| A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML. | A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML.
Bamezai S, Pulikkottil AJ, Yadav T, Vegi NM, Mueller J, Mark J, Mandal T, Feder K, Ihme S, Song C, Rosler R, Wiese S, Hoell JI, Kloetgen A, Karsan A, Kumari A, Wojenski L, Sinha AU, Gonzalez-Menendez I, Quintanilla-Martinez L, Donato E, Trumpp A, Kruse E, Hamperl S, Zou L, Rawat VPS, Buske C. | 07/12/2023 |
| HIWI2 induces G2/M cell cycle arrest and apoptosis in human fibrosarcoma via the ROS/DNA damage/p53 axis. | HIWI2 induces G2/M cell cycle arrest and apoptosis in human fibrosarcoma via the ROS/DNA damage/p53 axis.
Das B, Sahoo S, Mallick B. | 02/26/2022 |
| Role of PIWI-like 4 in modulating neuronal differentiation from human embryonal carcinoma cells. | Role of PIWI-like 4 in modulating neuronal differentiation from human embryonal carcinoma cells.
Subhramanyam CS, Cao Q, Wang C, Heng ZSL, Zhou Z, Hu Q., Free PMC Article | 09/18/2021 |
| PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat. | PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat.
He Z, Jing S, Yang T, Chen J, Huang F, Zhang W, Peng Z, Liu B, Ma X, Wu L, Pan T, Zhang X, Li L, Cai W, Tang X, Zhang J, Zhang H., Free PMC Article | 10/31/2020 |
| these findings revealed that Piwil4 is a novel regulator of ER signaling that could be targeted to inhibit breast cancer growth and migration. | The role of 17β‑estradiol‑induced upregulation of Piwi‑like 4 in modulating gene expression and motility in breast cancer cells.
Heng ZSL, Lee JY, Subhramanyam CS, Wang C, Thanga LZ, Hu Q., Free PMC Article | 12/29/2018 |
| Results revealed that Piwil4 exhibits lower expression in the cell nucleus than in the cytoplasm. Along with nuclear location of PIWIL2, PIWIL4 expression is associated with worse prognosis of hepatocellular carcinoma. | Co-expression of Piwil2/Piwil4 in nucleus indicates poor prognosis of hepatocellular carcinoma.
Zeng G, Zhang D, Liu X, Kang Q, Fu Y, Tang B, Guo W, Zhang Y, Wei G, He D., Free PMC Article | 02/24/2018 |
| HIWI2 is aberrantly expressed in cells of the Retinoblastoma (RB) line (Y79) and silencing of HIWI2 downregulates OTX2, suggesting that HIWI2 might affects cell cycle and plays a role in the progression of RB. | PIWI-like protein, HIWI2 is aberrantly expressed in retinoblastoma cells and affects cell-cycle potentially through OTX2.
Sivagurunathan S, Arunachalam JP, Chidambaram S., Free PMC Article | 11/4/2017 |
| data delineate MIWI2-dependent functions outside of the germline and demonstrate the presence of distinct subsets of airway multiciliated cells that can be discriminated by MIWI2 expression. | Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells.
Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O'Carroll D, Jones MR., Free PMC Article | 10/21/2017 |
| PIWIL2 and PIWIL4 genes expression in synovial fibroblasts of the rheumatoid arthritis patients.PIWIL4 does not regulate methylation or expression of LINE-1. | Expression and Regulation of PIWIL-Proteins and PIWI-Interacting RNAs in Rheumatoid Arthritis.
Pleštilová L, Neidhart M, Russo G, Frank-Bertoncelj M, Ospelt C, Ciurea A, Kolling C, Gay RE, Michel BA, Vencovský J, Gay S, Jüngel A., Free PMC Article | 07/1/2017 |
| study demonstrates the presence of PIWI-like proteins in somatic cells and the possible role of HIWI2 in preserving the functional integrity of epithelial cells probably by modulating the phosphorylation status of Akt. | Possible role of HIWI2 in modulating tight junction proteins in retinal pigment epithelial cells through Akt signaling pathway.
Sivagurunathan S, Palanisamy K, Arunachalam JP, Chidambaram S. | 02/18/2017 |
| PIWIL4 is highly expressed in both breast cancer tissues and the cytoplasm of MDA-MB-231 cells derived from breast cancer. Reducing PIWIL4 expression drastically impairs the migration ability of MDA-MB-231 cells, significantly increases their apoptosis, and mildly affects their proliferation. | The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer.
Wang Z, Liu N, Shi S, Liu S, Lin H., Free PMC Article | 12/17/2016 |
| Results show that three CpG loci within FYN were hypermethylated in obese individuals, while obesity was associated with lower methylation of CpG loci within PIWIL4 and TAOK3. | Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood.
Huang RC, Garratt ES, Pan H, Wu Y, Davis EA, Barton SJ, Burdge GC, Godfrey KM, Holbrook JD, Lillycrop KA., Free PMC Article | 10/22/2016 |
| study to evaluate frequency of PIWIL4 genetic variants in order to better define the relationship between PIWIL4 SNPs and defective spermatogenesis and specific spermatogenic disorders; results suggest genetic and epigenetic alterations that affect the PIWI pathway contribute to unsuccessful sperm production | Association of PIWIL4 genetic variants with germ cell maturation arrest in infertile Spanish men.
Muñoz X, Navarro M, Mata A, Bassas L, Larriba S., Free PMC Article | 10/17/2015 |
| Data suggest that MIWI2 and MIWI2-associated piRNAs have functions beyond TE suppression. | Conditional inactivation of Miwi2 reveals that MIWI2 is only essential for prospermatogonial development in mice.
Bao J, Zhang Y, Schuster AS, Ortogero N, Nilsson EE, Skinner MK, Yan W., Free PMC Article | 01/24/2015 |
| Immunoprecipitation of Hiwi2 from MDAMB231 cancer cells enriches for piRNAs that are predominantly derived from processed tRNAs and expressed genes. | The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells.
Keam SP, Young PE, McCorkindale AL, Dang TH, Clancy JL, Humphreys DT, Preiss T, Hutvagner G, Martin DI, Cropley JE, Suter CM., Free PMC Article | 11/8/2014 |
| associations were determined between the Piwi-like family member expression levels and clinicopathological parameters of ccRCC, suggesting a potential role for these genes/proteins in ccRCC diagnostics and tumorigenesis | Piwi-like 1 and 4 gene transcript levels are associated with clinicopathological parameters in renal cell carcinomas.
Al-Janabi O, Wach S, Nolte E, Weigelt K, Rau TT, Stöhr C, Legal W, Schick S, Greither T, Hartmann A, Wullich B, Taubert H. | 05/10/2014 |
| we identified a significant association between the expression of Piwi-like 2 and 4 mRNAs and the tumor-specific survival of soft tissue sarcoma patients. | Expression of human Piwi-like genes is associated with prognosis for soft tissue sarcoma patients.
Greither T, Koser F, Kappler M, Bache M, Lautenschläger C, Göbel S, Holzhausen HJ, Wach S, Würl P, Taubert H., Free PMC Article | 01/26/2013 |
| PIWIL4 might play an oncogenic role in cervical cancer | PIWIL4 regulates cervical cancer cell line growth and is involved in down-regulating the expression of p14ARF and p53.
Su C, Ren ZJ, Wang F, Liu M, Li X, Tang H. | 06/30/2012 |
| An SNP in the 3'untranslated region of HIWI2 and a non-synonymous SNP in HIWI3 were significantly associated with an altered risk of oligozoospermia. | Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population.
Gu A, Ji G, Shi X, Long Y, Xia Y, Song L, Wang S, Wang X, Gu A, Ji G, Shi X, Long Y, Xia Y, Song L, Wang S, Wang X. | 03/26/2011 |
| EIF2C2-4 and PIWIL4 appear increased in advanced tumors with distant metastasis, suggesting they may promote tumor invasion | Argonaute proteins: potential biomarkers for human colon cancer.
Li L, Yu C, Gao H, Li Y., Free PMC Article | 01/1/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population.
Gu A, Ji G, Shi X, Long Y, Xia Y, Song L, Wang S, Wang X, Gu A, Ji G, Shi X, Long Y, Xia Y, Song L, Wang S, Wang X. Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.
Kim JS, Choi YY, Jin G, Kang HG, Choi JE, Jeon HS, Lee WK, Kim DS, Kim CH, Kim YJ, Son JW, Jung TH, Park JY. | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| PIWIL4 plays important roles in the chromatin-modifying pathway in human somatic cells | The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus.
Sugimoto K, Kage H, Aki N, Sano A, Kitagawa H, Nagase T, Yatomi Y, Ohishi N, Takai D. | 01/21/2010 |