| Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype. | Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype.
Li W, He S, Tan J, Li N, Zhao C, Wang X, Zhang Z, Liu J, Huang J, Li X, Zhou Q, Hu K, Yang P, Hou S., Free PMC Article | 09/25/2024 |
| Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis. | Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis.
Song A, Yan R, Xiong W, Xiang H, Huang J, Jiang A, Zhang C. | 06/21/2024 |
| MicroRNA-150-5P regulates Th1/Th2 cytokines expression levels by targeting EGR2 in allergic rhinitis. | MicroRNA-150-5P regulates Th1/Th2 cytokines expression levels by targeting EGR2 in allergic rhinitis.
Jian H, Feng H, Zhu L, Li X, Ma Z. | 04/4/2024 |
| EGR2 gene-linked hereditary neuropathies present with a bimodal age distribution at symptoms onset. | EGR2 gene-linked hereditary neuropathies present with a bimodal age distribution at symptoms onset.
Echaniz-Laguna A, Cauquil C, Chanson JB, Tard C, Guyant-Marechal L, Kuntzer T, Ion IM, Lia AS, Bouligand J, Poinsignon V. | 09/11/2023 |
| EGR2 drives TH17 cell pathogenicity in autoimmune neuroinflammation. | EGR2 drives T(H)17 cell pathogenicity in autoimmune neuroinflammation.
| 08/14/2023 |
| Transcription factor EGR2 controls homing and pathogenicity of TH17 cells in the central nervous system. | Transcription factor EGR2 controls homing and pathogenicity of T(H)17 cells in the central nervous system.
Gao Y, Wang Y, Chauss D, Villarino AV, Link VM, Nagashima H, Spinner CA, Koparde VN, Bouladoux N, Abers MS, Break TJ, Chopp LB, Park JH, Zhu J, Wiest DL, Leonard WJ, Lionakis MS, O'Shea JJ, Afzali B, Belkaid Y, Lazarevic V., Free PMC Article | 08/14/2023 |
| Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells. | Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.
Symonds ALJ, Miao T, Busharat Z, Li S, Wang P., Free PMC Article | 08/11/2023 |
| Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell-Intrinsic Dysfunction. | Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell-Intrinsic Dysfunction.
Jung IY, Bartoszek RL, Rech AJ, Collins SM, Ooi SK, Williams EF, Hopkins CR, Narayan V, Haas NB, Frey NV, Hexner EO, Siegel DL, Plesa G, Porter DL, Cantu A, Everett JK, Guedan S, Berger SL, Bushman FD, Herbst F, Fraietta JA., Free PMC Article | 07/23/2023 |
| Temozolomide protects against the progression of glioblastoma via SOX4 downregulation by inhibiting the LINC00470-mediated transcription factor EGR2. | Temozolomide protects against the progression of glioblastoma via SOX4 downregulation by inhibiting the LINC00470-mediated transcription factor EGR2.
Li W, Wang M, Ma W, Liu P, Zhang M, He J, Cui Y., Free PMC Article | 07/19/2023 |
| EGR2-related mixed demyelinating and axonal Charcot-Marie-Tooth disease: An electrodiagnostic, nerve imaging, and histological study. | EGR2-related mixed demyelinating and axonal Charcot-Marie-Tooth disease: An electrodiagnostic, nerve imaging, and histological study.
Chu XJ, Du K, Meng LC, Xie ZY, Zhu Y, Zhang W, Wang ZX, Yuan Y. | 12/17/2022 |
| The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair. | The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair.
McCowan J, Fercoq F, Kirkwood PM, T'Jonck W, Hegarty LM, Mawer CM, Cunningham R, Mirchandani AS, Hoy A, Humphries DC, Jones GR, Hansen CG, Hirani N, Jenkins SJ, Henri S, Malissen B, Walmsley SR, Dockrell DH, Saunders PTK, Carlin LM, Bain CC., Free PMC Article | 03/12/2022 |
| EGR2-mediated regulation of m(6)A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization. | EGR2-mediated regulation of m(6)A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization.
Ying Y, Ma X, Fang J, Chen S, Wang W, Li J, Xie H, Wu J, Xie B, Liu B, Wang X, Zheng X, Xie L., Free PMC Article | 01/29/2022 |
| EGR1/2 Inhibits Papillary Thyroid Carcinoma Cell Growth by Suppressing the Expression of PTEN and BAX. | EGR1/2 Inhibits Papillary Thyroid Carcinoma Cell Growth by Suppressing the Expression of PTEN and BAX.
Guo H, Zhang L. | 01/22/2022 |
| MicroRNA-17-5p inhibits thyroid cancer progression by suppressing Early growth response 2 (EGR2). | MicroRNA-17-5p inhibits thyroid cancer progression by suppressing Early growth response 2 (EGR2).
Geng X, Sun Y, Fu J, Cao L, Li Y., Free PMC Article | 12/4/2021 |
| Early growth response 2 (EGR2) is a novel regulator of the senescence programme. | Early growth response 2 (EGR2) is a novel regulator of the senescence programme.
Tyler EJ, Gutierrez Del Arroyo A, Hughes BK, Wallis R, Garbe JC, Stampfer MR, Koh J, Lowe R, Philpott MP, Bishop CL., Free PMC Article | 10/9/2021 |
| Bi-allelic mutations in EGR2 cause autosomal recessive demyelinating neuropathy by disrupting the EGR2-NAB complex. | Bi-allelic mutations in EGR2 cause autosomal recessive demyelinating neuropathy by disrupting the EGR2-NAB complex.
Lupo V, Won S, Frasquet M, Schnitzler MS, Komath SS, Pascual-Pascual SI, Espinós C, Svaren J, Sevilla T. | 08/14/2021 |
| NFAT2 overexpression suppresses the malignancy of hepatocellular carcinoma through inducing Egr2 expression. | NFAT2 overexpression suppresses the malignancy of hepatocellular carcinoma through inducing Egr2 expression.
Wang J, Zhang Y, Liu L, Cui Z, Shi R, Hou J, Liu Z, Yang L, Wang L, Li Y., Free PMC Article | 04/24/2021 |
| The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites. | The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites.
Mendes K, Schmidhofer S, Minderjahn J, Glatz D, Kiesewetter C, Raithel J, Wimmer J, Gebhard C, Rehli M., Free PMC Article | 04/13/2021 |
| MiR-224-5p targets EGR2 to promote the development of papillary thyroid carcinoma. | MiR-224-5p targets EGR2 to promote the development of papillary thyroid carcinoma.
Zang CS, Huang HT, Qiu J, Sun J, Ge RF, Jiang LW. | 04/3/2021 |
| Downregulation of miR-140-5p affects the pathogenesis of HSCR by targeting EGR2. | Downregulation of miR-140-5p affects the pathogenesis of HSCR by targeting EGR2.
Du G, Wang X, Wu Y, Zhang Y, Liu W, Wu R. | 12/12/2020 |
| Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination. | Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination.
Wüst HM, Wegener A, Fröb F, Hartwig AC, Wegwitz F, Kari V, Schimmel M, Tamm ER, Johnsen SA, Wegner M, Sock E., Free PMC Article | 10/31/2020 |
| LncRNA MEG3 aggravates palmitate-induced insulin resistance by regulating miR-185-5p/Egr2 axis in hepatic cells. | LncRNA MEG3 aggravates palmitate-induced insulin resistance by regulating miR-185-5p/Egr2 axis in hepatic cells.
Chen DL, Shen DY, Han CK, Tian Y. | 10/3/2020 |
| expression in tendon cells appeared to be sensitive to overloading and unloading but did not respond to the single episode of physiologic-range loading | Early Growth Response Genes Increases Rapidly After Mechanical Overloading and Unloading in Tendon Constructs.
Herchenhan A, Dietrich-Zagonel F, Schjerling P, Kjaer M, Eliasson P. | 02/15/2020 |
| In Greek Charcot-Marie-Tooth type 1 patients, 3 pathogenic mutations were found (3.5%); two recently reported micromutations in PMP22 3, and one known point mutation in EGR2 | Mutational analysis of PMP22, EGR2, LITAF and NEFL in Greek Charcot-Marie-Tooth type 1 patients.
Koutsis G, Pandraud A, Karadima G, Panas M, Reilly MM, Floroskufi P, Wood NW, Houlden H. | 05/25/2019 |
| LAG3(+) Tregs suppress humoral immune responses via transforming growth factor beta3 production in an Egr2- and Egr3-dependent manner. | Early Growth Response Gene 2-Expressing CD4(+)LAG3(+) Regulatory T Cells: The Therapeutic Potential for Treating Autoimmune Diseases.
Okamura T, Yamamoto K, Fujio K., Free PMC Article | 03/30/2019 |