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    DSC1 desmocollin 1 [ Homo sapiens (human) ]

    Gene ID: 1823, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Desmocollin-1 is associated with pro-metastatic phenotype of luminal A breast cancer cells and is modulated by parthenolide.

    Desmocollin-1 is associated with pro-metastatic phenotype of luminal A breast cancer cells and is modulated by parthenolide.
    Lapcik P, Sulc P, Janacova L, Jilkova K, Potesil D, Bouchalova P, Müller P, Bouchal P., Free PMC Article

    09/1/2023
    Uniting biobank resources reveals novel genetic pathways modulating susceptibility for atopic dermatitis.

    Uniting biobank resources reveals novel genetic pathways modulating susceptibility for atopic dermatitis.
    Sliz E, Huilaja L, Pasanen A, Laisk T, Reimann E, Mägi R, FinnGen, Estonian Biobank Research Team, Hannula-Jouppi K, Peltonen S, Salmi T, Koulu L, Tasanen K, Kettunen J.

    05/7/2022
    CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129.

    CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129.
    Zhang Z, Zhu H, Hu J., Free PMC Article

    09/18/2021
    desmocollin-1 (DSC1) is validated as a protein connected with lymph node status of luminal A breast cancer, tumor grade, and Her-2 status and catechol-O-methyltransferase is successfully verified as a protein associated with lymph node metastasis of triple negative breast cancer.

    Proteomics Identification and Validation of Desmocollin-1 and Catechol-O-Methyltransferase as Proteins Associated with Breast Cancer Cell Migration and Metastasis.
    Faktor J, Knopfova L, Lapcik P, Janacova L, Paralova V, Bouchalova P, Muller P, Benes P, Bouchal P.

    06/27/2020
    DSC1 expression is significantly downregulated in human masticatory mucosa during wound healing

    Human gingiva transcriptome during wound healing.
    Wang Y, Tatakis DN.

    03/22/2017
    Increased expression of DSC1 can promote the occurrence of head and neck squamous cell carcinoma (HNSCC) and is associated with tumor. The increased expression of DSC1 also indicates a poor prognosis of the patients with HNSCC.

    Lower DSC1 expression is related to the poor differentiation and prognosis of head and neck squamous cell carcinoma (HNSCC).
    Wang Y, Chen C, Wang X, Jin F, Liu Y, Liu H, Li T, Fu J.

    02/18/2017
    Low expression of DSC 1, 2, and 3 was observed in 55, 54, and 79 % of liver metastases.

    The influence of desmocollin 1-3 expression on prognosis after curative resection of colorectal liver metastases.
    Schüle S, Neuhäuser C, Rauchfuß F, Knösel T, Settmacher U, Altendorf-Hofmann A.

    10/4/2014
    High expression of desmocollin 1 (DSC1) was observed in 41.6%, DSC2 in 58.0%, DSC3 in 61.4%, E-cadherin in 71.4%, CDX2 in 58.0%, PITX1 in 55.0%, CDK4 in 0.2%, TLE1 in 1.3%, Factor H in 42.5%, and MDM2 in 0.2% of colorectal carcinomas.

    Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma.
    Knösel T, Chen Y, Hotovy S, Settmacher U, Altendorf-Hofmann A, Petersen I.

    03/23/2013
    Increased Dsc1 protein is associated with colorectal cancer

    Desmocollin switching in colorectal cancer.
    Khan K, Hardy R, Haq A, Ogunbiyi O, Morton D, Chidgey M., Free PMC Article

    01/21/2010
    in majority of patients with Netherton syndrome, Dsg1 & Dsc1 were reduced in living layers of epidermis; SCTE-like & SCCE-like activities were increased, suggesting these proteases participate in premature degradation of corneodesmosomal cadherins

    Corneodesmosomal cadherins are preferential targets of stratum corneum trypsin- and chymotrypsin-like hyperactivity in Netherton syndrome.
    Descargues P, Deraison C, Prost C, Fraitag S, Mazereeuw-Hautier J, D'Alessio M, Ishida-Yamamoto A, Bodemer C, Zambruno G, Hovnanian A.

    01/21/2010
    The ultrastructural modifications of desmosomes during terminal differentiation of hair follicles are paralleled by the modulation of the synthesis of desmocollin 1.

    Desmocollin 1 expression and desmosomal remodeling during terminal differentiation of human anagen hair follicle: an electron microscopic study.
    Donetti E, Boschini E, Cerini A, Selleri S, Rumio C, Barajon I.

    01/21/2010
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