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    ETV4 ETS variant transcription factor 4 [ Homo sapiens (human) ]

    Gene ID: 2118, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Transcription Factor ETV4 Activates AURKA to Promote PD-L1 Expression and Mediate Immune Escape in Lung Adenocarcinoma.

    Transcription Factor ETV4 Activates AURKA to Promote PD-L1 Expression and Mediate Immune Escape in Lung Adenocarcinoma.
    Yang P, He S, Ye L, Weng H.

    09/9/2024
    ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification.

    ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification.
    Yang S, Golkaram M, Oh S, Oh Y, Cho Y, Yoe J, Ju S, Lalli MA, Park SY, Lee Y, Jang J., Free PMC Article

    06/28/2024
    An oncogenic enhancer promotes melanoma progression via regulating ETV4 expression.

    An oncogenic enhancer promotes melanoma progression via regulating ETV4 expression.
    Zhang J, Wang Q, Qi S, Duan Y, Liu Z, Liu J, Zhang Z, Li C., Free PMC Article

    06/17/2024
    ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma.

    ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma.
    Neri P, Barwick BG, Jung D, Patton JC, Maity R, Tagoug I, Stein CK, Tilmont R, Leblay N, Ahn S, Lee H, Welsh SJ, Riggs DL, Stong N, Flynt E, Thakurta A, Keats JJ, Lonial S, Bergsagel PL, Boise LH, Bahlis NJ., Free PMC Article

    01/11/2024
    The Mediating Role of miR-451/ETV4/MMP13 Signaling Axis on Epithelialmesenchymal Transition in Promoting Non-small Cell Lung Cancer Progression.

    The Mediating Role of miR-451/ETV4/MMP13 Signaling Axis on Epithelialmesenchymal Transition in Promoting Non-small Cell Lung Cancer Progression.
    Qian XJ, Wang JW, Liu JB, Yu X.

    11/30/2023
    Differential expression of PEA3 in odontogenic cysts and tumors.

    Differential expression of PEA3 in odontogenic cysts and tumors.
    Tun KM, Kitkumthorn N, Bumalee D, Arayapisit T, Lapthanasupkul P.

    09/26/2023
    Down-regulated MiRNA 29-b as a diagnostic marker in colorectal cancer and its correlation with ETV4 and Cyclin D1 immunohistochemical expression.

    Down-regulated MiRNA 29-b as a diagnostic marker in colorectal cancer and its correlation with ETV4 and Cyclin D1 immunohistochemical expression.
    Mosaad H, Ahmed MM, Elaidy MM, Elfarargy OM, Abdelwahab MM, Abdelnour HM.

    09/6/2023
    Identification and characterization of novel ETV4 splice variants in prostate cancer.

    Identification and characterization of novel ETV4 splice variants in prostate cancer.
    Cosi I, Moccia A, Pescucci C, Munagala U, Di Giorgio S, Sineo I, Conticello SG, Notaro R, De Angioletti M., Free PMC Article

    08/10/2023
    ETV4 Mediated Tumor-Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer.

    ETV4 Mediated Tumor-Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer.
    Zhang Q, Liu S, Wang H, Xiao K, Lu J, Chen S, Huang M, Xie R, Lin T, Chen X., Free PMC Article

    04/19/2023
    A homozygous truncating ETV4 variant in a Nigerian family with congenital anomalies of the kidney and urinary tract.

    A homozygous truncating ETV4 variant in a Nigerian family with congenital anomalies of the kidney and urinary tract.
    Kolvenbach CM, Zheng B, Merz LM, Mertens ND, Mansour B, Wang C, Seltzsam S, Schneider S, Schierbaum L, Pantel D, Chen J, van der Ven AT, Bello JO, Shril S, Hildebrandt F., Free PMC Article

    04/12/2023
    ETV4 potentiates nuclear YAP retention and activities to enhance the progression of hepatocellular carcinoma.

    ETV4 potentiates nuclear YAP retention and activities to enhance the progression of hepatocellular carcinoma.
    Xu X, Wang B, Liu Y, Jing T, Xu G, Zhang L, Kun Jiao, Chen Z, Xiang L, Xu C, Yang Z, Liu Y.

    05/7/2022
    ETV4 mediated lncRNA C2CD4D-AS1 overexpression contributes to the malignant phenotype of lung adenocarcinoma cells via miR-3681-3p/NEK2 axis.

    ETV4 mediated lncRNA C2CD4D-AS1 overexpression contributes to the malignant phenotype of lung adenocarcinoma cells via miR-3681-3p/NEK2 axis.
    Wang B, Cai Y, Li X, Kong Y, Fu H, Zhou J., Free PMC Article

    04/23/2022
    HBx increases chromatin accessibility and ETV4 expression to regulate dishevelled-2 and promote HCC progression.

    HBx increases chromatin accessibility and ETV4 expression to regulate dishevelled-2 and promote HCC progression.
    Zheng C, Liu M, Ge Y, Qian Y, Fan H., Free PMC Article

    04/16/2022
    ETV4 mediates the Wnt/beta-catenin pathway through transcriptional activation of ANXA2 to promote hepatitis B virus-associated liver hepatocellular carcinoma progression.

    ETV4 mediates the Wnt/β-catenin pathway through transcriptional activation of ANXA2 to promote hepatitis B virus-associated liver hepatocellular carcinoma progression.
    Sun T, Zhang J.

    03/26/2022
    ETV4 transcriptionally activates HES1 and promotes Stat3 phosphorylation to promote malignant behaviors of colon adenocarcinoma.

    ETV4 transcriptionally activates HES1 and promotes Stat3 phosphorylation to promote malignant behaviors of colon adenocarcinoma.
    Yao D, Bao Z, Qian X, Yang Y, Mao Z.

    01/22/2022
    ETV4 promotes pancreatic ductal adenocarcinoma metastasis through activation of the CXCL13/CXCR5 signaling axis.

    ETV4 promotes pancreatic ductal adenocarcinoma metastasis through activation of the CXCL13/CXCR5 signaling axis.
    Gao X, Jiang M, Chu Y, Han Y, Jin Y, Zhang W, Wang W, Yang S, Li W, Fan A, Cao J, Wang J, Liu H, Fu X, Chen D, Nie Y, Fan D.

    01/8/2022
    Expression quantitative trait loci for ETV4 and MEOX1 are associated with adult asthma in Japanese populations.

    Expression quantitative trait loci for ETV4 and MEOX1 are associated with adult asthma in Japanese populations.
    Yatagai Y, Oshima H, Sakamoto T, Shigemasa R, Kitazawa H, Hyodo K, Masuko H, Iijima H, Naito T, Saito T, Hirota T, Tamari M, Hizawa N., Free PMC Article

    12/18/2021
    Circular RNA hsa_circ_0001666 sponges miR3305p, miR193a5p and miR326, and promotes papillary thyroid carcinoma progression via upregulation of ETV4.

    Circular RNA hsa_circ_0001666 sponges miR‑330‑5p, miR‑193a‑5p and miR‑326, and promotes papillary thyroid carcinoma progression via upregulation of ETV4.
    Qi Y, He J, Zhang Y, Wang L, Yu Y, Yao B, Tian Z., Free PMC Article

    10/9/2021
    The Knockdown of ETV4 Inhibits the Papillary Thyroid Cancer Development by Promoting Ferroptosis Upon SLC7A11 Downregulation.

    The Knockdown of ETV4 Inhibits the Papillary Thyroid Cancer Development by Promoting Ferroptosis Upon SLC7A11 Downregulation.
    Wang L, Zhang Y, Yang J, Liu L, Yao B, Tian Z, He J.

    09/25/2021
    ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer.

    ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer.
    Fonseca AS, Ramão A, Bürger MC, de Souza JES, Zanette DL, de Molfetta GA, de Araújo LF, de Barros E Lima Bueno R, Aguiar GM, Plaça JR, Alves CP, Dos Santos ARD, Vidal DO, Silva GEB, Panepucci RA, Peria FM, Feres O, da Rocha JJR, Zago MA, Silva WA Jr., Free PMC Article

    05/1/2021
    ETV4 promotes late development of prostatic intraepithelial neoplasia and cell proliferation through direct and p53-mediated downregulation of p21.

    ETV4 promotes late development of prostatic intraepithelial neoplasia and cell proliferation through direct and p53-mediated downregulation of p21.
    Cosi I, Pellecchia A, De Lorenzo E, Torre E, Sica M, Nesi G, Notaro R, De Angioletti M., Free PMC Article

    04/13/2021
    ETV4 promotes the progression of gastric cancer through regulating KDM5D.

    ETV4 promotes the progression of gastric cancer through regulating KDM5D.
    Cai LS, Chen QX, Fang SY, Lian MQ, Lian MJ, Cai MZ.

    03/20/2021
    Knockdown of P3H4 inhibits proliferation and invasion of bladder cancer.

    Knockdown of P3H4 inhibits proliferation and invasion of bladder cancer.
    Hao L, Pang K, Pang H, Zhang J, Zhang Z, He H, Zhou R, Shi Z, Han C., Free PMC Article

    01/16/2021
    ETV4 is a theranostic target in clear cell renal cell carcinoma that promotes metastasis by activating the pro-metastatic gene FOSL1 in a PI3K-AKT dependent manner.

    ETV4 is a theranostic target in clear cell renal cell carcinoma that promotes metastasis by activating the pro-metastatic gene FOSL1 in a PI3K-AKT dependent manner.
    Xu L, Hu H, Zheng LS, Wang MY, Mei Y, Peng LX, Qiang YY, Li CZ, Meng DF, Wang MD, Liu ZJ, Li XJ, Huang BJ, Qian CN.

    01/9/2021
    ETV4 Is Necessary for Estrogen Signaling and Growth in Endometrial Cancer Cells.

    ETV4 Is Necessary for Estrogen Signaling and Growth in Endometrial Cancer Cells.
    Rodriguez AC, Vahrenkamp JM, Berrett KC, Clark KA, Guillen KP, Scherer SD, Yang CH, Welm BE, Janát-Amsbury MM, Graves BJ, Gertz J., Free PMC Article

    10/24/2020
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