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    ELF3 E74 like ETS transcription factor 3 [ Homo sapiens (human) ]

    Gene ID: 1999, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Switch of ELF3 and ATF4 transcriptional axis programs the amino acid insufficiency-linked epithelial-to-mesenchymal transition.

    Switch of ELF3 and ATF4 transcriptional axis programs the amino acid insufficiency-linked epithelial-to-mesenchymal transition.
    Lin J, Hou L, Zhao X, Zhong J, Lv Y, Jiang X, Ye B, Qiao Y.,

    10/22/2024
    ELF3 plays an important role in defining TRAIL sensitivity in breast cancer by modulating the expression of decoy receptor 2 (DCR2).

    ELF3 plays an important role in defining TRAIL sensitivity in breast cancer by modulating the expression of decoy receptor 2 (DCR2).
    Ghosal N, Tapadar P, Biswas D, Pal R.

    09/13/2024
    HLA-C expression in extravillous trophoblasts is determined by an ELF3-NLRP2/NLRP7 regulatory axis.

    HLA-C expression in extravillous trophoblasts is determined by an ELF3-NLRP2/NLRP7 regulatory axis.
    Gu B, Le GH, Herrera S, Blair SJ, Meissner TB, Strominger JL., Free PMC Article

    07/26/2024
    WTAP Mediated N6-methyladenosine RNA Modification of ELF3 Drives Cellular Senescence by Upregulating IRF8.

    WTAP Mediated N6-methyladenosine RNA Modification of ELF3 Drives Cellular Senescence by Upregulating IRF8.
    Zhou L, Zhong Y, Wang F, Guo Y, Mao R, Xie H, Zhang Y, Li J., Free PMC Article

    03/15/2024
    Expression of CD44 is regulated by ELF3 in 5-FU treated colorectal cancer cells.

    Expression of CD44 is regulated by ELF3 in 5-FU treated colorectal cancer cells.
    Li F, Qiu F, Fan X, Yu Q, Liu S, Guo Y, Zhu Y, Xi X, Du B.

    11/3/2023
    ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer.

    ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer.
    Yang L, Wang H, Guo M, He M, Zhang W, Zhan M, Liu Y.

    07/21/2023
    An integrative epigenomic approach identifies ELF3 as an oncogenic regulator in ASCL1-positive neuroendocrine carcinoma.

    An integrative epigenomic approach identifies ELF3 as an oncogenic regulator in ASCL1-positive neuroendocrine carcinoma.
    Horie M, Tanaka H, Suzuki M, Sato Y, Takata S, Takai E, Miyashita N, Saito A, Nakatani Y, Yachida S., Free PMC Article

    06/5/2023
    ESE1/AGR2 axis antagonizes TGF-beta-induced epithelial-mesenchymal transition in low-grade pancreatic cancer.

    ESE1/AGR2 axis antagonizes TGF-β-induced epithelial-mesenchymal transition in low-grade pancreatic cancer.
    Xu HJ, Bai J, Tian Y, Feng X, Chen AP, Wang J, Wu J, Jin XR, Zhang F, Quan MY, Chen C, Lee KY, Zhang JS., Free PMC Article

    03/24/2023
    MYB and ELF3 differentially modulate labor-inducing gene expression in myometrial cells.

    MYB and ELF3 differentially modulate labor-inducing gene expression in myometrial cells.
    Shchuka VM, Khader N, Dorogin A, Shynlova O, Mitchell JA., Free PMC Article

    01/11/2023
    LncRNA ELF3-AS1 inhibits gastric cancer by forming a negative feedback loop with SNAI2 and regulates ELF3 mRNA stability via interacting with ILF2/ILF3 complex.

    LncRNA ELF3-AS1 inhibits gastric cancer by forming a negative feedback loop with SNAI2 and regulates ELF3 mRNA stability via interacting with ILF2/ILF3 complex.
    Li D, Shen L, Zhang X, Chen Z, Huang P, Huang C, Qin S., Free PMC Article

    12/10/2022
    Hypoxia-induced ELF3 promotes tumor angiogenesis through IGF1/IGF1R.

    Hypoxia-induced ELF3 promotes tumor angiogenesis through IGF1/IGF1R.
    Seo SH, Hwang SY, Hwang S, Han S, Park H, Lee YS, Rho SB, Kwon Y., Free PMC Article

    08/13/2022
    Downregulation of LINC00886 facilitates epithelial-mesenchymal transition through SIRT7/ELF3/miR-144 pathway in esophageal squamous cell carcinoma.

    Downregulation of LINC00886 facilitates epithelial-mesenchymal transition through SIRT7/ELF3/miR-144 pathway in esophageal squamous cell carcinoma.
    Dong Z, Yang L, Lu J, Guo Y, Shen S, Liang J, Guo W.

    08/6/2022
    ETS transcription factor ELF3 (ESE-1) is a cell cycle regulator in benign and malignant prostate.

    ETS transcription factor ELF3 (ESE-1) is a cell cycle regulator in benign and malignant prostate.
    Archer LK, Frame FM, Walker HF, Droop AP, McDonald GLK, Kucko S, Berney DM, Mann VM, Simms MS, Maitland NJ., Free PMC Article

    07/16/2022
    ELF3 mediates IL-1alpha induced differentiation of mesenchymal stem cells to inflammatory iCAFs.

    ELF3 mediates IL-1α induced differentiation of mesenchymal stem cells to inflammatory iCAFs.
    Tran LL, Dang T, Thomas R, Rowley DR., Free PMC Article

    05/7/2022
    WNT7B represses epithelial-mesenchymal transition and stem-like properties in bladder urothelial carcinoma.

    WNT7B represses epithelial-mesenchymal transition and stem-like properties in bladder urothelial carcinoma.
    Na L, Wang Z, Bai Y, Sun Y, Dong D, Wang W, Zhao C.

    01/1/2022
    FZD5 prevents epithelial-mesenchymal transition in gastric cancer.

    FZD5 prevents epithelial-mesenchymal transition in gastric cancer.
    Dong D, Na L, Zhou K, Wang Z, Sun Y, Zheng Q, Gao J, Zhao C, Wang W., Free PMC Article

    01/1/2022
    ELF3 Is a Target That Promotes Therapeutic Efficiency in EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer Cells via Inhibiting PKCiota.

    ELF3 Is a Target That Promotes Therapeutic Efficiency in EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer Cells via Inhibiting PKCί.
    Lee JS, Choi YE, Kim S, Han JY, Goh SH., Free PMC Article

    12/25/2021
    Nanopore Sequencing Unveils Diverse Transcript Variants of the Epithelial Cell-Specific Transcription Factor Elf-3 in Human Malignancies.

    Nanopore Sequencing Unveils Diverse Transcript Variants of the Epithelial Cell-Specific Transcription Factor Elf-3 in Human Malignancies.
    Boti MA, Adamopoulos PG, Tsiakanikas P, Scorilas A., Free PMC Article

    12/18/2021
    Inhibition of ELF3 confers synthetic lethality of PARP inhibitor in non-small cell lung cancer.

    Inhibition of ELF3 confers synthetic lethality of PARP inhibitor in non-small cell lung cancer.
    Wang Y, Zuo M, Jin H, Lai M, Luo J, Cheng Z.

    11/13/2021
    Vorinostat ameliorates IL-1alpha-induced reduction of type II collagen by inhibiting the expression of ELF3 in chondrocytes.

    Vorinostat ameliorates IL-1α-induced reduction of type II collagen by inhibiting the expression of ELF3 in chondrocytes.
    Miao X, Wu Y, Wang P, Zhang Q, Zhou C, Yu X, Cao L., Free PMC Article

    10/2/2021
    Epithelium-specific ETS transcription factor-1 regulates NANOG expression and inhibits NANOG-induced proliferation of human embryonic carcinoma cells.

    Epithelium-specific ETS transcription factor-1 regulates NANOG expression and inhibits NANOG-induced proliferation of human embryonic carcinoma cells.
    Park SW, Do HJ, Choi W, Lim DS, Park KH, Kim JH.

    08/7/2021
    ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts.

    ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts.
    Li Q, Meissner TB, Wang F, Du Z, Ma S, Kshirsagar S, Tilburgs T, Buenrostro JD, Uesugi M, Strominger JL., Free PMC Article

    08/7/2021
    ELF3 Overexpression as Prognostic Biomarker for Recurrence of Stage II Colorectal Cancer.

    ELF3 Overexpression as Prognostic Biomarker for Recurrence of Stage II Colorectal Cancer.
    Takaoka A, Ishikawa T, Okazaki S, Watanabe S, Miya F, Tsunoda T, Kikuchi A, Yamauchi S, Matsuyama T, Tokunaga M, Uetake H, Kinugasa Y., Free PMC Article

    07/31/2021
    A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma.

    A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma.
    Ma S, Zhou B, Yang Q, Pan Y, Yang W, Freedland SJ, Ding LW, Freeman MR, Breunig JJ, Bhowmick NA, Pan J, Koeffler HP, Lin DC., Free PMC Article

    05/22/2021
    E74-Like Factor 3 Is a Key Regulator of Epithelial Integrity and Immune Response Genes in Biliary Tract Cancer.

    E74-Like Factor 3 Is a Key Regulator of Epithelial Integrity and Immune Response Genes in Biliary Tract Cancer.
    Suzuki M, Saito-Adachi M, Arai Y, Fujiwara Y, Takai E, Shibata S, Seki M, Rokutan H, Maeda D, Horie M, Suzuki Y, Shibata T, Kiyono T, Yachida S.

    05/8/2021
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