| Impact of Serotonin Transporter Absence on Brain Insulin Receptor Expression, Plasma Metabolome Changes, and ADHD-like Behavior in Mice fed a Western Diet. | Impact of Serotonin Transporter Absence on Brain Insulin Receptor Expression, Plasma Metabolome Changes, and ADHD-like Behavior in Mice fed a Western Diet.
Anthony DC, Probert F, Gorlova A, Hebert J, Radford-Smith D, Nefedova Z, Umriukhin A, Nedorubov A, Cespuglio R, Shulgin B, Lyundup A, Lesch KP, Strekalova T., Free PMC Article | 09/11/2024 |
| Long-term Environmental Enrichment Normalizes Schizophrenia-like Abnormalities and Promotes Hippocampal Slc6a4 Promoter Demethylation in Mice Submitted to a Two-hit Model. | Long-term Environmental Enrichment Normalizes Schizophrenia-like Abnormalities and Promotes Hippocampal Slc6a4 Promoter Demethylation in Mice Submitted to a Two-hit Model.
Arraes GC, Barreto FS, Vasconcelos GS, Lima CNC, da Silva FER, Ribeiro WLC, de Sousa FCF, Furtado CLM, Macêdo DS. | 08/8/2024 |
| Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice. | Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice.
Araki R, Kita A, Ago Y, Yabe T. | 08/7/2024 |
| Serotonin Transporter Deficiency Induces Metabolic Alterations in the Ileal Mucosa. | Serotonin Transporter Deficiency Induces Metabolic Alterations in the Ileal Mucosa.
Calzadilla N, Jayawardena D, Qazi A, Sharma A, Mongan K, Comiskey S, Eathara A, Saksena S, Dudeja PK, Alrefai WA, Gill RK., Free PMC Article | 05/21/2024 |
| Serotonin Transporter-dependent Histone Serotonylation in Placenta Contributes to the Neurodevelopmental Transcriptome. | Serotonin Transporter-dependent Histone Serotonylation in Placenta Contributes to the Neurodevelopmental Transcriptome.
Chan JC, Alenina N, Cunningham AM, Ramakrishnan A, Shen L, Bader M, Maze I., | 03/26/2024 |
| Serotonin Transporter (SERT) Expression Modulates the Composition of the Western-Diet-Induced Microbiota in Aged Female Mice. | Serotonin Transporter (SERT) Expression Modulates the Composition of the Western-Diet-Induced Microbiota in Aged Female Mice.
Bloemendaal M, Veniaminova E, Anthony DC, Gorlova A, Vlaming P, Khairetdinova A, Cespuglio R, Lesch KP, Arias Vasquez A, Strekalova T., Free PMC Article | 09/9/2023 |
| Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures. | Developing Brain Glucose Transporters, Serotonin, Serotonin Transporter, and Oxytocin Receptor Expression in Response to Early-Life Hypocaloric and Hypercaloric Dietary, and Air Pollutant Exposures.
Ye X, Shin BC, Baldauf C, Ganguly A, Ghosh S, Devaskar SU., Free PMC Article | 01/22/2022 |
| Sex and brain region-specific regulation of serotonin transporter activity in synaptosomes in guanine nucleotide-binding protein G(q) alpha knockout mice. | Sex and brain region-specific regulation of serotonin transporter activity in synaptosomes in guanine nucleotide-binding protein G(q) alpha knockout mice.
Haase J, Jones AKC, Mc Veigh CJ, Brown E, Clarke G, Ahnert-Hilger G. | 11/22/2021 |
| Effect of serotonin transporter genotype on carbon dioxide-induced fear-related behavior in mice. | Effect of serotonin transporter genotype on carbon dioxide-induced fear-related behavior in mice.
Leibold NK, van den Hove D, Weidner MT, Buchanan GF, Steinbusch HW, Lesch KP, Schruers KR., Free PMC Article | 11/6/2021 |
| LncRNA XIST modulates 5-hydroxytrytophan-induced visceral hypersensitivity by epigenetic silencing of the SERT gene in mice with diarrhea-predominant IBS. | LncRNA XIST modulates 5-hydroxytrytophan-induced visceral hypersensitivity by epigenetic silencing of the SERT gene in mice with diarrhea-predominant IBS.
Zhang Y, Zhang H, Zhang W, Zhang Y, Wang W, Nie L. | 10/30/2021 |
| Involvement of PKCbetaI-SERT activity in stress vulnerability of mice exposed to twice-swim stress. | Involvement of PKCβI-SERT activity in stress vulnerability of mice exposed to twice-swim stress.
Ito T, Hiramatsu Y, Mouri A, Yoshigai T, Takahashi A, Yoshimi A, Mamiya T, Ozaki N, Noda Y. | 09/11/2021 |
| Serotonin transporter genotype modulates resting state and predator stress-induced amygdala perfusion in mice in a sex-dependent manner. | Serotonin transporter genotype modulates resting state and predator stress-induced amygdala perfusion in mice in a sex-dependent manner.
Kolter JF, Hildenbrand MF, Popp S, Nauroth S, Bankmann J, Rother L, Waider J, Deckert J, Asan E, Jakob PM, Lesch KP, Schmitt-Böhrer A., Free PMC Article | 08/28/2021 |
| Female serotonin transporter-knockout rat: A potential model of irritable bowel syndrome. | Female serotonin transporter-knockout rat: A potential model of irritable bowel syndrome.
Bi Z, Zhang S, Meng Y, Feng Y, Wang Y, Wang E, Pan X, Zhu R, Fan H, Pang S, Zhu L, Yuan J. | 07/24/2021 |
| Disruption of Transient SERT Expression in Thalamic Glutamatergic Neurons Alters Trajectory of Postnatal Interneuron Development in the Mouse Cortex. | Disruption of Transient SERT Expression in Thalamic Glutamatergic Neurons Alters Trajectory of Postnatal Interneuron Development in the Mouse Cortex.
De Gregorio R, Chen X, Petit EI, Dobrenis K, Sze JY., Free PMC Article | 06/26/2021 |
| Gut Barrier Proteins Mediate Liver Regulation by the Effects of Serotonin on the Non-Alcoholic Fatty Liver Disease. | Gut Barrier Proteins Mediate Liver Regulation by the Effects of Serotonin on the Non-Alcoholic Fatty Liver Disease.
Zhang K, Li X, Wang X, Zheng H, Tang S, Lu L, Ma X. | 05/29/2021 |
| Attenuation of auditory mismatch negativity in serotonin transporter knockout mice with anxiety-related behaviors. | Attenuation of auditory mismatch negativity in serotonin transporter knockout mice with anxiety-related behaviors.
Pan W, Lyu K, Zhang H, Li C, Chen P, Ying M, Chen F, Tang J. | 05/8/2021 |
| 1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain. | 1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain.
Lu Q, Murakami C, Murakami Y, Hoshino F, Asami M, Usuki T, Sakai H, Sakane F. | 04/17/2021 |
| 5-HTT independent effects of fluoxetine on neuroplasticity. | 5-HTT independent effects of fluoxetine on neuroplasticity.
Levy MJF, Boulle F, Emerit MB, Poilbout C, Steinbusch HWM, Van den Hove DLA, Kenis G, Lanfumey L., Free PMC Article | 10/10/2020 |
| Potentiated serotonin signaling in serotonin re-uptake transporter knockout mice increases enterocyte mass and small intestinal absorptive function. | Potentiated serotonin signaling in serotonin re-uptake transporter knockout mice increases enterocyte mass and small intestinal absorptive function.
Greig CJ, Zhang L, Cowles RA., Free PMC Article | 08/29/2020 |
| Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease. Decreased SERT density was observed in the parietal and frontal cortex of 18-24-month-old APPswe/PS1dE9 mice, compared to age-matched, wild-type animals. | Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease.
Metaxas A, Anzalone M, Vaitheeswaran R, Petersen S, Landau AM, Finsen B., Free PMC Article | 05/9/2020 |
| 5-HTT KO mice have superior aversive learning and larger fear-evoked amygdala TO2 responses | Enhanced discriminative aversive learning and amygdala responsivity in 5-HT transporter mutant mice.
Lima J, Sharp T, Bannerman DM, McHugh SB., Free PMC Article | 01/11/2020 |
| Study is the first demonstration of a quantitative in vivo evaluation of serotonin transporter (SERT) density in subregions of the mouse brain using [11C]DASB-PET. | PET imaging of the mouse brain reveals a dynamic regulation of SERT density in a chronic stress model.
Reisinger SN, Wanek T, Langer O, Pollak DD., Free PMC Article | 06/15/2019 |
| altered 5-HT reuptake due to the downregulation of SERT, together with enterochromaffin cell hyperplasia, are the underlying mechanisms of increased 5-HT availability in Winnie mice | The Onset and Progression of Chronic Colitis Parallels Increased Mucosal Serotonin Release via Enterochromaffin Cell Hyperplasia and Downregulation of the Serotonin Reuptake Transporter.
Stavely R, Fraser S, Sharma S, Rahman AA, Stojanovska V, Sakkal S, Apostolopoulos V, Bertrand P, Nurgali K. | 06/8/2019 |
| amyloid- and tau-associated lesions were observed in the midbrain raphe of 12 month old APPswe/PS1dE9 mice. SERT binding levels were reduced in transgenic animals compared to age-matched controls, and SERT mRNA levels were decreased by at least 50% from control values. Intense microglial, but not astrocytic immunoreactivity was observed in APPswe/PS1dE9 vs. wild-type mice. | Reduced Serotonin Transporter Levels and Inflammation in the Midbrain Raphe of 12 Month Old APPswe/PSEN1dE9 Mice.
Metaxas A, Vaitheeswaran R, Jensen KT, Thygesen C, Ilkjaer L, Darvesh S, Finsen B. | 05/18/2019 |
| we propose a generalized epigenetic mechanism behind the development of ASD-like characteristics in embryos developing in Slc6a4 +/- dams exposed to prenatal stress. | Interplay between maternal Slc6a4 mutation and prenatal stress: a possible mechanism for autistic behavior development.
Sjaarda CP, Hecht P, McNaughton AJM, Zhou A, Hudson ML, Will MJ, Smith G, Ayub M, Liang P, Chen N, Beversdorf D, Liu X., Free PMC Article | 03/16/2019 |