| Unraveling the role of CD24 in Hepatocellular carcinoma: Involvement of inactivated Hippo signaling and SOX4-mediated regulation. | Unraveling the role of CD24 in Hepatocellular carcinoma: Involvement of inactivated Hippo signaling and SOX4-mediated regulation.
He X, Zhang Y, Fang Q, Sun Y, Zheng X, Fu Y, Fan W, Yang L, Hong Y, Du Y, Wang Z, Chen L. | 05/14/2024 |
| Dendritic cell expression of CD24 contributes to optimal priming of T lymphocytes in lymph nodes. | Dendritic cell expression of CD24 contributes to optimal priming of T lymphocytes in lymph nodes.
Zhang X, Yu C, Liu JQ, Bai XF., Free PMC Article | 03/31/2023 |
| Cancer-associated fibroblasts promoted self-renewal, chemotherapy resistance, metastasis, and tumorigenicity of CD24+ hepatocellular carcinoma cells. | Cancer-associated fibroblasts promote the stemness of CD24(+) liver cells via paracrine signaling.
Li Y, Wang R, Xiong S, Wang X, Zhao Z, Bai S, Wang Y, Zhao Y, Cheng B. | 05/30/2020 |
| this study shows that CD24 aggravates acute liver injury in autoimmune hepatitis by promoting IFN-gamma production by CD4(+) T cells | CD24 aggravates acute liver injury in autoimmune hepatitis by promoting IFN-γ production by CD4(+) T cells.
Zheng C, Yin S, Yang Y, Yu Y, Xie X., Free PMC Article | 10/5/2019 |
| CD24 regulates lipid accumulation but not glucose uptake in 3T3-L1 adipocytes. CD24 regulates gene expression in differentiating adipocytes in vitro in a depot specific manner. | CD24 is required for regulating gene expression, but not glucose uptake, during adipogenesis.
Smith NC, Swaminathan V, Pallegar NK, Cordova C, Buchanan SC, Christian SL., Free PMC Article | 09/7/2019 |
| CD24 and CD49f expressions of E14.5 mouse mammary anlagen cells define putative distribution of earlier embryonic mammary stem cell activities. | CD24 and CD49f expressions of E14.5 mouse mammary anlagen cells define putative distribution of earlier embryonic mammary stem cell activities.
Song J, Ding F, Li S, Li W, Li N, Xue K. | 12/1/2018 |
| CD24 has a role in determining the epithelial phenotype of pancreatic cancer | Membranous CD24 drives the epithelial phenotype of pancreatic cancer.
Lubeseder-Martellato C, Hidalgo-Sastre A, Hartmann C, Alexandrow K, Kamyabi-Moghaddam Z, Sipos B, Wirth M, Neff F, Reichert M, Heid I, Schneider G, Braren R, Schmid RM, Siveke JT., Free PMC Article | 02/24/2018 |
| While no obvious role was found for CD24 in the normal development and maintenance of the dopaminergic nigrostriatal system in mice, it may have a role in mediating the neuroprotective aspects of GDNF in this system. | CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease.
Stott SR, Hayat S, Carnwath T, Garas S, Sleeman JP, Barker RA., Free PMC Article | 09/9/2017 |
| CD24 cell surface expression may serve as a valuable biomarker in order to identify mammary tumors that will positively respond to targeted IGF1R therapies. | CD24 cell surface expression in Mvt1 mammary cancer cells serves as a biomarker for sensitivity to anti-IGF1R therapy.
Rostoker R, Ben-Shmuel S, Rashed R, Shen Orr Z, LeRoith D., Free PMC Article | 08/12/2017 |
| mice negative or positive for CD24 did not differ in terms of tumor initiation and burden in 3 mammary and prostate tumor models tested, except for Apc1572T/+ mice, in which lack of CD24 reduced the mammary tumor burden slightly but significantly. | CD24 Is Not Required for Tumor Initiation and Growth in Murine Breast and Prostate Cancer Models.
Cremers N, Neeb A, Uhle T, Dimmler A, Rothley M, Allgayer H, Fodde R, Sleeman JP, Thiele W., Free PMC Article | 07/30/2016 |
| Loss of CD24 in Mice Leads to Metabolic Dysfunctions and a Reduction in White Adipocyte Tissue. | Loss of CD24 in Mice Leads to Metabolic Dysfunctions and a Reduction in White Adipocyte Tissue.
Fairbridge NA, Southall TM, Ayre DC, Komatsu Y, Raquet PI, Brown RJ, Randell E, Kovacs CS, Christian SL., Free PMC Article | 06/28/2016 |
| CD24 controls breast cancer radiation response. Loss of CD24 expression leads to radiation resistance. | Forced extinction of CD24 stem-like breast cancer marker alone promotes radiation resistance through the control of oxidative stress.
Bensimon J, Biard D, Paget V, Goislard M, Morel-Altmeyer S, Konge J, Chevillard S, Lebeau J. | 06/28/2016 |
| Delayed wound-healing in the absence of HSA/CD24 suggests that CD24 plays an important role in this process | Delayed Wound Healing in Heat Stable Antigen (HSA/CD24)-Deficient Mice.
Shapira S, Ben-Amotz O, Sher O, Kazanov D, Mashiah J, Kraus S, Gur E, Arber N., Free PMC Article | 06/4/2016 |
| Findings indicate that CD24(+) antigen cells play a role in tumor migration and metastasis and support Janus kinase 2 protein (JAK2) as a therapeutic target in ovarian cancer. | CD24+ Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis.
Burgos-Ojeda D, Wu R, McLean K, Chen YC, Talpaz M, Yoon E, Cho KR, Buckanovich RJ., Free PMC Article | 05/14/2016 |
| CD24 is a conserved marker for tracking divergent states in both reprogramming and standard pluripotent culture. | CD24 tracks divergent pluripotent states in mouse and human cells.
Shakiba N, White CA, Lipsitz YY, Yachie-Kinoshita A, Tonge PD, Hussein SMI, Puri MC, Elbaz J, Morrissey-Scoot J, Li M, Munoz J, Benevento M, Rogers IM, Hanna JH, Heck AJR, Wollscheid B, Nagy A, Zandstra PW., Free PMC Article | 04/9/2016 |
| CD24 in non-immune cells might be crucialfor the guidance and recruitment of leukocytes. | Lack of CD24 expression in mice reduces the number of leukocytes in the colon.
Bretz NP, Salnikov AV, Doberstein K, Garbi N, Kloess V, Joumaa S, Naumov I, Boon L, Moldenhauer G, Arber N, Altevogt P. | 04/4/2015 |
| CD24 expression negatively regulates the NF-kappaB pathway following experimental traumatic brain injury. | Elevated cerebral cortical CD24 levels in patients and mice with traumatic brain injury: a potential negative role in nuclear factor κb/inflammatory factor pathway.
Li W, Ling HP, You WC, Liu HD, Sun Q, Zhou ML, Shen W, Zhao JB, Zhu L, Hang CH. | 11/8/2014 |
| the deletion of CD24 in an HSP-driven model of autoimmunity led to the unexpected development of regulatory T cell and MDSC populations that augmented immune tolerance. | Deletion of CD24 impairs development of heat shock protein gp96-driven autoimmune disease through expansion of myeloid-derived suppressor cells.
Thaxton JE, Liu B, Zheng P, Liu Y, Li Z., Free PMC Article | 08/23/2014 |
| CD24 is shown in vitro and in vivo as being an important oncogene in the gut, and one that plays a critical role in the initiation and progression of carcinogenesis. | CD24 knockout prevents colorectal cancer in chemically induced colon carcinogenesis and in APC(Min)/CD24 double knockout transgenic mice.
Naumov I, Zilberberg A, Shapira S, Avivi D, Kazanov D, Rosin-Arbesfeld R, Arber N, Kraus S. | 08/16/2014 |
| Siglec-G-CD24 axis, controls the severity of GVHD and suggest that enhancing this interaction may represent a novel strategy for mitigating GVHD. | Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice.
Toubai T, Hou G, Mathewson N, Liu C, Wang Y, Oravecz-Wilson K, Cummings E, Rossi C, Evers R, Sun Y, Wu J, Choi SW, Fang D, Zheng P, Liu Y, Reddy P., Free PMC Article | 08/9/2014 |
| CD24 was shown to regulate CD8(+) T cell activation through HMGB1-mediated engagement of T cell RAGE. | Distinct dendritic cell subsets dictate the fate decision between effector and memory CD8(+) T cell differentiation by a CD24-dependent mechanism.
Kim TS, Gorski SA, Hahn S, Murphy KM, Braciale TJ., Free PMC Article | 05/17/2014 |
| CD24 has a role in urothelial tumorigenesis and metastasis in male mice and is androgen regulated in mice and humans | CD24 expression is important in male urothelial tumorigenesis and metastasis in mice and is androgen regulated.
Overdevest JB, Knubel KH, Duex JE, Thomas S, Nitz MD, Harding MA, Smith SC, Frierson HF, Conaway M, Theodorescu D., Free PMC Article | 03/2/2013 |
| CD24 is expressed in gastric parietal cells, where it modulates gastric responses to H. felis and gamma-radiation. CD24 also regulates susceptibility to apoptosis in the distal murine gastrointestinal tract. | CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to Helicobacter felis infection in the murine stomach.
Duckworth CA, Clyde D, Pritchard DM. | 01/12/2013 |
| CD24-based sorting in wild-type mice isolates a colonic epithelial fraction highly enriched in actively cycling and quiescent Lgr5 positive putative colonic epithelial stem cells. | CD24 can be used to isolate Lgr5+ putative colonic epithelial stem cells in mice.
King JB, von Furstenberg RJ, Smith BJ, McNaughton KK, Galanko JA, Henning SJ., Free PMC Article | 10/27/2012 |
| Results suggest that LKB1 inactivation in the context of RAS activation facilitates metastasis by inducing an SFK-dependent expansion of a prometastatic, CD24(+) tumor subpopulation. | LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma.
Liu W, Monahan KB, Pfefferle AD, Shimamura T, Sorrentino J, Chan KT, Roadcap DW, Ollila DW, Thomas NE, Castrillon DH, Miller CR, Perou CM, Wong KK, Bear JE, Sharpless NE., Free PMC Article | 09/1/2012 |