| Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles. | Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles.
Haddad G, Blaine J., Free PMC Article | 04/23/2024 |
| Neonatal Fc Receptor Inhibition Enables Adeno-Associated Virus Gene Therapy Despite Pre-Existing Humoral Immunity. | Neonatal Fc Receptor Inhibition Enables Adeno-Associated Virus Gene Therapy Despite Pre-Existing Humoral Immunity.
Horiuchi M, Hinderer CJ, Shankle HN, Hayashi PM, Chichester JA, Kissel C, Bell P, Dyer C, Wilson JM. | 11/16/2023 |
| Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes. | Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes.
Haddad G, Dylewski J, Evans R, Lewis L, Blaine J., Free PMC Article | 05/19/2023 |
| Dynamics of intracellular neonatal Fc receptor-ligand interactions in primary macrophages using biophysical fluorescence techniques. | Dynamics of intracellular neonatal Fc receptor-ligand interactions in primary macrophages using biophysical fluorescence techniques.
Pannek A, Houghton FJ, Verhagen AM, Dower SK, Hinde E, Gleeson PA., Free PMC Article | 03/26/2022 |
| Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of glomerulonephritis. | Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of glomerulonephritis.
Dylewski JF, Tonsawan P, Garcia G, Lewis L, Blaine J., Free PMC Article | 01/16/2021 |
| FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages. | FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages.
Toh WH, Louber J, Mahmoud IS, Chia J, Bass GT, Dower SK, Verhagen AM, Gleeson PA. | 09/26/2020 |
| In podocytes, Fcgrt modulates the IL-6 mediated response to inflammatory stimuli and regulates podocytes actin structure. | Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton.
Tonsawan P, Dylewski J, Lewis L, Blaine J., Free PMC Article | 04/11/2020 |
| The studies demonstrate a pivotal role for FcRn-mediated salvage in compensating for the high pinocytic and degradative activities of macrophages to maintain IgG homeostasis. | Neonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis.
Challa DK, Wang X, Montoyo HP, Velmurugan R, Ober RJ, Ward ES., Free PMC Article | 02/15/2020 |
| Knockout of FcRn leads to IgG accumulation in podocytes but does not alter albumin trafficking. | Differential trafficking of albumin and IgG facilitated by the neonatal Fc receptor in podocytes in vitro and in vivo.
Dylewski J, Dobrinskikh E, Lewis L, Tonsawan P, Miyazaki M, Jat PS, Blaine J., Free PMC Article | 11/9/2019 |
| These findings support the critical role of FcRn downregulation in the tumor microenvironment in anti-tumor immunity, via NK cell maturation and activation. | Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment.
Castaneda DC, Dhommée C, Baranek T, Dalloneau E, Lajoie L, Valayer A, Arnoult C, Demattéi MV, Fouquenet D, Parent C, Heuzé-Vourc'h N, Gouilleux-Gruart V., Free PMC Article | 10/26/2019 |
| Low FcRN expression is associated with proteinuria. | Reduced proximal tubular expression of protein endocytic receptors in proteinuria is associated with urinary receptor shedding.
Fatah H, Benfaed N, Chana RS, Chunara MH, Barratt J, Baines RJ, Brunskill NJ. | 09/14/2019 |
| the measurement of FcRn protein may be preferred to FcRn mRNA for quantitative applications. Significant differences were found in FcRn expression in transgenic mice, Swiss Webster mice, and human tissues, which may have implications for the use of mouse models in the assessment of monoclonal antibody disposition, efficacy, and safety. | FcRn Expression in Wildtype Mice, Transgenic Mice, and in Human Tissues.
Li T, Balthasar JP., Free PMC Article | 06/1/2019 |
| The main function of hepatic FcRn is to direct albumin into the circulation, thereby also increasing hepatocyte sensitivity to toxicity. | Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.
Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS., Free PMC Article | 05/19/2018 |
| Preproinsulin fused to Fc administered to pregnant mice efficiently accumulated in fetuses through the placental neonatal Fc receptor and protected them from subsequent diabetes development. | Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes.
Culina S, Gupta N, Boisgard R, Afonso G, Gagnerault MC, Dimitrov J, Østerbye T, Justesen S, Luce S, Attias M, Kyewski B, Buus S, Wong FS, Lacroix-Desmazes S, Mallone R. | 01/16/2016 |
| The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity. | The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.
Abdiche YN, Yeung YA, Chaparro-Riggers J, Barman I, Strop P, Chin SM, Pham A, Bolton G, McDonough D, Lindquist K, Pons J, Rajpal A., Free PMC Article | 12/5/2015 |
| Characterization and screening of IgG binding to the neonatal Fc receptor. | Characterization and screening of IgG binding to the neonatal Fc receptor.
Neuber T, Frese K, Jaehrling J, Jäger S, Daubert D, Felderer K, Linnemann M, Höhne A, Kaden S, Kölln J, Tiller T, Brocks B, Ostendorp R, Pabst S., Free PMC Article | 02/14/2015 |
| Fc receptor promotes formation of subepithelial immune complexes and subsequent glomerular pathology leading to proteinuria | Neonatal Fc receptor promotes immune complex-mediated glomerular disease.
Olaru F, Luo W, Suleiman H, St John PL, Ge L, Mezo AR, Shaw AS, Abrahamson DR, Miner JH, Borza DB., Free PMC Article | 08/30/2014 |
| Abundant intracellular IgG in enterocytes and endoderm lacking FcRn. | Abundant intracellular IgG in enterocytes and endoderm lacking FcRn.
Mohanty S, Kim J, Ganesan LP, Phillips GS, Robinson JM, Anderson CL., Free PMC Article | 08/23/2014 |
| Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding. | Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding.
Andersen JT, Dalhus B, Viuff D, Ravn BT, Gunnarsen KS, Plumridge A, Bunting K, Antunes F, Williamson R, Athwal S, Allan E, Evans L, Bjørås M, Kjærulff S, Sleep D, Sandlie I, Cameron J., Free PMC Article | 06/28/2014 |
| FcRn thus has a primary role within mucosal tissues in activating local immune responses that are critical for priming efficient anti-tumor immunosurveillance | Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer.
Baker K, Rath T, Flak MB, Arthur JC, Chen Z, Glickman JN, Zlobec I, Karamitopoulou E, Stachler MD, Odze RD, Lencer WI, Jobin C, Blumberg RS., Free PMC Article | 03/1/2014 |
| Neonatal Fc receptor for IgG uptake mediates intestinal absorption of IgG(1) anti-IgE/IgE immune complexes. | FcRn-mediated intestinal absorption of IgG anti-IgE/IgE immune complexes in mice.
Paveglio S, Puddington L, Rafti E, Matson AP., Free PMC Article | 06/1/2013 |
| Nck and Cdc42 co-operate to recruit N-WASP to promote FcgammaR-mediated phagocytosis. | Nck and Cdc42 co-operate to recruit N-WASP to promote FcγR-mediated phagocytosis.
Dart AE, Donnelly SK, Holden DW, Way M, Caron E. | 01/26/2013 |
| AMG 386 clearance in FcRn-knockout mice was 18-fold faster at the 3-mg/kg dose. | Investigation of the mechanism of clearance of AMG 386, a selective angiopoietin-1/2 neutralizing peptibody, in splenectomized, nephrectomized, and FcRn knockout rodent models.
Wu B, Johnson J, Soto M, Ponce M, Calamba D, Sun YN., Free PMC Article | 09/15/2012 |
| an increase in lymphoid follicles and Helicobacter bacterial load in knock-out mice | Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates bacterial infection in mice.
Ben Suleiman Y, Yoshida M, Nishiumi S, Tanaka H, Mimura T, Nobutani K, Yamamoto K, Takenaka M, Aoganghua A, Miki I, Ota H, Takahashi S, Matsui H, Nakamura M, Blumberg RS, Azuma T., Free PMC Article | 05/5/2012 |
| Data show that FcRn traps antigen and protects it from degradation within an acidic loading compartment in association with the rapid recruitment of key components of the phagosome-to-cytosol cross-presentation machinery. | Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells.
Baker K, Qiao SW, Kuo TT, Aveson VG, Platzer B, Andersen JT, Sandlie I, Chen Z, de Haar C, Lencer WI, Fiebiger E, Blumberg RS., Free PMC Article | 10/1/2011 |