| Oral lupus erythematosus: Immunohistochemical evaluation of CD1a, CD21, CD123, and langerin expression in dendritic cells. | Oral lupus erythematosus: Immunohistochemical evaluation of CD1a, CD21, CD123, and langerin expression in dendritic cells.
Marques ERMDC, Hsieh R, Lourenço SV, Nico MMS. | 04/15/2024 |
| Complement receptor type 1 and 2 (CR1 and CR2) gene polymorphisms and plasma protein levels are associated with the Dengue disease severity. | Complement receptor type 1 and 2 (CR1 and CR2) gene polymorphisms and plasma protein levels are associated with the Dengue disease severity.
Diep NT, Giang NT, Diu NTT, Nam NM, Khanh LV, Quang HV, Hang NT, Mao CV, Son HV, Hieu NL, Linh PT, Sklan EH, Toan NL, Tong HV., Free PMC Article | 10/24/2023 |
| Identification and Characterization of chCR2, a Protein That Binds Chicken Complement Component 3d. | Identification and Characterization of chCR2, a Protein That Binds Chicken Complement Component 3d.
Jin H, Kong Z, Jiang B, Tu M, Xu J, Cheng J, Liu W, Zhang Z, Li Y., Free PMC Article | 04/19/2023 |
| The expansion of human T-bet(high)CD21(low) B cells is T cell dependent. | The expansion of human T-bet(high)CD21(low) B cells is T cell dependent.
Keller B, Strohmeier V, Harder I, Unger S, Payne KJ, Andrieux G, Boerries M, Felixberger PT, Landry JJM, Nieters A, Rensing-Ehl A, Salzer U, Frede N, Usadel S, Elling R, Speckmann C, Hainmann I, Ralph E, Gilmour K, Wentink MWJ, van der Burg M, Kuehn HS, Rosenzweig SD, Kölsch U, von Bernuth H, Kaiser-Labusch P, Gothe F, Hambleton S, Vlagea AD, Garcia Garcia A, Alsina L, Markelj G, Avcin T, Vasconcelos J, Guedes M, Ding JY, Ku CL, Shadur B, Avery DT, Venhoff N, Thiel J, Becker H, Erazo-Borrás L, Trujillo-Vargas CM, Franco JL, Fieschi C, Okada S, Gray PE, Uzel G, Casanova JL, Fliegauf M, Grimbacher B, Eibel H, Ehl S, Voll RE, Rizzi M, Stepensky P, Benes V, Ma CS, Bossen C, Tangye SG, Warnatz K. | 03/12/2022 |
| Revisiting the Coreceptor Function of Complement Receptor Type 2 (CR2, CD21); Coengagement With the B-Cell Receptor Inhibits the Activation, Proliferation, and Antibody Production of Human B Cells. | Revisiting the Coreceptor Function of Complement Receptor Type 2 (CR2, CD21); Coengagement With the B-Cell Receptor Inhibits the Activation, Proliferation, and Antibody Production of Human B Cells.
Kovács KG, Mácsik-Valent B, Matkó J, Bajtay Z, Erdei A., Free PMC Article | 07/3/2021 |
| Association Between Genetic Polymorphisms of CR2 Gene and the Risk of Steroid-Induced Osteonecrosis of the Femoral Head in the Chinese Han Male Population. | Association Between Genetic Polymorphisms of CR2 Gene and the Risk of Steroid-Induced Osteonecrosis of the Femoral Head in the Chinese Han Male Population.
Zhao Z, Zhang L, Kang X, Zheng J, Tian B. | 06/26/2021 |
| High proportion of anergic B cells in the bone marrow defined phenotypically by CD21(-/low)/CD38- expression predicts poor survival in diffuse large B cell lymphoma. | High proportion of anergic B cells in the bone marrow defined phenotypically by CD21(-/low)/CD38- expression predicts poor survival in diffuse large B cell lymphoma.
Rijal S, Kok J, Coombes C, Smyth L, Hourigan J, Jain S, Talaulikar D., Free PMC Article | 04/24/2021 |
| Naive- and Memory-like CD21(low) B Cell Subsets Share Core Phenotypic and Signaling Characteristics in Systemic Autoimmune Disorders. | Naive- and Memory-like CD21(low) B Cell Subsets Share Core Phenotypic and Signaling Characteristics in Systemic Autoimmune Disorders.
Freudenhammer M, Voll RE, Binder SC, Keller B, Warnatz K. | 04/3/2021 |
| Notch signaling induces a transcriptionally permissive state at the Complement C3d Receptor 2 (CR2) promoter in a pre-B cell model. | Notch signaling induces a transcriptionally permissive state at the Complement C3d Receptor 2 (CR2) promoter in a pre-B cell model.
Ng HL, Taylor RL, Cheng J, Abraham LJ, Quail E, Cruickshank MN, Ulgiati D. | 02/2/2021 |
| Association of complement C3d receptor 2 genotypes with the acquisition of HIV infection in a trial of recombinant glycoprotein 120 vaccine. | Association of complement C3d receptor 2 genotypes with the acquisition of HIV infection in a trial of recombinant glycoprotein 120 vaccine.
Meza G, Expósito A, Royo JL, Ruiz-García C, Sánchez-Arcas B, Marquez FJ, Gómez-Vidal MA, Omar M, Sinangil F, Higgins K, Forthal D, Real LM, Caruz A. | 02/2/2021 |
| CD21 (Complement Receptor 2) Is the Receptor for Epstein-Barr Virus Entry into T Cells. | CD21 (Complement Receptor 2) Is the Receptor for Epstein-Barr Virus Entry into T Cells.
Smith NA, Coleman CB, Gewurz BE, Rochford R., Free PMC Article | 10/24/2020 |
| Study reported that low CD19/CD21 expression is a general early feature of B cells in systemic lupus erythematosus (SLE) and is associated with an impairment of TLR9 response in these cells. Plasmacytoid dendritic cells from SLE patients that express TLR9, but not CD19, display normal TLR9 function. Thus, decreased CD19/CD21 expression combined with defective TLR9 function may fail to prevent autoreactive B cell death. | Impaired TLR9 responses in B cells from patients with systemic lupus erythematosus.
Gies V, Schickel JN, Jung S, Joublin A, Glauzy S, Knapp AM, Soley A, Poindron V, Guffroy A, Choi JY, Gottenberg JE, Anolik JH, Martin T, Soulas-Sprauel P, Meffre E, Korganow AS., Free PMC Article | 12/7/2019 |
| FCRL5 has dual signaling capacity, while CD21 co-engagement serves as molecular switch, converting FCRL5 from a negative to a positive co-receptor; in tissues, B cells that co-express FCRL5 and CD21 could robustly respond to IgG immune complexes loaded with C3 fragments | CD21 and FCRL5 form a receptor complex with robust B-cell activating capacity.
Franco A, Kraus Z, Li H, Seibert N, Dement-Brown J, Tolnay M. | 09/7/2019 |
| this study shows CD21 deficiency in 2 siblings with recurrent respiratory infections and hypogammaglobulinemia | CD21 deficiency in 2 siblings with recurrent respiratory infections and hypogammaglobulinemia.
Rosain J, Miot C, Lambert N, Rousselet MC, Pellier I, Picard C. | 08/10/2019 |
| Our data indicate that a distinct inflammatory process accompanies IL17A and CD21L co-expression. Clearly B-cells are involved and their prominence indicates that therapies targeting B-cells, such as rituximab, are likely to be more efficacious towards IL17A+/CD21L+ synovia. | Co-expression of CD21L and IL17A defines a subset of rheumatoid synovia, characterised by large lymphoid aggregates and high inflammation.
McKelvey KJ, Millier MJ, Doyle TC, Stamp LK, Highton J, Hessian PA., Free PMC Article | 02/2/2019 |
| This study shown the C3d+ microglial clusters were found in chronic but not acute multiple sclerosis. | Complement C3 on microglial clusters in multiple sclerosis occur in chronic but not acute disease: Implication for disease pathogenesis.
Michailidou I, Naessens DM, Hametner S, Guldenaar W, Kooi EJ, Geurts JJ, Baas F, Lassmann H, Ramaglia V., Free PMC Article | 01/13/2018 |
| This study uncovers the origin of the effect of ionic strength on C3d-CR2 interaction and deepens the understanding of the molecular mechanism of their interaction, which is valuable for the design of vaccines and small molecule inhibitors. | The solvent at antigen-binding site regulated C3d-CR2 interactions through the C-terminal tail of C3d at different ion strengths: insights from molecular dynamics simulation.
Zhang Y, Guo J, Li L, Liu X, Yao X, Liu H. | 11/4/2017 |
| Binding of PF4/heparin complexes to B cells is mediated through the interaction between complement and complement receptor 2. | The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21).
Khandelwal S, Lee GM, Hester CG, Poncz M, McKenzie SE, Sachais BS, Rauova L, Kelsoe G, Cines DB, Frank M, Arepally GM., Free PMC Article | 09/30/2017 |
| high pERK expression and accelerated apoptosis revert within 4 weeks after beginning therapy, whereas clonal B cells unresponsive to TLR9 stimulation persist for at least 24 weeks, although they may partially rescue normal CD21 expression. | Reversion of anergy signatures in clonal CD21(low) B cells of mixed cryoglobulinemia after clearance of HCV viremia.
Del Padre M, Todi L, Mitrevski M, Marrapodi R, Colantuono S, Fiorilli M, Casato M, Visentini M. | 08/19/2017 |
| Cerebrospinal fluid (CSF) soluble complement receptor 2 (sCR2) levels correlated significantly both with CSF complements C3 and C1q as well as to a disease severity measure. | Complement Receptor 2 is increased in cerebrospinal fluid of multiple sclerosis patients and regulates C3 function.
Lindblom RP, Aeinehband S, Ström M, Al Nimer F, Sandholm K, Khademi M, Nilsson B, Piehl F, Ekdahl KN. | 04/1/2017 |
| CR2 contributes to human Osteonecrosis of the femoral head susceptibility in Korean systemic lupus erythematosus patients. | Association of Complement Receptor 2 Gene Polymorphisms with Susceptibility to Osteonecrosis of the Femoral Head in Systemic Lupus Erythematosus.
Kim TH, Bae SC, Lee SH, Kim SY, Baek SH., Free PMC Article | 02/18/2017 |
| In this study, we have shown that the CR2 +24T>C polymorphism is not a risk marker for nasopharyngeal carcinoma development in the North region of Portugal. | 5'UTR +24T>C CR2 is not associated with nasopharyngeal carcinoma development in the North Region of Portugal.
Sousa H, Bastos MJ, Ribeiro J, Oliveira S, Breda E, Catarino R, Medeiros R. | 02/4/2017 |
| In mature B cells, CD21 transcription proceeds from a focused transcriptional start site regulated by a non-consensus TATA box, an initiator element and a downstream promoter element. | Focused transcription from the human CR2/CD21 core promoter is regulated by synergistic activity of TATA and Initiator elements in mature B cells.
Taylor RL, Cruickshank MN, Karimi M, Ng HL, Quail E, Kaufman KM, Harley JB, Abraham LJ, Tsao BP, Boackle SA, Ulgiati D., Free PMC Article | 10/1/2016 |
| Reduced expression of CD21 on CLL B-cells appears functionally relevant and was associated with poor clinical outcomes. | A CD21 low phenotype, with no evidence of autoantibodies to complement proteins, is consistent with a poor prognosis in CLL.
Nichols EM, Jones R, Watson R, Pepper CJ, Fegan C, Marchbank KJ., Free PMC Article | 08/13/2016 |
| These data suggest that rs1876453 in CR2 has long-range effects on gene regulation that decrease susceptibility to systemic lupus erythematosus. | Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA.
Zhao J, Giles BM, Taylor RL, Yette GA, Lough KM, Ng HL, Abraham LJ, Wu H, Kelly JA, Glenn SB, Adler AJ, Williams AH, Comeau ME, Ziegler JT, Marion M, Alarcón-Riquelme ME, BIOLUPUS and GENLES Networks, Alarcón GS, Anaya JM, Bae SC, Kim D, Lee HS, Criswell LA, Freedman BI, Gilkeson GS, Guthridge JM, Jacob CO, James JA, Kamen DL, Merrill JT, Sivils KM, Niewold TB, Petri MA, Ramsey-Goldman R, Reveille JD, Scofield RH, Stevens AM, Vilá LM, Vyse TJ, Kaufman KM, Harley JB, Langefeld CD, Gaffney PM, Brown EE, Edberg JC, Kimberly RP, Ulgiati D, Tsao BP, Boackle SA., Free PMC Article | 04/9/2016 |