| RHOQ is induced by DLL4 and regulates angiogenesis by determining the intracellular route of the Notch intracellular domain. | RHOQ is induced by DLL4 and regulates angiogenesis by determining the intracellular route of the Notch intracellular domain.
Bridges E, Sheldon H, Kleibeuker E, Ramberger E, Zois C, Barnard A, Harjes U, Li JL, Masiero M, MacLaren R, Harris A., Free PMC Article | 07/10/2021 |
| Exocytosis of Rab11- and L1-positive vesicles may play a central role in TC10-mediated neurite outgrowth | GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70.
Fujita A, Koinuma S, Yasuda S, Nagai H, Kamiguchi H, Wada N, Nakamura T., Free PMC Article | 08/23/2014 |
| Novel tumor-associated increase of RNA editing in ras homologue family member Q (RHOQ) transcripts, is reported. | RNA editing in RHOQ promotes invasion potential in colorectal cancer.
Han SW, Kim HP, Shin JY, Jeong EG, Lee WC, Kim KY, Park SY, Lee DW, Won JK, Jeong SY, Park KJ, Park JG, Kang GH, Seo JS, Kim JI, Kim TY., Free PMC Article | 05/31/2014 |
| The enhancement of Cb-induced gephyrin clustering by GTP-TC10 does not depend on the guanine nucleotide exchange activity of Cb but involves an interaction that resembles reported interactions of other small GTPases with their effectors | Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission.
Mayer S, Kumar R, Jaiswal M, Soykan T, Ahmadian MR, Brose N, Betz H, Rhee JS, Papadopoulos T., Free PMC Article | 03/1/2014 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Identification of type 2 diabetes-associated combination of SNPs using support vector machine.
Ban HJ, Heo JY, Oh KS, Park KJ., Free PMC Article | 06/30/2010 |
| These findings reveal a novel signaling pathway in human skeletal muscle that involves obscurin and the Rho GTPase TC10 and implicate this pathway in new sarcomere formation. | TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin.
Coisy-Quivy M, Touzet O, Bourret A, Hipskind RA, Mercier J, Fort P, Philips A., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM. | 09/24/2008 |
| Overexpression of the Rho family member TC10alpha, disrupts adipocyte cortical actin structure and inhibits insulin-stimulated GLUT4 translocation | Lipid Raft targeting of the TC10 amino terminal domain is responsible for disruption of adipocyte cortical actin.
Chunqiu Hou J, Pessin JE., Free PMC Article | 01/21/2010 |
| The crystal structure of TC10 proved that the basic region of WASp and two unique glutamates in Cdc42 generate favorable electrostatic steering forces that control the accelerated WASp-Cdc42 association reaction. | An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins.
Hemsath L, Dvorsky R, Fiegen D, Carlier MF, Ahmadian MR. | 01/21/2010 |
| The GTP-bound form of TC10 directs the trafficking of CFTR from the juxtanuclear region to the secretory pathway toward the plasma membrane | Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10.
Cheng J, Wang H, Guggino WB. | 01/21/2010 |
| The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin | The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin.
Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR. | 01/21/2010 |
| We propose that an EGF-stimulated GAP accelerates GTP hydrolysis of TC10, thereby promoting vesicle fusion. | GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion.
Kawase K, Nakamura T, Takaya A, Aoki K, Namikawa K, Kiyama H, Inagaki S, Takemoto H, Saltiel AR, Matsuda M. | 01/21/2010 |