| LncRNA AC100826.1 regulated PLCB1 to promote progression in non-small cell lung cancer. | LncRNA AC100826.1 regulated PLCB1 to promote progression in non-small cell lung cancer.
Dai S, Wang Q, Lyu Y, Chen Z, Liu X, Zhao G, Zhang H., Free PMC Article | 07/25/2024 |
| Lnc-PLCB1 is stabilized by METTL14 induced m6A modification and inhibits Helicobacter pylori mediated gastric cancer by destabilizing DDX21. | Lnc-PLCB1 is stabilized by METTL14 induced m6A modification and inhibits Helicobacter pylori mediated gastric cancer by destabilizing DDX21.
Chang M, Cui X, Sun Q, Wang Y, Liu J, Sun Z, Ren J, Sun Y, Han L, Li W. | 04/12/2024 |
| PLCB1 Enhances Cell Migration and Invasion in Gastric Cancer Via Regulating Actin Cytoskeletal Remodeling and Epithelial-Mesenchymal Transition. | PLCB1 Enhances Cell Migration and Invasion in Gastric Cancer Via Regulating Actin Cytoskeletal Remodeling and Epithelial-Mesenchymal Transition.
Wang Y, Tu Z, Zhao W, Wang L, Jiang J, Gu L, Li M, Jiang L, Wang Y, Bi Y. | 11/25/2023 |
| Conformational alteration in glycan induces phospholipase Cbeta1 activation and angiogenesis. | Conformational alteration in glycan induces phospholipase Cβ1 activation and angiogenesis.
Wang SH, Cheng JY, Tsai HH, Lo TC, Hung JT, Lin CC, Lee CW, Ho YH, Kuo HH, Yu AL, Yu J., Free PMC Article | 01/11/2023 |
| MicroRNA-1297 participates in the repair of intestinal barrier injury in patients with HIV/AIDS via negative regulation of PLCbeta1. | MicroRNA-1297 participates in the repair of intestinal barrier injury in patients with HIV/AIDS via negative regulation of PLCβ1.
Bao Y, Guo H, Yang B, Chen F, Zhang Z, Gao J. | 07/9/2022 |
| Elevation of phospholipase C-beta1 expression by amyloid-beta facilitates calcium overload in neuronal cells. | Elevation of phospholipase C-β1 expression by amyloid-β facilitates calcium overload in neuronal cells.
Park J, Kim SH, Kim YJ, Kim H, Oh Y, Choi KY, Kim BC, Lee KH, Song WK. | 06/18/2022 |
| Impact of phospholipase C beta1 in glioblastoma: a study on the main mechanisms of tumor aggressiveness. | Impact of phospholipase C β1 in glioblastoma: a study on the main mechanisms of tumor aggressiveness.
Ratti S, Marvi MV, Mongiorgi S, Obeng EO, Rusciano I, Ramazzotti G, Morandi L, Asioli S, Zoli M, Mazzatenta D, Suh PG, Manzoli L, Cocco L., Free PMC Article | 04/16/2022 |
| A PLCB1-PI3K-AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression. | A PLCB1-PI3K-AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression.
Liang S, Guo H, Ma K, Li X, Wu D, Wang Y, Wang W, Zhang S, Cui Y, Liu Y, Sun L, Zhang B, Xin M, Zhang N, Zhou H, Liu Y, Wang J, Liu L., Free PMC Article | 01/15/2022 |
| Three novel patients with epileptic encephalopathy due to biallelic mutations in the PLCB1 gene. | Three novel patients with epileptic encephalopathy due to biallelic mutations in the PLCB1 gene.
Desprairies C, Valence S, Maurey H, Helal SI, Weckhuysen S, Soliman H, Mefford HC, Spentchian M, Héron D, Leguern E, Nava C, Bouilleret V, Moretti R, Mignot C. | 02/6/2021 |
| During osteogenic differentiation, PLC-beta1 expression varies concomitantly with cyclin E expression and the two proteins interact. | Phospholipase C-β1 interacts with cyclin E in adipose- derived stem cells osteogenic differentiation.
Ramazzotti G, Fiume R, Chiarini F, Campana G, Ratti S, Billi AM, Manzoli L, Follo MY, Suh PG, McCubrey J, Cocco L, Faenza I. | 03/7/2020 |
| this study revealed the important role of circ-PRKCI-miR-1324-PLCB1 regulatory network in Hirschsprung disease (HSCR), providing a novel insight for the pathogenesis of HSCR. | Down-regulation of circ-PRKCI inhibits cell migration and proliferation in Hirschsprung disease by suppressing the expression of miR-1324 target PLCB1.
Zhou L, Li Y, Jiang W, Zhang H, Wen Z, Su Y, Wu F, Zhi Z, Shen Q, Li H, Xu X, Tang W., Free PMC Article | 12/21/2019 |
| rs1047383 in the PLCB1 gene is associated with cocaine dependence. PLCB1 expression is upregulated in the nucleus accumbens of cocaine abusers. | Association of the PLCB1 gene with drug dependence.
Cabana-Domínguez J, Roncero C, Pineda-Cirera L, Palma-Álvarez RF, Ros-Cucurull E, Grau-López L, Esojo A, Casas M, Arenas C, Ramos-Quiroga JA, Ribasés M, Fernàndez-Castillo N, Cormand B., Free PMC Article | 05/4/2019 |
| The intronic PLCB1 InDel is the first variant found in familial multiple papilloid adenomata-type multinodular goiter and in a subset of patients with sporadic multinodular goiter. | An InDel in Phospholipase-C-B-1 Is Linked with Euthyroid Multinodular Goiter.
Bakhsh AD, Ladas I, Hamshere ML, Bullock M, Kirov G, Zhang L, Taylor PN, Gregory JW, Scott-Coombes D, Völzke H, Teumer A, Mantripragada K, Williams ED, Clifton-Bligh RJ, Williams NM, Ludgate ME. | 03/23/2019 |
| PLCbeta1 is a candidate signature gene for proneural subtype high-grade glioma. | Phospholipase C Beta 1: a Candidate Signature Gene for Proneural Subtype High-Grade Glioma.
Lu G, Chang JT, Liu Z, Chen Y, Li M, Zhu JJ., Free PMC Article | 01/27/2018 |
| Dysregulation of primary PLC signaling is linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression and Alzheimer's disease. (Review) | Primary phospholipase C and brain disorders.
Yang YR, Kang DS, Lee C, Seok H, Follo MY, Cocco L, Suh PG. | 11/18/2017 |
| Phospholipase C beta connects G protein signaling with RNA interference. (Review) | Phospholipase Cβ connects G protein signaling with RNA interference.
Scarlata S, Garwain O, Williams L, Burguera IG, Rosati B, Sahu S, Guo Y, Philip F, Golebiewska U., Free PMC Article | 11/18/2017 |
| The role of PLCb1 nuclear isoform is being analyzed in relation to the cell cycle regulation, the cell differentiation, and different physiopathological pathways focusing on the importance of the nuclear localization from both molecular and clinical point of view. (Review) | Nuclear Inositide Signaling Via Phospholipase C.
Ratti S, Mongiorgi S, Ramazzotti G, Follo MY, Mariani GA, Suh PG, McCubrey JA, Cocco L, Manzoli L. | 11/4/2017 |
| PI-PLCbeta1 is a modulator of hematopoiesis. [review] | Modulation of nuclear PI-PLCbeta1 during cell differentiation.
Cocco L, Manzoli L, Faenza I, Ramazzotti G, Yang YR, McCubrey JA, Suh PG, Follo MY. | 01/28/2017 |
| Polymorphism of the PLCB4/B1 genes might be involved in the coronary artery aneurysm pathogenesis of Kawasaki disease. | Genetic variants in PLCB4/PLCB1 as susceptibility loci for coronary artery aneurysm formation in Kawasaki disease in Han Chinese in Taiwan.
Lin YJ, Chang JS, Liu X, Tsang H, Chien WK, Chen JH, Hsieh HY, Hsueh KC, Shiao YT, Li JP, Lin CW, Lai CH, Wu JY, Chen CH, Lin JG, Lin TH, Liao CC, Huang SM, Lan YC, Ho TJ, Liang WM, Yeh YC, Lin JC, Tsai FJ., Free PMC Article | 08/20/2016 |
| Reduction in plasma membrane PI(4,5)P2 abundance by PTPRN2 and PLCbeta1 releases the PI(4,5)P2-binding protein cofilin from its inactive membrane-associated state into the cytoplasm where it mediates actin turnover dynamics. | PTPRN2 and PLCβ1 promote metastatic breast cancer cell migration through PI(4,5)P2-dependent actin remodeling.
Sengelaub CA, Navrazhina K, Ross JB, Halberg N, Tavazoie SF., Free PMC Article | 05/7/2016 |
| The rs6108160 polymorphism in the PLCB1 gene reached statistical significance after antidepressant drug use. | Identifying genetic loci associated with antidepressant drug response with drug-gene interaction models in a population-based study.
Noordam R, Direk N, Sitlani CM, Aarts N, Tiemeier H, Hofman A, Uitterlinden AG, Psaty BM, Stricker BH, Visser LE. | 03/5/2016 |
| results show that PI-PLCbeta1 quantification in MDS predicts the response to azacitidine and is associated with an increased myeloid differentiation. | An increased expression of PI-PLCβ1 is associated with myeloid differentiation and a longer response to azacitidine in myelodysplastic syndromes.
Cocco L, Finelli C, Mongiorgi S, Clissa C, Russo D, Bosi C, Quaranta M, Malagola M, Parisi S, Stanzani M, Ramazzotti G, Mariani GA, Billi AM, Manzoli L, Follo MY. | 02/13/2016 |
| one specific Egr-1 binding site was identified at nt-451/-419 and PLCB1 promoter activity was increased more than 5-fold | Characterization of the PLCB1 promoter and regulation by early growth response transcription factor EGR-1.
Klenke S, Rump K, Buschkamp K, Engler A, Peters J, Siffert W, Frey UH. | 08/29/2015 |
| Cholesterol regulates HERG K+ channel activation by increasing phospholipase C beta1 expression | Cholesterol regulates HERG K+ channel activation by increasing phospholipase C β1 expression.
Chun YS, Oh HG, Park MK, Cho H, Chung S., Free PMC Article | 04/4/2015 |
| Our data indicate that the amplification of PLCb1a expression, following treatment with kinamycin F, confers a real advantage to K562 cells viability and protects cells themselves from apoptosis. | PLCβ1a and PLCβ1b selective regulation and cyclin D3 modulation reduced by kinamycin F during k562 cell differentiation.
Bavelloni A, Dmitrienko GI, Goodfellow VJ, Ghavami A, Piazzi M, Blalock W, Chiarini F, Cocco L, Faenza I. | 02/14/2015 |