| Multidrug resistance transporter-1 dysfunction perturbs meiosis and Ca2+ homeostasis in oocytes. | Multidrug resistance transporter-1 dysfunction perturbs meiosis and Ca2+ homeostasis in oocytes.
Nabi D, Bosi D, Gupta N, Thaker N, Fissore R, Brayboy LM., Free PMC Article | 12/17/2022 |
| Air pollution exposure increases ABCB1 and ASCT1 transporter levels in mouse cortex. | Air pollution exposure increases ABCB1 and ASCT1 transporter levels in mouse cortex.
Puris E, Saveleva L, Górová V, Vartiainen P, Kortelainen M, Lamberg H, Sippula O, Malm T, Jalava PI, Auriola S, Fricker G, Kanninen KM. | 12/3/2022 |
| Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers. | Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers.
Fujita A, Noguchi S, Hamada R, Inoue S, Shimada T, Katakura S, Maruyama T, Sai Y, Nishimura T, Tomi M., Free PMC Article | 07/9/2022 |
| Role of the efflux transporters Abcb1 and Abcg2 in the brain distribution of olaparib in mice. | Role of the efflux transporters Abcb1 and Abcg2 in the brain distribution of olaparib in mice.
Song YK, Kim MJ, Kim MS, Lee JH, Chung SJ, Song JS, Chae YJ, Lee KR. | 05/7/2022 |
| MDR-1 function protects oocyte mitochondria against the transgenerational effects of nitrogen mustard exposure. | MDR-1 function protects oocyte mitochondria against the transgenerational effects of nitrogen mustard exposure.
Clark H, Pereira Vera B, Zhang Z, Brayboy LM. | 10/23/2021 |
| Malaria in pregnancy regulates P-glycoprotein (P-gp/Abcb1a) and ABCA1 efflux transporters in the Mouse Visceral Yolk Sac. | Malaria in pregnancy regulates P-glycoprotein (P-gp/Abcb1a) and ABCA1 efflux transporters in the Mouse Visceral Yolk Sac.
Martinelli LM, Fontes KN, Reginatto MW, Andrade CBV, Monteiro VRS, Gomes HR, Silva-Filho JL, Pinheiro AAS, Vago AR, Almeida FRCL, Bloise FF, Matthews SG, Ortiga-Carvalho TM, Bloise E., Free PMC Article | 05/15/2021 |
| Mdr1a, Bcrp and Mrp2 regulate the efficacy and toxicity of mesaconitine and hypaconitine by altering their tissue accumulation and in vivo residence. | Mdr1a, Bcrp and Mrp2 regulate the efficacy and toxicity of mesaconitine and hypaconitine by altering their tissue accumulation and in vivo residence.
Li X, Ou X, Luo G, Ou X, Xie Y, Ying M, Qu W, Zuo H, Qi X, Wang Y, Liu Z, Zhu L. | 01/16/2021 |
| Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling. | Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling.
Okyar A, Kumar SA, Filipski E, Piccolo E, Ozturk N, Xandri-Monje H, Pala Z, Abraham K, Gomes ARGJ, Orman MN, Li XM, Dallmann R, Lévi F, Ballesta A., Free PMC Article | 11/21/2020 |
| Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET. | Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET.
Zoufal V, Wanek T, Krohn M, Mairinger S, Filip T, Sauberer M, Stanek J, Pekar T, Bauer M, Pahnke J, Langer O., Free PMC Article | 08/22/2020 |
| WYE354 stimulated the ATPase activity of ABCB1, which was consistent with in silico predictions using a human ABCB1 mouse homology model, indicating that WYE354 is a potent substrate of ABCB1. | WYE-354 restores Adriamycin sensitivity in multidrug-resistant acute myeloid leukemia cell lines.
Ibrahim SM, Bakhashab S, Ilyas AM, Pushparaj PN, Karim S, Khan JA, Abuzenadah AM, Chaudhary AG, Al-Qahtani MH, Ahmed F., Free PMC Article | 08/17/2019 |
| The activation of P-Glycoprotein, Abcb1a, -mediated ATP hydrolysis by methadone was monophasic, whereas loperamide activation of ATP hydrolysis was biphasic implying methadone has a single binding site and loperamide has 2 binding sites on P-gp. | A Conformationally Gated Model of Methadone and Loperamide Transport by P-Glycoprotein.
Gibbs ME, Wilt LA, Ledwitch KV, Roberts AG., Free PMC Article | 06/29/2019 |
| P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state. | P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state.
Urbatsch IL, Tyndall GA, Tombline G, Senior AE. | 04/22/2019 |
| A panel of 18 P-gp substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp can affect the pulmonary kinetics of a subset of P-gp substrates. | The Differential Absorption of a Series of P-Glycoprotein Substrates in Isolated Perfused Lungs from Mdr1a/1b Genetic Knockout Mice can be Attributed to Distinct Physico-Chemical Properties: an Insight into Predicting Transporter-Mediated, Pulmonary Specific Disposition.
Price DF, Luscombe CN, Eddershaw PJ, Edwards CD, Gumbleton M., Free PMC Article | 08/4/2018 |
| The results of this study suggested suggest that THC exposure decreased the neurobehavioral effects of risperidone because of P-gp upregulation in the brain. | The Differential Binding of Antipsychotic Drugs to the ABC Transporter P-Glycoprotein Predicts Cannabinoid-Antipsychotic Drug Interactions.
Brzozowska NI, de Tonnerre EJ, Li KM, Wang XS, Boucher AA, Callaghan PD, Kuligowski M, Wong A, Arnold JC., Free PMC Article | 05/19/2018 |
| The results show that the absence of P-gp results in a significant disturbance of Abeta removal from the brain and increased intraparenchymal cerebral amyloid angiopathy after immunization against Beta-Amyloid. | Lack of P-glycoprotein Results in Impairment of Removal of Beta-Amyloid and Increased Intraparenchymal Cerebral Amyloid Angiopathy after Active Immunization in a Transgenic Mouse Model of Alzheimer's Disease.
Bruckmann S, Brenn A, Grube M, Niedrig K, Holtfreter S, von Bohlen und Halbach O, Groschup M, Keller M, Vogelgesang S. | 04/7/2018 |
| These data confirm that seliciclib displays a limited brain exposure and Abcb1a is at least partly responsible for limited brain exposure of seliciclib in mice. | Abcb1a (P-glycoprotein) limits brain exposure of the anticancer drug candidate seliciclib in vivo in adult mice.
Erdő F, Nagy I, Tóth B, Bui A, Molnár É, Tímár Z, Magnan R, Krajcsi P. | 02/10/2018 |
| Data suggest that, in the presence of verapamil (a substrate that activates ATP hydrolysis), the nucleotide-binding domains of Abcb1a (reconstituted in lipid bilayer nanodiscs) are never far apart during cycle of ATP hydrolysis. | Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer-associated P-glycoprotein during ATP hydrolysis.
Zoghbi ME, Mok L, Swartz DJ, Singh A, Fendley GA, Urbatsch IL, Altenberg GA., Free PMC Article | 01/27/2018 |
| Interactions and cooperativity between P-glycoprotein structural domains determined by thermal unfolding have been reported. | Interactions and cooperativity between P-glycoprotein structural domains determined by thermal unfolding provides insights into its solution structure and function.
Yang Z, Zhou Q, Mok L, Singh A, Swartz DJ, Urbatsch IL, Brouillette CG., Free PMC Article | 10/28/2017 |
| MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis. | MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis.
Hennenberg EM, Eyking A, Reis H, Cario E., Free PMC Article | 09/23/2017 |
| multiple pathways, including MMP9 cleavage and ubiquitinylation, mediated P-gp downmodulation. | A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier.
Kim DG, Bynoe MS., Free PMC Article | 09/2/2017 |
| Data suggest that MDR3 isoforms, both human and mouse isoforms, exhibit different affinities for fluorescent dyes and drugs; thus, ligands likely occupy partially overlapping but distinct binding sites. | Differential Coupling of Binding, ATP Hydrolysis, and Transport of Fluorescent Probes with P-Glycoprotein in Lipid Nanodiscs.
Li MJ, Nath A, Atkins WM., Free PMC Article | 06/24/2017 |
| using double electron-electron resonance and molecular dynamics simulations to describe the ATP- and substrate-coupled conformational cycle of the mouse ABC efflux transporter P-glycoprotein (Pgp; also known as ABCB1) | Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein.
Verhalen B, Dastvan R, Thangapandian S, Peskova Y, Koteiche HA, Nakamoto RK, Tajkhorshid E, Mchaourab HS., Free PMC Article | 06/24/2017 |
| Mdr1a deficiency significantly enhanced the analgesic effect of aconitine and exacerbated its toxicity in the brain. | Mdr1a plays a crucial role in regulating the analgesic effect and toxicity of aconitine by altering its pharmacokinetic characteristics.
Zhu L, Wu J, Zhao M, Song W, Qi X, Wang Y, Lu L, Liu Z. | 06/3/2017 |
| Chrysosplenetin inhibited P-gp activity and reverse the up-regulated P-gp and MDR1 levels induced by artemisinin. | Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine.
Ma L, Wei S, Yang B, Ma W, Wu X, Ji H, Sui H, Chen J., Free PMC Article | 03/11/2017 |
| Tamsulosin and tolterodine with P-gp gene expression and activity in an enantiomer-specific way. | Differential effects of the enantiomers of tamsulosin and tolterodine on P-glycoprotein and cytochrome P450 3A4.
Doricakova A, Theile D, Weiss J, Vrzal R. | 02/25/2017 |