| Molecular Oxygen Binding in the Mitochondrial Electron Transfer Flavoprotein. | Molecular Oxygen Binding in the Mitochondrial Electron Transfer Flavoprotein.
Husen P, Nielsen C, Martino CF, Solov'yov IA. | 10/10/2020 |
| Molecular and Clinical Investigations on Portuguese Patients with Multiple acyl-CoA Dehydrogenase Deficiency. | Molecular and Clinical Investigations on Portuguese Patients with Multiple acyl-CoA Dehydrogenase Deficiency.
Henriques BJ, Lucas TG, Martins E, Gaspar A, Bandeira A, Nogueira C, Brandão O, Rocha H, Vilarinho L, Gomes CM. | 08/22/2020 |
| Data suggest that ETF (heterodimer of ETFA and ETFB) catalyzes irreversible and pH-dependent oxidation of 8alpha-methyl group of FAD to form to 8-formyl-FAD (8f-FAD). | Oxidation of the FAD cofactor to the 8-formyl-derivative in human electron-transferring flavoprotein.
Augustin P, Toplak M, Fuchs K, Gerstmann EC, Prassl R, Winkler A, Macheroux P., Free PMC Article | 12/26/2018 |
| We identified and replicated a novel gene, ETFB, strongly associated with chronic anthracycline-induced cardiotoxicity independently of age at tumor onset and related to anthracycline-mediated mitochondrial dysfunction | Exome array analysis identifies ETFB as a novel susceptibility gene for anthracycline-induced cardiotoxicity in cancer patients.
Ruiz-Pinto S, Pita G, Martín M, Alonso-Gordoa T, Barnes DR, Alonso MR, Herraez B, García-Miguel P, Alonso J, Pérez-Martínez A, Cartón AJ, Gutiérrez-Larraya F, García-Sáenz JA, Benítez J, Easton DF, Patiño-García A, González-Neira A. | 10/27/2018 |
| These results suggested that increasing levels of ATP5B and ETFB were associated with worsening renal injury. | ATP5B and ETFB metabolic markers in children with congenital hydronephrosis.
Zhao Q, Yang Y, Wang C, Hou Y, Chen H., Free PMC Article | 04/8/2017 |
| the findings of our present study suggest that ETFbeta plays an important role in renal tubular cell apoptosis during the progression of DN. | The decreased expression of electron transfer flavoprotein β is associated with tubular cell apoptosis in diabetic nephropathy.
Wang H, Zhang H, Chen X, Zhao T, Kong Q, Yan M, Zhang B, Sun S, Lan HY, Li N, Li P., Free PMC Article | 12/31/2016 |
| Electron Transfer Flavoprotein Subunit Beta Is a Candidate Endothelial Cell Autoantigen in Behcet's Disease | Electron Transfer Flavoprotein Subunit Beta Is a Candidate Endothelial Cell Autoantigen in Behçet's Disease.
Chen P, Yang W, Tian Y, Sun S, Chen G, Zhang C, Ma F, Xun Y, Shi L, Yang C, Zhao L, Zhou Y, Du H., Free PMC Article | 02/6/2016 |
| Human METTL20 is a mitochondrial lysine methyltransferase that targets ETFbeta and modulates its activity. | Human METTL20 is a mitochondrial lysine methyltransferase that targets the β subunit of electron transfer flavoprotein (ETFβ) and modulates its activity.
Małecki J, Ho AY, Moen A, Dahl HA, Falnes PØ., Free PMC Article | 04/11/2015 |
| ETFB knockdown can affect TGF-beta-induced tissue remodeling and/or fibrotic processes in vitro. | Knockdown of electron transfer flavoprotein β subunit reduced TGF-β-induced α-SMA mRNA expression but not COL1A1 in fibroblast-populated three-dimensional collagen gel cultures.
Hirokawa S, Shimanuki T, Kitajima H, Nishimori Y, Shimosaka M. | 05/4/2013 |
| Point mutations in electron-transfer-flavoprotein beta is associated with destabilized conformations and defective protein:protein interactions leading to mitochondrial dysfunction. | Mechanism of superoxide and hydrogen peroxide generation by human electron-transfer flavoprotein and pathological variants.
Rodrigues JV, Gomes CM. | 10/20/2012 |
| ETFB participates in the mechanoregulation of fibroblast cell number in collagen gel culture. | Identification of ETFB as a candidate protein that participates in the mechanoregulation of fibroblast cell number in collagen gel culture.
Hirokawa S, Shimanuki T, Kitajima H, Nishimori Y, Shimosaka M. | 02/11/2012 |
| Data established structural hotspots within the ETF fold, and provided a rationale for the prediction of effects of mutations in ETF. | Mutational hotspots in electron transfer flavoprotein underlie defective folding and function in multiple acyl-CoA dehydrogenase deficiency.
Henriques BJ, Bross P, Gomes CM. | 12/11/2010 |
| conformational and stability properties of the disease-causing variant ETFbeta-D128N, and our findings on the effect of flavinylation in modulating protein conformational stability and activity. | Role of flavinylation in a mild variant of multiple acyl-CoA dehydrogenation deficiency: a molecular rationale for the effects of riboflavin supplementation.
Henriques BJ, Rodrigues JV, Olsen RK, Bross P, Gomes CM. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Clinical and genetic analysis of lipid storage myopathies.
Ohkuma A, Noguchi S, Sugie H, Malicdan MC, Fukuda T, Shimazu K, López LC, Hirano M, Hayashi YK, Nonaka I, Nishino I. | 03/25/2009 |
| Tissue samples from 16 unrelated patients with ETF deficiency were analysed, two of them harboured mutations in the ETFB gene. | Electron transfer flavoprotein deficiency: functional and molecular aspects.
Schiff M, Froissart R, Olsen RK, Acquaviva C, Vianey-Saban C. | 01/21/2010 |
| non-productive conformation stabilization underpins rapid electron transfer to electron-transferring flavoprotein | Stabilization of non-productive conformations underpins rapid electron transfer to electron-transferring flavoprotein.
Toogood HS, van Thiel A, Scrutton NS, Leys D. | 01/21/2010 |