| ELK4 targets CHMP6 to inhibit ferroptosis and enhance malignant properties of skin cutaneous melanoma cells. | ELK4 targets CHMP6 to inhibit ferroptosis and enhance malignant properties of skin cutaneous melanoma cells.
Li H, Chen Z, Huang Y, Chen C, Cai L. | 09/30/2024 |
| ELK4 Promotes Cell Cycle Progression and Stem Cell-like Characteristics in HPV-associated Cervical Cancer by Regulating the FBXO22/PTEN Axis. | ELK4 Promotes Cell Cycle Progression and Stem Cell-like Characteristics in HPV-associated Cervical Cancer by Regulating the FBXO22/PTEN Axis.
Gao F, Wang C, Bai X, Ji J, Huang X., Free PMC Article | 11/3/2023 |
| IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia. | IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia.
Zheng K, Sha N, Hou G, Leng Z, Zhao Q, Zhang L, He L, Xu M, Jiang Y, Chen T., Free PMC Article | 10/10/2023 |
| ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis. | ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis.
Mao X, Ji T, Liu A, Weng Y., Free PMC Article | 02/5/2022 |
| ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis. | ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis.
Zheng L, Xu H, Di Y, Chen L, Liu J, Kang L, Gao L., Free PMC Article | 09/11/2021 |
| TRA2A-induced upregulation of LINC00662 regulates blood-brain barrier permeability by affecting ELK4 mRNA stability in Alzheimer's microenvironment. | TRA2A-induced upregulation of LINC00662 regulates blood-brain barrier permeability by affecting ELK4 mRNA stability in Alzheimer's microenvironment.
Liu Q, Zhu L, Liu X, Zheng J, Liu Y, Ruan X, Cao S, Cai H, Li Z, Xue Y., Free PMC Article | 07/10/2021 |
| Data suggest that SIRT7 undergoes Lys-63 polyubiquitination, later removed by USP7 to repress enzymatic activity of SIRT7; USP7 and SIRT7 regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC); SIRT7 targets G6PC promoter through ELK4. (SIRT7 = sirtuin 7; USP7 = ubiquitin specific peptidase 7; G6PC = glucose-6-phosphatase catalytic subunit; ELK4 = transcription factor ELK4) | Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.
Jiang L, Xiong J, Zhan J, Yuan F, Tang M, Zhang C, Cao Z, Chen Y, Lu X, Li Y, Wang H, Wang L, Wang J, Zhu WG, Wang H., Free PMC Article | 08/26/2017 |
| SLC45A3-ELK4 may represent the first description of a recurrent RNA chimaeric transcript specific to prostate cancer that does not have a detectable DNA aberration | Transcriptome sequencing to detect gene fusions in cancer.
Maher CA, Kumar-Sinha C, Cao X, Kalyana-Sundaram S, Han B, Jing X, Sam L, Barrette T, Palanisamy N, Chinnaiyan AM., Free PMC Article | 08/29/2016 |
| ELK4 is overexpressed in melanoma and knocking down the ELK4 or CDK2 expression significantly attenuated the malignant phenotype of melanoma cells | Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway.
Peng C, Zeng W, Su J, Kuang Y, He Y, Zhao S, Zhang J, Ma W, Bode AM, Dong Z, Chen X., Free PMC Article | 08/6/2016 |
| CTCF has a role in regulating SLC45A3-ELK4 Chimeric RNA | Role of CTCF in Regulating SLC45A3-ELK4 Chimeric RNA.
Qin F, Song Y, Zhang Y, Facemire L, Frierson H, Li H., Free PMC Article | 07/30/2016 |
| Data suggest that chimeric SLC45A3-ELK4 controls prostate cancer cell proliferation, and the chimera level correlates with prostate cancer disease progression. | Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferation.
Zhang Y, Gong M, Yuan H, Park HG, Frierson HF, Li H. | 12/22/2012 |
| ELK4 is a direct androgen receptor target in prostate cancer cells. Androgens may thus contribute to the growth of prostate cancer via influencing ELK4 levels | Identification of ETS-like transcription factor 4 as a novel androgen receptor target in prostate cancer cells.
Makkonen H, Jääskeläinen T, Pitkänen-Arsiola T, Rytinki M, Waltering KK, Mättö M, Visakorpi T, Palvimo JJ. | 01/21/2010 |
| Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex | Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex.
Mo Y, Ho W, Johnston K, Marmorstein R. | 01/21/2010 |