| A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis. | A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis.
Shi J, Wu X, Wang Z, Li F, Meng Y, Moore RM, Cui J, Xue C, Croce KR, Yurdagul A Jr, Doench JG, Li W, Zarbalis KS, Tabas I, Yamamoto A, Zhang H., Free PMC Article | 01/21/2023 |
| ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration. | ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration.
Søreng K, Pankiv S, Bergsmark C, Haugsten EM, Dahl AK, de la Ballina LR, Yamamoto A, Lystad AH, Simonsen A., Free PMC Article | 03/12/2022 |
| A highly conserved glutamic acid in ALFY inhibits membrane binding to aid in aggregate clearance. | A highly conserved glutamic acid in ALFY inhibits membrane binding to aid in aggregate clearance.
Reinhart EF, Litt NA, Katzenell S, Pellegrini M, Yamamoto A, Ragusa MJ., Free PMC Article | 05/15/2021 |
| Alfy is required in the adult brain for the autophagy-dependent clearance of proteinaceous deposits, and its depletion in neurons derived from Huntington's disease patient fibroblasts accelerates the aberrant accumulation of this pathological hallmark shared across adult-onset neurodegenerative diseases. | Huntington's Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy.
Fox LM, Kim K, Johnson CW, Chen S, Croce KR, Victor MB, Eenjes E, Bosco JR, Randolph LK, Dragatsis I, Dragich JM, Yoo AS, Yamamoto A., Free PMC Article | 07/11/2020 |
| Proliferating cortical neural progenitors of human embryonic brain regions highly express WDFY3. | Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size.
Le Duc D, Giulivi C, Hiatt SM, Napoli E, Panoutsopoulos A, Harlan De Crescenzo A, Kotzaeridou U, Syrbe S, Anagnostou E, Azage M, Bend R, Begtrup A, Brown NJ, Büttner B, Cho MT, Cooper GM, Doering JH, Dubourg C, Everman DB, Hildebrand MS, Santos FJR, Kellam B, Keller-Ramey J, Lemke JR, Liu S, Niyazov D, Payne K, Person R, Quélin C, Schnur RE, Smith BT, Strober J, Walker S, Wallis M, Walsh L, Yang S, Yuen RKC, Ziegler A, Sticht H, Pride MC, Orosco L, Martínez-Cerdeño V, Silverman JL, Crawley JN, Scherer SW, Zarbalis KS, Jamra R., Free PMC Article | 05/16/2020 |
| a crucial role for ALFY in retinoid triggered maturation of acute myeloid leukemia cells, is reported. | The autophagy scaffold protein ALFY is critical for the granulocytic differentiation of AML cells.
Schläfli AM, Isakson P, Garattini E, Simonsen A, Tschan MP., Free PMC Article | 07/6/2019 |
| The Autophagy linked FYVE protein (Alfy), also known as WDFY3, is required for development of the central nervous system (CNS) in mice. | Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain.
Dragich JM, Kuwajima T, Hirose-Ikeda M, Yoon MS, Eenjes E, Bosco JR, Fox LM, Lystad AH, Oo TF, Yarygina O, Mita T, Waguri S, Ichimura Y, Komatsu M, Simonsen A, Burke RE, Mason CA, Yamamoto A., Free PMC Article | 05/30/2019 |
| we demonstrate that normally ALFY attenuates the canonical Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2. | ALFY-Controlled DVL3 Autophagy Regulates Wnt Signaling, Determining Human Brain Size.
Kadir R, Harel T, Markus B, Perez Y, Bakhrat A, Cohen I, Volodarsky M, Feintsein-Linial M, Chervinski E, Zlotogora J, Sivan S, Birnbaum RY, Abdu U, Shalev S, Birk OS., Free PMC Article | 08/6/2016 |
| ALFY binds selectively to LC3C and the GABARAPs through a LC3-interacting region in its WD40 domain. | Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.
Lystad AH, Ichimura Y, Takagi K, Yang Y, Pankiv S, Kanegae Y, Kageyama S, Suzuki M, Saito I, Mizushima T, Komatsu M, Simonsen A., Free PMC Article | 01/17/2015 |
| increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others | Alfy-dependent elimination of aggregated proteins by macroautophagy: can there be too much of a good thing?
Yamamoto A, Simonsen A., Free PMC Article | 12/31/2011 |
| Data suggest that p62 and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy. | p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy.
Clausen TH, Lamark T, Isakson P, Finley K, Larsen KB, Brech A, Øvervatn A, Stenmark H, Bjørkøy G, Simonsen A, Johansen T. | 08/16/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. | The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.
Filimonenko M, Isakson P, Finley KD, Anderson M, Jeong H, Melia TJ, Bartlett BJ, Myers KM, Birkeland HC, Lamark T, Krainc D, Brech A, Stenmark H, Simonsen A, Yamamoto A., Free PMC Article | 05/31/2010 |
| Alfy might target cytosolic protein aggregates for autophagic degradation. | Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes.
Simonsen A, Birkeland HC, Gillooly DJ, Mizushima N, Kuma A, Yoshimori T, Slagsvold T, Brech A, Stenmark H. | 01/21/2010 |