| DEAD/H-box helicase 11 is transcriptionally activated by Yin Yang-1 and accelerates oral squamous cell carcinoma progression. | DEAD/H-box helicase 11 is transcriptionally activated by Yin Yang-1 and accelerates oral squamous cell carcinoma progression.
Yang G, Shi X, Zhang M, Wang K, Tian X, Wang X. | 10/16/2024 |
| Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency. | Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency.
Amitzi L, Cozma E, Tong AHY, Chan K, Ross C, O'Neil N, Moffat J, Stirling P, Hieter P., Free PMC Article | 06/3/2024 |
| Mutations in DEAD/H-box helicase 11 correlate with increased relapse risk in adults with acute myeloid leukaemia with normal cytogenetics. | Mutations in DEAD/H-box helicase 11 correlate with increased relapse risk in adults with acute myeloid leukaemia with normal cytogenetics.
Zhou YL, Zhao MY, Gale RP, Jiang H, Jiang Q, Liu LX, Qin JY, Cao SB, Lou F, Xu LP, Zhang XH, Huang XJ, Ruan GR. | 01/12/2024 |
| Finding underlying genetic mechanisms of two patients with autism spectrum disorder carrying familial apparently balanced chromosomal translocations. | Finding underlying genetic mechanisms of two patients with autism spectrum disorder carrying familial apparently balanced chromosomal translocations.
Toraman B, Bilginer SÇ, Hesapçıoğlu ST, Göker Z, Soykam HO, Ergüner B, Dinçer T, Yıldız G, Ünsal S, Kasap BK, Kandil S, Kalay E. | 01/22/2022 |
| Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility. | Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility.
Saeed M, Ibáñez-Costa A, Patiño-Trives AM, Muñoz-Barrera L, Collantes Estévez E, Aguirre MÁ, López-Pedrera C., Free PMC Article | 08/7/2021 |
| Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication. | Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.
Lerner LK, Holzer S, Kilkenny ML, Šviković S, Murat P, Schiavone D, Eldridge CB, Bittleston A, Maman JD, Branzei D, Stott K, Pellegrini L, Sale JE., Free PMC Article | 04/13/2021 |
| E2F1 mediated DDX11 transcriptional activation promotes hepatocellular carcinoma progression through PI3K/AKT/mTOR pathway. | E2F1 mediated DDX11 transcriptional activation promotes hepatocellular carcinoma progression through PI3K/AKT/mTOR pathway.
Yu Y, Zhao D, Li K, Cai Y, Xu P, Li R, Li J, Chen X, Chen P, Cui G., Free PMC Article | 04/3/2021 |
| The long non-coding RNA DDX11-AS1 facilitates cell progression and oxaliplatin resistance via regulating miR-326/IRS1 axis in gastric cancer. | The long non-coding RNA DDX11-AS1 facilitates cell progression and oxaliplatin resistance via regulating miR-326/IRS1 axis in gastric cancer.
Song W, Qian Y, Zhang MH, Wang H, Wen X, Yang XZ, Dai WJ. | 03/20/2021 |
| The iron-sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation. | The iron-sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation.
Simon AK, Kummer S, Wild S, Lezaja A, Teloni F, Jozwiakowski SK, Altmeyer M, Gari K., Free PMC Article | 03/20/2021 |
| DDX11-AS1exacerbates bladder cancer progression by enhancing CDK6 expression via suppressing miR-499b-5p. | DDX11-AS1exacerbates bladder cancer progression by enhancing CDK6 expression via suppressing miR-499b-5p.
Li Q, Wang S, Wu Z, Liu Y. | 02/13/2021 |
| LncRNA DDX11-AS1: a novel oncogene in human cancer. | LncRNA DDX11-AS1: a novel oncogene in human cancer.
Feng Y, Wu M, Hu S, Peng X, Chen F. | 10/31/2020 |
| Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion. | Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion.
van Schie JJM, Faramarz A, Balk JA, Stewart GS, Cantelli E, Oostra AB, Rooimans MA, Parish JL, de Almeida Estéves C, Dumic K, Barisic I, Diderich KEM, van Slegtenhorst MA, Mahtab M, Pisani FM, Te Riele H, Ameziane N, Wolthuis RMF, de Lange J., Free PMC Article | 09/26/2020 |
| Final rescue tests in vitro and in vivo further elucidated that DDX11 overexpression could reversed the DDX11-AS1 downregulation-mediated effect on osteosarcoma progression | DDX11-AS1 contributes to osteosarcoma progression via stabilizing DDX11.
Zhang H, Lin J, Chen J, Gu W, Mao Y, Wang H, Zhang Y, Liu W. | 07/25/2020 |
| The DDX11-AS1 may be a novel oncogene in hepatocarcinogenesis by repressing LATS2, providing a potential therapeutic target for hepatocellular carcinoma treatment. | Long noncoding RNA DDX11-AS1 epigenetically represses LATS2 by interacting with EZH2 and DNMT1 in hepatocellular carcinoma.
Li Y, Zhuang W, Huang M, Li X. | 07/25/2020 |
| DDX11, ESCO1 and ESCO2 control different fractions of cohesin that are spatially and mechanistically separated. | Non-redundant roles in sister chromatid cohesion of the DNA helicase DDX11 and the SMC3 acetyl transferases ESCO1 and ESCO2.
Faramarz A, Balk JA, van Schie JJM, Oostra AB, Ghandour CA, Rooimans MA, Wolthuis RMF, de Lange J., Free PMC Article | 04/4/2020 |
| Results indicate a role for the DDX11-Timeless interaction in coordinating DNA replication with sister chromatid cohesion, and suggest implications for understanding the molecular basis of Warsaw breakage syndrome (WABS). | Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion.
Cortone G, Zheng G, Pensieri P, Chiappetta V, Tatè R, Malacaria E, Pichierri P, Yu H, Pisani FM., Free PMC Article | 01/26/2019 |
| DDX11 orchestrates jointly with 9-1-1 and its loader, RAD17, DNA damage tolerance at sites of bulky lesions, and endogenous abasic sites. These functions may explain the essential roles of DDX11 and its similarity with 9-1-1 during development. | Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites.
Abe T, Ooka M, Kawasumi R, Miyata K, Takata M, Hirota K, Branzei D., Free PMC Article | 09/22/2018 |
| We present two new cases of Warsaw Breakage Syndrome (WABS), an autosomal recessive cohesinopathy, in sisters aged 13 and 11 years who both had compound heterozygous mutations in DDX11 | Clinical Report: Warsaw Breakage Syndrome with small radii and fibulae.
Eppley S, Hopkin RJ, Mendelsohn B, Slavotinek AM. | 06/9/2018 |
| A mutation has been identified in HPV16 E2 that abrogates interaction with ChlR1, and it was shown that ChlR1 regulates the chromatin association of HPV16 E2 and that this virus-host interaction is essential for viral episome maintenance. | The Cellular DNA Helicase ChlR1 Regulates Chromatin and Nuclear Matrix Attachment of the Human Papillomavirus 16 E2 Protein and High-Copy-Number Viral Genome Establishment.
Harris L, McFarlane-Majeed L, Campos-León K, Roberts S, Parish JL., Free PMC Article | 05/20/2017 |
| In this study, we found that cohesion establishment factors, like CHlR1, cooperatively stimulate endonuclease activity of hFen1 in in vivo mimic condition, including replication protein-A-coated DNA and high salt. | Cohesion Establishment Factors Stimulate Endonuclease Activity of hFen1 Independently and Cooperatively.
Kim DH, Kim JH, Park BC, Cho S, Park SG. | 07/30/2016 |
| DDX11 and Tim proteins physically and functionally interact and act in concert to preserve replication fork progression in perturbed conditions. | Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway.
Calì F, Bharti SK, Di Perna R, Brosh RM Jr, Pisani FM., Free PMC Article | 06/28/2016 |
| Q Motif Is Involved in DNA Binding but Not ATP Binding in ChlR1 Helicase | The Q Motif Is Involved in DNA Binding but Not ATP Binding in ChlR1 Helicase.
Ding H, Guo M, Vidhyasagar V, Talwar T, Wu Y., Free PMC Article | 06/11/2016 |
| our results indicate that DDX11 functions as a positive regulator of rRNA transcription and provides a novel insight into the pathogenesis of WABS. | The Warsaw breakage syndrome-related protein DDX11 is required for ribosomal RNA synthesis and embryonic development.
Sun X, Chen H, Deng Z, Hu B, Luo H, Zeng X, Han L, Cai G, Ma L. | 05/14/2016 |
| A distinct triplex DNA unwinding activity of ChlR1 helicase. | A distinct triplex DNA unwinding activity of ChlR1 helicase.
Guo M, Hundseth K, Ding H, Vidhyasagar V, Inoue A, Nguyen CH, Zain R, Lee JS, Wu Y., Free PMC Article | 05/9/2015 |
| ChlR1 plays a critically important role in cellular replication and/or DNA repair. [review] | Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome.
Bharti SK, Khan I, Banerjee T, Sommers JA, Wu Y, Brosh RM Jr., Free PMC Article | 08/23/2014 |