| Effects of single nucleotide polymorphisms of the folylpolyglutamate synthase gene on pemetrexed administration-induced nephropathy. | Effects of single nucleotide polymorphisms of the folylpolyglutamate synthase gene on pemetrexed administration-induced nephropathy.
Mitarai Y, Tanino R, Nakashima K, Hotta T, Isobe T, Tsubata Y. | 11/29/2023 |
| Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon. | Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon.
Fernandes MR, Rodrigues JCG, Dobbin EAF, Pastana LF, da Costa DF, Barra WF, Modesto AAC, de Assumpção PB, da Costa Silva AL, Dos Santos SEB, Burbano RMR, de Assumpção PP, Dos Santos NPC. | 01/8/2022 |
| Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis. | Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis.
Muller IB, Lin M, Lems WF, Ter Wee MM, Wojtuszkiewicz A, Nurmohamed MT, Cloos J, Assaraf YG, Jansen G, de Jonge R., Free PMC Article | 08/21/2021 |
| Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia. | Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia.
Tulstrup M, Moriyama T, Jiang C, Grosjean M, Nersting J, Abrahamsson J, Grell K, Hjalgrim LL, Jónsson ÓG, Kanerva J, Lund B, Nielsen SN, Nielsen RL, Overgaard U, Quist-Paulsen P, Pruunsild K, Vaitkeviciene G, Wolthers BO, Zhang H, Gupta R, Yang JJ, Schmiegelow K., Free PMC Article | 03/27/2021 |
| Association of NUDT15*3 and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia. | Association of NUDT15*3 and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia.
Kodidela S, Dorababu P, Thakkar DN, Dubashi B, Sundaram R, Muralidharan N, Nidanapu RP, Aribandi A, Pradhan SC, Uppugunduri CRS., Free PMC Article | 03/20/2021 |
| FPGS relapse-specific mutations in relapsed childhood acute lymphoblastic leukemia. | FPGS relapse-specific mutations in relapsed childhood acute lymphoblastic leukemia.
Yu SL, Zhang H, Ho BC, Yu CH, Chang CC, Hsu YC, Ni YL, Lin KH, Jou ST, Lu MY, Chen SH, Wu KH, Wang SC, Chang HH, Pui CH, Yang JJ, Zhang J, Lin DT, Lin SW, Ma X, Yang YL., Free PMC Article | 02/13/2021 |
| our study has established the de novo MTX-resistant cell line SF-86 and identified SKA1 as a novel regulator of FPGS, playing a key role in the development of de novo MTX-resistance in osteosarcoma (OS). | SKA1 induces de novo MTX-resistance in osteosarcoma through inhibiting FPGS transcription.
Yu W, Min D, Lin F, Zheng S, Tang L, He A, Hu H, Shen Z. | 05/16/2020 |
| analysis of seven polymorphisms in genes of folate transport and (de)glutamation pathway on methotrexate polyglutamate levels and response in patients with rheumatoid arthritis: ABCB1, FPGS, GGH and RFC1 | Do SNPs in folate pharmacokinetic pathway alter levels of intracellular methotrexate polyglutamates and affect response? A prospective study in Indian patients.
Sandhu A, Ahmad S, Kaur J, Bhatnagar A, Dhawan V, Dhir V. | 07/6/2019 |
| The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia. | The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia.
Wojtuszkiewicz A, Assaraf YG, Hoekstra M, Sciarrillo R, Jansen G, Peters GJ, Pieters R, Sonneveld E, Escherich G, Kaspers GJ, Cloos J., Free PMC Article | 01/27/2018 |
| Low expression level of FPGS is associated with neuroendocrine lung tumors. | Folic-acid metabolism and DNA-repair phenotypes differ between neuroendocrine lung tumors and associate with aggressive subtypes, therapy resistance and outcome.
Walter RF, Mairinger FD, Werner R, Vollbrecht C, Hager T, Schmid KW, Wohlschlaeger J, Christoph DC., Free PMC Article | 01/20/2018 |
| Our results revealed a significant difference of overall survival between patients with AA genotype and GA + GG genotype (P<0.05). Our study demonstrated a correlation of the polymorphism of FPGS rs1544105 with MTX treatment efficacy, as well as with overall survival, suggesting it could be used as an effective approach in the prediction of MTX treatment efficacy | Effect of the Polymorphism of Folylpolyglutamate Synthetase on Treatment of High-Dose Methotrexate in Pediatric Patients with Acute Lymphocytic Leukemia.
Huang Z, Tong HF, Li Y, Qian JC, Wang JX, Wang Z, Ruan JC., Free PMC Article | 04/1/2017 |
| These results indicate that elevated expressions of the tumor-related genes FPGS/GGH and VEGF are correlated with malignancy of thymic carcinoma and B3 thymoma tumors. | Tumor-related gene expression levels in thymic carcinoma and Type B3 thymoma.
Karube Y, Kobayashi S, Maeda S, Sado T, Ishihama H, Chida M., Free PMC Article | 01/28/2017 |
| 529 adults (n = 325 European-Americans, 204 Egyptians) on a stable warfarin dose were genotyped for GGCX rs12714145 and rs10654848, FPGS rs7856096, and STX1B rs4889606. | Impact of GGCX, STX1B and FPGS Polymorphisms on Warfarin Dose Requirements in European-Americans and Egyptians.
Hamadeh IS, Shahin MH, Lima SM, Oliveira F, Wilson L, Khalifa SI, Langaee TY, Cooper-DeHoff RM, Cavallari LH, Johnson JA., Free PMC Article | 11/19/2016 |
| data suggest that FPGS modulation affects global and promoter CpG DNA methylation and expression of several genes involved in important biological pathways | Effects of folylpolyglutamate synthase modulation on global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells.
Kim SE, Hinoue T, Kim MS, Sohn KJ, Cho RC, Weisenberger DJ, Laird PW, Kim YI., Free PMC Article | 11/5/2016 |
| the highest expression of GGH and EGFR was noted in the left-sided colon; the highest expression of DHFR, FPGS, TOP1 and ERCC1 was noted in the rectosigmoid, whereas TYMP expression was approximately equivalent in the right-sided colon and rectum | Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis.
Shimamoto Y, Nukatsuka M, Takechi T, Fukushima M., Free PMC Article | 10/29/2016 |
| FPGS and ABCB1 genetic variants can influence the outcome in RA patients receiving MTX monotherapy. | Methotrexate pharmacokinetic genetic variants are associated with outcome in rheumatoid arthritis patients.
Moya P, Salazar J, Arranz MJ, Díaz-Torné C, del Río E, Casademont J, Corominas H, Baiget M. | 09/3/2016 |
| Genetic polymorphisms in the FPGS coding region are significantly associated with increased Acute Lymphoblastic Leukemia risk. | Mutation Screening and Association Study of the Folylpolyglutamate Synthetase (FPGS) Gene with Susceptibility to Childhood Acute Lymphoblastic Leukemia.
Piwkham D, Siriboonpiputtana T, Beuten J, Pakakasama S, Gelfond JA, Paisooksantivatana K, Tomlinson GE, Rerkamnuaychoke B. | 04/9/2016 |
| study found that genetic polymorphism of FPGS rs10760502A > G is associated with susceptibility to primary retroperitoneal liposasrcoma | Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma.
Miao C, Liu D, Zhang F, Wang Y, Zhang Y, Yu J, Zhang Z, Liu G, Li B, Liu X, Luo C., Free PMC Article | 12/12/2015 |
| antifolate resistant leukemia cells harbor a heterozygous point mutation in exon12 of FPGS which disrupts FPGS activity by abolishing ATP binding, and alters the binding pattern of transcription factors to the genomic region of exon12. | Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia.
Raz S, Stark M, Assaraf YG., Free PMC Article | 08/8/2015 |
| Genome-wide association studies identify 10 novel genetic loci as risk factors for methotrexate response in rheumatoid arthritis patients additionally to polymorphism in DHFR, FPGS and TYMS. | Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation.
Senapati S, Singh S, Das M, Kumar A, Gupta R, Kumar U, Jain S, Juyal RC, Thelma BK. | 02/14/2015 |
| mitochondrial FPGS is required because folate polyglutamates are not substrates for transport across the mitochondrial membrane | Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates.
Lawrence SA, Titus SA, Ferguson J, Heineman AL, Taylor SM, Moran RG., Free PMC Article | 12/27/2014 |
| Polymorphism of FPGS rs1544105 G>A is associated with response to therapy in acute lymphoblastic leukemia. | Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia.
Wang SM, Sun LL, Zeng WX, Wu WS, Zhang GL. | 11/8/2014 |
| An interaction term, between FPGS rs7033913 heterozygotes and GGH rs11988534 homozygotes for the minor allele, had a p-value <0.0001 and may contribute to methotrexate toxicity in rheumatoid arthritis. | Folic acid pathway single nucleotide polymorphisms associated with methotrexate significant adverse events in United States veterans with rheumatoid arthritis.
Davis LA, Polk B, Mann A, Wolff RK, Kerr GS, Reimold AM, Cannon GW, Mikuls TR, Caplan L., Free PMC Article | 08/16/2014 |
| High Folylpoly-glutamate synthetase expression is associated with response to therapy in non-small-cell lung cancer. | Folylpoly-glutamate synthetase expression is associated with tumor response and outcome from pemetrexed-based chemotherapy in malignant pleural mesothelioma.
Christoph DC, Asuncion BR, Mascaux C, Tran C, Lu X, Wynes MW, Gauler TC, Wohlschlaeger J, Theegarten D, Neumann V, Hepp R, Welter S, Stamatis G, Tannapfel A, Schuler M, Eberhardt WE, Hirsch FR., Free PMC Article | 01/26/2013 |
| A novel missense mutation 502/490 T>C (L151/101P) in exon 5 of FPGS gene is firstly found in Chinese Han children, and the cytosolic and mitochondrial variants display allelic frequencies of 0.70 % and 0.47 % respectively. | [A novel missense mutation of folypolyglutamate synthetase gene].
Hu CY, Yue LJ, Yu J, Zhang HH, Yang CL. | 10/27/2012 |