p53-mediated ferroptosis | ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway.
Chu B, Kon N, Chen D, Li T, Liu T, Jiang L, Song S, Tavana O, Gu W., Free PMC Article | 07/6/2019 |
| this study has revealed previously uncharacterized metabolic reprogramming involving an ALOX12-12-HETE-GPR31 axis that functionally determines hepatic ischemia-reperfusion injury procession | An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury.
Zhang XJ, Cheng X, Yan ZZ, Fang J, Wang X, Wang W, Liu ZY, Shen LJ, Zhang P, Wang PX, Liao R, Ji YX, Wang JY, Tian S, Zhu XY, Zhang Y, Tian RF, Wang L, Ma XL, Huang Z, She ZG, Li H. | 05/25/2019 |
| This review summarizes our current knowledge on the role of 12/15-LOX in inflammation and various human diseases. [Review] | Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies.
Singh NK, Rao GN., Free PMC Article | 05/11/2019 |
| ALOX15 orthologs, commonly known as 12/15-lipoxygenases, were suggested to exhibit mainly arachidonic acid 12-lipoxygenating specificity in mammals ranked in evolution lower than gibbons and 15-lipoxygenating specificity in the higher ranking primates [Review]. | The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs.
Kuhn H, Humeniuk L, Kozlov N, Roigas S, Adel S, Heydeck D. | 12/22/2018 |
| ALOX12 rs14309 GG genotype expression was found to be significantly associated with Cardiovascular events in patients with Diabetic Nephropathy. | Association of ALOX12 gene polymorphism with all-cause and cardiovascular mortality in diabetic nephropathy.
Roumeliotis AK, Roumeliotis SK, Panagoutsos SA, Tsetsos F, Georgitsi M, Manolopoulos V, Paschou P, Passadakis PS. | 09/1/2018 |