| Distinct and overlapping RGS14 and RGS12 actions regulate NPT2A-mediated phosphate transport. | Distinct and overlapping RGS14 and RGS12 actions regulate NPT2A-mediated phosphate transport.
Sneddon WB, Ramineni S, Van Doorn GE, Hepler JR, Friedman PA. | 10/16/2024 |
| Hepatic regulator of G protein signaling 14 ameliorates NAFLD through activating cAMP-AMPK signaling by targeting Gialpha1/3. | Hepatic regulator of G protein signaling 14 ameliorates NAFLD through activating cAMP-AMPK signaling by targeting Giα1/3.
Wang J, Guo Y, He Y, Qin Y, Li X, Yang L, Liu K, Xiao L., Free PMC Article | 02/14/2024 |
| RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease. | RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease.
Montanez-Miranda C, Bramlett SN, Hepler JR., Free PMC Article | 03/1/2023 |
| RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein. | RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein.
Friedman PA, Sneddon WB, Mamonova T, Montanez-Miranda C, Ramineni S, Harbin NH, Squires KE, Gefter JV, Magyar CE, Emlet DR, Hepler JR., Free PMC Article | 06/11/2022 |
| Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. | Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons.
Squires KE, Gerber KJ, Tillman MC, Lustberg DJ, Montañez-Miranda C, Zhao M, Ramineni S, Scharer CD, Saha RN, Shu FJ, Schroeder JP, Ortlund EA, Weinshenker D, Dudek SM, Hepler JR., Free PMC Article | 08/28/2021 |
| Genetic Polymorphisms of RGS14 and Renal Stone Disease. | Genetic Polymorphisms of RGS14 and Renal Stone Disease.
Guan F, Han W, Ni T, Zhao L, Li X, Zhang B, Zhang T. | 07/3/2021 |
| The rs1256328 (ALPL) and rs12654812 (RGS14) Polymorphisms are Associated with Susceptibility to Calcium Nephrolithiasis in a Taiwanese population. | The rs1256328 (ALPL) and rs12654812 (RGS14) Polymorphisms are Associated with Susceptibility to Calcium Nephrolithiasis in a Taiwanese population.
Chen WC, Chou WH, Chu HW, Huang CC, Liu X, Chang WP, Chou YH, Chang WC., Free PMC Article | 11/21/2020 |
| We discovered 154 SNPs from five independent regions associated with FGF23 concentration. A locus strongly associated with variations in FGF23 concentration is rs11741640, within RGS14 and upstream of SLC34A1 (a gene involved in renal phosphate transport). | Genetic Variants Associated with Circulating Fibroblast Growth Factor 23.
Robinson-Cohen C, Bartz TM, Lai D, Ikizler TA, Peacock M, Imel EA, Michos ED, Foroud TM, Akesson K, Taylor KD, Malmgren L, Matsushita K, Nethander M, Eriksson J, Ohlsson C, Mellström D, Wolf M, Ljunggren O, McGuigan F, Rotter JI, Karlsson M, Econs MJ, Ix JH, Lutsey PL, Psaty BM, de Boer IH, Kestenbaum BR., Free PMC Article | 09/21/2019 |
| The findings of this study suggested new pre- and postsynaptic regulatory functions of RGS14 and RGS14 variants, specific to the primate brain, and provide evidence for unconventional roles of RGS14 in the nuclei of striatal neuron. | Regulator of G protein signaling 14 (RGS14) is expressed pre- and postsynaptically in neurons of hippocampus, basal ganglia, and amygdala of monkey and human brain.
Squires KE, Gerber KJ, Pare JF, Branch MR, Smith Y, Hepler JR., Free PMC Article | 02/23/2019 |
| Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS14 in fine-tuning TRPC4 activities. | Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o.
Jeon JP, Thakur DP, Tian JB, So I, Zhu MX., Free PMC Article | 05/20/2017 |
| The RBD region associates with the RGS domain region, producing an intramolecular interaction within RGS14 that enhances the GTPase activating function. | The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins.
Zhao P, Nunn C, Ramineni S, Hepler JR, Chidiac P., Free PMC Article | 09/6/2014 |
| RGS14 can form complexes with GPCRs in cells that are dependent on Galpha(i/o) and these RGS14.Galpha(i1).GPCR complexes may be substrates for other signaling partners such as Ric-8A | G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cells.
Vellano CP, Maher EM, Hepler JR, Blumer JB., Free PMC Article | 01/14/2012 |
| RGS-14 may facilitate cognitive processing by modulating Cav1 channel-mediated intracellular divalent calcium ion Ca(2)+ transients. | Regulator of G-protein signaling 14 protein modulates Ca²+ influx through Cav1 channels.
Martín-Montañez E, Acevedo MJ, López-Téllez JF, Duncan RS, Mateos AG, Pavía J, Koulen P, Khan ZU., Free PMC Article | 08/20/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
Wang J, Lippman SM, Lee JJ, Yang H, Khuri FR, Kim E, Lin J, Chang DW, Lotan R, Hong WK, Wu X., Free PMC Article | 09/15/2010 |
| RGS14 serves as a novel scaffold to integrate GTP-Binding Protein alpha Subunit and Ras/Raf/MAPkinase signalling events through the action of its GL domain. | RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways.
Shu FJ, Ramineni S, Hepler JR., Free PMC Article | 03/15/2010 |
| NMR 1H, 13C and 15N resonances of the RGS domain (residues 56-207) | Backbone and sidechain 1H, 13C and 15N resonance assignments of the RGS domain from human RGS14.
Dowler EF, Diehl A, Schmieder P, Brockmann C, Elkins J, Soundararajan M, Oschkinat H, Ball LJ. | 01/21/2010 |
| We show that RGS14 is a component of mitotic asters formed in vitro from HeLa cell extracts and that depletion of RGS14 from cell extracts blocks aster formation. | RGS14 is a microtubule-associated protein.
Martin-McCaffrey L, Willard FS, Pajak A, Dagnino L, Siderovski DP, D'Souza SJ. | 01/21/2010 |