| Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for normal breathing and chemosensory reflexes. | Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for normal breathing and chemosensory reflexes.
Chang Y, Lusk S, Chang A, Ward CS, Ray RS., Free PMC Article | 11/12/2024 |
| Anatomical distribution of micro-opioid receptors, neurokinin-1 receptors, and vesicular glutamate transporter 2 in the mouse brainstem respiratory network. | Anatomical distribution of µ-opioid receptors, neurokinin-1 receptors, and vesicular glutamate transporter 2 in the mouse brainstem respiratory network.
Furdui A, da Silveira Scarpellini C, Montandon G. | 07/24/2024 |
| VGLUT2 and APP family: unraveling the neurobiochemical mechanisms of neurostimulation therapy to STZ-induced diabetes and neuropathy. | VGLUT2 and APP family: unraveling the neurobiochemical mechanisms of neurostimulation therapy to STZ-induced diabetes and neuropathy.
Zhang Y, Wu C, Jiang W, Cao Y, Chen D., Free PMC Article | 03/21/2024 |
| Increase of vesicular glutamate transporter 2 co-expression in the deep cerebellar nuclei related to skilled reach learning. | Increase of vesicular glutamate transporter 2 co-expression in the deep cerebellar nuclei related to skilled reach learning.
Mao H, Mediavilla T, Estévez-Silva H, Marcellino D, Sultan F. | 07/23/2022 |
| Efferent projections of Vglut2, Foxp2, and Pdyn parabrachial neurons in mice. | Efferent projections of Vglut2, Foxp2, and Pdyn parabrachial neurons in mice.
Huang D, Grady FS, Peltekian L, Geerling JC., Free PMC Article | 01/1/2022 |
| Activation of VGluT2-expressing neurons in the bed nuclei of the stria terminalis produces mouse manic-like behaviors. | Activation of VGluT2-expressing neurons in the bed nuclei of the stria terminalis produces mouse manic-like behaviors.
Liu TT, Lin W, Zhang YQ., Free PMC Article | 01/1/2022 |
| Posterodorsal Medial Amygdala Regulation of Female Social Behavior: GABA versus Glutamate Projections. | Posterodorsal Medial Amygdala Regulation of Female Social Behavior: GABA versus Glutamate Projections.
Johnson CS, Hong W, Micevych PE., Free PMC Article | 11/27/2021 |
| Deletion of VGLUT2 in midbrain dopamine neurons attenuates dopamine and glutamate responses to methamphetamine in mice. | Deletion of VGLUT2 in midbrain dopamine neurons attenuates dopamine and glutamate responses to methamphetamine in mice.
Shen H, Chen K, Marino RAM, McDevitt RA, Xi ZX., Free PMC Article | 08/14/2021 |
| Operant self-stimulation of thalamic terminals in the dorsomedial striatum is constrained by metabotropic glutamate receptor 2. | Operant self-stimulation of thalamic terminals in the dorsomedial striatum is constrained by metabotropic glutamate receptor 2.
Johnson KA, Voyvodic L, Loewinger GC, Mateo Y, Lovinger DM., Free PMC Article | 07/17/2021 |
| VGluT2 Expression in Dopamine Neurons Contributes to Postlesional Striatal Reinnervation. | VGluT2 Expression in Dopamine Neurons Contributes to Postlesional Striatal Reinnervation.
Kouwenhoven WM, Fortin G, Penttinen AM, Florence C, Delignat-Lavaud B, Bourque MJ, Trimbuch T, Luppi MP, Salvail-Lacoste A, Legault P, Poulin JF, Rosenmund C, Awatramani R, Trudeau LÉ., Free PMC Article | 02/6/2021 |
| Diverse glutamatergic inputs target spines expressing M1 muscarinic receptors in the basolateral amygdala: An ultrastructural analysis. | Diverse glutamatergic inputs target spines expressing M1 muscarinic receptors in the basolateral amygdala: An ultrastructural analysis.
McDonald AJ, Jones GC, Mott DD., Free PMC Article | 10/24/2020 |
| Results demonstrate that most mesopontine cholinergic neurons may transiently express VGLUT2, but that a large majority of parabigeminal nucleus neurons retain VGLUT2 expression throughout adulthood, and support a growing body of literature indicating that distinct cholinergic populations have differing potential for GABA or glutamate co-release. | Differential Expression of VGLUT2 in Mouse Mesopontine Cholinergic Neurons.
Steinkellner T, Yoo JH, Hnasko TS., Free PMC Article | 03/7/2020 |
| Specifically, we show that mice lacking SRPX2 show a specific reduction in excitatory VGlut2 synapses in the cerebral cortex, while VGlut1 and inhibitory synapses were largely unaffected. SRPX2 KO mice also exhibit an abnormal ultrasonic vocalization ontogenetic profile in neonatal pups, and reduced preference for social novelty. | Sociability and synapse subtype-specific defects in mice lacking SRPX2, a language-associated gene.
Soteros BM, Cong Q, Palmer CR, Sia GM., Free PMC Article | 04/13/2019 |
| These findings indicate that VgluT2 expression in DA neurons is neuroprotective. | Genetic deletion of vesicular glutamate transporter in dopamine neurons increases vulnerability to MPTP-induced neurotoxicity in mice.
Shen H, Marino RAM, McDevitt RA, Bi GH, Chen K, Madeo G, Lee PT, Liang Y, De Biase LM, Su TP, Xi ZX, Bonci A., Free PMC Article | 02/9/2019 |
| Study concludes that a variable number but functionally significant percentage of Intrinsically photosensitive retinal ganglion cells (ipRGCs) in two vGlut2 knockout mouse lines continue to release glutamate. Thus, the residual suprachiasmatic Nucleus -mediated light responses in these knockout mouse lines cannot be attributed solely to ipRGC pituitary adenylate cyclase-activating polypeptide release. | Circadian Behavioral Responses to Light and Optic Chiasm-Evoked Glutamatergic EPSCs in the Suprachiasmatic Nucleus of ipRGC Conditional vGlut2 Knock-Out Mice.
Moldavan MG, Sollars PJ, Lasarev MR, Allen CN, Pickard GE., Free PMC Article | 01/26/2019 |
| the essential role of supraspinal VGLUT2 in neuropathic pain | Selective downregulation of vesicular glutamate transporter2 in ventral posterolateral nucleus of thalamus attenuates neuropathic mechanical allodynia in mice.
Zhang ZL, Yu G, Liang XN, Su RB, Gong ZH. | 09/22/2018 |
| suggest that VGluT2 and GLT-1 may be differentially involved in the pathogenesis of amyotrophic lateral sclerosis via abnormal glutamate homeostasis at the presymptomatic stage and end stage of disease, respectively | Differential involvement of vesicular and glial glutamate transporters around spinal α-motoneurons in the pathogenesis of SOD1(G93A) mouse model of amyotrophic lateral sclerosis.
Ohgomori T, Yamasaki R, Takeuchi H, Kadomatsu K, Kira JI, Jinno S. | 04/14/2018 |
| Vglut2 conditional knockout mice showed less interest in fatty rewards, decreased sugar consumption and strong rearing behavior, altered dopaminergic and peptidergic activity in the striatum. Significant cell loss and disorganization of the subthalamic nucleus structure was identified, which likely accounts for the observed alterations. | Reduced Vglut2/Slc17a6 Gene Expression Levels throughout the Mouse Subthalamic Nucleus Cause Cell Loss and Structural Disorganization Followed by Increased Motor Activity and Decreased Sugar Consumption.
Schweizer N, Viereckel T, Smith-Anttila CJ, Nordenankar K, Arvidsson E, Mahmoudi S, Zampera A, Wärner Jonsson H, Bergquist J, Lévesque D, Konradsson-Geuken Å, Andersson M, Dumas S, Wallén-Mackenzie Å., Free PMC Article | 11/4/2017 |
| depolarization-induced hyperacidification is mediated by the vesicular glutamate transporter 2 (VGLUT). | Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT.
Aguilar JI, Dunn M, Mingote S, Karam CS, Farino ZJ, Sonders MS, Choi SJ, Grygoruk A, Zhang Y, Cela C, Choi BJ, Flores J, Freyberg RJ, McCabe BD, Mosharov EV, Krantz DE, Javitch JA, Sulzer D, Sames D, Rayport S, Freyberg Z., Free PMC Article | 09/30/2017 |
| The observed changes in gene and protein expression of vesicular transporter 1, regional architecture, and morphology of mouse auditory forebrain may relate to-and to some extent enable-the emergence of mature sound-evoked activity patterns. | Differential maturation of vesicular glutamate and GABA transporter expression in the mouse auditory forebrain during the first weeks of hearing.
Hackett TA, Clause AR, Takahata T, Hackett NJ, Polley DB., Free PMC Article | 09/23/2017 |
| The data of this study indicated that the Grpr-Cre spinal cord neural population is composed of interneurons that use VGLUT2-mediated signaling for transmitting chemical and spontaneous itch stimuli to the next, currently unknown, neurons in the labeled line of itch. | Spinal cord interneurons expressing the gastrin-releasing peptide receptor convey itch through VGLUT2-mediated signaling.
Aresh B, Freitag FB, Perry S, Blümel E, Lau J, Franck MCM, Lagerström MC., Free PMC Article | 04/29/2017 |
| Data show that activation of nucleotide receptor P2Y4 (P2Y4) in the differentiating embryonic stem cells (ESCs) resulted in an increased proportion of neurons expressing vesicular glutamate transporter (vGluT). | P2Y4 Nucleotide Receptor in Neuronal Precursors Induces Glutamatergic Subtype Markers in Their Descendant Neurons.
Uda Y, Xu S, Matsumura T, Takei Y., Free PMC Article | 01/14/2017 |
| Study detected increased expression levels of the vesicular glutamate transporter 2 in motor cortex Layer V of G93A (Amyotrophic lateral sclerosis) mice. | Altered Functionality, Morphology, and Vesicular Glutamate Transporter Expression of Cortical Motor Neurons from a Presymptomatic Mouse Model of Amyotrophic Lateral Sclerosis.
Saba L, Viscomi MT, Caioli S, Pignataro A, Bisicchia E, Pieri M, Molinari M, Ammassari-Teule M, Zona C. | 12/17/2016 |
| Male, but not female, mice lacking vGlut2 in POMC neurons were unable to maintain energy balance to the same extent as control mice. | Age-dependent changes in amino acid phenotype and the role of glutamate release from hypothalamic proopiomelanocortin neurons.
Dennison CS, King CM, Dicken MS, Hentges ST., Free PMC Article | 12/17/2016 |
| Distribution of VGLUT1 and VGLUT2 in the CN, previously described for guinea pig, was replicated in mouse and showed similar changes in VGLUT1 and 2 distributions after unilateral cochlear insult | Altered vesicular glutamate transporter distributions in the mouse cochlear nucleus following cochlear insult.
Heeringa AN, Stefanescu RA, Raphael Y, Shore SE., Free PMC Article | 10/22/2016 |