| Deubiquitinating Enzyme USP19 Regulates Ferroptosis and Mitochondrial Damage in SH-SY5Y Cells by Targeting the NOX4 Protein. | Deubiquitinating Enzyme USP19 Regulates Ferroptosis and Mitochondrial Damage in SH-SY5Y Cells by Targeting the NOX4 Protein.
Yu W, Zhuang S, Zhan M, Chen Y, Zhang J, Chen L, Tu C, Zheng L, Chen S. | 09/11/2024 |
| The deubiquitinating enzyme USP19 facilitates hepatocellular carcinoma progression through stabilizing YAP. | The deubiquitinating enzyme USP19 facilitates hepatocellular carcinoma progression through stabilizing YAP.
Tian Z, Xu C, He W, Lin Z, Zhang W, Tao K, Ding R, Zhang X, Dou K. | 11/28/2023 |
| Opposing USP19 splice variants in TGF-beta signaling and TGF-beta-induced epithelial-mesenchymal transition of breast cancer cells. | Opposing USP19 splice variants in TGF-β signaling and TGF-β-induced epithelial-mesenchymal transition of breast cancer cells.
Zhang J, van Dinther M, Thorikay M, Gourabi BM, Kruithof BPT, Ten Dijke P., Free PMC Article | 01/21/2023 |
| Dual role of deubiquitinating enzyme USP19 regulates mitotic progression and tumorigenesis by stabilizing survivin. | Dual role of deubiquitinating enzyme USP19 regulates mitotic progression and tumorigenesis by stabilizing survivin.
Chandrasekaran AP, Tyagi A, Poondla N, Sarodaya N, Karapurkar JK, Kaushal K, Park CH, Hong SH, Kim KS, Ramakrishna S., Free PMC Article | 11/12/2022 |
| Deubiquitinase USP19 extends the residual enzymatic activity of phenylalanine hydroxylase variants. | Deubiquitinase USP19 extends the residual enzymatic activity of phenylalanine hydroxylase variants.
Sarodaya N, Tyagi A, Kim HJ, Kang JS, Singh V, Hong SH, Kim WJ, Kim KS, Ramakrishna S., Free PMC Article | 09/3/2022 |
| USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites. | USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
Chai P, Cheng Y, Hou C, Yin L, Zhang D, Hu Y, Chen Q, Zheng P, Teng J, Chen J., Free PMC Article | 10/9/2021 |
| Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma. | Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma.
Hu W, Su Y, Fei X, Wang X, Zhang G, Su C, Du T, Yang T, Wang G, Tang Z, Zhang J., Free PMC Article | 10/24/2020 |
| USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth. | USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth.
Gierisch ME, Pedot G, Walser F, Lopez-Garcia LA, Jaaks P, Niggli FK, Schäfer BW., Free PMC Article | 08/15/2020 |
| BAP1 is highly positively correlated with RBM15B and USP19 expression in invasive breast carcinoma, UM, and colon adenocarcinoma | BAP1 expression is prognostic in breast and uveal melanoma but not colon cancer and is highly positively correlated with RBM15B and USP19.
Shahriyari L, Abdel-Rahman M, Cebulla C., Free PMC Article | 11/2/2019 |
| HSP90 interacts with Htt-N90 on the N-terminal amphipathic alpha-helix, and then recruits USP19 to modulate the protein level and aggregation of Htt-N90. | HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19.
He WT, Xue W, Gao YG, Hong JY, Yue HW, Jiang LL, Hu HY., Free PMC Article | 07/6/2019 |
| USP19 mRNA expression in human adipose tissue was positively correlated with the expression of important adipocyte genes in abdominal fat depots, but not subcutaneous fat depots. | The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice.
Coyne ES, Bédard N, Gong YJ, Faraj M, Tchernof A, Wing SS. | 06/8/2019 |
| USP19 modulates GR levels and in so doing may modulate both insulin and glucocorticoid signaling, two critical pathways that control protein turnover in muscle and overall glucose homeostasis. | Knockout of USP19 Deubiquitinating Enzyme Prevents Muscle Wasting by Modulating Insulin and Glucocorticoid Signaling.
Coyne ES, Bedard N, Wykes L, Stretch C, Jammoul S, Li S, Zhang K, Sladek RS, Bathe OF, Jagoe RT, Posner BI, Wing SS. | 03/2/2019 |
| USP19 is a key factor in modulating DNA damage repair by targeting HDAC1/2 K63-linked ubiquitination, cells with deletion or decreased expression of USP19 might cause genome instability and even contribute to tumorigenesis. | USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability.
Wu M, Tu HQ, Chang Y, Tan B, Wang G, Zhou J, Wang L, Mu R, Zhang WN., Free PMC Article | 03/3/2018 |
| findings establish USP19 is a negative regulator of the cellular type I IFN antiviral response to enterovirus 71 (EV71) infection; through the decrease of K63-linked polyubiquitination of TRAF3, USP19 suppresses cellular type I IFN signaling, supporting EV71 propagation in host cells | USP19 suppresses cellular type I interferon signaling by targeting TRAF3 for deubiquitination.
Gu Z, Shi W, Zhang L, Hu Z, Xu C. | 01/20/2018 |
| The regulation of CORO2A through the deubiquitinating activity of USP19 affected the transcriptional repression activity of the retinoic acid receptor (RAR), suggesting that USP19 may be involved in the regulation of RAR-mediated adipogenesis. | Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A.
Lim KH, Choi JH, Park JH, Cho HJ, Park JJ, Lee EJ, Li L, Choi YK, Baek KH., Free PMC Article | 12/30/2017 |
| HRD1 is a novel substrate for USP19. USP19 negatively regulates the ubiquitination of HRD1 and prevents it from undergoing proteasomal degradation. | USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 Ubiquitin Ligase.
Harada K, Kato M, Nakamura N., Free PMC Article | 04/8/2017 |
| USP19 positively regulates autophagy and antiviral immune responses by deubiquitinating Beclin-1. | USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1.
Jin S, Tian S, Chen Y, Zhang C, Xie W, Xia X, Cui J, Wang RF., Free PMC Article | 09/10/2016 |
| In conjunction with HSP90, the cytoplasmic USP19 may play a key role in triage decision for the disease-related polyQ-expanded substrates, suggesting a function of USP19 in quality control of misfolded proteins by regulating their protein levels | Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone.
He WT, Zheng XM, Zhang YH, Gao YG, Song AX, van der Goot FG, Hu HY., Free PMC Article | 07/16/2016 |
| Expression of USP19 correlates with that of MuRF1 and MAFbx/atrogin-1 in skeletal muscles | Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.
Bédard N, Jammoul S, Moore T, Wykes L, Hallauer PL, Hastings KE, Stretch C, Baracos V, Chevalier S, Plourde M, Coyne E, Wing SS. | 11/28/2015 |
| These results clarify the role of USP19 in ERAD and suggest a novel DUB regulation that involves chaperone association and membrane integration | Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation.
Lee JG, Kim W, Gygi S, Ye Y., Free PMC Article | 04/12/2014 |
| USP19 interacts with the ubiquitin ligases SIAH1 and SIAH2, which promote USP19 ubiquitylation and degradation by the proteasome. | An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19.
Velasco K, Zhao B, Callegari S, Altun M, Liu H, Hassink G, Masucci MG, Lindsten K. | 06/15/2013 |
| experimentally verified the targets heterogeneous nuclear ribonucleoprotein U, phosphatidylinositol-3-OH kinase, the WNK (with-no-lysine) kinase family and USP19 (ubiquitin-specific peptidase 19) as vulnerable nodes in the host cellular defence system against viruses | Viral immune modulators perturb the human molecular network by common and unique strategies.
Pichlmair A, Kandasamy K, Alvisi G, Mulhern O, Sacco R, Habjan M, Binder M, Stefanovic A, Eberle CA, Goncalves A, Bürckstümmer T, Müller AC, Fauster A, Holze C, Lindsten K, Goodbourn S, Kochs G, Weber F, Bartenschlager R, Bowie AG, Bennett KL, Colinge J, Superti-Furga G. | 11/24/2012 |
| ubiquitin-specific protease-19 (USP19) interacts with components of the hypoxia pathway including HIF-1alpha and rescues it from degradation independent of its catalytic activity | Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1α (HIF-1α) during hypoxia.
Altun M, Zhao B, Velasco K, Liu H, Hassink G, Paschke J, Pereira T, Lindsten K., Free PMC Article | 03/10/2012 |
| The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2. | The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.
Mei Y, Hahn AA, Hu S, Yang X., Free PMC Article | 12/17/2011 |
| ability of USP19 to regulate cell proliferation and p27(Kip1) levels; complete loss of USP19 function on cell growth may arise as a result of oncogenic transformation of cells. | Identification of distinctive patterns of USP19-mediated growth regulation in normal and malignant cells.
Lu Y, Bedard N, Chevalier S, Wing SS., Free PMC Article | 08/6/2011 |