| Tfap2b acts in GABAergic neurons to control sleep in mice. | Tfap2b acts in GABAergic neurons to control sleep in mice.
Hu Y, Bringmann H., Free PMC Article | 06/7/2023 |
| De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission. | De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission.
Platzer K, Sticht H, Bupp C, Ganapathi M, Pereira EM, Le Guyader G, Bilan F, Henderson LB, Lemke JR, Taschenberger H, Brose N, Abou Jamra R, Wojcik SM. | 11/26/2022 |
| Posterodorsal Medial Amygdala Regulation of Female Social Behavior: GABA versus Glutamate Projections. | Posterodorsal Medial Amygdala Regulation of Female Social Behavior: GABA versus Glutamate Projections.
Johnson CS, Hong W, Micevych PE., Free PMC Article | 11/27/2021 |
| Characterization of kindled VGAT-Cre mice as a new animal model of temporal lobe epilepsy. | Characterization of kindled VGAT-Cre mice as a new animal model of temporal lobe epilepsy.
Straub J, Gawda A, Ravichandran P, McGrew B, Nylund E, Kang J, Burke C, Vitko I, Scott M, Williamson J, Joshi S, Kapur J, Perez-Reyes E., Free PMC Article | 02/6/2021 |
| the formation of inhibitory and excitatory synapses onto excitatory neurons requires Vgat in interneurons | Regulation of Synapse Development by Vgat Deletion from ErbB4-Positive Interneurons.
Lin TW, Tan Z, Barik A, Yin DM, Brudvik E, Wang H, Xiong WC, Mei L., Free PMC Article | 07/13/2019 |
| Intense VIAAT immunoreactivity was found largely confined to the distal tubule epithelia, especially distinct in the inner medulla, although the immunoreactivity was discerned more or less in all tubules and glomeruli | Expression and localization of VIAAT in distal uriniferous tubular epithelium of mouse.
Sakaew W, Tachow A, Thoungseabyoun W, Khrongyut S, Rawangwong A, Polsan Y, Masahiko W, Kondo H, Hipkaeo W. | 06/15/2019 |
| Study investigated VIAAT expression during development in: 4 different wildtype-strains, 1 transgenic mouse line with congenital deafness and 1 mouse line with cochlear ablation. Results identify an activity-regulated gradient of VIAAT in the superior olivary complex of NRMI mice. Its absence in other mouse strains adds a novel layer of strain-specific features in the auditory system. | Activity-dependent formation of a vesicular inhibitory amino acid transporter gradient in the superior olivary complex of NMRI mice.
Ebbers L, Weber M, Nothwang HG., Free PMC Article | 08/18/2018 |
| GABAergic SVs that lacked the vesicular GABA transporter (VGAT) did not show the pH overshoot and acidified further to approximately 6.0. Comparison of luminal pH dynamics in the presence or absence of VGAT showed that VGAT operates as a GABA/H(+) exchanger, which is continuously required to offset GABA leakage | Unique pH dynamics in GABAergic synaptic vesicles illuminates the mechanism and kinetics of GABA loading.
Egashira Y, Takase M, Watanabe S, Ishida J, Fukamizu A, Kaneko R, Yanagawa Y, Takamori S., Free PMC Article | 01/27/2018 |
| The observed changes in gene and protein expression of vesicular GABA transporter, regional architecture, and morphology of mouse auditory forebrain may relate to-and to some extent enable-the emergence of mature sound-evoked activity patterns. | Differential maturation of vesicular glutamate and GABA transporter expression in the mouse auditory forebrain during the first weeks of hearing.
Hackett TA, Clause AR, Takahata T, Hackett NJ, Polley DB., Free PMC Article | 09/23/2017 |
| the AD-like tau accumulation induces anxiety through disrupting miR92a-vGAT-GABA signaling, which reveals molecular mechanisms underlying the anxiety behavior in AD patients and potentially leads to the development of new therapeutics for tauopathies. | Correcting miR92a-vGAT-Mediated GABAergic Dysfunctions Rescues Human Tau-Induced Anxiety in Mice.
Li X, Wang Z, Tan L, Wang Y, Lu C, Chen R, Zhang S, Gao Y, Liu Y, Yin Y, Liu X, Liu E, Yang Y, Hu Y, Xu Z, Xu F, Wang J, Liu GP, Wang JZ., Free PMC Article | 06/10/2017 |
| This study demonstrated that Alterations in hypoglossal motor neurons due to VGAT deficiency in mice. | Alterations in hypoglossal motor neurons due to GAD67 and VGAT deficiency in mice.
Fogarty MJ, Kanjhan R, Yanagawa Y, Noakes PG, Bellingham MC. | 05/20/2017 |
| The results suggest that vesicular release of GABA from horizontal cells is required for feedback inhibition of photoreceptors. | Targeted Deletion of Vesicular GABA Transporter from Retinal Horizontal Cells Eliminates Feedback Modulation of Photoreceptor Calcium Channels.
Hirano AA, Liu X, Boulter J, Grove J, Pérez de Sevilla Müller L, Barnes S, Brecha NC., Free PMC Article | 12/17/2016 |
| the deletion of VIAAT in GlyT2-Cre expressing neurons also strongly affects GABAergic transmission | Genetic ablation of VIAAT in glycinergic neurons causes a severe respiratory phenotype and perinatal death.
Rahman J, Besser S, Schnell C, Eulenburg V, Hirrlinger J, Wojcik SM, Hülsmann S. | 08/20/2016 |
| This study showed that Conditional Knock-Out of Vesicular GABA Transporter Gene from Starburst Amacrine Cells Reveals the Contributions of Multiple Synaptic Mechanisms Underlying Direction Selectivity in the Retina. | Conditional Knock-Out of Vesicular GABA Transporter Gene from Starburst Amacrine Cells Reveals the Contributions of Multiple Synaptic Mechanisms Underlying Direction Selectivity in the Retina.
Pei Z, Chen Q, Koren D, Giammarinaro B, Acaron Ledesma H, Wei W., Free PMC Article | 01/2/2016 |
| Results indicate the significant contribution of not only GAD65, GAD67 and VGAT-mediated GABAergic but also glycinergic transmissions to both palate and abdominal wall formations | GAD65/GAD67 double knockout mice exhibit intermediate severity in both cleft palate and omphalocele compared with GAD67 knockout and VGAT knockout mice.
Kakizaki T, Oriuchi N, Yanagawa Y. | 10/31/2015 |
| This study demonstrated that Genetic absence of the vesicular inhibitory amino acid transporter differentially regulates respiratory and locomotor motor neuron development. | Genetic absence of the vesicular inhibitory amino acid transporter differentially regulates respiratory and locomotor motor neuron development.
Fogarty MJ, Yanagawa Y, Obata K, Bellingham MC, Noakes PG. | 08/29/2015 |
| results provide genetic, behavioral, and electrophysiological evidence that VGAT-mediated inhibitory drive alters very specific forms of sensory processing: those related to pain processing | Impaired glycinergic synaptic transmission and enhanced inflammatory pain in mice with reduced expression of vesicular GABA transporter (VGAT).
Yamada MH, Nishikawa K, Kubo K, Yanagawa Y, Saito S. | 05/12/2012 |
| Results suggest that the vesicular GABA transporter VGAT is fundamental for the GABA- and/or glycine-mediated transmission that supports embryonic development. | The physiological roles of vesicular GABA transporter during embryonic development: a study using knockout mice.
Saito K, Kakizaki T, Hayashi R, Nishimaru H, Furukawa T, Nakazato Y, Takamori S, Ebihara S, Uematsu M, Mishina M, Miyazaki J, Yokoyama M, Konishi S, Inoue K, Fukuda A, Fukumoto M, Nakamura K, Obata K, Yanagawa Y., Free PMC Article | 04/23/2011 |
| Cleft palate is caused by CNS dysfunction in Gad1 and Viaat knockout mice | Cleft palate is caused by CNS dysfunction in Gad1 and Viaat knockout mice.
Oh WJ, Westmoreland JJ, Summers R, Condie BG., Free PMC Article | 01/15/2011 |
| VGLUT1 is sorted diurnally to the plasma membrane to modulate glutamate transmission during a day/night cycle, whereas VGAT expression is not oscillating but is increased in the presence of a light/dark cycle. | Time of day-dependent sorting of the vesicular glutamate transporter to the plasma membrane.
Darna M, Schmutz I, Richter K, Yelamanchili SV, Pendyala G, Höltje M, Albrecht U, Ahnert-Hilger G. | 01/21/2010 |
| These findings demonstrate that GABA uptake and release via GAT-1, GAT-3, and VGAT are initially established in the inner retina during the first postnatal week and that these systems then mature in the outer retina during the second postnatal week. | Plasmalemmal and vesicular gamma-aminobutyric acid transporter expression in the developing mouse retina.
Guo C, Stella SL Jr, Hirano AA, Brecha NC., Free PMC Article | 01/21/2010 |
| The vesicular GABA transporter (VGAT) possesses an uneven number of transmembrane domains, with the N terminus facing the cytoplasm and the C terminus residing in the synaptic vesicle lumen. | Unique luminal localization of VGAT-C terminus allows for selective labeling of active cortical GABAergic synapses.
Martens H, Weston MC, Boulland JL, Grønborg M, Grosche J, Kacza J, Hoffmann A, Matteoli M, Takamori S, Harkany T, Chaudhry FA, Rosenmund C, Erck C, Jahn R, Härtig W., Free PMC Article | 01/21/2010 |
| Viaat is expressed in horizontal cells of the outer retina not only at terminals invaginating into cone pedicles but also at terminals contacting rod spherules. | Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina.
Jellali A, Stussi-Garaud C, Gasnier B, Rendon A, Sahel JA, Dreyfus H, Picaud S. | 01/21/2010 |
| functional neuronal VIAAT is present in glucagon-containing secretory granules in pancreatic alpha-cells | Vesicular inhibitory amino acid transporter is present in glucagon-containing secretory granules in alphaTC6 cells, mouse clonal alpha-cells, and alpha-cells of islets of Langerhans.
Hayashi M, Otsuka M, Morimoto R, Muroyama A, Uehara S, Yamamoto A, Moriyama Y. | 01/21/2010 |
| lack of vgat impairs the function of the respiratory network in mouse fetuses and the impairment progresses with fetal age | Respiratory activity in brainstem of fetal mice lacking glutamate decarboxylase 65/67 and vesicular GABA transporter.
Fujii M, Arata A, Kanbara-Kume N, Saito K, Yanagawa Y, Obata K. | 01/21/2010 |