| HIV-1 Reverse Transcriptase Expression in HPV16-Infected Epidermoid Carcinoma Cells Alters E6 Expression and Cellular Metabolism, and Induces a Hybrid Epithelial/Mesenchymal Cell Phenotype. | HIV-1 Reverse Transcriptase Expression in HPV16-Infected Epidermoid Carcinoma Cells Alters E6 Expression and Cellular Metabolism, and Induces a Hybrid Epithelial/Mesenchymal Cell Phenotype.
Zhitkevich A, Bayurova E, Avdoshina D, Zakirova N, Frolova G, Chowdhury S, Ivanov A, Gordeychuk I, Palefsky JM, Isaguliants M., Free PMC Article | 06/21/2024 |
| Role of I182, R187, and K188 Amino Acid Residues in the Catalytic Domain of HIV-1 Integrase in the Processes of Reverse Transcription and Integration. | Role of I182, R187, and K188 Amino Acid Residues in the Catalytic Domain of HIV-1 Integrase in the Processes of Reverse Transcription and Integration.
Kikhai TF, Agapkina YY, Prikazchikova TA, Vdovina MV, Shekhtman SP, Fomicheva SV, Korolev SP, Gottikh MB. | 05/7/2024 |
| The impact of the M184V resistance mutation on treatment outcomes in patients with HIV infection: a systematic review and meta-analysis. | The impact of the M184V resistance mutation on treatment outcomes in patients with HIV infection: a systematic review and meta-analysis.
Kandeel M. | 04/24/2024 |
| Effect of the L74I Polymorphism on Fitness of Cabotegravir-Resistant Variants of Human Immunodeficiency Virus 1 Subtype A6. | Effect of the L74I Polymorphism on Fitness of Cabotegravir-Resistant Variants of Human Immunodeficiency Virus 1 Subtype A6.
Hu Z, Cordwell T, Nguyen H, Li J, Jeffrey JL, Kuritzkes DR. | 03/21/2024 |
| HIV-1 reverse transcriptase stability correlates with Gag cleavage efficiency: reverse transcriptase interaction implications for modulating protease activation. | HIV-1 reverse transcriptase stability correlates with Gag cleavage efficiency: reverse transcriptase interaction implications for modulating protease activation.
Hsieh SH, Yu FH, Huang KJ, Wang CT., Free PMC Article | 10/5/2023 |
| Genetic and antiretroviral drug resistance mutations analysis of reverse transcriptase and protease gene from Pakistani people living with HIV-1. | Genetic and antiretroviral drug resistance mutations analysis of reverse transcriptase and protease gene from Pakistani people living with HIV-1.
Siddiqui D, Badar U, Javaid M, Farooqui N, Shah SA, Iftikhar A, Sultan F, Mir F, Furqan S, Mahmood SF, Abidi SH., Free PMC Article | 09/15/2023 |
| Biophysical Characterization of Novel DNA Aptamers against K103N/Y181C Double Mutant HIV-1 Reverse Transcriptase. | Biophysical Characterization of Novel DNA Aptamers against K103N/Y181C Double Mutant HIV-1 Reverse Transcriptase.
Ratanabunyong S, Seetaha S, Hannongbua S, Yanaka S, Yagi-Utsumi M, Kato K, Paemanee A, Choowongkomon K., Free PMC Article | 02/12/2022 |
| HIV-1 integrase binding to genomic RNA 5'-UTR induces local structural changes in vitro and in virio. | HIV-1 integrase binding to genomic RNA 5'-UTR induces local structural changes in vitro and in virio.
Liu S, Koneru PC, Li W, Pathirage C, Engelman AN, Kvaratskhelia M, Musier-Forsyth K., Free PMC Article | 01/8/2022 |
| Vulnerable targets in HIV-1 Pol for attenuation-based vaccine design. | Vulnerable targets in HIV-1 Pol for attenuation-based vaccine design.
Ojwach DBA, Madlala P, Gordon M, Ndung'u T, Mann JK., Free PMC Article | 01/1/2022 |
| Changes in dynamic and static structures of the HIV-1 p24 capsid protein N-domain caused by amino-acid substitution are associated with its viral viability. | Changes in dynamic and static structures of the HIV-1 p24 capsid protein N-domain caused by amino-acid substitution are associated with its viral viability.
Sato Y, Matsugami A, Watanabe S, Hayashi F, Arai M, Kigawa T, Nishimura C., Free PMC Article | 12/25/2021 |
| Computational design of small molecular modulators of protein-protein interactions with a novel thermodynamic cycle: Allosteric inhibitors of HIV-1 integrase. | Computational design of small molecular modulators of protein-protein interactions with a novel thermodynamic cycle: Allosteric inhibitors of HIV-1 integrase.
Sun Q, Ramaswamy VSK, Levy R, Deng N., Free PMC Article | 07/3/2021 |
| HIV-1 Integrase Diversity and Resistance-Associated Mutations and Polymorphisms Among Integrase Strand Transfer Inhibitor-Naive HIV-1 Patients from Cameroon. | HIV-1 Integrase Diversity and Resistance-Associated Mutations and Polymorphisms Among Integrase Strand Transfer Inhibitor-Naive HIV-1 Patients from Cameroon.
Mikasi SG, Gichana JO, Van der Walt C, Brado D, Obasa AE, Njenda D, Messembe M, Lyonga E, Assoumou O, Cloete R, Ikomey GM, Jacobs GB. | 06/26/2021 |
| Influence of the amino-terminal sequence on the structure and function of HIV integrase. | Influence of the amino-terminal sequence on the structure and function of HIV integrase.
Eilers G, Gupta K, Allen A, Zhou J, Hwang Y, Cory MB, Bushman FD, Van Duyne G., Free PMC Article | 06/26/2021 |
| Close-up: HIV/SIV intasome structures shed new light on integrase inhibitor binding and viral escape mechanisms. | Close-up: HIV/SIV intasome structures shed new light on integrase inhibitor binding and viral escape mechanisms.
Engelman AN, Cherepanov P., Free PMC Article | 06/19/2021 |
| INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication. | INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication.
Dixit U, Bhutoria S, Wu X, Qiu L, Spira M, Mathew S, Harris R, Adams LJ, Cahill S, Pathak R, Rajesh Kumar P, Nguyen M, Acharya SA, Brenowitz M, Almo SC, Zou X, Steven AC, Cowburn D, Girvin M, Kalpana GV., Free PMC Article | 05/29/2021 |
| High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs. | High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs.
Ha B, Larsen KP, Zhang J, Fu Z, Montabana E, Jackson LN, Chen DH, Puglisi EV., Free PMC Article | 05/29/2021 |
| HIV-1 Gag-Pol Sequences from Ugandan Early Infections Reveal Sequence Variants Associated with Elevated Replication Capacity. | HIV-1 Gag-Pol Sequences from Ugandan Early Infections Reveal Sequence Variants Associated with Elevated Replication Capacity.
Kapaata A, Balinda SN, Xu R, Salazar MG, Herard K, Brooks K, Laban K, Hare J, Dilernia D, Kamali A, Ruzagira E, Mukasa F, Gilmour J, Salazar-Gonzalez JF, Yue L, Cotten M, Hunter E, Kaleebu P., Free PMC Article | 05/22/2021 |
| CARD8 is an inflammasome sensor for HIV-1 protease activity. | CARD8 is an inflammasome sensor for HIV-1 protease activity.
Wang Q, Gao H, Clark KM, Mugisha CS, Davis K, Tang JP, Harlan GH, DeSelm CJ, Presti RM, Kutluay SB, Shan L., Free PMC Article | 03/28/2021 |
| Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion Morphogenesis. | Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion Morphogenesis.
Elliott JL, Kutluay SB., Free PMC Article | 03/13/2021 |
| Structural investigation of 2-naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site. | Structural investigation of 2-naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site.
Duong VN, Ippolito JA, Chan AH, Lee WG, Spasov KA, Jorgensen WL, Anderson KS., Free PMC Article | 02/6/2021 |
| HIV-1 Mutant Assembly, Processing and Infectivity Expresses Pol Independent of Gag. | HIV-1 Mutant Assembly, Processing and Infectivity Expresses Pol Independent of Gag.
Yu FH, Huang KJ, Wang CT., Free PMC Article | 02/6/2021 |
| Accessory mutations balance the marginal stability of the HIV-1 protease in drug resistance. | Accessory mutations balance the marginal stability of the HIV-1 protease in drug resistance.
Weikl TR, Hemmateenejad B. | 01/9/2021 |
| NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases. | NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases.
Kanja M, Cappy P, Levy N, Oladosu O, Schmidt S, Rossolillo P, Winter F, Gasser R, Moog C, Ruff M, Negroni M, Lener D., Free PMC Article | 12/19/2020 |
| this study shows that HIV-1 reverse transcriptase promotes tumor growth and metastasis via reactive oxygen species -dependent upregulation of Twist | HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist.
Bayurova E, Jansons J, Skrastina D, Smirnova O, Mezale D, Kostyusheva A, Kostyushev D, Petkov S, Podschwadt P, Valuev-Elliston V, Sasinovich S, Korolev S, Warholm P, Latanova A, Starodubova E, Tukhvatulin A, Latyshev O, Selimov R, Metalnikov P, Komarov A, Ivanova O, Gorodnicheva T, Kochetkov S, Gottikh M, Strumfa I, Ivanov A, Gordeychuk I, Isaguliants M., Free PMC Article | 06/27/2020 |
| These results show that HDAC1 interacts with the HIV-1 integrase and affects virus replication before and after integration. Overall, HDAC1 appears to facilitate HIV-1 replication with a major effect on a preintegration step, which likely occurs at the reverse transcription step. | Histone deacetylase 1 interacts with HIV-1 Integrase and modulates viral replication.
Larguet F, Caté C, Barbeau B, Rassart E, Edouard E., Free PMC Article | 05/2/2020 |