| PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity. | PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity.
Jayakumar S, Patel M, Boulet F, Aziz H, Brooke GN, Tummala H, Pradeepa MM., Free PMC Article | 02/5/2024 |
| The LncRNA MIR155HG is Upregulated by SP1 in Melanoma Cells and Drives Melanoma Progression via Modulating the MiR-485-3p/PSIP1 Axis. | The LncRNA MIR155HG is Upregulated by SP1 in Melanoma Cells and Drives Melanoma Progression via Modulating the MiR-485-3p/PSIP1 Axis.
Huo J, Wang Y, Zhang Y, Wang W, Yang P, Zhao W, Zhang M, Cui L, Zhang D. | 03/12/2022 |
| Modulation of the intrinsic chromatin binding property of HIV-1 integrase by LEDGF/p75. | Modulation of the intrinsic chromatin binding property of HIV-1 integrase by LEDGF/p75.
Lapaillerie D, Lelandais B, Mauro E, Lagadec F, Tumiotto C, Miskey C, Ferran G, Kuschner N, Calmels C, Métifiot M, Rooryck C, Ivics Z, Ruff M, Zimmer C, Lesbats P, Toutain J, Parissi V., Free PMC Article | 12/25/2021 |
| The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells. | The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells.
Ortiz-Hernandez GL, Sanchez-Hernandez ES, Ochoa PT, Elix CC, Alkashgari HR, McMullen JRW, Soto U, Martinez SR, Diaz Osterman CJ, Mahler M, Roy S, Casiano CA., Free PMC Article | 12/4/2021 |
| LEDGF/p75 Is Required for an Efficient DNA Damage Response. | LEDGF/p75 Is Required for an Efficient DNA Damage Response.
Liedtke V, Schröder C, Roggenbuck D, Weiss R, Stohwasser R, Schierack P, Rödiger S, Schenk L., Free PMC Article | 06/26/2021 |
| Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival. | Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival.
Van Belle S, El Ashkar S, Čermáková K, Matthijssens F, Goossens S, Canella A, Hodges CH, Christ F, De Rijck J, Van Vlierberghe P, Veverka V, Debyser Z., Free PMC Article | 06/26/2021 |
| Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection. | Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection.
Lampi Y, Van Looveren D, Vranckx LS, Thiry I, Bornschein S, Debyser Z, Gijsbers R., Free PMC Article | 09/19/2020 |
| LEDGF and HDGF2 colocalize with Histone H3 lysine 36 methylation 2/3 at genomic regions containing active genes. | LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells.
LeRoy G, Oksuz O, Descostes N, Aoi Y, Ganai RA, Kara HO, Yu JR, Lee CH, Stafford J, Shilatifard A, Reinberg D., Free PMC Article | 05/23/2020 |
| This study reports the cryo-electron microscopy structure of the PWWP reader domain of human transcriptional coactivator LEDGF in complex with an H3K36-methylated nucleosome at 3.2-A resolution. | Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding.
Wang H, Farnung L, Dienemann C, Cramer P., Free PMC Article | 05/2/2020 |
| antibodies more frequent in systemic autoimmune rheumatic disease patients than in blood donors | Investigation of anti-DFS70 antibody in patients with systemic autoimmune rheumatic diseases.
Peker BO, Şener AG, Tarhan EF, Kaya S. | 04/11/2020 |
| Levels of anti-DFS70 antibodies were significantly higher in the fibromyalgia and heathy groups than in those with systemic lupus erythematosus. | Clinical significance of anti-dense fine speckled 70 antibody in patients with fibromyalgia.
Jeong J, Kim DH, Park G, Park S, Kim HS., Free PMC Article | 01/18/2020 |
| Due to its major importance in the early steps of HIV replication, the interaction between IN and LEDGF/p75 has become a pleasing target for anti-HIV drug discovery. The present study involves the finding of novel inhibitor based on the information of dimeric CCD of IN in complex with known inhibitor, which were carried out by applying a structure-based virtual screening concept with molecular docking | Structure-based virtual screening toward the discovery of novel inhibitors for impeding the protein-protein interaction between HIV-1 integrase and human lens epithelium-derived growth factor (LEDGF/p75).
Panwar U, Singh SK. | 06/1/2019 |
| structurally conserved IBD-binding motifs (IBMs) on known LEDGF/p75 binding partners can be regulated by phosphorylation, permitting switching between low- and high-affinity states. | Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.
Sharma S, Čermáková K, De Rijck J, Demeulemeester J, Fábry M, El Ashkar S, Van Belle S, Lepšík M, Tesina P, Duchoslav V, Novák P, Hubálek M, Srb P, Christ F, Řezáčová P, Hodges HC, Debyser Z, Veverka V., Free PMC Article | 09/22/2018 |
| findings suggest a novel role of LEDGF/p75 in protecting the unintegrated 3' processed linear HIV-1 cDNA from exonucleolytic degradation. | LEDGF/p75 Deficiency Increases Deletions at the HIV-1 cDNA Ends.
Bueno MTD, Reyes D, Llano M., Free PMC Article | 05/5/2018 |
| mono-specific anti-DFS70 antibodies are a strong discriminator between ANA positive healthy controls and patients with systemic autoimmune rheumatic diseases. | Prevalence of anti-DFS70 antibodies in patients with and without systemic autoimmune rheumatic diseases.
Shovman O, Gilburd B, Chayat C, Amital H, Langevitz P, Watad A, Guy A, Perez D, Azoulay D, Blank M, Segal Y, Bentow C, Mahler M, Shoenfeld Y. | 04/28/2018 |
| Authors report here that the endogenous levels of LEDGF/p75 are upregulated in metastatic castration resistant prostate cancer (mCRPC) cells selected for resistance to the taxane drug docetaxel (DTX). | Targeting the stress oncoprotein LEDGF/p75 to sensitize chemoresistant prostate cancer cells to taxanes.
Ríos-Colón L, Cajigas-Du Ross CK, Basu A, Elix C, Alicea-Polanco I, Sanchez TW, Radhakrishnan V, Chen CS, Casiano CA., Free PMC Article | 04/7/2018 |
| An important role of PSIP1 in triple negative breast cancer tumorigenicity by promoting the expression of genes that control the cell cycle and tumor metastasis | PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes.
Singh DK, Gholamalamdari O, Jadaliha M, Ling Li X, Lin YC, Zhang Y, Guang S, Hashemikhabir S, Tiwari S, Zhu YJ, Khan A, Thomas A, Chakraborty A, Macias V, Balla AK, Bhargava R, Janga SC, Ma J, Prasanth SG, Lal A, Prasanth KV., Free PMC Article | 11/4/2017 |
| We identify the Myc-interacting protein JPO2 and its partner binding protein LEDGF/p75 as critical modulators of PI3K/AKT signaling and metastasis in medulloblastoma | JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma.
Chan TS, Hawkins C, Krieger JR, McGlade CJ, Huang A. | 07/29/2017 |
| The association of LEDGF proteins with the FACT complex and give further support to a role of SSRP1 in HIV-1 infection. | The Structure-Specific Recognition Protein 1 Associates with Lens Epithelium-Derived Growth Factor Proteins and Modulates HIV-1 Replication.
Lopez AP, Kugelman JR, Garcia-Rivera J, Urias E, Salinas SA, Fernandez-Zapico ME, Llano M., Free PMC Article | 06/24/2017 |
| short isoform (p52) of a transcriptional co-activator-PC4 and SF2 interacting protein (Psip1), which is known to be involved in linking transcription to RNA processing, specifically regulates the expression of the lncRNA Hottip-located at the 5' end of the Hoxa locus | Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip.
Pradeepa MM, McKenna F, Taylor GC, Bengani H, Grimes GR, Wood AJ, Bhatia S, Bickmore WA., Free PMC Article | 05/20/2017 |
| Germline polymorphisms in an enhancer of PSIP1 are associated with epithelial ovarian cancer. | Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.
French JD, Johnatty SE, Lu Y, Beesley J, Gao B, Kalimutho M, Henderson MJ, Russell AJ, Kar S, Chen X, Hillman KM, Kaufmann S, Sivakumaran H, O'Reilly M, Wang C, Korbie DJ, Australian Ovarian Cancer Study Group, Australian Ovarian Cancer Study, Lambrechts D, Despierre E, Van Nieuwenhuysen E, Lambrechts S, Vergote I, Karlan B, Lester J, Orsulic S, Walsh C, Fasching PA, Beckmann MW, Ekici AB, Hein A, Matsuo K, Hosono S, Pisterer J, Hillemanns P, Nakanishi T, Yatabe Y, Goodman MT, Lurie G, Matsuno RK, Thompson PJ, Pejovic T, Bean Y, Heitz F, Harter P, du Bois A, Schwaab I, Hogdall E, Kjaer SK, Jensen A, Hogdall C, Lundvall L, Engelholm SA, Brown B, Flanagan JM, Metcalf MD, Siddiqui N, Sellers T, Fridley B, Cunningham J, Schildkraut JM, Iversen E, Weber RP, Brennan D, Berchuck A, Pharoah P, Harnett P, Norris MD, Haber M, Goode EL, Lee JS, Khanna KK, Meyer KB, Chenevix-Trench G, deFazio A, Edwards SL, MacGregor S, Ovarian Cancer Association Consortium., Free PMC Article | 12/24/2016 |
| PSIP1 likely plays an important role in Hereditary Hearing Loss. | PSIP1/LEDGF: a new gene likely involved in sensorineural progressive hearing loss.
Girotto G, Scheffer DI, Morgan A, Vozzi D, Rubinato E, Di Stazio M, Muzzi E, Pensiero S, Giersch AB, Corey DP, Gasparini P., Free PMC Article | 12/17/2016 |
| LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer | LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer.
Basu A, Cajigas-Du Ross CK, Rios-Colon L, Mediavilla-Varela M, Daniels-Wells TR, Leoh LS, Rojas H, Banerjee H, Martinez SR, Acevedo-Martinez S, Casiano CA., Free PMC Article | 07/16/2016 |
| common LEDGF/p75 interaction interface shared by JPO2, PogZ, MLL1, IWS1 and HIV IN | Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.
Tesina P, Čermáková K, Hořejší M, Procházková K, Fábry M, Sharma S, Christ F, Demeulemeester J, Debyser Z, Rijck J, Veverka V, Řezáčová P. | 05/14/2016 |
| Results show that these antibodies are highly specific for dense fine speckles 70 protein DFS70/LEDGFp75 and do not target methyl CpG binding protein 2 (MeCP2). | Specificity of antinuclear autoantibodies recognizing the dense fine speckled nuclear pattern: Preferential targeting of DFS70/LEDGFp75 over its interacting partner MeCP2.
Basu A, Woods-Burnham L, Ortiz G, Rios-Colon L, Figueroa J, Albesa R, Andrade LE, Mahler M, Casiano CA., Free PMC Article | 03/19/2016 |