| LncRNA ACVR2B-as1 interacts with ALDOA to regulate the self-renewal and apoptosis of human spermatogonial stem cells by controlling glycolysis activity. | LncRNA ACVR2B-as1 interacts with ALDOA to regulate the self-renewal and apoptosis of human spermatogonial stem cells by controlling glycolysis activity.
Xu Z, Lv C, Gao J, Cui Y, Liu W, He Z, He L., Free PMC Article | 10/31/2024 |
| The POU2F1-ALDOA axis promotes the proliferation and chemoresistance of colon cancer cells by enhancing glycolysis and the pentose phosphate pathway activity. | The POU2F1-ALDOA axis promotes the proliferation and chemoresistance of colon cancer cells by enhancing glycolysis and the pentose phosphate pathway activity.
Lin J, Xia L, Oyang L, Liang J, Tan S, Wu N, Yi P, Pan Q, Rao S, Han Y, Tang Y, Su M, Luo X, Yang Y, Chen X, Yang L, Zhou Y, Liao Q., Free PMC Article | 08/27/2024 |
| ALDOA coordinates PDE3A through the beta-catenin/ID3 axis to stimulate cancer metastasis and M2 polarization in lung cancer with EGFR mutations. | ALDOA coordinates PDE3A through the β-catenin/ID3 axis to stimulate cancer metastasis and M2 polarization in lung cancer with EGFR mutations.
Yeh CY, Cai HY, Kuo HH, Lin YY, He ZJ, Cheng HC, Yang CJ, Huang CF, Chang YC. | 06/26/2024 |
| Aldolase A promotes cervical cancer cell radioresistance by regulating the glycolysis and DNA damage after irradiation. | Aldolase A promotes cervical cancer cell radioresistance by regulating the glycolysis and DNA damage after irradiation.
Zhou J, Lei N, Qin B, Chen M, Gong S, Sun H, Qiu L, Wu F, Guo R, Ma Q, Li Y, Chang L., Free PMC Article | 12/1/2023 |
| Correlations of ALD, Keap-1, and FoxO4 expression with traditional tumor markers and clinicopathological characteristics in colorectal carcinoma. | Correlations of ALD, Keap-1, and FoxO4 expression with traditional tumor markers and clinicopathological characteristics in colorectal carcinoma.
Huang P, Wang S, Wu Z, Zhou Z, Kuang M, Ren C, Qian X, Jiang A, Zhou Y, Wang X, Shao G., Free PMC Article | 09/3/2022 |
| The role of fructose 1,6-bisphosphate-mediated glycolysis/gluconeogenesis genes in cancer prognosis. | The role of fructose 1,6-bisphosphate-mediated glycolysis/gluconeogenesis genes in cancer prognosis.
Li CH, Chan MH, Chang YC., Free PMC Article | 05/7/2022 |
| Aldolase A Enhances Intrahepatic Cholangiocarcinoma Proliferation and Invasion through Promoting Glycolysis. | Aldolase A Enhances Intrahepatic Cholangiocarcinoma Proliferation and Invasion through Promoting Glycolysis.
Li X, Yu C, Luo Y, Lin J, Wang F, Sun X, Gao Y, Tan W, Xia Q, Kong X., Free PMC Article | 04/2/2022 |
| Substitutions at a rheostat position in human aldolase A cause a shift in the conformational population. | Substitutions at a rheostat position in human aldolase A cause a shift in the conformational population.
Fenton KD, Meneely KM, Wu T, Martin TA, Swint-Kruse L, Fenton AW, Lamb AL., Free PMC Article | 03/26/2022 |
| Loss-of-Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia. | Loss-of-Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia.
Niu Y, Lin Z, Wan A, Sun L, Yan S, Liang H, Zhan S, Chen D, Bu X, Liu P, Chen C, He W, Lu X, Wan G., Free PMC Article | 01/15/2022 |
| A novel lncRNA ARST represses glioma progression by inhibiting ALDOA-mediated actin cytoskeleton integrity. | A novel lncRNA ARST represses glioma progression by inhibiting ALDOA-mediated actin cytoskeleton integrity.
Sun J, He D, Fu Y, Zhang R, Guo H, Wang Z, Wang Y, Gao T, Wei Y, Guo Y, Pang Q, Liu Q., Free PMC Article | 12/11/2021 |
| ALDOA protects cardiomyocytes against H/R-induced apoptosis and oxidative stress by regulating the VEGF/Notch 1/Jagged 1 pathway. | ALDOA protects cardiomyocytes against H/R-induced apoptosis and oxidative stress by regulating the VEGF/Notch 1/Jagged 1 pathway.
Luo G, Wang R, Zhou H, Liu X. | 07/24/2021 |
| A Robust and Cost-Effective Luminescent-Based High-Throughput Assay for Fructose-1,6-Bisphosphate Aldolase A. | A Robust and Cost-Effective Luminescent-Based High-Throughput Assay for Fructose-1,6-Bisphosphate Aldolase A.
Cho EJ, Devkota AK, Stancu G, Edupunganti R, Debevec G, Giulianotti M, Houghten R, Powis G, Dalby KN. | 07/17/2021 |
| Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness. | Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness.
Chang YC, Yang YF, Chiou J, Tsai HF, Fang CY, Yang CJ, Chen CL, Hsiao M., Free PMC Article | 04/17/2021 |
| Exosomes carrying ALDOA and ALDH3A1 from irradiated lung cancer cells enhance migration and invasion of recipients by accelerating glycolysis. | Exosomes carrying ALDOA and ALDH3A1 from irradiated lung cancer cells enhance migration and invasion of recipients by accelerating glycolysis.
Wang C, Xu J, Yuan D, Bai Y, Pan Y, Zhang J, Shao C. | 01/16/2021 |
| Aldolase A promotes epithelial-mesenchymal transition to increase malignant potentials of cervical adenocarcinoma. | Aldolase A promotes epithelial-mesenchymal transition to increase malignant potentials of cervical adenocarcinoma.
Saito Y, Takasawa A, Takasawa K, Aoyama T, Akimoto T, Ota M, Magara K, Murata M, Hirohashi Y, Hasegawa T, Sawada N, Saito T, Osanai M., Free PMC Article | 12/12/2020 |
| Glycolytic biomarkers predict transformation in patients with follicular lymphoma. | Glycolytic biomarkers predict transformation in patients with follicular lymphoma.
Monrad I, Madsen C, Lauridsen KL, Honoré B, Plesner TL, Hamilton-Dutoit S, d'Amore F, Ludvigsen M., Free PMC Article | 08/29/2020 |
| Targeting a moonlighting function of aldolase induces apoptosis in cancer cells. | Targeting a moonlighting function of aldolase induces apoptosis in cancer cells.
Gizak A, Wiśniewski J, Heron P, Mamczur P, Sygusch J, Rakus D., Free PMC Article | 08/29/2020 |
| ALDOLASE A regulates invasion of bladder cancer cells via E-cadherin-EGFR signaling. | ALDOLASE A regulates invasion of bladder cancer cells via E-cadherin-EGFR signaling.
Li J, Wang F, Gao H, Huang S, Cai F, Sun J. | 08/15/2020 |
| High ALDOA expression is associated with Lung Cancer Metastasis. | Therapeutic Targeting of Aldolase A Interactions Inhibits Lung Cancer Metastasis and Prolongs Survival.
Chang YC, Chiou J, Yang YF, Su CY, Lin YF, Yang CN, Lu PJ, Huang MS, Yang CJ, Hsiao M. | 05/30/2020 |
| ALDOA is significantly up-regulated in hepatocellular carcinoma tissue and is closely related to hepatocellular carcinoma malignancy. | Fructose-Bisphosphate Aldolase A Regulates Hypoxic Adaptation in Hepatocellular Carcinoma and Involved with Tumor Malignancy.
Li X, Jiang F, Ge Z, Chen B, Yu J, Xin M, Wang J, An L, Wei J, Wu L. | 05/9/2020 |
| ALDOA affected the HIF-1a activity in gastric cancer, and could serve as a prognostic factor for the 5-year overall survival. | Aldolase A as a prognostic factor and mediator of progression via inducing epithelial-mesenchymal transition in gastric cancer.
Jiang Z, Wang X, Li J, Yang H, Lin X., Free PMC Article | 11/2/2019 |
| we detected ALDOA somatic promoter mutations in two cases | Promoter Mutation Analysis of ALDOA Gene in Solid Tumors and Acute Leukemias.
Son HJ, Choi EJ, Yoo NJ, Lee SH. | 08/3/2019 |
| Low ALDOA expression promotes invasion of colorectal cancer. | Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth.
Ma D, Chen X, Zhang PY, Zhang H, Wei LJ, Hu S, Tang JZ, Zhou MT, Xie C, Ou R, Xu Y, Tang KF. | 03/9/2019 |
| Aldolase A (ALDOA) knockdown reduced cyclin D1 expression by regulating epidermal growth factor receptor/mitogen-activated protein kinase (EGFR/MAPK) pathway. | Aldolase A promotes proliferation and G(1)/S transition via the EGFR/MAPK pathway in non-small cell lung cancer.
Fu H, Gao H, Qi X, Zhao L, Wu D, Bai Y, Li H, Liu X, Hu J, Shao S., Free PMC Article | 03/2/2019 |
| Results showed that ALDOA was upregulated in renal cell carcinoma (RCC) samples and cell lines and significantly associated with metastasis and survival. Overall, data revealed that ALDOA functions as a tumor promoter, plays a prominent role in proliferation, migration, and invasion of RCC cells with high expression, and may promote EMT and activate the Wnt/betacatenin signaling pathway. | High expression of fructose-bisphosphate aldolase A induces progression of renal cell carcinoma.
Huang Z, Hua Y, Tian Y, Qin C, Qian J, Bao M, Liu Y, Wang S, Cao Q, Ju X, Wang Z, Gu M. | 09/29/2018 |