| Increased activity of epithelial Cdc42 Rho GTPase and tight junction permeability in the Cftr knockout intestine. | Increased activity of epithelial Cdc42 Rho GTPase and tight junction permeability in the Cftr knockout intestine.
Woode RA, Strubberg AM, Liu J, Walker NM, Clarke LL. | 09/19/2024 |
| The anion exchanger slc26a3 regulates colonic mucus expansion during steady state and in response to prostaglandin E2, while Cftr regulates de novo mucus release in response to carbamylcholine. | The anion exchanger slc26a3 regulates colonic mucus expansion during steady state and in response to prostaglandin E(2), while Cftr regulates de novo mucus release in response to carbamylcholine.
Ljungholm PL, Ermund A, Söderlund Garsveden MM, Pettersson VL, Gustafsson JK., Free PMC Article | 07/23/2024 |
| A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts. | A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts.
Su S, Wahl A, Rugis J, Suresh V, Yule DI, Sneyd J., | 05/6/2024 |
| Role of CFTR in diabetes-induced pancreatic ductal fluid and HCO3 [-] secretion. | Role of CFTR in diabetes-induced pancreatic ductal fluid and HCO(3) (-) secretion.
Ébert A, Gál E, Tóth E, Szögi T, Hegyi P, Venglovecz V. | 03/19/2024 |
| Fecal dysbiosis and inflammation in intestinal-specific Cftr knockout mice on regimens preventing intestinal obstruction. | Fecal dysbiosis and inflammation in intestinal-specific Cftr knockout mice on regimens preventing intestinal obstruction.
Young SM, Woode RA, Williams EC, Ericsson AC, Clarke LL., | 02/20/2024 |
| CTNNAL1 deficiency suppresses CFTR expression in HDM-induced asthma mouse model through ROCK1-CAL signaling pathway. | CTNNAL1 deficiency suppresses CFTR expression in HDM-induced asthma mouse model through ROCK1-CAL signaling pathway.
Wu D, Zhu J, Yang F, Li R, Liu L, Liu D, Liu C, Qu X, Liu H, Ji M, Qin X, Hua L, Xiang Y., Free PMC Article | 11/8/2023 |
| Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis. | Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis.
Reyes EA, Castillo-Azofeifa D, Rispal J, Wald T, Zwick RK, Palikuqi B, Mujukian A, Rabizadeh S, Gupta AR, Gardner JM, Boffelli D, Gartner ZJ, Klein OD., Free PMC Article | 11/1/2023 |
| CFTR and PC2, partners in the primary cilia in autosomal dominant polycystic kidney disease. | CFTR and PC2, partners in the primary cilia in autosomal dominant polycystic kidney disease.
Yanda MK, Ciobanu C, Guggino WB, Cebotaru L., Free PMC Article | 09/1/2023 |
| CFTR Modulates Hypothalamic Neuron Excitability to Maintain Female Cycle. | CFTR Modulates Hypothalamic Neuron Excitability to Maintain Female Cycle.
Wu Y, Que Y, Chen J, Sun L, Guo J, Ruan YC., Free PMC Article | 08/30/2023 |
| CFTR dysfunction in smooth muscle drives TGFbeta dependent airway hyperreactivity. | CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity.
Kramer EL, Hudock KM, Davidson CR, Clancy JP., Free PMC Article | 08/17/2023 |
| CFTR regulates brown adipocyte thermogenesis via the cAMP/PKA signaling pathway. | CFTR regulates brown adipocyte thermogenesis via the cAMP/PKA signaling pathway.
Choi KM, Cho SH, Kim JH, Kim AL, Kong X, Yoon JC., Free PMC Article | 03/17/2023 |
| Pharmacological inhibition of CFTR attenuates nonalcoholic steatohepatitis (NASH) progression in mice. | Pharmacological inhibition of CFTR attenuates nonalcoholic steatohepatitis (NASH) progression in mice.
Rajak S, Tewari A, Raza S, Gupta P, Chakravarti B, Anjum B, Tripathi M, Singh BK, Yen PM, Goel A, Ghosh S, Sinha RA. | 03/7/2023 |
| Loss-of-function CFTR p.G970D missense mutation might cause congenital bilateral absence of the vas deferens and be associated with impaired spermatogenesis. | Loss-of-function CFTR p.G970D missense mutation might cause congenital bilateral absence of the vas deferens and be associated with impaired spermatogenesis.
Hou JW, Li XL, Wang L, Dai CL, Li N, Jiang XH, Tan YQ, Tian EP, Li QT, Xu WM., Free PMC Article | 01/21/2023 |
| Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation. | Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation.
Erfinanda L, Zou L, Gutbier B, Kneller L, Weidenfeld S, Michalick L, Lei D, Reppe K, Teixeira Alves LG, Schneider B, Zhang Q, Li C, Fatykhova D, Schneider P, Liedtke W, Sohara E, Mitchell TJ, Gruber AD, Hocke A, Hippenstiel S, Suttorp N, Olschewski A, Mall MA, Witzenrath M, Kuebler WM. | 12/17/2022 |
| CFTR modulates aquaporin-mediated glycerol permeability in mouse Sertoli cells. | CFTR modulates aquaporin-mediated glycerol permeability in mouse Sertoli cells.
Ribeiro JC, Bernardino RL, Carrageta DF, Soveral G, Calamita G, Alves MG, Oliveira PF. | 12/3/2022 |
| Cystic fibrosis transmembrane conductance regulator prevents ischemia/reperfusion induced intestinal apoptosis via inhibiting PI3K/AKT/NF-kappaB pathway. | Cystic fibrosis transmembrane conductance regulator prevents ischemia/reperfusion induced intestinal apoptosis via inhibiting PI3K/AKT/NF-κB pathway.
Dong ZW, Liu H, Su FF, Fan XZ, Zhang Y, Liu P., Free PMC Article | 04/2/2022 |
| Therapeutic Potential for CFTR Correctors in Autosomal Recessive Polycystic Kidney Disease. | Therapeutic Potential for CFTR Correctors in Autosomal Recessive Polycystic Kidney Disease.
Yanda MK, Tomar V, Cebotaru L., Free PMC Article | 04/2/2022 |
| Mislocalization of CFTR expression in acute pancreatitis and the beneficial effect of VX-661 + VX-770 treatment on disease severity. | Mislocalization of CFTR expression in acute pancreatitis and the beneficial effect of VX-661 + VX-770 treatment on disease severity.
Fűr G, Bálint ER, Orján EM, Balla Z, Kormányos ES, Czira B, Szűcs A, Kovács DP, Pallagi P, Maléth J, Venglovecz V, Hegyi P, Kiss L, Rakonczay Z Jr. | 01/29/2022 |
| CFTR deficiency aggravates Ang II induced vasoconstriction and hypertension by regulating Ca2+ influx and RhoA/Rock pathway in VSMCs. | CFTR deficiency aggravates Ang II induced vasoconstriction and hypertension by regulating Ca2+ influx and RhoA/Rock pathway in VSMCs.
Zhao L, Yuan F, Pan N, Yu Y, Yang H, Liu Y, Wang R, Zhang B, Wang G. | 01/22/2022 |
| Serum inflammatory profiles in cystic fibrosis mice with and without Bordetella pseudohinzii infection. | Serum inflammatory profiles in cystic fibrosis mice with and without Bordetella pseudohinzii infection.
Litman PM, Day A, Kelley TJ, Darrah RJ., Free PMC Article | 12/25/2021 |
| beta-Catenin-NF-kappaB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction. | β-Catenin-NF-κB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction.
Hu S, Russell JO, Liu S, Cao C, McGaughey J, Rai R, Kosar K, Tao J, Hurley E, Poddar M, Singh S, Bell A, Shin D, Raeman R, Singhi AD, Nejak-Bowen K, Ko S, Monga SP., Free PMC Article | 11/27/2021 |
| Vibrio parahaemolyticus induces inflammation-associated fluid accumulation via activation of the cystic fibrosis transmembrane conductance regulator. | Vibrio parahaemolyticus induces inflammation-associated fluid accumulation via activation of the cystic fibrosis transmembrane conductance regulator.
Iba H, Shimohata T, Kido J, Hatayama S, Uebanso T, Mawatari K, Takahashi A. | 11/6/2021 |
| Respiratory syncytial virus persistent infection causes acquired CFTR dysfunction in human bronchial epithelial cells.", trans ". | Respiratory syncytial virus persistent infection causes acquired CFTR dysfunction in human bronchial epithelial cells.
Long C, Qi M, Wang J, Luo J, Qin X, Gao G, Xiang Y., Free PMC Article | 11/6/2021 |
| The chloride channel CFTR is not required for cyst growth in an ADPKD mouse model. | The chloride channel CFTR is not required for cyst growth in an ADPKD mouse model.
Talbi K, Cabrita I, Kraus A, Hofmann S, Skoczynski K, Kunzelmann K, Buchholz B, Schreiber R. | 10/16/2021 |
| Isorhamnetin Ameliorates Dry Eye Disease via CFTR Activation in Mice. | Isorhamnetin Ameliorates Dry Eye Disease via CFTR Activation in Mice.
Lee HK, Park J, Kim BR, Jun I, Kim TI, Namkung W., Free PMC Article | 05/15/2021 |