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    F2 coagulation factor II, thrombin [ Homo sapiens (human) ]

    Gene ID: 2147, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Effect of prothrombin Belgrade mutation, causing antithrombin resistance, on fibrin clot properties.

    Effect of prothrombin Belgrade mutation, causing antithrombin resistance, on fibrin clot properties.
    Dunjic Manevski S, Cumbo M, Pruner I, Gvozdenov M, Tomic B, Taxiarchis A, Antovic J, Djordjevic V.

    03/20/2024
    The Complex Role of Thrombin in Cancer and Metastasis: Focus on Interactions with the Immune System.

    The Complex Role of Thrombin in Cancer and Metastasis: Focus on Interactions with the Immune System.
    Aleksandrowicz K, Hempel D, Polityńska B, Wojtukiewicz AM, Honn KV, Tang DG, Wojtukiewicz MZ.

    03/11/2024
    Comprehensive Analysis of the Role of Fibrinogen and Thrombin in Clot Formation and Structure for Plasma and Purified Fibrinogen.

    Comprehensive Analysis of the Role of Fibrinogen and Thrombin in Clot Formation and Structure for Plasma and Purified Fibrinogen.
    Risman RA, Belcher HA, Ramanujam RK, Weisel JW, Hudson NE, Tutwiler V., Free PMC Article

    02/28/2024
    Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin.

    Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin.
    Biswas I, Giri H, Panicker SR, Rezaie AR.,

    02/23/2024
    Thrombin Priming Promotes the Neuroprotective Effects of Human Wharton's Jelly-Derived Mesenchymal Stem Cells Via the HGF/AKT/STAT3 Signaling Pathway.

    Thrombin Priming Promotes the Neuroprotective Effects of Human Wharton's Jelly-Derived Mesenchymal Stem Cells Via the HGF/AKT/STAT3 Signaling Pathway.
    Ha GH, Yeon JY, Kim KH, Lee DM, Chae HY, Nam H, Lee K, Kim DO, Kim CK, Joo KM.

    02/20/2024
    Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation.

    Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation.
    Li X, Song X, Mahmood DFD, Sim MMS, Bidarian SJ, Wood JP., Free PMC Article

    10/10/2023
    Impact of Fibrinogen, Fibrin Thrombi, and Thrombin on Cancer Cell Extravasation Using In Vitro Microvascular Networks.

    Impact of Fibrinogen, Fibrin Thrombi, and Thrombin on Cancer Cell Extravasation Using In Vitro Microvascular Networks.
    Angelidakis E, Chen S, Zhang S, Wan Z, Kamm RD, Shelton SE., Free PMC Article

    07/31/2023
    Low alpha-Thrombin/GPIbalpha Interaction Is a Potential Contributor to Platelet Hyper-reactivity in COVID-19 Patients.

    Low α-Thrombin/GPIbα Interaction Is a Potential Contributor to Platelet Hyper-reactivity in COVID-19 Patients.
    Zaid Y, Khalki L, Jalali F, Tijani Y, Zaid N, Naya A, Oudghiri M, Akarid K, Agbani EO, Guessous F., Free PMC Article

    07/26/2023
    Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation.

    Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation.
    Parunov LA, Liang Y, Lu Q, Shibeko AM, Tucker EI, Lee TK, Ataullakhanov FI, Scott DE, Ovanesov MV., Free PMC Article

    06/16/2023
    Thrombin, a Key Driver of Pathological Inflammation in the Brain.

    Thrombin, a Key Driver of Pathological Inflammation in the Brain.
    Iannucci J, Grammas P., Free PMC Article

    05/24/2023
    Intraindividual variability over time of thrombin generation in patients with cirrhosis.

    Intraindividual variability over time of thrombin generation in patients with cirrhosis.
    Sinegre T, Duron C, Lecompte T, Lamblin G, Talon L, Muti L, Massoulier S, Pereira B, Lebreton A, Abergel A.

    05/19/2023
    Inflammatory Response and Activation of Coagulation after COVID-19 Infection.

    Inflammatory Response and Activation of Coagulation after COVID-19 Infection.
    Teodoro AGF, Rodrigues WF, Farnesi-de-Assunção TS, Borges AVBE, Obata MMS, Neto JRDC, da Silva DAA, Andrade-Silva LE, Desidério CS, Costa-Madeira JC, Barbosa RM, Cunha ACCH, Pereira LQ, de Vito FB, Vaz Tanaka SCS, Helmo FR, Lemes MR, Barbosa LM, Trevisan RO, Mundim FV, Oliveira-Scussel ACM, Junior PRR, Monteiro IB, Ferreira YM, Machado GH, Ferreira-Paim K, Moraes-Souza H, de Oliveira CJF, Rodrigues Júnior V, Silva MVD., Free PMC Article

    05/12/2023
    Integrative analysis of HASMCs gene expression profile revealed the role of thrombin in the pathogenesis of atherosclerosis.

    Integrative analysis of HASMCs gene expression profile revealed the role of thrombin in the pathogenesis of atherosclerosis.
    Zhang Y, Sun L, Wang X, Zhou Q., Free PMC Article

    04/15/2023
    Impact of prothrombin and factor V Leiden mutations on the progression of fibrosis in patients with chronic hepatitis C.

    Impact of prothrombin and factor V Leiden mutations on the progression of fibrosis in patients with chronic hepatitis C.
    Naguib M, Abdel-Razek W, Estaphan S, Abdelsameea E, Abdel-Samiee M, Shafik NF., Free PMC Article

    11/19/2022
    Effects of Thrombin on the Neurovascular Unit in Cerebral Ischemia.

    Effects of Thrombin on the Neurovascular Unit in Cerebral Ischemia.
    Cao H, Seto SW, Bhuyan DJ, Chan HH, Song W.

    04/9/2022
    How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen.

    How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen.
    Peacock RB, McGrann T, Zaragoza S, Komives EA., Free PMC Article

    02/19/2022
    Acidic Region Residues 1680-1684 in the A3 Domain of Factor VIII Contain a Thrombin-Interactive Site Responsible for Proteolytic Cleavage at Arg1689.

    Acidic Region Residues 1680-1684 in the A3 Domain of Factor VIII Contain a Thrombin-Interactive Site Responsible for Proteolytic Cleavage at Arg1689.
    Nakajima Y, Minami H, Nogami K.

    02/12/2022
    Recognition Interface of the Thrombin Binding Aptamer Requires Antiparallel Topology of the Quadruplex Core.

    Recognition Interface of the Thrombin Binding Aptamer Requires Antiparallel Topology of the Quadruplex Core.
    Svetlova J, Sardushkin M, Kolganova N, Timofeev E., Free PMC Article

    01/15/2022
    Coagulation Characterization of Prothrombin 20209C > T Variant: About 27 New Cases.

    Coagulation Characterization of Prothrombin 20209C > T Variant: About 27 New Cases.
    Jourdi G, Lobies S, Kosmider O, Duchemin J, Audureau E, Conard J, Mazoyer E, Horellou MH, Gouin-Thibault I, Flaujac C, Fontenay M.

    01/8/2022
    Association of venous thromboembolism and myocardial infarction with Factor V Leiden and Factor II gene mutations among Libyan patients.

    Association of venous thromboembolism and myocardial infarction with Factor V Leiden and Factor II gene mutations among Libyan patients.
    Msalati A, Bashein A, Ghrew M, Khalil I, Sedaa K, Ali A, Zaid A., Free PMC Article

    12/18/2021
    Relationship between thrombin generation parameters and prothrombin fragment 1 + 2 plasma levels.

    Relationship between thrombin generation parameters and prothrombin fragment 1 + 2 plasma levels.
    Capecchi M, Scalambrino E, Griffini S, Grovetti E, Clerici M, Merati G, Chantarangkul V, Cugno M, Peyvandi F, Tripodi A.

    12/4/2021
    Maternal thrombin generation and D-dimer levels in obesity and pregnancy: results from the maternal thrombin generation in obesity and pregnancy (MaTOPs) study.

    Maternal thrombin generation and D-dimer levels in obesity and pregnancy: results from the maternal thrombin generation in obesity and pregnancy (MaTOPs) study.
    Mandlebe B, Orundami OI, Lynch LA, Teale G, Said JM, Cutts BA.

    11/27/2021
    Thrombomodulin in patients with mild to moderate bleeding tendency.

    Thrombomodulin in patients with mild to moderate bleeding tendency.
    Mehic D, Tolios A, Hofer S, Ay C, Haslacher H, Downes K, Haimel M, Pabinger I, Gebhart J., Free PMC Article

    11/22/2021
    Urinary Thrombin as a Marker of Glomerular Inflammation Associated with Renal Injury in Type 2 Diabetes.

    Urinary Thrombin as a Marker of Glomerular Inflammation Associated with Renal Injury in Type 2 Diabetes.
    Kitamoto Y, Imamura T, Taguma Y, Iwaoka T, Yorinaka H, Arizono K.

    11/6/2021
    MTHFR (C677T, A1298C), FV Leiden polymorphisms, and the prothrombin G20210A mutation in arterial ischemic stroke among young tunisian adults.

    MTHFR (C677T, A1298C), FV Leiden polymorphisms, and the prothrombin G20210A mutation in arterial ischemic stroke among young tunisian adults.
    M'barek L, Sakka S, Meghdiche F, Turki D, Maalla K, Dammak M, Kallel C, Mhiri C.

    10/30/2021
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