| The clinical significance and diagnostic value of serum Dickkopf1 and CKAP4 levels in patients with gastric cancer: a prospective study. | The clinical significance and diagnostic value of serum Dickkopf1 and CKAP4 levels in patients with gastric cancer: a prospective study.
Peksöz R, Dişçi E, Laloğlu E, Yıldırım M, Ağırman E, Hannarici Z, Atamanalp SS. | 11/7/2023 |
| Expression of cytoskeleton-associated protein 4 is associated with poor prognosis and metastasis in nasopharyngeal carcinoma. | Expression of cytoskeleton-associated protein 4 is associated with poor prognosis and metastasis in nasopharyngeal carcinoma.
Cai M, Wu W, Deng S, Yang Q, Wu H, Wang H, Zhang J, Feng Q, Shao J, Zeng Y, Li J., Free PMC Article | 10/11/2023 |
| Cytoskeleton-associated protein 4 (CKAP4) promotes malignant progression of human gliomas through inhibition of the Hippo signaling pathway. | Cytoskeleton-associated protein 4 (CKAP4) promotes malignant progression of human gliomas through inhibition of the Hippo signaling pathway.
Luo T, Ding K, Ji J, Zhang X, Yang X, Chen A, Huang B, Zhang D, Wang J, Li X. | 02/5/2022 |
| Plasmalemma vesicle-associated protein promotes angiogenesis in cholangiocarcinoma via the DKK1/CKAP4/PI3K signaling pathway. | Plasmalemma vesicle-associated protein promotes angiogenesis in cholangiocarcinoma via the DKK1/CKAP4/PI3K signaling pathway.
Wang Y, Yu H, Xie X, Deng T, Ye L, Wu L, Ding X, Yang Z, Zhu Q, Li J, Zheng Y, Yu Z, Chen G. | 12/25/2021 |
| DKK1 activates noncanonical NF-kappaB signaling via IL-6-induced CKAP4 receptor in multiple myeloma. | DKK1 activates noncanonical NF-κB signaling via IL-6-induced CKAP4 receptor in multiple myeloma.
Li X, Wang J, Zhu S, Zheng J, Xie Y, Jiang H, Guo J, Wang Y, Peng Z, Wang M, Wang J, Wang S, Zhong Y, Liu Z., Free PMC Article | 11/6/2021 |
| Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER-mitochondria contact sites. | Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER-mitochondria contact sites.
Harada T, Sada R, Osugi Y, Matsumoto S, Matsuda T, Hayashi-Nishino M, Nagai T, Harada A, Kikuchi A. | 07/3/2021 |
| The RBP1-CKAP4 axis activates oncogenic autophagy and promotes cancer progression in oral squamous cell carcinoma. | The RBP1-CKAP4 axis activates oncogenic autophagy and promotes cancer progression in oral squamous cell carcinoma.
Gao L, Wang Q, Ren W, Zheng J, Li S, Dou Z, Kong X, Liang X, Zhi K., Free PMC Article | 03/20/2021 |
| p63 overexpression in the epidermis of spiny keratoderma. | p63 overexpression in the epidermis of spiny keratoderma.
Widyasaputra MT, Ogawa E, Saiki M, Kiniwa Y, Okuyama R. | 09/26/2020 |
| Dynamic palmitoylation controls the microdomain localization of the DKK1 receptors CKAP4 and LRP6. | Dynamic palmitoylation controls the microdomain localization of the DKK1 receptors CKAP4 and LRP6.
Sada R, Kimura H, Fukata Y, Fukata M, Yamamoto H, Kikuchi A. | 08/22/2020 |
| CKAP4 was secreted with small extracellular vesicles (SEVs) from pancreatic ductal adenocarcinoma (PDAC) cells, and the SEVs exhibited the characteristics of exosomes. The secretion of CKAP4-containing exosomes was mediated by DKK1-dependent endocytosis routes and required exosome biogenesis molecules. The serum CKAP4 levels were higher in patients with PDAC than healthy control individuals. | CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy.
Kimura H, Yamamoto H, Harada T, Fumoto K, Osugi Y, Sada R, Maehara N, Hikita H, Mori S, Eguchi H, Ikawa M, Takehara T, Kikuchi A. | 05/30/2020 |
| High-speed (40 ms/frame) live cell STED imaging shows that RTN4a and CLIMP-63 regulate dynamic nanoscale lumenal compartmentalization along peripheral ER tubules. RTN4a enhances and CLIMP-63 disrupts the local accumulation of lumenal ERmoxGFP at spatially defined sites along ER tubules. | Reticulon and CLIMP-63 regulate nanodomain organization of peripheral ER tubules.
Gao G, Zhu C, Liu E, Nabi IR., Free PMC Article | 02/29/2020 |
| Study showed that CKAP4 is involved in the regulation of cell adhesion sites and migration through the recycling of alpha5beta1 integrin independently of DKK1. | CKAP4 Regulates Cell Migration via the Interaction with and Recycling of Integrin.
Osugi Y, Fumoto K, Kikuchi A., Free PMC Article | 02/5/2020 |
| CKAP4 has a role in esophageal cancer cell proliferation through p63 dependent DKK3 expression | p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4.
Kajiwara C, Fumoto K, Kimura H, Nojima S, Asano K, Odagiri K, Yamasaki M, Hikita H, Takehara T, Doki Y, Morii E, Kikuchi A. | 10/12/2019 |
| High CKAP4 expression is associated with Lung Cancer. | Cytoskeleton-Associated Protein 4 Is a Novel Serodiagnostic Marker for Lung Cancer.
Yanagita K, Nagashio R, Jiang SX, Kuchitsu Y, Hachimura K, Ichinoe M, Igawa S, Fukuda E, Goshima N, Satoh Y, Murakumo Y, Saegusa M, Sato Y. | 07/6/2019 |
| These findings support SENCR as a flow-responsive lncRNA that promotes EC adherens junction integrity through physical association with CKAP4, thereby stabilizing cell membrane-bound CDH5. | SENCR stabilizes vascular endothelial cell adherens junctions through interaction with CKAP4.
Lyu Q, Xu S, Lyu Y, Choi M, Christie CK, Slivano OJ, Rahman A, Jin ZG, Long X, Xu Y, Miano JM., Free PMC Article | 03/16/2019 |
| The findings suggest that the DKK1-CKAP4 pathway promotes esophageal squamous cell carcinoma cell proliferation and that CKAP4 might represent a novel therapeutic target for esophageal squamous cell carcinomas expressing both DKK1 and CKAP4. | Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug.
Shinno N, Kimura H, Sada R, Takiguchi S, Mori M, Fumoto K, Doki Y, Kikuchi A. | 03/9/2019 |
| Both DKK1 and CKAP4 are frequently expressed in pancreatic and lung tumours, and their simultaneous expression is negatively correlated with prognosis. | The Dickkopf1-cytoskeleton-associated protein 4 axis creates a novel signalling pathway and may represent a molecular target for cancer therapy.
Kikuchi A, Fumoto K, Kimura H., Free PMC Article | 07/21/2018 |
| CKAP4 has a role as a Dickkopf1 receptor and in pancreatic and lung tumor progression | CKAP4 is a Dickkopf1 receptor and is involved in tumor progression.
Kimura H, Fumoto K, Shojima K, Nojima S, Osugi Y, Tomihara H, Eguchi H, Shintani Y, Endo H, Inoue M, Doki Y, Okumura M, Morii E, Kikuchi A., Free PMC Article | 09/30/2017 |
| Human Prostate Basal cell hyperplasia is an expansion of p63. | Molecular pathogenesis of human prostate basal cell hyperplasia.
Henry G, Malewska A, Mauck R, Gahan J, Hutchinson R, Torrealba J, Francis F, Roehrborn C, Strand D., Free PMC Article | 09/23/2017 |
| APF binds specifically to sites within the cytoskeleton-associated protein 4 (CKAP4) extracellular domain | Antiproliferative factor (APF) binds specifically to sites within the cytoskeleton-associated protein 4 (CKAP4) extracellular domain.
Chavda B, Ling J, Majernick T, Planey SL., Free PMC Article | 09/16/2017 |
| CLIMP-63 (also known as CKAP4), is the partner of triadin, is responsible for this association of triads and microtubules. | Triadin and CLIMP-63 form a link between triads and microtubules in muscle cells.
Osseni A, Sébastien M, Sarrault O, Baudet M, Couté Y, Fauré J, Fourest-Lieuvin A, Marty I. | 08/5/2017 |
| The still rudimentary information of how CLIMP-63 fulfills these different roles, what these are exactly and how post-translational modifications control them, will be discussed. | How many lives does CLIMP-63 have?
Sandoz PA, van der Goot FG., Free PMC Article | 01/2/2016 |
| Although VIMP can interact with CLIMP-63 and Syn5L, it does not interact with MT-binding ER proteins (such as Reep1) that shape the tubular smooth ER | Valosin-containing protein-interacting membrane protein (VIMP) links the endoplasmic reticulum with microtubules in concert with cytoskeleton-linking membrane protein (CLIMP)-63.
Noda C, Kimura H, Arasaki K, Matsushita M, Yamamoto A, Wakana Y, Inoue H, Tagaya M., Free PMC Article | 01/24/2015 |
| revealed that CKAP4 could associate with EGFR at basal status and the complex was reduced upon EGF stimulation, leading to release EGFR into cytoplasm | CKAP4 inhibited growth and metastasis of hepatocellular carcinoma through regulating EGFR signaling.
Li SX, Liu LJ, Dong LW, Shi HG, Pan YF, Tan YX, Zhang J, Zhang B, Ding ZW, Jiang TY, Hu HP, Wang HY. | 01/17/2015 |
| Single nucleotide polymorphisms in p63 are implicated in the etiology of nonsyndromic bladder-exstrophy-epispadias complex. | Candidate gene association study implicates p63 in the etiology of nonsyndromic bladder-exstrophy-epispadias complex.
Qi L, Wang M, Yagnik G, Mattheisen M, Gearhart JP, Lakshmanan Y, Ebert AK, Rösch W, Ludwig M, Draaken M, Reutter H, Boyadjiev SA. | 08/9/2014 |