| DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis. | DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis.
Adamczyk-Grochala J, Bloniarz D, Zielinska K, Lewinska A, Wnuk M., Free PMC Article | 02/28/2023 |
| Position 34 of tRNA is a discriminative element for m5C38 modification by human DNMT2. | Position 34 of tRNA is a discriminative element for m5C38 modification by human DNMT2.
Huang ZX, Li J, Xiong QP, Li H, Wang ED, Liu RJ., Free PMC Article | 01/15/2022 |
| Decoding the Genetic Alterations in Genes of DNMT Family (DNA Methyl-Transferase) and their Association with Head and Neck Squamous Cell Carcinoma. | Decoding the Genetic Alterations in Genes of DNMT Family (DNA Methyl-Transferase) and their Association with Head and Neck Squamous Cell Carcinoma.
Fathima T, Arumugam P, Girija As S, Priyadharsini JV., Free PMC Article | 09/4/2021 |
| The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence. | The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence.
Bloniarz D, Adamczyk-Grochala J, Lewinska A, Wnuk M., Free PMC Article | 07/24/2021 |
| TRDMT1 participates in the DNA damage repair of granulosa cells in premature ovarian failure. | TRDMT1 participates in the DNA damage repair of granulosa cells in premature ovarian failure.
Sha C, Chen L, Lin L, Li T, Wei H, Yang M, Gao W, Zhao D, Chen Q, Liu Y, Chen X, Xu W, Li Y, Zhu X., Free PMC Article | 07/24/2021 |
| Trdmt1 3'-untranslated region functions as a competing endogenous RNA in leukemia HL-60 cell differentiation. | Trdmt1 3'-untranslated region functions as a competing endogenous RNA in leukemia HL-60 cell differentiation.
Xu S, Xiong J, Wu M, Yang Y, Jiang J, Ni H, Zhao Y, Wang Y., Free PMC Article | 02/6/2021 |
| TRDMT1 has a role in 5-methylcytosine modification of mRNA and in HEK293 cell proliferation and migration | Depletion of TRDMT1 affects 5-methylcytosine modification of mRNA and inhibits HEK293 cell proliferation and migration.
Xue S, Xu H, Sun Z, Shen H, Chen S, Ouyang J, Zhou Q, Hu X, Cui H. | 06/27/2020 |
| Data suggest that, upon HIV-1 infection, DNMT2 is re-localized from the nucleus to cytoplasmic stress granules where DNMT2 methylates HIV-1 messenger RNA; this methylation increases the stability of the HIV-1 RNA genome and up-regulates virus replication; thus, DNMT2 appears to facilitate HIV-1 infection. | Cytosine methylation by DNMT2 facilitates stability and survival of HIV-1 RNA in the host cell during infection.
Dev RR, Ganji R, Singh SP, Mahalingam S, Banerjee S, Khosla S. | 07/15/2017 |
| The strong effect of some of the somatic cancer mutations on DNMT2 activity suggests that these mutations have a functional role in tumorigenesis. | Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties.
Elhardt W, Shanmugam R, Jurkowski TP, Jeltsch A. | 01/16/2016 |
| DNMT1, DNMT2 and DNMT3A may play important roles in gastric cancer carcinogenesis. | Risk-association of DNA methyltransferases polymorphisms with gastric cancer in the Southern Chinese population.
Yang XX, He XQ, Li FX, Wu YS, Gao Y, Li M., Free PMC Article | 08/8/2015 |
| Mapped is the tRNA binding site of DNMT2 by systematically mutating surface-exposed lysine and arginine residues to alanine and studying the tRNA methylation activity and binding of the corresponding variants. | Mapping the tRNA binding site on the surface of human DNMT2 methyltransferase.
Jurkowski TP, Shanmugam R, Helm M, Jeltsch A. | 12/8/2012 |
| the role of Dnmt2 in stress granules could represent a primitive cellular defense mechanism against viral infection. | The DNA methyltranferase Dnmt2 participates in RNA processing during cellular stress.
Thiagarajan D, Dev RR, Khosla S. | 04/30/2011 |
| The expression of DNMT1, DNMT2, DNMT3A and DNMT3B in pediatric acute lymphoblastic leukemia patients, was investigated. | DNA methyltransferase expression differs with proliferation in childhood acute lymphoblastic leukemia.
Sayin DB, Kürekçi E, Karabulut HG, Ezer U, Bökesoy I. | 10/4/2010 |
| Hepatitis B virus-induced overexpression of DNMTs leads to viral DNA methylation and decreased viral gene expression and also leads to methylation of host CpG islands. | Hepatitis B virus replication induces methylation of both host and viral DNA.
Vivekanandan P, Daniel HD, Kannangai R, Martinez-Murillo F, Torbenson M., Free PMC Article | 05/3/2010 |
| An association study of 45 folate-related genes in spina bifida: Involvement of tRNA aspartic acid methyltransferase 1 (TRDMT1) | An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).
Franke B, Vermeulen SH, Steegers-Theunissen RP, Coenen MJ, Schijvenaars MM, Scheffer H, den Heijer M, Blom HJ, Franke B, Vermeulen SH, Steegers-Theunissen RP, Coenen MJ, Schijvenaars MM, Scheffer H, den Heijer M, Blom HJ. | 01/21/2010 |
| Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group., Free PMC Article | 01/11/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (6) articlesInvestigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. Genetic variation in healthy oldest-old.
Halaschek-Wiener J, Amirabbasi-Beik M, Monfared N, Pieczyk M, Sailer C, Kollar A, Thomas R, Agalaridis G, Yamada S, Oliveira L, Collins JA, Meneilly G, Marra MA, Madden KM, Le ND, Connors JM, Brooks-Wilson AR. A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation.
El-Maarri O, Kareta MS, Mikeska T, Becker T, Diaz-Lacava A, Junen J, Nüsgen N, Behne F, Wienker T, Waha A, Oldenburg J, Chédin F. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).
Franke B, Vermeulen SH, Steegers-Theunissen RP, Coenen MJ, Schijvenaars MM, Scheffer H, den Heijer M, Blom HJ, Franke B, Vermeulen SH, Steegers-Theunissen RP, Coenen MJ, Schijvenaars MM, Scheffer H, den Heijer M, Blom HJ. Prognostic significance of folate metabolism polymorphisms for lung cancer.
Matakidou A, El Galta R, Rudd MF, Webb EL, Bridle H, Eisen T, Houlston RS. | 03/13/2008 |
| cDNA microarray analysis identified several genes involved in DNA methylation, such as DNMT2 and DNMT3a that were more highly expressed in LNCaP-r (an androgen sensitive prostate cancer cell line). | Cytogenetic and expression profiles associated with transformation to androgen-resistant prostate cancer.
Pang ST, Weng WH, Flores-Morales A, Johansson B, Pourian MR, Nilsson P, Pousette A, Larsson C, Norstedt G. | 01/21/2010 |
| genetic and biochemical approach revealed that DNMT2 did not methylate DNA but instead methylated aspartic acid transfer RNA (tRNA(Asp)) and that DNMT2 specifically methylated cytosine 38 in the anticodon loop | Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.
Goll MG, Kirpekar F, Maggert KA, Yoder JA, Hsieh CL, Zhang X, Golic KG, Jacobsen SE, Bestor TH. | 01/21/2010 |
| identification of residual DNA-(cytosine-C5) methyltransferase activity | The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity.
Hermann A, Schmitt S, Jeltsch A. | 01/21/2010 |