| KLF8 Promotes the Survival of Lung Adenocarcinoma During Nutrient Deprivation by Regulating the Pentose Phosphate Pathway through SIRT2. | KLF8 Promotes the Survival of Lung Adenocarcinoma During Nutrient Deprivation by Regulating the Pentose Phosphate Pathway through SIRT2.
Bai Q, Jin W, Chen F, Zhu J, Cao L, Yang Y, Zhong F, Li L. | 03/1/2024 |
| CircRNA PVT1 promotes proliferation and chemoresistance of osteosarcoma cells via the miR-24-3p/KLF8 axis. | CircRNA PVT1 promotes proliferation and chemoresistance of osteosarcoma cells via the miR-24-3p/KLF8 axis.
Wang B, Yan L, Shi W, Xie H, Chen R, Shao Y, Liang W. | 07/2/2022 |
| KLF8 is activated by TGF-beta1 via Smad2 and contributes to ovarian cancer progression. | KLF8 is activated by TGF-β1 via Smad2 and contributes to ovarian cancer progression.
Cherukunnath A, Davargaon RS, Ashraf R, Kamdar U, Srivastava AK, Tripathi PP, Chatterjee N, Kumar S. | 05/28/2022 |
| Oncogenic E3 ubiquitin ligase NEDD4 binds to KLF8 and regulates the microRNA-132/NRF2 axis in bladder cancer. | Oncogenic E3 ubiquitin ligase NEDD4 binds to KLF8 and regulates the microRNA-132/NRF2 axis in bladder cancer.
Mao M, Yang L, Hu J, Liu B, Zhang X, Liu Y, Wang P, Li H., Free PMC Article | 04/30/2022 |
| miR-24-3p/KLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT. | miR-24-3p/KLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT.
Jing P, Xie N, Zhao N, Zhu X, Li P, Gao G, Dang H, Gu Z., Free PMC Article | 03/13/2021 |
| Circ_0067934 promotes non-small cell lung cancer development by regulating miR-1182/KLF8 axis and activating Wnt/beta-catenin pathway. | Circ_0067934 promotes non-small cell lung cancer development by regulating miR-1182/KLF8 axis and activating Wnt/β-catenin pathway.
Zhao M, Ma W, Ma C. | 02/27/2021 |
| Upregulated miRNA-1236-3p in osteosarcoma inhibits cell proliferation and induces apoptosis via targeting KLF8. | Upregulated miRNA-1236-3p in osteosarcoma inhibits cell proliferation and induces apoptosis via targeting KLF8.
Sun Y, Cao L, Lin JT, Yuan Y, Cao ZL, Jia JD. | 10/3/2020 |
| KLF8 promotes cancer stem cell-like phenotypes in osteosarcoma through miR-429-SOX2 signaling. | KLF8 promotes cancer stem cell-like phenotypes in osteosarcoma through miR-429-SOX2 signaling.
Zhang L, Yang P, Liu Q, Wang J, Yan F, Duan L, Lin F. | 09/12/2020 |
| KLF8 is associated with poor prognosis and regulates glycolysis by targeting GLUT4 in gastric cancer. | KLF8 is associated with poor prognosis and regulates glycolysis by targeting GLUT4 in gastric cancer.
Mao A, Zhou X, Liu Y, Ding J, Miao A, Pan G., Free PMC Article | 08/15/2020 |
| KLF8-overexpressing hepatocellular carcinoma cells had a higher potential for inducing angiogenesis. The up-regulation of KLF8 increased VEGFA protein levels and induced VEGFA promoter activity by binding to the CACCC region of the VEGFA promoter. | Krüppel-like factor 8 regulates VEGFA expression and angiogenesis in hepatocellular carcinoma.
Cheng S, Zhang X, Xu Y, Dai X, Li J, Zhang T, Chen X., Free PMC Article | 10/26/2019 |
| This study has unraveled a novel mechanism of ELF3-AS1-mediated oncogenesis in bladder cancer by reinforcement of ELF3-AS1/KLF8 signaling with potential implications for therapeutic intervention. | The lncRNA ELF3-AS1 promotes bladder cancer progression by interaction with Krüppel-like factor 8.
Guo Y, Chen D, Su X, Chen J, Li Y. | 09/14/2019 |
| High KLF8 expression is associated with Non-Small Cell Lung Cancer. | Krüppel-Like Factor 8 Overexpression Correlates with Poor Prognosis in Non-Small Cell Lung Cancer.
Li J, Liu Y, Xue J, Xu M, Zhang J, Liu J, Wang W. | 02/16/2019 |
| High KLF8 expression is associated with breast cancer cell invasion, transendothelial migration and metastasis. | Krüppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis.
Mukherjee D, Lu H, Yu L, He C, Lahiri SK, Li T, Zhao J., Free PMC Article | 02/10/2018 |
| expression of miR-1236-3p was lower in lung adenocarcinoma tissues than that in adjacent normal tissue; in A549 cell line, miR-1236-3p decreased ability of cell invasion and migration; furthermore, KLF8 is targeted by miR-1236-3p, and expression of miR-1236-3p is negatively correlated with KLF8; additionally, miR-1236-3p suppressed the expression of KLF8 and EMT (epithelial mesenchymal transition)-related genes | miR-1236-3p suppresses the migration and invasion by targeting KLF8 in lung adenocarcinoma A549 cells.
Bian T, Jiang D, Liu J, Yuan X, Feng J, Li Q, Zhang Q, Li X, Liu Y, Zhang J. | 10/28/2017 |
| Overexpression of KLF8 may contribute to the progression of pancreatic cancer, and downregulation of KLF8 expression by lentivirus-delivered shRNA is a novel therapeutic approach for PC. | KLF8 knockdown triggered growth inhibition and induced cell phase arrest in human pancreatic cancer cells.
Yi X, Li Y, Zai H, Long X, Li W. | 09/10/2016 |
| KLF8-induced FHL2 activation is a novel and critical signaling mechanism underlying human colorectal cancer invasion and metastasis. | KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2.
Yan Q, Zhang W, Wu Y, Wu M, Zhang M, Shi X, Zhao J, Nan Q, Chen Y, Wang L, Cheng T, Li J, Bai Y, Liu S, Wang J., Free PMC Article | 07/30/2016 |
| KLF8 and miR141/EGFR have roles in signaling pathway potentially crucial for breast cancer malignancy | Identification of epidermal growth factor receptor and its inhibitory microRNA141 as novel targets of Krüppel-like factor 8 in breast cancer.
Li T, Lu H, Mukherjee D, Lahiri SK, Shen C, Yu L, Zhao J., Free PMC Article | 06/11/2016 |
| KLF8 suppression induced cell differentiation and inhibited tumorigenesis in colorectal cancer | Suppression of KLF8 induces cell differentiation and sensitizes colorectal cancer to 5-fluorouracil.
Shi X, Luo X, Yan Q, Zhang W, Wu Y, Zhang M, Zhao J, Peng Y, Chen Y, Zhang Y, Chen C, Cheng T, Chen C, Liu S, Bai Y, Wang J. | 06/4/2016 |
| MiR-135a inhibits migration and invasion and regulates epithelial-mesenchymal transition-related marker genes by targeting KLF8 in lung cancer cells. | MiR-135a inhibits migration and invasion and regulates EMT-related marker genes by targeting KLF8 in lung cancer cells.
Shi H, Ji Y, Zhang D, Liu Y, Fang P. | 11/28/2015 |
| KLF8 is a novel epithelial to mesenchymal transition regulating transcription factor that involved in the progression of gastric cancer. | Krüppel-like factor 8 involved in hypoxia promotes the invasion and metastasis of gastric cancer via epithelial to mesenchymal transition.
Liu N, Wang Y, Zhou Y, Pang H, Zhou J, Qian P, Liu L, Zhang H. | 06/27/2015 |
| In this review, we focus on the functions, roles, and regulatory networks of these five KLFs in HCC, summarize key pathways, and propose areas for further investigation | Krüppel-like factors in hepatocellular carcinoma.
Lu XJ, Shi Y, Chen JL, Ma S. | 06/20/2015 |
| A novel KLF8 to EPSTI1 to VCP to NF-kappaB signaling mechanism potentially critical for breast cancer invasion and metastasis. | Identification of epithelial stromal interaction 1 as a novel effector downstream of Krüppel-like factor 8 in breast cancer invasion and metastasis.
Li T, Lu H, Shen C, Lahiri SK, Wason MS, Mukherjee D, Yu L, Zhao J., Free PMC Article | 12/20/2014 |
| KLF8 is involved in hypoxia-induced multidrug resistance through inhibiting apoptosis and increasing the drug release rate by directly regulating MDR1 transcription. | Krüppel-like factor 8 contributes to hypoxia-induced MDR in gastric cancer cells.
Zhang H, Sun L, Xiao X, Xie R, Liu C, Wang Y, Wei Y, Zhang H, Liu L., Free PMC Article | 11/22/2014 |
| Positive nuclear KLF8 might be correlated with lower survival in gastric adenocarcinoma patients and might be an oncogene property in gastric adenocarcinoma carcinogenesis. | Positive nuclear expression of KLF8 might be correlated with shorter survival in gastric adenocarcinoma.
Hsu LS, Wu PR, Yeh KT, Yeh CM, Shen KH, Chen CJ, Soon MS. | 11/22/2014 |
| KLF8 knockdown suppresses proliferation and invasion in human osteosarcoma cells. | KLF8 knockdown suppresses proliferation and invasion in human osteosarcoma cells.
Lin F, Shen Z, Tang LN, Zheng SE, Sun YJ, Min DL, Yao Y., Free PMC Article | 11/22/2014 |