| USP10 promotes cell proliferation, migration, and invasion in NSCLC through deubiquitination and stabilization of EIF4G1. | USP10 promotes cell proliferation, migration, and invasion in NSCLC through deubiquitination and stabilization of EIF4G1.
Li F, He Z, Zhang X, Gao D, Xu R, Zhang Z, Cao X, Shan Q, Liu Y, Xu Z., Free PMC Article | 10/21/2024 |
| The Insulin Receptor and Insulin like Growth Factor Receptor 5' UTRs Support Translation Initiation Independently of EIF4G1. | The Insulin Receptor and Insulin like Growth Factor Receptor 5' UTRs Support Translation Initiation Independently of EIF4G1.
Clark NK, Harris MT, Dahl WB, Knotts Z, Marr MT 2nd., Free PMC Article | 02/15/2024 |
| Computational inference of eIF4F complex function and structure in human cancers. | Computational inference of eIF4F complex function and structure in human cancers.
Wu S, Wagner G., Free PMC Article | 02/5/2024 |
| Thermodynamically Favorable Interactions between eIF4E Binding Domain of eIF4GI with Structured 5'-Untranslated Regions Drive Cap-Independent Translation of Selected mRNAs. | Thermodynamically Favorable Interactions between eIF4E Binding Domain of eIF4GI with Structured 5'-Untranslated Regions Drive Cap-Independent Translation of Selected mRNAs.
Saha B, Bhardwaj U, Goss DJ. | 06/13/2023 |
| Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma. | Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma.
Bai B, Dong L, Feng M, Zhang Z, Lu Y, Xu Z, Liu Y., Free PMC Article | 04/19/2023 |
| EIF4G1 Is a Potential Prognostic Biomarker of Breast Cancer. | EIF4G1 Is a Potential Prognostic Biomarker of Breast Cancer.
Li K, Tan G, Zhang X, Lu W, Ren J, Si Y, Adu-Gyamfi EA, Li F, Wang Y, Xie B, Wang M., Free PMC Article | 01/21/2023 |
| Inhibitors of eIF4G1-eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2alpha-phosphorylation. | Inhibitors of eIF4G1-eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation.
Sehrawat U, Haimov O, Weiss B, Tamarkin-Ben Harush A, Ashkenazi S, Plotnikov A, Noiman T, Leshkowitz D, Stelzer G, Dikstein R., Free PMC Article | 07/30/2022 |
| Phosphorylation of Eukaryotic Initiation Factor 4G1 (eIF4G1) at Ser1147 Is Specific for eIF4G1 Bound to eIF4E in Delayed Neuronal Death after Ischemia. | Phosphorylation of Eukaryotic Initiation Factor 4G1 (eIF4G1) at Ser1147 Is Specific for eIF4G1 Bound to eIF4E in Delayed Neuronal Death after Ischemia.
Martínez-Alonso E, Guerra-Pérez N, Escobar-Peso A, Peracho L, Vera-Lechuga R, Cruz-Culebras A, Masjuan J, Alcázar A., Free PMC Article | 03/12/2022 |
| Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease. | Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease.
Saini P, Rudakou U, Yu E, Ruskey JA, Asayesh F, Laurent SB, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Dupré N, Greenbaum L, Hassin-Baer S, Espay AJ, Rouleau GA, Alcalay RN, Fon EA, Postuma RB, Gan-Or Z., Free PMC Article | 11/13/2021 |
| Role of EIF4G1 network in non-small cell lung cancers (NSCLC) cell survival and disease progression. | Role of EIF4G1 network in non-small cell lung cancers (NSCLC) cell survival and disease progression.
Del Valle L, Dai L, Lin HY, Lin Z, Chen J, Post SR, Qin Z., Free PMC Article | 09/25/2021 |
| Elevation of EIF4G1 promotes non-small cell lung cancer progression by activating mTOR signalling. | Elevation of EIF4G1 promotes non-small cell lung cancer progression by activating mTOR signalling.
Lu Y, Yu S, Wang G, Ma Z, Fu X, Cao Y, Li Q, Xu Z., Free PMC Article | 09/25/2021 |
| LINCS gene expression signature analysis revealed bosutinib as a radiosensitizer of breast cancer cells by targeting eIF4G1. | LINCS gene expression signature analysis revealed bosutinib as a radiosensitizer of breast cancer cells by targeting eIF4G1.
Hu S, Xie D, Zhou P, Liu X, Yin X, Huang B, Guan H., Free PMC Article | 07/17/2021 |
| EIF4G1 and RAN as Possible Drivers for Malignant Pleural Mesothelioma. | EIF4G1 and RAN as Possible Drivers for Malignant Pleural Mesothelioma.
Dell'Anno I, Barbarino M, Barone E, Giordano A, Luzzi L, Bottaro M, Migliore L, Agostini S, Melani A, Melaiu O, Catalano C, Cipollini M, Silvestri R, Corrado A, Gemignani F, Landi S., Free PMC Article | 02/20/2021 |
| 5'-UTR recruitment of the translation initiation factor eIF4GI or DAP5 drives cap-independent translation of a subset of human mRNAs. | 5'-UTR recruitment of the translation initiation factor eIF4GI or DAP5 drives cap-independent translation of a subset of human mRNAs.
Haizel SA, Bhardwaj U, Gonzalez RL Jr, Mitra S, Goss DJ., Free PMC Article | 01/23/2021 |
| eIF4G-driven translation initiation of downstream ORFs in mammalian cells. | eIF4G-driven translation initiation of downstream ORFs in mammalian cells.
Nobuta R, Machida K, Sato M, Hashimoto S, Toriumi Y, Nakajima S, Suto D, Imataka H, Inada T., Free PMC Article | 11/21/2020 |
| Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells. | Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells.
Frosi Y, Ramlan SR, Brown CJ. | 10/10/2020 |
| EIF4G1 gene is a novel candidate gene that may be relevant to severe Asthenozoospermia. | EIF4G1 is a novel candidate gene associated with severe asthenozoospermia.
Sha Y, Liu W, Huang X, Li Y, Ji Z, Mei L, Lin S, Kong S, Lu J, Kong L, Zhu X, Lu Z, Ding L., Free PMC Article | 06/27/2020 |
| eIF4G1 expression was increased in prostate cancer and that increased eIF4G1 expression was associated with tumor progression and metastasis. | Eukaryotic Translation Initiation Factor 4 Gamma 1 (eIF4G1) is upregulated during Prostate cancer progression and modulates cell growth and metastasis.
Jaiswal PK, Koul S, Shanmugam PST, Koul HK., Free PMC Article | 10/12/2019 |
| For unraveling mechanisms of RACK1:PKCbetaII-mediated translation stimulation, we used sequentially truncated eIF4G1 in coimmunoprecipitation analyses to delineate a set of autoinhibitory elements in the N-terminal unstructured region (surrounding the eIF4E-binding motif) and the interdomain linker (within the eIF3-binding site) of eIF4G1. | Ribosomal RACK1:Protein Kinase C βII Modulates Intramolecular Interactions between Unstructured Regions of Eukaryotic Initiation Factor 4G (eIF4G) That Control eIF4E and eIF3 Binding.
Dobrikov MI, Dobrikova EY, Gromeier M., Free PMC Article | 06/29/2019 |
| We found that RACK1:PKCbetaII phosphorylates eukaryotic initiation factor 4G1 (eIF4G1) at S1093 and eIF3a at S1364. Our findings reveal a physiological role for ribosomal RACK1 in providing the molecular scaffold for PKCbetaII and its role in coordinating the translational response to PKC-Raf-ERK1/2 activation. | Ribosomal RACK1:Protein Kinase C βII Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation.
Dobrikov MI, Dobrikova EY, Gromeier M., Free PMC Article | 06/29/2019 |
| We report that eIF4G1 exists in two complexes, either with eIF4E or with eIF1. Using an eIF1 mutant impaired in eIF4G1 binding, we demonstrate that eIF1-eIF4G1 interaction is important for leaky scanning and for avoiding m7G-cap-proximal initiation. | Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1) with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent Translation.
Haimov O, Sehrawat U, Tamarkin-Ben Harush A, Bahat A, Uzonyi A, Will A, Hiraishi H, Asano K, Dikstein R., Free PMC Article | 06/29/2019 |
| eIF4GI acts as a translational switch via reversible O-GlcNAcylation | O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response.
Zhang X, Shu XE, Qian SB. | 05/11/2019 |
| MET-eIF4G1-HIF-1alpha pathway is further supported by a co-occurrence of their expression. | Identification of a MET-eIF4G1 translational regulation axis that controls HIF-1α levels under hypoxia.
Glück AA, Orlando E, Leiser D, Poliaková M, Nisa L, Quintin A, Gavini J, Stroka DM, Berezowska S, Bubendorf L, Blaukat A, Aebersold DM, Medová M, Zimmer Y. | 03/2/2019 |
| Lack of regulation of the interaction between the eIF4E/eIF4G subunits of the translation initiation factor complex eIF4F is a hallmark of cancer. The inhibitor 4EGI-1 binds to eIF4E, thereby preventing association with eIF4G through an allosteric mechanism. Binding of 4EGI-1 perturbs native correlated motions and increases correlated fluctuations in part of the eIF4G binding site. | The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex.
Salvi N, Papadopoulos E, Blackledge M, Wagner G., Free PMC Article | 08/18/2018 |
| The polymorphism of the rs200221361 may have no association with the occurrence of Parkinson disease in Uygur and Han people of Xinjiang. | Association analysis of EIF4G1 and Parkinson disease in Xinjiang Uygur and Han nationality.
Ma Y, Zheng D, Li H., Free PMC Article | 05/19/2018 |