| Neonatal Fc receptor is a functional receptor for classical human astrovirus. | Neonatal Fc receptor is a functional receptor for classical human astrovirus.
Haga K, Tokui T, Miyamoto K, Takai-Todaka R, Kudo S, Ishikawa A, Ishiyama R, Kato A, Yokoyama M, Katayama K, Nakanishi A., Free PMC Article | 11/8/2024 |
| The role of immunoglobulin transport receptor, neonatal Fc receptor in mucosal infection and immunity and therapeutic intervention. | The role of immunoglobulin transport receptor, neonatal Fc receptor in mucosal infection and immunity and therapeutic intervention.
Qian S, Zhang D, Yang Z, Li R, Zhang X, Gao F, Yu L. | 07/30/2024 |
| Albumin influences leucocyte FcRn expression in the early days of kidney transplantation. | Albumin influences leucocyte FcRn expression in the early days of kidney transplantation.
Boulard P, Azzopardi N, Levard R, Cornec JM, Lamamy J, Prieur B, Demattei MV, Watier H, Gatault P, Gouilleux-Gruart V., Free PMC Article | 07/16/2024 |
| Association of the neonatal Fc receptor promoter variable number of tandem repeat polymorphism with immunoglobulin response in patients with chronic inflammatory demyelinating polyneuropathy. | Association of the neonatal Fc receptor promoter variable number of tandem repeat polymorphism with immunoglobulin response in patients with chronic inflammatory demyelinating polyneuropathy.
Fisse AL, Schäfer E, Hieke A, Schröder M, Klimas R, Brünger J, Huckemann S, Grüter T, Sgodzai M, Schneider-Gold C, Gold R, Nguyen HP, Pitarokoili K, Motte J, Arning L., Free PMC Article | 03/15/2024 |
| The therapeutic age of the neonatal Fc receptor. | The therapeutic age of the neonatal Fc receptor.
Pyzik M, Kozicky LK, Gandhi AK, Blumberg RS., Free PMC Article | 06/30/2023 |
| Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18. | Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18.
Chen X, Qu X, Liu C, Zhang Y, Zhang G, Han P, Duan Y, Li Q, Wang L, Ruan W, Wang P, Wei W, Gao GF, Zhao X, Xie Z., Free PMC Article | 09/10/2022 |
| Human IgE does not bind to human FcRn. | Human IgE does not bind to human FcRn.
Brinkhaus M, van der Kooi EJ, Bentlage AEH, Ooijevaar-de Heer P, Derksen NIL, Rispens T, Vidarsson G., Free PMC Article | 02/26/2022 |
| An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript. | An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript.
Riveros-Mckay F, Roberts D, Di Angelantonio E, Yu B, Soranzo N, Danesh J, Selvin E, Butterworth AS, Barroso I., Free PMC Article | 02/26/2022 |
| Neonatal Fc receptor expression in lymphoid and myeloid cells in systemic lupus erythematosus. | Neonatal Fc receptor expression in lymphoid and myeloid cells in systemic lupus erythematosus.
Yanis R, Bergua C, Christelle B, Maillot F, Bigot A, Beurier P, Ferreira-Maldent N, Diot E, Gouilleux-Gruart V. | 02/5/2022 |
| Research progress on neonatal Fc receptor and its application. | Research progress on neonatal Fc receptor and its application.
Hu M, Wei S, Zhou W, Wang P., Free PMC Article | 11/6/2021 |
| Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice. | Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice.
Low BE, Christianson GJ, Lowell E, Qin W, Wiles MV., Free PMC Article | 08/14/2021 |
| Demonstration of fibrinogen-FcRn binding at acidic pH by means of Fluorescence Correlation Spectroscopy. | Demonstration of fibrinogen-FcRn binding at acidic pH by means of Fluorescence Correlation Spectroscopy.
Vesco G, Lualdi M, Fasano M, Nardo L, Alberio T. | 04/24/2021 |
| V Region of IgG Controls the Molecular Properties of the Binding Site for Neonatal Fc Receptor. | V Region of IgG Controls the Molecular Properties of the Binding Site for Neonatal Fc Receptor.
Rossini S, Noé R, Daventure V, Lecerf M, Justesen S, Dimitrov JD. | 04/17/2021 |
| FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity. | FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity.
Hubbard JJ, Pyzik M, Rath T, Kozicky LK, Sand KMK, Gandhi AK, Grevys A, Foss S, Menzies SC, Glickman JN, Fiebiger E, Roopenian DC, Sandlie I, Andersen JT, Sly LM, Baker K, Blumberg RS., Free PMC Article | 03/13/2021 |
| Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge. | Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge.
Stapleton NM, Brinkhaus M, Armour KL, Bentlage AEH, de Taeye SW, Temming AR, Mok JY, Brasser G, Maas M, van Esch WJE, Clark MR, Williamson LM, van der Schoot CE, Vidarsson G., Free PMC Article | 10/24/2020 |
| Contribution of DNA methylation to the expression of FCGRT in human liver and myocardium. | Contribution of DNA methylation to the expression of FCGRT in human liver and myocardium.
Cejas RB, Ferguson DC, Quiñones-Lombraña A, Bard JE, Blanco JG., Free PMC Article | 10/24/2020 |
| FcRn, but not FcgammaRs, drives maternal-fetal transplacental transport of human IgG antibodies. | FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies.
Borghi S, Bournazos S, Thulin NK, Li C, Gajewski A, Sherwood RW, Zhang S, Harris E, Jagannathan P, Wang LX, Ravetch JV, Wang TT., Free PMC Article | 08/22/2020 |
| Placental FcRn expression in endothelial cells and macrophages is analogous to the expression pattern in other organs. FcRn expression suggests an involvement of FcRn in IgG transcytosis and/or participation in recycling/salvaging of maternal IgG present in the fetal circulation. FcRn expression in placental macrophages may account for recycling of monomeric IgG and/or processing and presentation of immune complexes. | Expression of the neonatal Fc-receptor in placental-fetal endothelium and in cells of the placental immune system.
Kiskova T, Mytsko Y, Schepelmann M, Helmer H, Fuchs R, Miedl H, Wadsack C, Ellinger I. | 05/2/2020 |
| this study shows that the IgG transfer from maternal serum to the fetus is positively correlated with FcRn expression in placental tissue throughout gestati | Expression of FcRn receptor in placental tissue and its relationship with IgG levels in term and preterm newborns.
Lozano NA, Lozano A, Marini V, Saranz RJ, Blumberg RS, Baker K, Agresta MF, Ponzio MF., Free PMC Article | 11/2/2019 |
| Study shows that human cytomegalovirus US11 inhibits the assembly of FcRn with beta2m and retains FcRn in the endoplasmic reticulum (ER), consequently blocking FcRn trafficking to the endosome. US11 recruits the ubiquitin enzymes Derlin-1, TMEM129 and UbE2J2 to engage FcRn, consequently initiating the dislocation of FcRn from the ER to the cytosol and facilitating its degradation. | Human cytomegalovirus evades antibody-mediated immunity through endoplasmic reticulum-associated degradation of the FcRn receptor.
Liu X, Palaniyandi S, Zhu I, Tang J, Li W, Wu X, Ochsner SP, Pauza CD, Cohen JI, Zhu X., Free PMC Article | 10/26/2019 |
| the presence of human serum albumin (HSA) or immunoglobulin G (IgG), which are both protected from intracellular degradation by the interaction with the neonatal Fc receptor (FcRn), results in a decreased amount of internalized fibrinogen. | Neonatal Fc receptor is involved in the protection of fibrinogen after its intake in peripheral blood mononuclear cells.
Alberio T, Forlani G, Lualdi M, Tosi G, Accolla RS, Fasano M., Free PMC Article | 07/13/2019 |
| This is the first time that FcRn expression and mAb transcytosis has been shown in a model of human nasal respiratory epithelium in vitro. | FcRn-Dependent Transcytosis of Monoclonal Antibody in Human Nasal Epithelial Cells In Vitro: A Prerequisite for a New Delivery Route for Therapy?
Bequignon E, Dhommée C, Angely C, Thomas L, Bottier M, Escudier E, Isabey D, Coste A, Louis B, Papon JF, Gouilleux-Gruart V., Free PMC Article | 07/13/2019 |
| the measurement of FcRn protein may be preferred to FcRn mRNA for quantitative applications. Significant differences were found in FcRn expression in transgenic mice, Swiss Webster mice, and human tissues, which may have implications for the use of mouse models in the assessment of monoclonal antibody disposition, efficacy, and safety. | FcRn Expression in Wildtype Mice, Transgenic Mice, and in Human Tissues.
Li T, Balthasar JP., Free PMC Article | 06/1/2019 |
| We show that loss of expression of FcRn or its binding partner beta 2 microglobulin (b2M) renders cells resistant to infection by a panel of echoviruses at the stage of virus attachment, and that a blocking antibody to b2M inhibits echovirus infection in cell lines and in primary human intestinal epithelial cells | The neonatal Fc receptor is a pan-echovirus receptor.
Morosky S, Wells AI, Lemon K, Evans AS, Schamus S, Bakkenist CJ, Coyne CB., Free PMC Article | 05/11/2019 |
| Down-regulation of FcRn is speculated to play a protective role in Hashimoto's thyroiditis pathogenesis by mainly reducing IgG1 transport in thyrocytes. | Unidirectional transport of IgG by neonatal Fc receptor in human thyrocytes varies across different IgG subclasses.
Zhao C, Gao Y, Yu N, Li T, Zhang Y, Zhang H, Lu G, Gao Y, Guo X. | 05/11/2019 |