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    FABP7 fatty acid binding protein 7 [ Homo sapiens (human) ]

    Gene ID: 2173, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    FABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer's disease.

    FABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer's disease.
    Hamilton HL, Kinscherf NA, Balmer G, Bresque M, Salamat SM, Vargas MR, Pehar M., Free PMC Article

    02/1/2024
    Stationary-to-migratory transition in glioblastoma stem-like cells driven by a fatty acid-binding protein 7-RXRalpha neurogenic pathway.

    Stationary-to-migratory transition in glioblastoma stem-like cells driven by a fatty acid-binding protein 7-RXRα neurogenic pathway.
    Liu RZ, Choi WS, Jain S, Xu X, Elsherbiny ME, Glubrecht DD, Tessier AG, Easaw JC, Fallone BG, Godbout R., Free PMC Article

    12/22/2023
    The HOPX and BLBP landscape and gliogenic regions in developing human brain.

    The HOPX and BLBP landscape and gliogenic regions in developing human brain.
    Holst CB, Brøchner CB, Vitting-Seerup K, Møllgård K., Free PMC Article

    06/22/2023
    Oleic acid-bound FABP7 drives glioma cell proliferation through regulation of nuclear lipid droplet formation.

    Oleic acid-bound FABP7 drives glioma cell proliferation through regulation of nuclear lipid droplet formation.
    Umaru BA, Kagawa Y, Ohsaki Y, Pan Y, Chen CT, Chen DK, Abe T, Shil SK, Miyazaki H, Kobayashi S, Maekawa M, Yamamoto Y, Wannakul T, Yang S, Bazinet RP, Owada Y.

    04/7/2023
    Metastatic Tumor Cell-Specific FABP7 Promotes NSCLC Metastasis via Inhibiting beta-Catenin Degradation.

    Metastatic Tumor Cell-Specific FABP7 Promotes NSCLC Metastasis via Inhibiting β-Catenin Degradation.
    Bai Q, Yang X, Li Q, Chen W, Tian H, Lian R, Liu X, Wang S, Yang Y., Free PMC Article

    07/16/2022
    Silencing of circular RNA PUM1 inhibits clear cell renal cell carcinoma progression through the miR-340-5p/FABP7 axis.

    Silencing of circular RNA PUM1 inhibits clear cell renal cell carcinoma progression through the miR-340-5p/FABP7 axis.
    Zeng F, Luo L, Song M, Li D.

    06/11/2022
    Circ_ZFR affects FABP7 expression to regulate breast cancer progression by acting as a sponge for miR-223-3p.

    Circ_ZFR affects FABP7 expression to regulate breast cancer progression by acting as a sponge for miR-223-3p.
    Tian X, Yang H, Fang Q, Quan H, Lu H, Wang X., Free PMC Article

    05/7/2022
    Nuclear FABP7 regulates cell proliferation of wild-type IDH1 glioma through caveolae formation.

    Nuclear FABP7 regulates cell proliferation of wild-type IDH1 glioma through caveolae formation.
    Kagawa Y, Umaru BA, Kanamori M, Zama R, Shil SK, Miyazaki H, Kobayashi S, Wannakul T, Yang S, Tominaga T, Owada Y., Free PMC Article

    04/16/2022
    Plasma fatty acid-binding protein 7 concentration correlates with depression/anxiety, cognition, and positive symptom in patients with schizophrenia.

    Plasma fatty acid-binding protein 7 concentration correlates with depression/anxiety, cognition, and positive symptom in patients with schizophrenia.
    Koga M, Nakagawa S, Sato A, Oka M, Makikhara K, Sakai Y, Toyomaki A, Sato M, Matsui M, Toda H, Kusumi I.

    03/5/2022
    FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells.

    FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells.
    Choi WS, Xu X, Goruk S, Wang Y, Patel S, Chow M, Field CJ, Godbout R., Free PMC Article

    10/9/2021
    Upregulation of FABP7 inhibits acute kidney injury-induced TCMK-1 cell apoptosis via activating the PPAR gamma signalling pathway.

    Upregulation of FABP7 inhibits acute kidney injury-induced TCMK-1 cell apoptosis via activating the PPAR gamma signalling pathway.
    Xu D, Shen L, Zhou L, Sha W, Yang J, Lu G.

    08/7/2021
    HIF1alpha-Regulated Expression of the Fatty Acid Binding Protein Family Is Important for Hypoxic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.

    HIF1α-Regulated Expression of the Fatty Acid Binding Protein Family Is Important for Hypoxic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.
    Singh RK, Bose D, Robertson ES., Free PMC Article

    06/19/2021
    Study of FABP's interactome and detecting new molecular targets in clear cell renal cell carcinoma.

    Study of FABP's interactome and detecting new molecular targets in clear cell renal cell carcinoma.
    Wu G, Zhang Z, Tang Q, Liu L, Liu W, Li Q, Wang Q.

    02/6/2021
    It sought to understand the function of fatty acid binding protein 7 (FABP7), which is expressed predominantly in Triple-negative breast cancer (TNBC) tissues.

    Metabolic role of fatty acid binding protein 7 in mediating triple-negative breast cancer cell death via PPAR-α signaling.
    Kwong SC, Jamil AHA, Rhodes A, Taib NA, Chung I., Free PMC Article

    09/12/2020
    Several studies on human tumors and tumor-derived cell lines put FABP7 in the center of tumorigenesis, and its high expression level has been reported to correlate with poor prognosis in different tumor types. Several types of FABP7-expressing tumors have shown an up-regulation of cell signaling activity, but molecular mechanisms of FABP7 involvement in tumorigenesis still remain elusive.

    Role of FABP7 in tumor cell signaling.
    Kagawa Y, Umaru BA, Ariful I, Shil SK, Miyazaki H, Yamamoto Y, Ogata M, Owada Y.

    03/7/2020
    FABP7 is shown to be required for upregulation of key metastatic genes and pathways, such as integrins-Src and VEGFA, and for the growth of HER2+ breast cancer cells in the brain microenvironment in vivo. Together, these results support FABP7 as a potential target for the treatment of HER2+ Breast cancer brain metastasis.

    FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis.
    Cordero A, Kanojia D, Miska J, Panek WK, Xiao A, Han Y, Bonamici N, Zhou W, Xiao T, Wu M, Ahmed AU, Lesniak MS., Free PMC Article

    02/1/2020
    FABP7 protects astrocytes from reactive oxygen species toxicity.

    FABP7 Protects Astrocytes Against ROS Toxicity via Lipid Droplet Formation.
    Islam A, Kagawa Y, Miyazaki H, Shil SK, Umaru BA, Yasumoto Y, Yamamoto Y, Owada Y.

    12/21/2019
    The genes FABP7 and NFYC(-AS1) could play a role in airflow obstruction in never-smokers specifically.

    Limited overlap in significant hits between genome-wide association studies on two airflow obstruction definitions in the same population.
    van der Plaat DA, Vonk JM, Lahousse L, de Jong K, Faiz A, Nedeljkovic I, Amin N, van Diemen CC, Brusselle GG, Bossé Y, Brandsma CA, Hao K, Paré PD, van Duijn CM, Postma DS, Boezen HM., Free PMC Article

    07/20/2019
    Study showed that higher FABP7 expression significantly correlated with distant metastasis and poor cancer-specific survival in clear cell renal cell carcinoma patients. Functional suppression of FABP7 significantly inhibited SKRC10 cell growth and resulted in a significant reduction of the invasive potential but did not cause growth inhibition of SKRC7 cells.

    Fatty acid binding protein 7 may be a marker and therapeutic targets in clear cell renal cell carcinoma.
    Nagao K, Shinohara N, Smit F, de Weijert M, Jannink S, Owada Y, Mulders P, Oosterwijk E, Matsuyama H., Free PMC Article

    04/6/2019
    FABP7 may be used as a novel diagnostic bio-marker and a potential therapeutic target for colon cancer.

    FABP7 promotes cell proliferation and survival in colon cancer through MEK/ERK signaling pathway.
    Ma R, Wang L, Yuan F, Wang S, Liu Y, Fan T, Wang F.

    03/16/2019
    Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7.

    Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7.
    Gerstner JR, Perron IJ, Riedy SM, Yoshikawa T, Kadotani H, Owada Y, Van Dongen HPA, Galante RJ, Dickinson K, Yin JCP, Pack AI, Frank MG., Free PMC Article

    10/13/2018
    BLBP was highly expressed in glioblastoma tissues.Increased BLBP expression in glioblastoma is associated with poor survival.BLBP mediates the proliferation of human glioblastoma cells by regulating ERK1/2 signaling pathway.

    Brain lipid binding protein mediates the proliferation of human glioblastoma cells by regulating ERK1/2 signaling pathway in vitro.
    Tian W, Shi J, Qin J, Jin G, Han X, Li H.

    08/11/2018
    Data indicate that the levels of fatty acid binding protein 7 (FABP7) dramatically decreased during passage of the renal cell carcinomas (RCCs) cell line TUHR14TKB.

    Functional analysis of fatty acid binding protein 7 and its effect on fatty acid of renal cell carcinoma cell lines.
    Takaoka N, Takayama T, Ozono S., Free PMC Article

    01/20/2018
    Data suggest that antinociceptive agent SBFI-26 binds at a portal site as well as at the canonical site in the substrate pocket of FABP5 and FABP7; only the S form of SBFI-26 binds to both FABP5 and FABP7 in their co-crystal structures; SBFI-26 induces conformational changes in FABP5 and FABP7.

    The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites.
    Hsu HC, Tong S, Zhou Y, Elmes MW, Yan S, Kaczocha M, Deutsch DG, Rizzo RC, Ojima I, Li H., Free PMC Article

    07/29/2017
    FABP7 is overexpressed in clear cell renal cell carcinoma and promotes cell growth by the activation of ERK and Stat3 signaling pathways

    Overexpression of FABP7 promotes cell growth and predicts poor prognosis of clear cell renal cell carcinoma.
    Zhou J, Deng Z, Chen Y, Gao Y, Wu D, Zhu G, Li L, Song W, Wang X, Wu K, He D.

    01/2/2016
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