| The Dopamine Transporter Is a New Target for Ischemic Stroke. | The Dopamine Transporter Is a New Target for Ischemic Stroke.
Cheng YQ, Zhang RX, Li XY, Zhou XT, Chen M, Liu AJ., Free PMC Article | 11/6/2024 |
| Leaky lessons learned: Efflux prone dopamine transporter variant reveals sex and circuit specific contributions of D2 receptor signalling to neuropsychiatric disease. | Leaky lessons learned: Efflux prone dopamine transporter variant reveals sex and circuit specific contributions of D2 receptor signalling to neuropsychiatric disease.
Mayer FP, Stewart A, Blakely RD. | 01/12/2024 |
| Abused drug-induced intracranial self-stimulation is correlated with the alteration of dopamine transporter availability in the medial prefrontal cortex and nucleus accumbens of mice. | Abused drug-induced intracranial self-stimulation is correlated with the alteration of dopamine transporter availability in the medial prefrontal cortex and nucleus accumbens of mice.
Zhang YQ, Min HK, Hong E, Yu E, Gu SM, Yoon SS, Lee D, Lee J, Hong JT, Yun J. | 12/15/2023 |
| Sex-dependent alterations in behavior, drug responses and dopamine transporter expression in heterozygous DAT-Cre mice. | Sex-dependent alterations in behavior, drug responses and dopamine transporter expression in heterozygous DAT-Cre mice.
Costa KM, Schenkel D, Roeper J., Free PMC Article | 11/13/2021 |
| Dopaminergic loss of cyclin-dependent kinase-like 5 recapitulates methylphenidate-remediable hyperlocomotion in mouse model of CDKL5 deficiency disorder. | Dopaminergic loss of cyclin-dependent kinase-like 5 recapitulates methylphenidate-remediable hyperlocomotion in mouse model of CDKL5 deficiency disorder.
Jhang CL, Lee HY, Chen JC, Liao W. | 08/21/2021 |
| Dopamine and the phosphorylated dopamine transporter are increased in the diacylglycerol kinase eta-knockout mouse brain. | Dopamine and the phosphorylated dopamine transporter are increased in the diacylglycerol kinase η-knockout mouse brain.
Asami M, Suzuki Y, Sakane F. | 07/24/2021 |
| Dopamine transporter gene expression within the nucleus accumbens plays important role in the acquisition and reinstatement of ethanol-seeking behavior in mice. | Dopamine transporter gene expression within the nucleus accumbens plays important role in the acquisition and reinstatement of ethanol-seeking behavior in mice.
Bahi A. | 05/29/2021 |
| Enhanced Dopamine Transmission and Hyperactivity in the Dopamine Transporter Heterozygous Mice Lacking the D3 Dopamine Receptor. | Enhanced Dopamine Transmission and Hyperactivity in the Dopamine Transporter Heterozygous Mice Lacking the D3 Dopamine Receptor.
Sotnikova TD, Efimova EV, Gainetdinov RR., Free PMC Article | 03/13/2021 |
| Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact. | Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact.
Fagan RR, Kearney PJ, Sweeney CG, Luethi D, Schoot Uiterkamp FE, Schicker K, Alejandro BS, O'Connor LC, Sitte HH, Melikian HE., Free PMC Article | 12/19/2020 |
| Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors. | Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors.
DiCarlo GE, Aguilar JI, Matthies HJ, Harrison FE, Bundschuh KE, West A, Hashemi P, Herborg F, Rickhag M, Chen H, Gether U, Wallace MT, Galli A., Free PMC Article | 05/30/2020 |
| The authors identify the dopamine transporter as a master regulator of dopamine short-term plasticity, governing the balance between release-dependent and independent mechanisms that also show region-specific gating. | Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter.
Condon MD, Platt NJ, Zhang YF, Roberts BM, Clements MA, Vietti-Michelina S, Tseu MY, Brimblecombe KR, Threlfell S, Mann EO, Cragg SJ., Free PMC Article | 01/11/2020 |
| Dopamine transporter plays an important role in controlling ethanol intake and nucleus accumbens dopamine transporter contributes to reinforcing effects of ethanol. | No effect of sex on ethanol intake and preference after dopamine transporter (DAT) knockdown in adult mice.
Bahi A, Dreyer JL. | 11/2/2019 |
| DAT knockdown in the nucleus accumbens, but not in the caudate putamen, improve anxiety- and depression-like symptoms in adult mice and the data illustrate the complex way DAT contributes to emotional behavior. | Dopamine transporter (DAT) knockdown in the nucleus accumbens improves anxiety- and depression-related behaviors in adult mice.
Bahi A, Dreyer JL. | 04/6/2019 |
| snapin/DAT interaction represents a direct link between exocytotic and reuptake mechanisms. | Structural and Functional Characterization of the Interaction of Snapin with the Dopamine Transporter: Differential Modulation of Psychostimulant Actions.
Erdozain AM, De Gois S, Bernard V, Gorgievski V, Pietrancosta N, Dumas S, Macedo CE, Vanhoutte P, Ortega JE, Meana JJ, Tzavara ET, Vialou V, Giros B., Free PMC Article | 02/9/2019 |
| PREP regulates the function of dopamine transporter, possibly by controlling the phosphorylation and transport of dopamine transporter into the striatum or synaptic membrane. | Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse.
Julku UH, Panhelainen AE, Tiilikainen SE, Svarcbahs R, Tammimäki AE, Piepponen TP, Savolainen MH, Myöhänen TT. | 12/22/2018 |
| Melatonin MT1 and MT2 receptors interact with dopamine transporter (DAT) in striatum. | Melatonin receptors limit dopamine reuptake by regulating dopamine transporter cell-surface exposure.
Benleulmi-Chaachoua A, Hegron A, Le Boulch M, Karamitri A, Wierzbicka M, Wong V, Stagljar I, Delagrange P, Ahmad R, Jockers R., Free PMC Article | 11/10/2018 |
| Study generated a transgenic rat model that overexpresses the mouse DAT gene via pronuclear microinjection. These rats specifically exhibited behavioral and pharmaco-therapeutic phenotype of repetitive disorders. Together, findings suggest that the DAT rat model will constitute a valuable tool for studying the pathological role of DAT overexpression on neural systems relevant to relevant to neuropsychiatric disorders. | Rats overexpressing the dopamine transporter display behavioral and neurobiological abnormalities with relevance to repetitive disorders.
Hadar R, Edemann-Callesen H, Reinel C, Wieske F, Voget M, Popova E, Sohr R, Avchalumov Y, Priller J, van Riesen C, Puls I, Bader M, Winter C., Free PMC Article | 06/23/2018 |
| The findings of thuis study indicated that the DAT Val559 variant induces impulsivity behaviors that are dependent upon the reward context, with increased impulsive action observed when mice are required to delay responding for a reward. | Functional coding variation in the presynaptic dopamine transporter associated with neuropsychiatric disorders drives enhanced motivation and context-dependent impulsivity in mice.
Davis GL, Stewart A, Stanwood GD, Gowrishankar R, Hahn MK, Blakely RD., Free PMC Article | 06/9/2018 |
| These results suggest that DAT expression affects TH expression and phosphorylation largely in DA terminal field compartments. | Regulation of Tyrosine Hydroxylase Expression and Phosphorylation in Dopamine Transporter-Deficient Mice.
Salvatore MF, Calipari ES, Jones SR., Free PMC Article | 10/21/2017 |
| These behavioral and molecular phenotypes indicate that a genetic-driven DAT hypofunction alters neurodevelopmental trajectories consistent with ADHD, but not with schizophrenia and bipolar disorders. | Dopamine transporter (DAT) genetic hypofunction in mice produces alterations consistent with ADHD but not schizophrenia or bipolar disorder.
Mereu M, Contarini G, Buonaguro EF, Latte G, Managò F, Iasevoli F, de Bartolomeis A, Papaleo F. | 09/9/2017 |
| An exquisite microanatomical regulation of dopamine by the dopamine transporter was identified in striosomes relative to the matrix in the corpus striatum. | Dopamine dynamics and cocaine sensitivity differ between striosome and matrix compartments of the striatum.
Salinas AG, Davis MI, Lovinger DM, Mateo Y., Free PMC Article | 07/22/2017 |
| Data suggest that environment pollutants methylmercury and 1-methyl-4-phenylpyridinium decrease release of dopamine from dopaminergic neurons; this mechanism involves down-regulation of expression of Slc6a3. | Effects of methylmercury on dopamine release in MN9D neuronal cells.
Shao Y, Chan HM. | 08/6/2016 |
| This study show that Dopamine transporter is enriched in filopodia and induces filopodia formation. | Dopamine transporter is enriched in filopodia and induces filopodia formation.
Caltagarone J, Ma S, Sorkin A., Free PMC Article | 07/16/2016 |
| The sigma-1R deficiency through suppressing NR2B function and DAT expression can reduce MPTP-induced death of dopaminergic neurons and parkinsonism. | Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons.
Hong J, Sha S, Zhou L, Wang C, Yin J, Chen L., Free PMC Article | 04/16/2016 |
| DAT gene knockout in mice results dendritic spine loss in pyramidal neurons in the CA1 field of the hippocampus. | Region-specific dendritic spine loss of pyramidal neurons in dopamine transporter knockout mice.
Kasahara Y, Arime Y, Hall FS, Uhl GR, Sora I. | 02/13/2016 |