| PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3. | PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3.
Sun M, Sheng H, Wu T, Song J, Sun H, Wang Y, Wang J, Li Z, Zhao H, Tan J, Li Y, Chen G, Huang Q, Zhang Y, Lan B, Liu S, Shan C, Zhang S. | 11/22/2021 |
| Exosomes derived from microRNA-199a-overexpressing mesenchymal stem cells inhibit glioma progression by down-regulating AGAP2. | Exosomes derived from microRNA-199a-overexpressing mesenchymal stem cells inhibit glioma progression by down-regulating AGAP2.
Yu L, Gui S, Liu Y, Qiu X, Zhang G, Zhang X, Pan J, Fan J, Qi S, Qiu B., Free PMC Article | 08/22/2020 |
| chromatin immunoprecipitation studies revealed the presence of RARalpha, RXRalpha and the lysine acetyl transferase PCAF in AGAP2 promoter. | SP1 and RARα regulate AGAP2 expression in cancer.
Doush Y, Surani AA, Navarro-Corcuera A, McArdle S, Billett EE, Montiel-Duarte C., Free PMC Article | 06/27/2020 |
| The role of AGAP2 in the pro-fibrogenic phenotype of hepatic stellate cells in response to TGFbeta. | Role of AGAP2 in the profibrogenic effects induced by TGFβ in LX-2 hepatic stellate cells.
Navarro-Corcuera A, López-Zabalza MJ, Martínez-Irujo JJ, Álvarez-Sola G, Ávila MA, Iraburu MJ, Ansorena E, Montiel-Duarte C. | 09/14/2019 |
| A pleckstrin homology domain in PIKE-L directly binds alpha-synuclein and antagonizes its aggregation. Accordingly, PIKE-L overexpression decreases dopaminergic cell death elicited by MPP(+), whereas PIKE-L knockdown elevates alpha-synuclein oligomerization and cell death. | α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.
Kang SS, Zhang Z, Liu X, Manfredsson FP, He L, Iuvone PM, Cao X, Sun YE, Jin L, Ye K., Free PMC Article | 04/28/2018 |
| these findings support that PIKE amplification or overexpression coordinately acts with CDK4 to drive glioblastoma tumorigenesis. | Co-amplification of phosphoinositide 3-kinase enhancer A and cyclin-dependent kinase 4 triggers glioblastoma progression.
Qi Q, Kang SS, Zhang S, Pham C, Fu H, Brat DJ, Ye K., Free PMC Article | 09/30/2017 |
| Studies showed that overexpression or mutation of PIKE has been observed in a variety of tumors, promoting cancer cell growth, transformation and invasion through AKT signaling or other signaling pathways, such as focal adhesion kinase. [review] | Phosphoinositide-3-Kinase Enhancers, PIKEs: Their Biological Functions and Roles in Cancer.
Jia W, Feng YI, Sanders AJ, Davies EL, Jiang WG. | 11/19/2016 |
| Mutation of Fyn phosphorylation sites on PIKE-A, depletion of Fyn, or pharmacological inhibition of Fyn blunts the association between PIKE-A and AMPK, resulting in loss of its inhibitory effect on AMPK. | Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity.
Zhang S, Qi Q, Chan CB, Zhou W, Chen J, Luo HR, Appin C, Brat DJ, Ye K., Free PMC Article | 09/10/2016 |
| expression of PLC-gamma1 and PIKE positively correlated with the tumor differentiation of oral squamous cell carcinoma. | Reduced expression of E-cadherin and p120-catenin and elevated expression of PLC-γ1 and PIKE are associated with aggressiveness of oral squamous cell carcinoma.
Jiang Y, Liao L, Shrestha C, Ji S, Chen Y, Peng J, Wang L, Liao E, Xie Z., Free PMC Article | 08/6/2016 |
| PIKE reduction rescued PI3K-dependent and -independent neuronal defects in fragile X syndrome. | Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome.
Gross C, Chang CW, Kelly SM, Bhattacharya A, McBride SM, Danielson SW, Jiang MQ, Chan CB, Ye K, Gibson JR, Klann E, Jongens TA, Moberg KH, Huber KM, Bassell GJ., Free PMC Article | 02/6/2016 |
| In this review the CENTG1 gene is amplified in a variety of human cancers which lead to the enhancement of tumor invasion. | The roles of PIKE in tumorigenesis.
Qi Q, Ye K., Free PMC Article | 07/19/2014 |
| AGAP2 plays a role in the signalling and recycling of beta2-adrenergic receptors. | The Arf GAP AGAP2 interacts with β-arrestin2 and regulates β2-adrenergic receptor recycling and ERK activation.
Wu Y, Zhao Y, Ma X, Zhu Y, Patel J, Nie Z., Free PMC Article | 08/10/2013 |
| Fyn regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a) through enhancing its interaction with the GTPase phosphoinositide 3-kinase enhancer A (PIKE-A). | Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction.
Tse MC, Liu X, Yang S, Ye K, Chan CB., Free PMC Article | 06/1/2013 |
| PIKE is highly expressed in human squamous cell carcinoma and has a critical role in EGF-induced squamous cell carcinoma proliferation. | PIKE mediates EGFR proliferative signaling in squamous cell carcinoma cells.
Xie Z, Jiang Y, Liao EY, Chen Y, Pennypacker SD, Peng J, Chang SM. | 04/27/2013 |
| The presence of heterogeneous missense mutations of GGAP2 in prostate cancer was associated with aggressive clinical behavior. | Frequent heterogeneous missense mutations of GGAP2 in prostate cancer: implications for tumor biology, clonality and mutation analysis.
Cai Y, Wang J, Ren C, Ittmann M., Free PMC Article | 07/7/2012 |
| PIKE is a critical factor in controlling synaptic AMPA receptor insertion. | PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression.
Chan CB, Chen Y, Liu X, Tang X, Lee CW, Mei L, Ye K., Free PMC Article | 12/17/2011 |
| Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner. [PIKE-A] | Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner.
He K, Jang SW, Joshi J, Yoo MH, Ye K., Free PMC Article | 10/1/2011 |
| regulates retrograde protein transport between early endosomes and the Golgi complex | AGAP2 regulates retrograde transport between early endosomes and the TGN.
Shiba Y, Römer W, Mardones GA, Burgos PV, Lamaze C, Johannes L., Free PMC Article | 11/27/2010 |
| AGAP2 regulates the FAK activity and the focal adhesion disassembly during cell migration. | Arf GTPase-activating protein AGAP2 regulates focal adhesion kinase activity and focal adhesion remodeling.
Zhu Y, Wu Y, Kim JI, Wang Z, Daaka Y, Nie Z., Free PMC Article | 01/21/2010 |
| Increased GGAP2 expression, which is present in three quarters of human prostate cancers, can activate two critical pathways that have been linked to prostate cancer initiation and progression. | GGAP2/PIKE-a directly activates both the Akt and nuclear factor-kappaB pathways and promotes prostate cancer progression.
Cai Y, Wang J, Li R, Ayala G, Ittmann M, Liu M., Free PMC Article | 01/21/2010 |
| PIKE-L acts as a downstream survival effector for netrin-1 through UNC5B in the nervous system | Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B.
Tang X, Jang SW, Okada M, Chan CB, Feng Y, Liu Y, Luo SW, Hong Y, Rama N, Xiong WC, Mehlen P, Ye K., Free PMC Article | 01/21/2010 |
| Cdk5 phosphorylates PIKE-A and stimulates its GTPase activity, which activates nuclear Akt and promotes glioblastoma cell migration and invasion. | Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion.
Liu R, Tian B, Gearing M, Hunter S, Ye K, Mao Z., Free PMC Article | 01/21/2010 |
| The cytoplasmic-nuclear shuttling of PIKE is dynamically regulated by the balancing actions of the lipid-binding property of both the split PH domain and the nuclear targeting function of its nuclear localization sequence. | Split pleckstrin homology domain-mediated cytoplasmic-nuclear localization of PI3-kinase enhancer GTPase.
Yan J, Wen W, Chan LN, Zhang M. | 01/21/2010 |
| In normal mice. PIKE-L strongly binds SET and prevents its degradation by AEP, leading to resistance of neuronal cell death. | Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase.
Liu Z, Jang SW, Liu X, Cheng D, Peng J, Yepes M, Li XJ, Matthews S, Watts C, Asano M, Hara-Nishimura I, Luo HR, Ye K., Free PMC Article | 01/21/2010 |
| PIKE binds PI 3-kinase & stimulates its lipid kinase activity. There are 3 isoforms which function throught the cell and meadiate processes from invasiveness to apoptosis. Review. | PIKE GTPase signaling and function.
Ahn JY, Ye K., Free PMC Article | 01/21/2010 |