| Transcriptional induction of NF-kappaB-inducing kinase by E2F4/5 facilitates collective invasion of GBM cells. | Transcriptional induction of NF-κB-inducing kinase by E2F4/5 facilitates collective invasion of GBM cells.
Pflug KM, Lee DW, McFadden K, Herrera L, Sitcheran R., Free PMC Article | 08/17/2023 |
| Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics. | Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics.
Sun YM, Zhang YM, Shi HL, Yang S, Zhao YL, Liu HJ, Li C, Liu HL, Yang JP, Song J, Sun GZ, Yang JK., Free PMC Article | 06/28/2023 |
| High Expression of E2F4 Is an Adverse Prognostic Factor and Related to Immune Infiltration in Oral Squamous Cell Carcinoma. | High Expression of E2F4 Is an Adverse Prognostic Factor and Related to Immune Infiltration in Oral Squamous Cell Carcinoma.
Zheng Y, Fei H., Free PMC Article | 01/14/2023 |
| E2F4 transcription factor is a prognostic biomarker related to immune infiltration of head and neck squamous cell carcinoma. | E2F4 transcription factor is a prognostic biomarker related to immune infiltration of head and neck squamous cell carcinoma.
Qi L, Ren Z, Li W., Free PMC Article | 07/30/2022 |
| E2F4 may be a core transcription factor in the lncRNA-TF regulatory network in cervical cancer. | E2F4 may be a core transcription factor in the lncRNA-TF regulatory network in cervical cancer.
Yang H, Qu X, Huang J, Zhang F, Fang Z, Zhao B, Wang Y., Free PMC Article | 04/23/2022 |
| E2F4's cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6. | E2F4's cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6.
Hazan R, Mori M, Danielian PS, Guen VJ, Rubin SM, Cardoso WV, Lees JA., Free PMC Article | 02/12/2022 |
| Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment. | Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment.
Muiño E, Maisterra O, Jiménez-Balado J, Cullell N, Carrera C, Torres-Aguila NP, Cárcel-Márquez J, Gallego-Fabrega C, Lledós M, González-Sánchez J, Olmos-Alpiste F, Espejo E, March Á, Pujol R, Rodríguez-Campello A, Romeral G, Krupinski J, Martí-Fàbregas J, Montaner J, Roquer J, Fernández-Cadenas I., Free PMC Article | 10/23/2021 |
| Involvement of TFAP2A in the activation of GSDMD gene promoter in hyperoxia-induced ALI. | Involvement of TFAP2A in the activation of GSDMD gene promoter in hyperoxia-induced ALI.
Cao Q, Feng D, He J, Zhou L, Fan Z, Chen Y, Chen X, Jin R, Zhou G. | 09/11/2021 |
| LncRNA HAND2-AS1 represses cervical cancer progression by interaction with transcription factor E2F4 at the promoter of C16orf74. | LncRNA HAND2-AS1 represses cervical cancer progression by interaction with transcription factor E2F4 at the promoter of C16orf74.
Gong J, Fan H, Deng J, Zhang Q., Free PMC Article | 05/1/2021 |
| E2F4 functions as a tumour suppressor in acute myeloid leukaemia via inhibition of the MAPK signalling pathway by binding to EZH2. | E2F4 functions as a tumour suppressor in acute myeloid leukaemia via inhibition of the MAPK signalling pathway by binding to EZH2.
Feng Y, Li L, Du Y, Peng X, Chen F., Free PMC Article | 05/1/2021 |
| Long non-coding RNA LINC00337 induces autophagy and chemoresistance to cisplatin in esophageal squamous cell carcinoma cells via upregulation of TPX2 by recruiting E2F4. | Long non-coding RNA LINC00337 induces autophagy and chemoresistance to cisplatin in esophageal squamous cell carcinoma cells via upregulation of TPX2 by recruiting E2F4.
Yang C, Shen S, Zheng X, Ye K, Ge H, Sun Y, Lu Y. | 02/2/2021 |
| overexpressing p130 or E2F4 significantly improved migration but not proliferation of mMSCs. Our data suggest that cell cycle regulation may be involved in p130/E2F4-mediated changes in the multipotential abilities of bone-marrow-derived mesenchymal stem cells (MSCs). | Stable overexpression of p130/E2F4 affects the multipotential abilities of bone-marrow-derived mesenchymal stem cells.
Zhang X, Chen J, Liu A, Xu X, Xue M, Xu J, Yang Y, Qiu H, Guo F. | 10/5/2019 |
| A point mutation in LxCxE motif of KDM5A/RBP2 renders it incapable of 130 kDa retinoblastoma-associated protein (p130)-interaction and hence, repression of E2F transcription factor 4 and (E2F)-regulated gene promoters. | Dynamic site-specific recruitment of RBP2 by pocket protein p130 modulates H3K4 methylation on E2F-responsive promoters.
Zargar ZU, Kimidi MR, Tyagi S., Free PMC Article | 07/20/2019 |
| E2F4 transcriptional repressor physically associates to the VHL demethylated promoter. These observations together with the finding of elevated E2F4 levels in early-onset preeclampsia (E-PE) placentae suggest that E2F4 inactivates VHL gene expression in E-PE due to enhanced binding to the VHL promoter as a consequence of the reduced methylation status of its binding site. | The von Hippel Lindau tumour suppressor gene is a novel target of E2F4-mediated transcriptional repression in preeclampsia.
Alahari S, Garcia J, Post M, Caniggia I. | 05/25/2019 |
| HSP27 promotes cell cycle progression of MRC-5 cells by suppressing expression of the transcriptional repressors E2F-4 and p130 | Heat shock protein 27 promotes cell cycle progression by down-regulating E2F transcription factor 4 and retinoblastoma family protein p130.
Park AM, Tsunoda I, Yoshie O., Free PMC Article | 03/9/2019 |
| E2f4 forms apical cytoplasmic organizing centres for assembly and nucleation of deuterosomes. Using genetically altered mice and E2F4 mutant proteins we demonstrate that centriole amplification is crucially dependent on these organizing centres and that, without cytoplasmic E2f4, deuterosomes are not assembled, halting multiciliogenesis | Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis.
Mori M, Hazan R, Danielian PS, Mahoney JE, Li H, Lu J, Miller ES, Zhu X, Lees JA, Cardoso WV., Free PMC Article | 12/22/2018 |
| Studied expression of E2F4 in breast cancer patients undergoing neoadjuvant chemotherapy; found target gene-based signature of E2F4 can be used to predict neoadjuvant response. | The E2F4 prognostic signature predicts pathological response to neoadjuvant chemotherapy in breast cancer patients.
Mark KMK, Varn FS, Ung MH, Qian F, Cheng C., Free PMC Article | 03/10/2018 |
| The authors found that phosphorylation of residues S650 and S975 in p107 weakens the E2F4 transactivation domain binding. | Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family.
Liban TJ, Thwaites MJ, Dick FA, Rubin SM., Free PMC Article | 06/24/2017 |
| E2F4 gene expression in glioblastoma. | E2F transcription factors associated with up-regulated genes in glioblastoma.
Donaires FS, Godoy PR, Leandro GS, Puthier D, Sakamoto-Hojo ET. | 03/25/2017 |
| Integrative genomic analyses confirm that E2F4 or E2F1 expression level is high in liposarcoma patients which associate with unfavorable prognosis. | Integrative Genomic Analyses Yield Cell-Cycle Regulatory Programs with Prognostic Value.
Cheng C, Lou S, Andrews EH, Ung MH, Varn FS., Free PMC Article | 01/14/2017 |
| This study found evidence that the number of triplet AGC repeats in the E2F4 gene may play a role in the susceptibility to early-onset colorectal cancer. | [E2F4 as susceptibility factor in the early onset colorectal cancer].
Ríos A, Rodríguez JM, Carbonel P, Parrilla P. | 12/24/2016 |
| PHF8 reduces the H3K9me2 level at the E2F4 transcriptional start site, demonstrating a direct function of PHF8 in endothelial E2F4 gene regulation | The Histone Demethylase PHF8 Is Essential for Endothelial Cell Migration.
Gu L, Hitzel J, Moll F, Kruse C, Malik RA, Preussner J, Looso M, Leisegang MS, Steinhilber D, Brandes RP, Fork C., Free PMC Article | 07/30/2016 |
| cell cycle-dependent transcription of the TRAIP gene by E2F1, E2F2, and E2F4 and rapid protein degradation leads to cell cycle-dependent expression with a maximum in G2/M | The TRAF-interacting protein (TRAIP) is a novel E2F target with peak expression in mitosis.
Chapard C, Hohl D, Huber M., Free PMC Article | 06/28/2016 |
| Authors show that BRCA1 and RAD17 genes, whose derived proteins play a pivotal role in DNA damage repair, are transcriptional targets of gain-of-function mutant p53 proteins. | Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression.
Valenti F, Ganci F, Fontemaggi G, Sacconi A, Strano S, Blandino G, Di Agostino S., Free PMC Article | 03/5/2016 |
| Data suggest that aberrant cell cycle activation in Ewing sarcoma is due to the de-repression of transcription factor E2F targets of transcriptional induction and physical recruitment of E2F3 by fusion protein EWS-FLI1 replacing E2F4 on their promoters. | EWS-FLI1 employs an E2F switch to drive target gene expression.
Schwentner R, Papamarkou T, Kauer MO, Stathopoulos V, Yang F, Bilke S, Meltzer PS, Girolami M, Kovar H., Free PMC Article | 06/27/2015 |