| CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage. | CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage.
Li Y, You C, Liu Z, He F, Zhao F, Song X, Xie Z, Wei S, Yang Y, Wei H, Che F, Yu J. | 02/15/2023 |
| Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation. | Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation.
Zhao B, Huang J, Lou X, Yao K, Ye M, Mou Q, Wen Z, Duan Q, Zhang H, Zhao Y. | 11/12/2022 |
| CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro. | CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro.
Ding Y, Tu P, Chen Y, Huang Y, Pan X, Chen W., Free PMC Article | 03/19/2022 |
| CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma. | CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma.
Zou X, Mo Z., Free PMC Article | 09/25/2021 |
| 6,8-Diprenylorobol Induces Apoptosis in Human Hepatocellular Carcinoma Cells via Activation of FOXO3 and Inhibition of CYP2J2. | 6,8-Diprenylorobol Induces Apoptosis in Human Hepatocellular Carcinoma Cells via Activation of FOXO3 and Inhibition of CYP2J2.
Lee CM, Lee J, Jang SN, Shon JC, Wu Z, Park K, Liu KH, Park SH., Free PMC Article | 09/11/2021 |
| Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population. | Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population.
Lu H, Yang Y, Chen X, Wu C, Zhao J, Feng Q, Zhou X, Xu D, Li Q, Niu H, He P, Liu J, Yao H, Ding Y. | 07/3/2021 |
| Molecular determinant of substrate binding and specificity of cytochrome P450 2J2. | Molecular determinant of substrate binding and specificity of cytochrome P450 2J2.
Xu L, Chen LY., Free PMC Article | 05/8/2021 |
| CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes. | CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes.
Evangelista EA, Aliwarga T, Sotoodehnia N, Jensen PN, McKnight B, Lemaitre RN, Totah RA, Gharib SA., Free PMC Article | 01/9/2021 |
| In conclusion, the rs2280275 and rs11572325 SNPs of CYP2J2 may be considered novel genetic markers of hypertension, at least in Russian women | A comprehensive study revealed SNP-SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension risk.
Polonikov AV, Ponomarenko IV, Bykanova MA, Sirotina SS, Bocharova AV, Vagaytseva KV, Stepanov VA, Azarova IE, Churnosov MI, Solodilova MA. | 08/1/2020 |
| CYP2J2 50G>T (rs890293) polymorphism was associated with an increased risk for psoriasis in the Turkish population | Association of CYP2J2 polymorphism with susceptibility to psoriasis in Turkish population: a case-control study.
Hayran Y, Allı N, Uysal Pİ, Çandar T., Free PMC Article | 05/16/2020 |
| Studies report on the role of the surrounding lipid environment and macromolecular crowding in modulating enzymatic function of CYP2J2-cytochrome P450 reductase membrane protein system. | Lipid composition and macromolecular crowding effects on CYP2J2-mediated drug metabolism in nanodiscs.
Huff HC, Maroutsos D, Das A., Free PMC Article | 04/4/2020 |
| The CYP2J2*7 SNP in the donor was associated with elevated risk of delayed graft function. | Polymorphisms in vasoactive eicosanoid genes of kidney donors affect biopsy scores and clinical outcomes in renal transplantation.
Mota-Zamorano S, González LM, Luna E, Fernández JJ, Gómez Á, Nieto-Fernández A, Robles NR, Gervasini G., Free PMC Article | 03/21/2020 |
| Our findings demonstrate that CYP2J2 improves cardiac function by increasing the concentration of circulating EETs, and boosting angiogenesis via the Jagged1/Notch1 signaling pathway in MI-induced heart failure. | Endothelium-specific CYP2J2 overexpression improves cardiac dysfunction by promoting angiogenesis via Jagged1/Notch1 signaling.
Zhao Q, Huang J, Wang D, Chen L, Sun D, Zhao C. | 10/26/2019 |
| A functionally relevant polymorphism of the CYP2J2 gene was independently associated with an increased risk of CAD. | Role of cytochrome epoxygenase (CYP2J2) in the pathophysiology of coronary artery disease in South Indian population.
Tantray JA, Reddy KP, Jamil K, Yerra SK., Free PMC Article | 09/7/2019 |
| There were 15 genetic variants identified in CYP2J2 genes in three Chinese populations: Han, Tibetan and Uighur. | Genetic polymorphisms of CYP2S1, CYP2J2 and CYP2R1 genes in three Chinese populations: Han, Tibetan and Uighur.
Kang X, Shi H, Zhang L, Wang Y, Zhang T, Han M, Chen C, Wang H. | 09/7/2019 |
| CYP2J2 50 G>T polymorphism is associated with increased risk of cerebral small vessel disease in Han Chinese. | Cerebral Small Vessel Disease is Associated with Genetic Variations in CYP2J.
Yao M, Lv D, Huo J, Sun Z. | 05/11/2019 |
| Single Nucleotide Polymorphism in CYP2J2, which synthesize epoxyeicosatrienoic acids, may modify Cardiovascular outcomes in Renal Transplant recipients. | Polymorphisms in genes involved in vasoactive eicosanoid synthesis affect cardiovascular risk in renal transplant recipients.
Gervasini G, Luna E, Garcia-Pino G, Azevedo L, Mota-Zamorano S, José Cubero J. | 04/20/2019 |
| Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide hydrolase expression. | Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide hydrolase expression.
Qiu YE, Qin J, Luo Y, Qin SL, Mu YF, Cun R, Jiang HL, Chen JJ, Yu MH, Zhong M. | 02/2/2019 |
| Cell survival decreases with ROS exposure when CYP2J2 is chemically inhibited. | CYP2J2 Expression in Adult Ventricular Myocytes Protects Against Reactive Oxygen Species Toxicity.
Evangelista EA, Lemaitre RN, Sotoodehnia N, Gharib SA, Totah RA., Free PMC Article | 11/10/2018 |
| In the villous trophoblast, CYP2C8 was the most abundant protein. Its expression is higher than the CYP2C9 and CYP2J2 in the cytotrophoblast in the embryonic stage of development and remains higher in syncytiotrophoblast of term placenta. | Time-dependent expression pattern of cytochrome P450 epoxygenases and soluble epoxide hydrolase in normal human placenta.
Cizkova K, Tauber Z. | 11/10/2018 |
| Data show the importance of the formation of a hydrogen bond between cytochrome P450 2J2 arginine 117 (R117) and the keto group of the substrates. | Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2.
Lafite P, André F, Graves JP, Zeldin DC, Dansette PM, Mansuy D., Free PMC Article | 11/3/2018 |
| these data can aid the design of other analogues that have reduced cardiotoxicity, which do not modulate CYP2J2's arachidonic acid metabolism. | An Emerging Pathway of Doxorubicin Cardiotoxicity Mediated through CYP2J2.
Arnold WR, Das A., Free PMC Article | 09/15/2018 |
| demonstrate that doxorubicin (DOX) and 7-de-aDOX inhibit CYP2J2-mediated AA metabolism and 7-de-aDOX binds close to the active site to alter the ratio of cardioprotective epoxyeicosatrienoic acids. | Arachidonic Acid Metabolism by Human Cardiovascular CYP2J2 Is Modulated by Doxorubicin.
Arnold WR, Baylon JL, Tajkhorshid E, Das A., Free PMC Article | 05/19/2018 |
| The use of LKY-047 as a selective CYP2J2 inhibitor. | LKY-047: First Selective Inhibitor of Cytochrome P450 2J2.
Phuc NM, Wu Z, O Y, Lee JH, Oh S, Song GY, Liu KH. | 03/10/2018 |
| Angiotensin II receptor blockers exhibit different degrees of inhibition of the metabolism of arachidonic acid by recombinant CYP2C9, CYP2J2 and liver microsomes. | Angiotensin II Receptor Blockers Inhibit the Generation of Epoxyeicosatrienoic Acid from Arachidonic Acid in Recombinant CYP2C9, CYP2J2 and Human Liver Microsomes.
Senda A, Mukai Y, Hayakawa T, Kato Y, Eliasson E, Rane A, Toda T, Inotsume N. | 02/3/2018 |