| [Effects of GLAST gene knockout on phenotype and hearing in mice]. | [Effects of GLAST gene knockout on phenotype and hearing in mice].
Wu FS, Ma KF, Zheng PF, She XJ, Liu HT, Zhai QF, Cui B. | 05/5/2023 |
| Early postnatal inhibition of GLAST causes abnormalities of psychobehaviors and neuronal morphology in adult mice. | Early postnatal inhibition of GLAST causes abnormalities of psychobehaviors and neuronal morphology in adult mice.
Uchida M, Noda Y, Hasegawa S, Hida H, Taniguchi M, Mouri A, Yoshimi A, Nabeshima T, Yamada K, Aida T, Tanaka K, Ozaki N. | 02/26/2022 |
| Chronic optogenetic stimulation of Bergman glia leads to dysfunction of EAAT1 and Purkinje cell death, mimicking the events caused by expression of pathogenic ataxin-1. | Chronic optogenetic stimulation of Bergman glia leads to dysfunction of EAAT1 and Purkinje cell death, mimicking the events caused by expression of pathogenic ataxin-1.
Shuvaev AN, Belozor OS, Mozhei O, Yakovleva DA, Potapenko IV, Shuvaev AN, Smolnikova MV, Salmin VV, Salmina AB, Hirai H, Teschemacher AG, Kasparov S. | 01/22/2022 |
| Auditory synaptopathy in mice lacking the glutamate transporter GLAST and its impact on brain activity. | Auditory synaptopathy in mice lacking the glutamate transporter GLAST and its impact on brain activity.
Tserga E, Damberg P, Canlon B, Cederroth CR., Free PMC Article | 12/11/2021 |
| Slc1a3-2A-CreERT2 mice reveal unique features of Bergmann glia and augment a growing collection of Cre drivers and effectors in the 129S4 genetic background. | Slc1a3-2A-CreERT2 mice reveal unique features of Bergmann glia and augment a growing collection of Cre drivers and effectors in the 129S4 genetic background.
Kaczmarczyk L, Reichenbach N, Blank N, Jonson M, Dittrich L, Petzold GC, Jackson WS., Free PMC Article | 12/11/2021 |
| Circadian vulnerability of cisplatin-induced ototoxicity in the cochlea. | Circadian vulnerability of cisplatin-induced ototoxicity in the cochlea.
Tserga E, Moreno-Paublete R, Sarlus H, Björn E, Guimaraes E, Göritz C, Cederroth CR, Canlon B., Free PMC Article | 05/1/2021 |
| Defining compartmentalized stem cell populations with distinct cell division dynamics in the ocular surface epithelium. | Defining compartmentalized stem cell populations with distinct cell division dynamics in the ocular surface epithelium.
Ishii R, Yanagisawa H, Sada A., Free PMC Article | 02/2/2021 |
| In vivo knockdown of astroglial glutamate transporters GLT-1 and GLAST increases excitatory neurotransmission in mouse infralimbic cortex: Relevance for depressive-like phenotypes. | In vivo knockdown of astroglial glutamate transporters GLT-1 and GLAST increases excitatory neurotransmission in mouse infralimbic cortex: Relevance for depressive-like phenotypes.
Fullana MN, Covelo A, Bortolozzi A, Araque A, Artigas F., Free PMC Article | 09/12/2020 |
| In the present study, we found for the first time the dilation of the retinal blood vessels and the thinning of the outer nuclear layer in GLAST(-/-) mice, in addition to the thinning of the ganglion cell complex (GCC). | Excess Glutamate May Cause Dilation of Retinal Blood Vessels in Glutamate/Aspartate Transporter-Deficient Mice.
Gonome T, Xie Y, Arai S, Yamauchi K, Maeda-Monai N, Tanabu R, Kudo T, Nakazawa M., Free PMC Article | 04/25/2020 |
| SLC1A3 rs1049522 showed significant association with ADHD risk. rs1049522-C allele enhanced SLC1A3 expression by disrupting the hsa-miR-3171 binding site. | A functional variant in SLC1A3 influences ADHD risk by disrupting a hsa-miR-3171 binding site: A two-stage association study.
Huang X, Zhang Q, Chen X, Gu X, Wang M, Wu J. | 01/4/2020 |
| GLAST role in the spontaneous firing pattern and survival of Purkinje cells. | Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells.
Perkins EM, Clarkson YL, Suminaite D, Lyndon AR, Tanaka K, Rothstein JD, Skehel PA, Wyllie DJA, Jackson M., Free PMC Article | 12/7/2019 |
| p53 promotes the expression of SLC1A3, an aspartate/glutamate transporter that allows the utilization of aspartate to support cells in the absence of extracellular glutamine. Tumor cells with high levels of SLC1A3 expression are resistant to glutamine starvation, and SLC1A3 depletion retards the growth of these cells in vitro and in vivo, suggesting a therapeutic potential for SLC1A3 inhibition. | A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3.
Tajan M, Hock AK, Blagih J, Robertson NA, Labuschagne CF, Kruiswijk F, Humpton TJ, Adams PD, Vousden KH., Free PMC Article | 10/5/2019 |
| Reduced Cerebellar EAAT1 Expression associated with loss of cerebellar Purkinje cells resluts in neurodegeneration and Niemann-Pick disease Type C1. | Impact of Reduced Cerebellar EAAT Expression on Purkinje Cell Firing Pattern of NPC1-deficient Mice.
Rabenstein M, Peter F, Rolfs A, Frech MJ., Free PMC Article | 09/21/2019 |
| Neither EAAT1 nor EAAT2 was detected at significant levels in murine kidney or intestine. In contrast, the liver only expressed EAAT2 (but 2 C-terminal splice variants). | Expression of Glutamate Transporters in Mouse Liver, Kidney, and Intestine.
Hu QX, Ottestad-Hansen S, Holmseth S, Hassel B, Danbolt NC, Zhou Y., Free PMC Article | 08/3/2019 |
| beta-catenin inactivation in GLAST-expressing cells enhanced anxious/depressive-like responses. | Targeting β-Catenin in GLAST-Expressing Cells: Impact on Anxiety and Depression-Related Behavior and Hippocampal Proliferation.
Vidal R, Garro-Martínez E, Díaz Á, Castro E, Florensa-Zanuy E, Taketo MM, Pazos Á, Pilar-Cuéllar F. | 04/6/2019 |
| These data reveal that stem/progenitor cell activation is synchronized over distinct niches during growth and identify SLC1A3 as a general marker and effector of activated epithelial stem/progenitor cells throughout the skin. | Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth.
Reichenbach B, Classon J, Aida T, Tanaka K, Genander M, Göritz C., Free PMC Article | 01/12/2019 |
| Study shows that high-fat feeding induces metabolic disorders and disrupts lactate metabolism in the hippocampus. Glial glutamate transporters GLAST and GLT-1 may contribute to the high-fat diet induced abnormalities of the hippocampal lactate metabolism. | High-fat diet reduces the hippocampal content level of lactate which is correlated with the expression of glial glutamate transporters.
Tsai SF, Chen YW, Kuo YM. | 06/30/2018 |
| glutamate transporter function by GLAST on Bergmann glia plays important roles in development and maintenance of proper synaptic wiring and wrapping in Purkinje cells | Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells.
Miyazaki T, Yamasaki M, Hashimoto K, Kohda K, Yuzaki M, Shimamoto K, Tanaka K, Kano M, Watanabe M., Free PMC Article | 06/16/2018 |
| Loss of EAAT4 accounts for the initial hyper-excitability of Purkinje cells lacking b-III spectrin and that loss of GLAST appears to work synergistically to worsen motor deficits. When levels of both EAAT4 and GLAST are compromised in b-III(-/-) mice, the proximal dendrites of Purkinje cells within the posterior cerebellum are the most vulnerable to degeneration. | Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST.
Perkins EM, Suminaite D, Clarkson YL, Lee SK, Lyndon AR, Rothstein JD, Wyllie DJ, Tanaka K, Jackson M., Free PMC Article | 03/3/2018 |
| The results of this study concluded that EAAT anion channels play an important and unexpected role in adjusting glial intracellular anion concentration during maturation and in response to cerebellar activity. | Glutamate transporter-associated anion channels adjust intracellular chloride concentrations during glial maturation.
Untiet V, Kovermann P, Gerkau NJ, Gensch T, Rose CR, Fahlke C. | 01/13/2018 |
| SLC1A3 maintains a constant import of acidic amino acids independently of nutritional status in adipocytes. | The amino acid transporter, SLC1A3, is plasma membrane-localised in adipocytes and its activity is insensitive to insulin.
Krycer JR, Fazakerley DJ, Cater RJ, C Thomas K, Naghiloo S, Burchfield JG, Humphrey SJ, Vandenberg RJ, Ryan RM, James DE. | 05/13/2017 |
| glutamate/aspartate transporter (GLAST) was elevated in 8- to 10- and/or 20- to 22-month GHR-KO mice when comparing genotypes | Inflammatory and Glutamatergic Homeostasis Are Involved in Successful Aging.
Hascup ER, Wang F, Kopchick JJ, Bartke A., Free PMC Article | 06/28/2016 |
| This study findings demonstrate that Ascl1(CreERT2) and Glast(CreERT2) mouse lines enable simple and reliable labeling of adult-born GC lineages within restricted time windows. | Reliable Genetic Labeling of Adult-Born Dentate Granule Cells Using Ascl1 CreERT2 and Glast CreERT2 Murine Lines.
Yang SM, Alvarez DD, Schinder AF., Free PMC Article | 03/5/2016 |
| arundic acid treatment prevented RGC death by upregulating GLAST in heterozygous (GLAST(+/-)) mice | Arundic acid attenuates retinal ganglion cell death by increasing glutamate/aspartate transporter expression in a model of normal tension glaucoma.
Yanagisawa M, Aida T, Takeda T, Namekata K, Harada T, Shinagawa R, Tanaka K., Free PMC Article | 12/5/2015 |
| Results show that expression of GLAST is decreased in cerebellar astrocytes in a mouse model of SCA1; decrease occurs in non-cell autonomous manner late in disease and correlates well with the loss of Purkinje neurons | Decreased expression of glutamate transporter GLAST in Bergmann glia is associated with the loss of Purkinje neurons in the spinocerebellar ataxia type 1.
Cvetanovic M. | 10/24/2015 |