| STAG2 mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia. | STAG2 mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia.
Fischer A, Hernández-Rodríguez B, Mulet-Lazaro R, Nuetzel M, Hölzl F, van Herk S, Kavelaars FG, Stanewsky H, Ackermann U, Niang AH, Diaz N, Reuschel E, Strieder N, Hernández-López I, Valk PJM, Vaquerizas JM, Rehli M, Delwel R, Gebhard C. | 10/8/2024 |
| STAG2 mutations regulate 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme. | STAG2 mutations regulate 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme.
Xu W, Kim JS, Yang T, Ya A, Sadzewicz L, Tallon L, Harris BT, Sarkaria J, Jin F, Waldman T., Free PMC Article | 07/24/2024 |
| Single-molecule imaging reveals a direct role of CTCF's zinc fingers in SA interaction and cluster-dependent RNA recruitment. | Single-molecule imaging reveals a direct role of CTCF's zinc fingers in SA interaction and cluster-dependent RNA recruitment.
Huber J, Tanasie NL, Zernia S, Stigler J., Free PMC Article | 06/24/2024 |
| STAG2: Computational Analysis of Missense Variants Involved in Disease. | STAG2: Computational Analysis of Missense Variants Involved in Disease.
Ros-Pardo D, Gómez-Puertas P, Marcos-Alcalde Í., Free PMC Article | 02/2/2024 |
| STAG2 Regulates Homologous Recombination Repair and Sensitivity to ATM Inhibition. | STAG2 Regulates Homologous Recombination Repair and Sensitivity to ATM Inhibition.
Zhou J, Nie RC, He ZP, Cai XX, Chen JW, Lin WP, Yin YX, Xiang ZC, Zhu TC, Xie JJ, Zhang YC, Wang X, Lin P, Xie D, D'Andrea AD, Cai MY., Free PMC Article | 01/4/2024 |
| Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2. | Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2.
Alonso-Gil D, Cuadrado A, Giménez-Llorente D, Rodríguez-Corsino M, Losada A., Free PMC Article | 10/26/2023 |
| STAG2 expression is associated with adverse survival outcomes and regulates cell phenotype in muscle-invasive bladder cancer. | STAG2 expression is associated with adverse survival outcomes and regulates cell phenotype in muscle-invasive bladder cancer.
Athans S, Krishnan N, Ramakrishnan S, Cortes Gomez E, Lage-Vickers S, Rak M, Kazmierczak Z, Ohm J, Attwood K, Wang J, Woloszynska A., Free PMC Article | 08/1/2023 |
| Clinical and prognostic impact of STAG2 mutations in myeloid neoplasms: the Mayo Clinic experience. | Clinical and prognostic impact of STAG2 mutations in myeloid neoplasms: the Mayo Clinic experience.
Katamesh B, Nanaa A, He R, Viswanatha D, Nguyen P, Greipp P, Bessonen K, Gangat N, Begna K, Mangaonkar A, Patnaik M, Hogan WJ, Tefferi A, Litzow M, Shah MV, Yi CA, Foran J, Badar T, Alkhateeb HB, Al-Kali A., Free PMC Article | 04/17/2023 |
| Alterations of cohesin complex genes in acute myeloid leukemia: differential co-mutations, clinical presentation and impact on outcome. | Alterations of cohesin complex genes in acute myeloid leukemia: differential co-mutations, clinical presentation and impact on outcome.
Eckardt JN, Stasik S, Röllig C, Sauer T, Scholl S, Hochhaus A, Crysandt M, Brümmendorf TH, Naumann R, Steffen B, Kunzmann V, Einsele H, Schaich M, Burchert A, Neubauer A, Schäfer-Eckart K, Schliemann C, Krause SW, Herbst R, Hänel M, Hanoun M, Kaiser U, Kaufmann M, Rácil Z, Mayer J, Cerqueira T, Kroschinsky F, Berdel WE, Serve H, Müller-Tidow C, Platzbecker U, Baldus CD, Schetelig J, Siepmann T, Bornhäuser M, Middeke JM, Thiede C., Free PMC Article | 02/4/2023 |
| Adverse prognostic impact of the loss of STAG2 protein expression in patients with newly diagnosed localised Ewing sarcoma: A report from the Children's Oncology Group. | Adverse prognostic impact of the loss of STAG2 protein expression in patients with newly diagnosed localised Ewing sarcoma: A report from the Children's Oncology Group.
Shulman DS, Chen S, Hall D, Nag A, Thorner AR, Lessnick SL, Stegmaier K, Janeway KA, DuBois SG, Krailo MD, Barkauskas DA, Church AJ, Crompton BD., Free PMC Article | 12/17/2022 |
| ASXL1 and STAG2 are common mutations in GATA2 deficiency patients with bone marrow disease and myelodysplastic syndrome. | ASXL1 and STAG2 are common mutations in GATA2 deficiency patients with bone marrow disease and myelodysplastic syndrome.
West RR, Calvo KR, Embree LJ, Wang W, Tuschong LM, Bauer TR, Tillo D, Lack J, Droll S, Hsu AP, Holland SM, Hickstein DD., Free PMC Article | 04/23/2022 |
| Modeling Down Syndrome Myeloid Leukemia by Sequential Introduction of GATA1 and STAG2 Mutations in Induced Pluripotent Stem Cells with Trisomy 21. | Modeling Down Syndrome Myeloid Leukemia by Sequential Introduction of GATA1 and STAG2 Mutations in Induced Pluripotent Stem Cells with Trisomy 21.
Barwe SP, Sebastian A, Sidhu I, Kolb EA, Gopalakrishnapillai A., Free PMC Article | 04/16/2022 |
| Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2. | Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2.
Bailey ML, Tieu D, Habsid A, Tong AHY, Chan K, Moffat J, Hieter P., Free PMC Article | 01/29/2022 |
| STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells. | STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells.
Richart L, Lapi E, Pancaldi V, Cuenca-Ardura M, Pau EC, Madrid-Mencía M, Neyret-Kahn H, Radvanyi F, Rodríguez JA, Cuartero Y, Serra F, Le Dily F, Valencia A, Marti-Renom MA, Real FX., Free PMC Article | 12/25/2021 |
| STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma. | STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma.
Adane B, Alexe G, Seong BKA, Lu D, Hwang EE, Hnisz D, Lareau CA, Ross L, Lin S, Dela Cruz FS, Richardson M, Weintraub AS, Wang S, Iniguez AB, Dharia NV, Conway AS, Robichaud AL, Tanenbaum B, Krill-Burger JM, Vazquez F, Schenone M, Berman JN, Kung AL, Carr SA, Aryee MJ, Young RA, Crompton BD, Stegmaier K., Free PMC Article | 12/18/2021 |
| STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma. | STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma.
Surdez D, Zaidi S, Grossetête S, Laud-Duval K, Ferre AS, Mous L, Vourc'h T, Tirode F, Pierron G, Raynal V, Baulande S, Brunet E, Hill V, Delattre O. | 12/18/2021 |
| BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells. | BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells.
Antony J, Gimenez G, Taylor T, Khatoon U, Day R, Morison IM, Horsfield JA., Free PMC Article | 08/14/2021 |
| Mapping the cellular origin and early evolution of leukemia in Down syndrome. | Mapping the cellular origin and early evolution of leukemia in Down syndrome.
Wagenblast E, Araújo J, Gan OI, Cutting SK, Murison A, Krivdova G, Azkanaz M, McLeod JL, Smith SA, Gratton BA, Marhon SA, Gabra M, Medeiros JJF, Manteghi S, Chen J, Chan-Seng-Yue M, Garcia-Prat L, Salmena L, De Carvalho DD, Abelson S, Abdelhaleem M, Chong K, Roifman M, Shannon P, Wang JCY, Hitzler JK, Chitayat D, Dick JE, Lechman ER. | 07/24/2021 |
| Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML. | Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML.
Smith JS, Lappin KM, Craig SG, Liberante FG, Crean CM, McDade SS, Thompson A, Mills KI, Savage KI., Free PMC Article | 07/10/2021 |
| STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers. | STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
van der Lelij P, Newman JA, Lieb S, Jude J, Katis V, Hoffmann T, Hinterndorfer M, Bader G, Kraut N, Pearson MA, Peters JM, Zuber J, Gileadi O, Petronczki M., Free PMC Article | 07/10/2021 |
| Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture. | Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture.
Cuadrado A, Losada A. | 06/19/2021 |
| Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation. | Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation.
Viny AD, Bowman RL, Liu Y, Lavallée VP, Eisman SE, Xiao W, Durham BH, Navitski A, Park J, Braunstein S, Alija B, Karzai A, Csete IS, Witkin M, Azizi E, Baslan T, Ott CJ, Pe'er D, Dekker J, Koche R, Levine RL., Free PMC Article | 09/12/2020 |
| Study provides a comprehensive review of the function of STAG1/2 in human physiology and disease and an integrative analysis of available omics data on STAG alterations in a wide array of cancers, comprising 53 691 patients and 1067 cell lines. | STAG Mutations in Cancer.
Romero-Pérez L, Surdez D, Brunet E, Delattre O, Grünewald TGP. | 08/1/2020 |
| Holoprosencephaly was associated with variants in the two X-linked cohesion complex genes, STAG2 and SMC1A. | Cohesin complex-associated holoprosencephaly.
Kruszka P, Berger SI, Casa V, Dekker MR, Gaesser J, Weiss K, Martinez AF, Murdock DR, Louie RJ, Prijoles EJ, Lichty AW, Brouwer OF, Zonneveld-Huijssoon E, Stephan MJ, Hogue J, Hu P, Tanima-Nagai M, Everson JL, Prasad C, Cereda A, Iascone M, Schreiber A, Zurcher V, Corsten-Janssen N, Escobar L, Clegg NJ, Delgado MR, Hajirnis O, Balasubramanian M, Kayserili H, Deardorff M, Poot RA, Wendt KS, Lipinski RJ, Muenke M., Free PMC Article | 05/16/2020 |
| Finding that patients with higher mutational burden are more likely to have STAG2 or TP53 alterations, both of which are negative prognostic factors in Ewing sarcoma (ES), supports the hypothesis that more aggressive subtypes of localized ES are marked by genomic instability. | Risk stratification by somatic mutation burden in Ewing sarcoma.
Liu KX, Lamba N, Hwang WL, Niemierko A, DuBois SG, Haas-Kogan DA. | 01/18/2020 |